Isolation and propagation of bovine blood-derived macrophages using a mixed culture with bovine endothelial B46 cells
In conclusion, this study provides a simple and efficient protocol for the isolation and propagation of BBMs using a primary mixed culture of bovine whole blood with B46 feeder cells. Isolated BBMs are expected to be useful for developing in vitro models for studying the interactions between bovine pathogens and host immune cells.PMID:37920877 | DOI:10.1002/cbin.12102 (Source: Cell Biology International)
Source: Cell Biology International - November 3, 2023 Category: Cytology Authors: Kanae Hiramatsu Rina Ikeda Satoko Kawaji Yuichi Ueno Reiko Nagata Ken-Go Hayashi Kosuke Iga Miyako Yoshioka Takato Takenouchi Source Type: research
Panax quinquefolium saponins attenuates microglia activation following acute cerebral ischemia-reperfusion injury via Nrf2/miR-103-3p/TANK pathway
In conclusion, our study not only revealed the new mechanism of PQS in protecting against the inflammatory activation of microglia cells caused by cerebral ischemia-reperfusion injury, but also suggested that Nrf2 is a potential target for development of new drugs of ischemic stroke. More importantly, our study also reminded that miR-103-3p might be used as a prognostic biomarker for patients with ischemic stroke.PMID:37885132 | DOI:10.1002/cbin.12100 (Source: Cell Biology International)
Source: Cell Biology International - October 27, 2023 Category: Cytology Authors: Xuesong Bai Yan Qiu Jian Wang Yafen Dong Tao Zhang Hui Jin Source Type: research
Neosetophomone B induces apoptosis in multiple myeloma cells via targeting of AKT/SKP2 signaling pathway
Cell Biol Int. 2023 Oct 26. doi: 10.1002/cbin.12101. Online ahead of print.ABSTRACTMultiple myeloma (MM) is a hematologic malignancy associated with malignant plasma cell proliferation in the bone marrow. Despite the available treatments, drug resistance and adverse side effects pose significant challenges, underscoring the need for alternative therapeutic strategies. Natural products, like the fungal metabolite neosetophomone B (NSP-B), have emerged as potential therapeutic agents due to their bioactive properties. Our study investigated NSP-B's antitumor effects on MM cell lines (U266 and RPMI8226) and the involved molec...
Source: Cell Biology International - October 27, 2023 Category: Cytology Authors: Shilpa Kuttikrishnan Fareed Ahmad Jericha M Mateo Kirti S Prabhu Tamam El-Elimat Nicholas H Oberlies Cedric J Pearce Ammira S Alshabeeb Akil Ajaz A Bhat Feras Q Alali Shahab Uddin Source Type: research
Panax quinquefolium saponins attenuates microglia activation following acute cerebral ischemia-reperfusion injury via Nrf2/miR-103-3p/TANK pathway
In conclusion, our study not only revealed the new mechanism of PQS in protecting against the inflammatory activation of microglia cells caused by cerebral ischemia-reperfusion injury, but also suggested that Nrf2 is a potential target for development of new drugs of ischemic stroke. More importantly, our study also reminded that miR-103-3p might be used as a prognostic biomarker for patients with ischemic stroke.PMID:37885132 | DOI:10.1002/cbin.12100 (Source: Cell Biology International)
Source: Cell Biology International - October 27, 2023 Category: Cytology Authors: Xuesong Bai Yan Qiu Jian Wang Yafen Dong Tao Zhang Hui Jin Source Type: research
Neosetophomone B induces apoptosis in multiple myeloma cells via targeting of AKT/SKP2 signaling pathway
Cell Biol Int. 2023 Oct 26. doi: 10.1002/cbin.12101. Online ahead of print.ABSTRACTMultiple myeloma (MM) is a hematologic malignancy associated with malignant plasma cell proliferation in the bone marrow. Despite the available treatments, drug resistance and adverse side effects pose significant challenges, underscoring the need for alternative therapeutic strategies. Natural products, like the fungal metabolite neosetophomone B (NSP-B), have emerged as potential therapeutic agents due to their bioactive properties. Our study investigated NSP-B's antitumor effects on MM cell lines (U266 and RPMI8226) and the involved molec...
