Dysregulated NUB1 and neddylation enhances rheumatoid arthritis fibroblast ‐like synoviocyte inflammatory responses

ConclusionCUL1 neddylation andNUB1 induction is dysregulated in RA, which increases FLS activation. Inhibition of neddylation is an effective therapy in an animal model of arthritis. These data suggest that neddylation system contributes to the pathogenesis of RA and that regulation of neddylation could be a novel therapeutic approach.

Source: Arthritis and Rheumatology - April 3, 2024 Category: Rheumatology Authors: Sho Sendo, Camilla R. L. Machado, David L Boyle, Robert J. Benschop, Narayanan B. Perumal, Eunice Choi, Wei Wang, Gary S Firestein Tags: Full Length Source Type: research