Voluntary alcohol consumption during distinct phases of adolescence differentially alters adult fear acquisition, extinction and renewal in male and female rats
Stress. 2023 Nov;26(1):2278315. doi: 10.1080/10253890.2023.2278315. Epub 2023 Nov 5.ABSTRACTAlcohol use during adolescence coincides with elevated risks of stress-related impairment in adults, particularly via disrupted developmental trajectories of vulnerable corticolimbic and mesolimbic systems involved in fear processing. Prior work has investigated the impact of binge-like alcohol consumption on adult fear and stress, but less is known about whether voluntarily consumed alcohol imparts differential effects based on adolescence phases and biological sex. Here, adolescent male and female Long Evans rats were granted dail...
Source: Stress - November 2, 2023 Category: Research Authors: J Alex Grizzell Maryam Vanbaelinghem Jessica Westerman Michael P Saddoris Source Type: research