Source: Cell Biology International - October 27, 2023 Category: Cytology Authors: Shilpa Kuttikrishnan Fareed Ahmad Jericha M Mateo Kirti S Prabhu Tamam El-Elimat Nicholas H Oberlies Cedric J Pearce Ammira S Alshabeeb Akil Ajaz A Bhat Feras Q Alali Shahab Uddin Source Type: research
Panax quinquefolium saponins attenuates microglia activation following acute cerebral ischemia-reperfusion injury via Nrf2/miR-103-3p/TANK pathway
In conclusion, our study not only revealed the new mechanism of PQS in protecting against the inflammatory activation of microglia cells caused by cerebral ischemia-reperfusion injury, but also suggested that Nrf2 is a potential target for development of new drugs of ischemic stroke. More importantly, our study also reminded that miR-103-3p might be used as a prognostic biomarker for patients with ischemic stroke.PMID:37885132 | DOI:10.1002/cbin.12100 (Source: Cell Biology International)
Source: Cell Biology International - October 27, 2023 Category: Cytology Authors: Xuesong Bai Yan Qiu Jian Wang Yafen Dong Tao Zhang Hui Jin Source Type: research
Neosetophomone B induces apoptosis in multiple myeloma cells via targeting of AKT/SKP2 signaling pathway
Cell Biol Int. 2023 Oct 26. doi: 10.1002/cbin.12101. Online ahead of print.ABSTRACTMultiple myeloma (MM) is a hematologic malignancy associated with malignant plasma cell proliferation in the bone marrow. Despite the available treatments, drug resistance and adverse side effects pose significant challenges, underscoring the need for alternative therapeutic strategies. Natural products, like the fungal metabolite neosetophomone B (NSP-B), have emerged as potential therapeutic agents due to their bioactive properties. Our study investigated NSP-B's antitumor effects on MM cell lines (U266 and RPMI8226) and the involved molec...
Source: Cell Biology International - October 27, 2023 Category: Cytology Authors: Shilpa Kuttikrishnan Fareed Ahmad Jericha M Mateo Kirti S Prabhu Tamam El-Elimat Nicholas H Oberlies Cedric J Pearce Ammira S Alshabeeb Akil Ajaz A Bhat Feras Q Alali Shahab Uddin Source Type: research
Panax quinquefolium saponins attenuates microglia activation following acute cerebral ischemia-reperfusion injury via Nrf2/miR-103-3p/TANK pathway
In conclusion, our study not only revealed the new mechanism of PQS in protecting against the inflammatory activation of microglia cells caused by cerebral ischemia-reperfusion injury, but also suggested that Nrf2 is a potential target for development of new drugs of ischemic stroke. More importantly, our study also reminded that miR-103-3p might be used as a prognostic biomarker for patients with ischemic stroke.PMID:37885132 | DOI:10.1002/cbin.12100 (Source: Cell Biology International)
Source: Cell Biology International - October 27, 2023 Category: Cytology Authors: Xuesong Bai Yan Qiu Jian Wang Yafen Dong Tao Zhang Hui Jin Source Type: research
Neosetophomone B induces apoptosis in multiple myeloma cells via targeting of AKT/SKP2 signaling pathway
Cell Biol Int. 2023 Oct 26. doi: 10.1002/cbin.12101. Online ahead of print.ABSTRACTMultiple myeloma (MM) is a hematologic malignancy associated with malignant plasma cell proliferation in the bone marrow. Despite the available treatments, drug resistance and adverse side effects pose significant challenges, underscoring the need for alternative therapeutic strategies. Natural products, like the fungal metabolite neosetophomone B (NSP-B), have emerged as potential therapeutic agents due to their bioactive properties. Our study investigated NSP-B's antitumor effects on MM cell lines (U266 and RPMI8226) and the involved molec...
Source: Cell Biology International - October 27, 2023 Category: Cytology Authors: Shilpa Kuttikrishnan Fareed Ahmad Jericha M Mateo Kirti S Prabhu Tamam El-Elimat Nicholas H Oberlies Cedric J Pearce Ammira S Alshabeeb Akil Ajaz A Bhat Feras Q Alali Shahab Uddin Source Type: research
Panax quinquefolium saponins attenuates microglia activation following acute cerebral ischemia-reperfusion injury via Nrf2/miR-103-3p/TANK pathway
In conclusion, our study not only revealed the new mechanism of PQS in protecting against the inflammatory activation of microglia cells caused by cerebral ischemia-reperfusion injury, but also suggested that Nrf2 is a potential target for development of new drugs of ischemic stroke. More importantly, our study also reminded that miR-103-3p might be used as a prognostic biomarker for patients with ischemic stroke.PMID:37885132 | DOI:10.1002/cbin.12100 (Source: Cell Biology International)
Source: Cell Biology International - October 27, 2023 Category: Cytology Authors: Xuesong Bai Yan Qiu Jian Wang Yafen Dong Tao Zhang Hui Jin Source Type: research
Neosetophomone B induces apoptosis in multiple myeloma cells via targeting of AKT/SKP2 signaling pathway
Cell Biol Int. 2023 Oct 26. doi: 10.1002/cbin.12101. Online ahead of print.ABSTRACTMultiple myeloma (MM) is a hematologic malignancy associated with malignant plasma cell proliferation in the bone marrow. Despite the available treatments, drug resistance and adverse side effects pose significant challenges, underscoring the need for alternative therapeutic strategies. Natural products, like the fungal metabolite neosetophomone B (NSP-B), have emerged as potential therapeutic agents due to their bioactive properties. Our study investigated NSP-B's antitumor effects on MM cell lines (U266 and RPMI8226) and the involved molec...
