Vitronectin promotes insulin resistance in trophoblast cells by activating JNK in gestational diabetes mellitus
Cell Biol Int. 2024 Apr 23. doi: 10.1002/cbin.12167. Online ahead of print.ABSTRACTGestational diabetes mellitus (GDM) is a common disorder in the clinic, which may lead to severe detrimental outcomes both for mothers and infants. However, the underlying mechanisms for GDM are still not clear. In the present study, we performed label-free proteomics using placentas from GDM patients and normal controls. Vitronectin caused our attention among differentially expressed proteins due to its potential role in the pathological progression of GDM. Vitronectin was increased in the placentas of GDM patients, which was confirmed by W...
Source: Cell Biology International - April 24, 2024 Category: Cytology Authors: Yuejun Ju Ting Shen Zhanhong Guo Yinghong Kong Yun Huang Ji Hu Source Type: research
PAI-1 transfected-conditioned media promotes osteogenic differentiation of hBMSCs
In conclusion, results demonstrate that P-CM treatment significantly enhanced the osteogenic differantiation efficiency and new bone formation, thus could be used as an ideal therapeutic biomolecule for constructing bone-specific implants, especially for orthopedic and dental applications.PMID:38654436 | DOI:10.1002/cbin.12166 (Source: Cell Biology International)
Source: Cell Biology International - April 24, 2024 Category: Cytology Authors: Zhang Li Hou Kegui Wang Piao Wang Xuejiu Ki-Taek Lim Hexiu Jin Source Type: research
Expression and localization of apelin and apelin receptor protein in the oviduct of letrozole-induced hyperandrogenized mice
In conclusion, hyperandrogenized conditions could also impair the gamete transport and fertilization process due to apoptosis in the oviduct. However, further study would be required to unravel the exact role of apelin signaling in the oviduct in relation to apoptosis.PMID:38634302 | DOI:10.1002/cbin.12164 (Source: Cell Biology International)
Source: Cell Biology International - April 18, 2024 Category: Cytology Authors: Ayushmita Dutta Borgohain Anima Preethi Riba Guruswami Gurusubramanian Vikas Kumar Roy Source Type: research
Expression and localization of apelin and apelin receptor protein in the oviduct of letrozole-induced hyperandrogenized mice
In conclusion, hyperandrogenized conditions could also impair the gamete transport and fertilization process due to apoptosis in the oviduct. However, further study would be required to unravel the exact role of apelin signaling in the oviduct in relation to apoptosis.PMID:38634302 | DOI:10.1002/cbin.12164 (Source: Cell Biology International)
Source: Cell Biology International - April 18, 2024 Category: Cytology Authors: Ayushmita Dutta Borgohain Anima Preethi Riba Guruswami Gurusubramanian Vikas Kumar Roy Source Type: research
Expression and localization of apelin and apelin receptor protein in the oviduct of letrozole-induced hyperandrogenized mice
In conclusion, hyperandrogenized conditions could also impair the gamete transport and fertilization process due to apoptosis in the oviduct. However, further study would be required to unravel the exact role of apelin signaling in the oviduct in relation to apoptosis.PMID:38634302 | DOI:10.1002/cbin.12164 (Source: Cell Biology International)
Source: Cell Biology International - April 18, 2024 Category: Cytology Authors: Ayushmita Dutta Borgohain Anima Preethi Riba Guruswami Gurusubramanian Vikas Kumar Roy Source Type: research
BMP7-induced osteoblast differentiation requires hedgehog signaling and involves nuclear mechanisms of gene expression control
In conclusion, this study highlights the positive impact of epigenetic control on the expression of genes related to hedgehog signaling during the morphogenetic changes induced by BMP7 signaling in osteoblasts.PMID:38591759 | DOI:10.1002/cbin.12161 (Source: Cell Biology International)
Source: Cell Biology International - April 9, 2024 Category: Cytology Authors: Georgia da Silva Feltran Amanda Fantini de Andrade C élio Jr da C Fernandes Rodrigo A Foganholi da Silva Willian F Zambuzzi Source Type: research
Effects of syndecan-4 silencing on the extracellular matrix remodeling in anoikis-resistant endothelial cells
In conclusion, these data demonstrate that SDC4 plays an important role in ECM remodeling. In addition, our findings represent an important step toward understanding the mechanism by which SDC4 can reverse the transformed phenotype of anoikis-resistant endothelial cells.PMID:38591778 | DOI:10.1002/cbin.12158 (Source: Cell Biology International)
Source: Cell Biology International - April 9, 2024 Category: Cytology Authors: Jessica Oyie Sousa Onyeisi Helena Bonciani Nader Carla Cristina Lopes Source Type: research
BMP7-induced osteoblast differentiation requires hedgehog signaling and involves nuclear mechanisms of gene expression control
