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Multiple brain regions are involved in reaction to acute restraint stress in CYLD-knockout mice
Stress. 2023 Nov;26(1):2228925. doi: 10.1080/10253890.2023.2228925.ABSTRACTThe lysine 63 deubiquitinase cylindromatosis (CYLD) is expressed at high levels in the brain and is considered to be involved in anxious and depressive behavior, cognitive inflexibility, and autism disorders. Previous research was limited in some brain regions, including the hippocampus, striatum, and amygdala. To better understand whether CYLD plays a role in adaptation to stress and which brain regions are involved, we analyzed the behavior of CYLD-knockout mice in the elevated plus maze (EPM) and light-dark box test (LDT) after acute restraint st...
Source: Stress - July 3, 2023 Category: Research Authors: Yuan-Yuan Han Jian-Wen Zhou Zhi-Wei Guo Zhuo-Qing Wu Zai-Yong Zhang De-Xiang Liu Cheng Long Source Type: research