Norepinephrine Promotes Neuronal Apoptosis of Hippocampal HT22 Cells by Up-regulating the Expression of Long Non-coding RNA MALAT1
In conclusion, high level of the stress-induced hormone NE promoted apoptosis of hippocampal neurons through elevating the expression of MALAT1. Our findings provide new experimental data supporting the epigenetic mechanisms in the regulation of stress response and may provide a potential therapeutic target for stress-related cognition dysfunction.PMID:37632346 | DOI:10.1080/10253890.2023.2252905 (Source: Stress)
Source: Stress - August 26, 2023 Category: Research Authors: Ying Wang Hui Hu Yuhan Wu Yun Zhao Fang Xie Zhaowei Sun Xue Wang Lingjia Qian Source Type: research
Diverse roles of glucocorticoids in the ruminant mammary gland: modulation of mammary growth, milk production, and mastitis
Stress. 2023 Aug 26:1-30. doi: 10.1080/10253890.2023.2252938. Online ahead of print.ABSTRACTAs endocrine hormones, glucocorticoids (GCs) play a pivotal role in numerous physiological processes, including mammary growth and lactation, circulatory metabolism, and responses to external stimuli. In the dairy industry, milk production from cows or goats is important for newborns and economic benefits. However, the milk yields from ruminant animals are always affected by the extent of mammary development, mammary disease, stress, or changes in metabolism. Thus, it is necessary to clarify how GCs changes in ruminants affect rumin...
Source: Stress - August 26, 2023 Category: Research Authors: Xiaoyue Ma Hanling Liu Qianqian Jia Yumiao Zheng Wentao Li Mengyu Chang Haixia Fu Hongmei Zhu Source Type: research
Norepinephrine Promotes Neuronal Apoptosis of Hippocampal HT22 Cells by Up-regulating the Expression of Long Non-coding RNA MALAT1
In conclusion, high level of the stress-induced hormone NE promoted apoptosis of hippocampal neurons through elevating the expression of MALAT1. Our findings provide new experimental data supporting the epigenetic mechanisms in the regulation of stress response and may provide a potential therapeutic target for stress-related cognition dysfunction.PMID:37632346 | DOI:10.1080/10253890.2023.2252905 (Source: Stress)
Source: Stress - August 26, 2023 Category: Research Authors: Ying Wang Hui Hu Yuhan Wu Yun Zhao Fang Xie Zhaowei Sun Xue Wang Lingjia Qian Source Type: research
Diverse roles of glucocorticoids in the ruminant mammary gland: modulation of mammary growth, milk production, and mastitis
Stress. 2023 Aug 26:1-30. doi: 10.1080/10253890.2023.2252938. Online ahead of print.ABSTRACTAs endocrine hormones, glucocorticoids (GCs) play a pivotal role in numerous physiological processes, including mammary growth and lactation, circulatory metabolism, and responses to external stimuli. In the dairy industry, milk production from cows or goats is important for newborns and economic benefits. However, the milk yields from ruminant animals are always affected by the extent of mammary development, mammary disease, stress, or changes in metabolism. Thus, it is necessary to clarify how GCs changes in ruminants affect rumin...
Source: Stress - August 26, 2023 Category: Research Authors: Xiaoyue Ma Hanling Liu Qianqian Jia Yumiao Zheng Wentao Li Mengyu Chang Haixia Fu Hongmei Zhu Source Type: research
Early life adversity ablates sex differences in active versus passive threat responding in mice
Stress. 2023 Aug 25:1-32. doi: 10.1080/10253890.2023.2244598. Online ahead of print.ABSTRACTEarly life adversity (ELA) heightens the risk for anxiety disorders (which are characterized by heightened fear and avoidance behaviors), with females being twice as likely as males to develop pathology. Pavlovian fear conditioning tasks have been used to study possible mechanisms supporting endophenotypes of pathology. Identification of sex and ELA selective effects on the nature of behavioral responding in these paradigms may provide a unique window into coping strategies in response to learned fear to guide more mechanistic studi...
Source: Stress - August 25, 2023 Category: Research Authors: Gabriela Manzano Nieves Marilyn Bravo Kevin G Bath Source Type: research
Glucocorticoid feedback paradox: a homage to Mary Dallman
Stress. 2023 Nov;26(1):2247090. doi: 10.1080/10253890.2023.2247090.ABSTRACTAs the end product of the hypothalamus-pituitary-adrenal (HPA) axis, the glucocorticoid hormones cortisol and corticosterone coordinate circadian activities, stress-coping, and adaptation to change. For this purpose, the hormone promotes energy metabolism and controls defense reactions in the body and brain. This life-sustaining action exerted by glucocorticoids occurs in concert with the autonomic nervous and immune systems, transmitters, growth factors/cytokines, and neuropeptides. The current contribution will focus on the glucocorticoid feedback...
Source: Stress - August 17, 2023 Category: Research Authors: Edo Ronald de Kloet Source Type: research
GLUCOCORTICOID FEEDBACK PARADOX a homage to Mary Dallman
Stress. 2023 Aug 17:1-35. doi: 10.1080/10253890.2023.2247090. Online ahead of print.ABSTRACTAs the end product of the hypothalamus-pituitary-adrenal (HPA) axis, the glucocorticoid hormones cortisol and corticosterone coordinate circadian activities, stress-coping, and adaptation to change. For this purpose, the hormone promotes energy metabolism and controls defense reactions in the body and brain. This life-sustaining action exerted by glucocorticoids occurs in concert with the autonomic nervous and immune systems, transmitters, growth factors/cytokines, and neuropeptides. The current contribution will focus on the glucoc...
Source: Stress - August 17, 2023 Category: Research Authors: Edo Ronald de Kloet Source Type: research
Female rats are more responsive than are males to the protective effects of voluntary physical activity against the behavioral consequences of inescapable stress
Stress. 2023 Aug 7:1-14. doi: 10.1080/10253890.2023.2245492. Online ahead of print.ABSTRACTCommon stress-related mental health disorders affect women more than men. Physical activity can provide protection against the development of future stress-related mental health disorders (i.e., stress resistance) in both sexes, but whether there are sex differences in exercise-induced stress resistance is unknown. We have previously observed that voluntary wheel running (VWR) protects both female and male rats against the anxiety- and exaggerated fear-like behavioral effects of inescapable stress, but the time-course and magnitude o...
Source: Stress - August 7, 2023 Category: Research Authors: Margaret K Tanner Alyssa A Hohorst Simone M Mellert Esteban C Loetz Michael V Baratta Benjamin N Greenwood Source Type: research