Source: Cell Biology International - October 27, 2023 Category: Cytology Authors: Shilpa Kuttikrishnan Fareed Ahmad Jericha M Mateo Kirti S Prabhu Tamam El-Elimat Nicholas H Oberlies Cedric J Pearce Ammira S Alshabeeb Akil Ajaz A Bhat Feras Q Alali Shahab Uddin Source Type: research
Panax quinquefolium saponins attenuates microglia activation following acute cerebral ischemia-reperfusion injury via Nrf2/miR-103-3p/TANK pathway
In conclusion, our study not only revealed the new mechanism of PQS in protecting against the inflammatory activation of microglia cells caused by cerebral ischemia-reperfusion injury, but also suggested that Nrf2 is a potential target for development of new drugs of ischemic stroke. More importantly, our study also reminded that miR-103-3p might be used as a prognostic biomarker for patients with ischemic stroke.PMID:37885132 | DOI:10.1002/cbin.12100 (Source: Cell Biology International)
Source: Cell Biology International - October 27, 2023 Category: Cytology Authors: Xuesong Bai Yan Qiu Jian Wang Yafen Dong Tao Zhang Hui Jin Source Type: research
Neosetophomone B induces apoptosis in multiple myeloma cells via targeting of AKT/SKP2 signaling pathway
Cell Biol Int. 2023 Oct 26. doi: 10.1002/cbin.12101. Online ahead of print.ABSTRACTMultiple myeloma (MM) is a hematologic malignancy associated with malignant plasma cell proliferation in the bone marrow. Despite the available treatments, drug resistance and adverse side effects pose significant challenges, underscoring the need for alternative therapeutic strategies. Natural products, like the fungal metabolite neosetophomone B (NSP-B), have emerged as potential therapeutic agents due to their bioactive properties. Our study investigated NSP-B's antitumor effects on MM cell lines (U266 and RPMI8226) and the involved molec...
Source: Cell Biology International - October 27, 2023 Category: Cytology Authors: Shilpa Kuttikrishnan Fareed Ahmad Jericha M Mateo Kirti S Prabhu Tamam El-Elimat Nicholas H Oberlies Cedric J Pearce Ammira S Alshabeeb Akil Ajaz A Bhat Feras Q Alali Shahab Uddin Source Type: research
Multifaceted TGF- β signaling, a master regulator: From bench-to-bedside, intricacies, and complexities
Cell Biol Int. 2023 Oct 19. doi: 10.1002/cbin.12097. Online ahead of print.ABSTRACTPhysiological embryogenesis and adult tissue homeostasis are regulated by transforming growth factor-β (TGF-β), an evolutionarily conserved family of secreted polypeptide factors, acting in an autocrine and paracrine manner. The role of TGF-β in inflammation, fibrosis, and cancer is complex and sometimes even contradictory, exhibiting either inhibitory or promoting effects depending on the stage of the disease. Under pathological conditions, especially fibrosis and cancer, overexpressed TGF-β causes extracellular matrix deposition, epith...
Source: Cell Biology International - October 20, 2023 Category: Cytology Authors: Sana Ahuja Sufian Zaheer Source Type: research
Multifaceted TGF- β signaling, a master regulator: From bench-to-bedside, intricacies, and complexities
Cell Biol Int. 2023 Oct 19. doi: 10.1002/cbin.12097. Online ahead of print.ABSTRACTPhysiological embryogenesis and adult tissue homeostasis are regulated by transforming growth factor-β (TGF-β), an evolutionarily conserved family of secreted polypeptide factors, acting in an autocrine and paracrine manner. The role of TGF-β in inflammation, fibrosis, and cancer is complex and sometimes even contradictory, exhibiting either inhibitory or promoting effects depending on the stage of the disease. Under pathological conditions, especially fibrosis and cancer, overexpressed TGF-β causes extracellular matrix deposition, epith...
Source: Cell Biology International - October 20, 2023 Category: Cytology Authors: Sana Ahuja Sufian Zaheer Source Type: research