In conclusion, this study highlights the positive impact of epigenetic control on the expression of genes related to hedgehog signaling during the morphogenetic changes induced by BMP7 signaling in osteoblasts.PMID:38591759 | DOI:10.1002/cbin.12161 (Source: Cell Biology International)
Source: Cell Biology International - April 9, 2024 Category: Cytology Authors: Georgia da Silva Feltran Amanda Fantini de Andrade C élio Jr da C Fernandes Rodrigo A Foganholi da Silva Willian F Zambuzzi Source Type: research
Effects of syndecan-4 silencing on the extracellular matrix remodeling in anoikis-resistant endothelial cells
In conclusion, these data demonstrate that SDC4 plays an important role in ECM remodeling. In addition, our findings represent an important step toward understanding the mechanism by which SDC4 can reverse the transformed phenotype of anoikis-resistant endothelial cells.PMID:38591778 | DOI:10.1002/cbin.12158 (Source: Cell Biology International)
Source: Cell Biology International - April 9, 2024 Category: Cytology Authors: Jessica Oyie Sousa Onyeisi Helena Bonciani Nader Carla Cristina Lopes Source Type: research
BMP7-induced osteoblast differentiation requires hedgehog signaling and involves nuclear mechanisms of gene expression control
In conclusion, this study highlights the positive impact of epigenetic control on the expression of genes related to hedgehog signaling during the morphogenetic changes induced by BMP7 signaling in osteoblasts.PMID:38591759 | DOI:10.1002/cbin.12161 (Source: Cell Biology International)
Source: Cell Biology International - April 9, 2024 Category: Cytology Authors: Georgia da Silva Feltran Amanda Fantini de Andrade C élio Jr da C Fernandes Rodrigo A Foganholi da Silva Willian F Zambuzzi Source Type: research
Effects of syndecan-4 silencing on the extracellular matrix remodeling in anoikis-resistant endothelial cells
In conclusion, these data demonstrate that SDC4 plays an important role in ECM remodeling. In addition, our findings represent an important step toward understanding the mechanism by which SDC4 can reverse the transformed phenotype of anoikis-resistant endothelial cells.PMID:38591778 | DOI:10.1002/cbin.12158 (Source: Cell Biology International)
Source: Cell Biology International - April 9, 2024 Category: Cytology Authors: Jessica Oyie Sousa Onyeisi Helena Bonciani Nader Carla Cristina Lopes Source Type: research
BMP7-induced osteoblast differentiation requires hedgehog signaling and involves nuclear mechanisms of gene expression control
In conclusion, this study highlights the positive impact of epigenetic control on the expression of genes related to hedgehog signaling during the morphogenetic changes induced by BMP7 signaling in osteoblasts.PMID:38591759 | DOI:10.1002/cbin.12161 (Source: Cell Biology International)
Source: Cell Biology International - April 9, 2024 Category: Cytology Authors: Georgia da Silva Feltran Amanda Fantini de Andrade C élio Jr da C Fernandes Rodrigo A Foganholi da Silva Willian F Zambuzzi Source Type: research
Effects of syndecan-4 silencing on the extracellular matrix remodeling in anoikis-resistant endothelial cells
In conclusion, these data demonstrate that SDC4 plays an important role in ECM remodeling. In addition, our findings represent an important step toward understanding the mechanism by which SDC4 can reverse the transformed phenotype of anoikis-resistant endothelial cells.PMID:38591778 | DOI:10.1002/cbin.12158 (Source: Cell Biology International)
Source: Cell Biology International - April 9, 2024 Category: Cytology Authors: Jessica Oyie Sousa Onyeisi Helena Bonciani Nader Carla Cristina Lopes Source Type: research
BMP7-induced osteoblast differentiation requires hedgehog signaling and involves nuclear mechanisms of gene expression control
In conclusion, this study highlights the positive impact of epigenetic control on the expression of genes related to hedgehog signaling during the morphogenetic changes induced by BMP7 signaling in osteoblasts.PMID:38591759 | DOI:10.1002/cbin.12161 (Source: Cell Biology International)
Source: Cell Biology International - April 9, 2024 Category: Cytology Authors: Georgia da Silva Feltran Amanda Fantini de Andrade C élio Jr da C Fernandes Rodrigo A Foganholi da Silva Willian F Zambuzzi Source Type: research
Effects of syndecan-4 silencing on the extracellular matrix remodeling in anoikis-resistant endothelial cells
In conclusion, these data demonstrate that SDC4 plays an important role in ECM remodeling. In addition, our findings represent an important step toward understanding the mechanism by which SDC4 can reverse the transformed phenotype of anoikis-resistant endothelial cells.PMID:38591778 | DOI:10.1002/cbin.12158 (Source: Cell Biology International)
Source: Cell Biology International - April 9, 2024 Category: Cytology Authors: Jessica Oyie Sousa Onyeisi Helena Bonciani Nader Carla Cristina Lopes Source Type: research
