Curcumin relieves oxaliplatin-induced neuropathic pain via reducing inflammation and activating antioxidant response
In conclusion, our findings suggest that CUR treatment inhibits GSK-3β activation, increases Nrf2 mediated antioxidant responses, inhibits oxidative damage and inflammatory reaction, and alleviates OXA-induced neuropathic pain.PMID:38480956 | DOI:10.1002/cbin.12153 (Source: Cell Biology International)
Source: Cell Biology International - March 14, 2024 Category: Cytology Authors: Meng-Wei Zhang Xu Sun Yi-Wen Xu Wei Meng Qiong Tang Hui Gao Ling Liu Shao-Hui Chen Source Type: research
Paynantheine more effectively reverses multidrug resistance in malignant EPG85.257RDB and MCF7MX cells than morphine and speciociliatine
Cell Biol Int. 2024 Mar 13. doi: 10.1002/cbin.12152. Online ahead of print.ABSTRACTThe possible interactions of morphine, paynantheine and speciociliatine alkaloids with ATP-binding cassette (ABC) transporters was investigated. The compounds were docked against ABCG2 and ABCB1 to predict the binding mode of alkaloids in active binding sites. The cytotoxicity of morphine, paynantheine and speciociliatine for EPG85.257RDB and MCF7MX cells was determined and ABCB1 and ABCG2 gene and protein expression were determined. The binding score of paynantheine to ABCB1 was higher in the docking studies. Paynantheine and speciociliatin...
Source: Cell Biology International - March 14, 2024 Category: Cytology Authors: Nayereh Abdali Mohammad Nadipour Borujeni Sayedeh Azimeh Hosseini Rahim Malekzadeh Marzieh Abolhasani Seyed Abbas Mirzaei Fatemeh Elahian Source Type: research
Curcumin relieves oxaliplatin-induced neuropathic pain via reducing inflammation and activating antioxidant response
In conclusion, our findings suggest that CUR treatment inhibits GSK-3β activation, increases Nrf2 mediated antioxidant responses, inhibits oxidative damage and inflammatory reaction, and alleviates OXA-induced neuropathic pain.PMID:38480956 | DOI:10.1002/cbin.12153 (Source: Cell Biology International)
Source: Cell Biology International - March 14, 2024 Category: Cytology Authors: Meng-Wei Zhang Xu Sun Yi-Wen Xu Wei Meng Qiong Tang Hui Gao Ling Liu Shao-Hui Chen Source Type: research
Paynantheine more effectively reverses multidrug resistance in malignant EPG85.257RDB and MCF7MX cells than morphine and speciociliatine
Cell Biol Int. 2024 Mar 13. doi: 10.1002/cbin.12152. Online ahead of print.ABSTRACTThe possible interactions of morphine, paynantheine and speciociliatine alkaloids with ATP-binding cassette (ABC) transporters was investigated. The compounds were docked against ABCG2 and ABCB1 to predict the binding mode of alkaloids in active binding sites. The cytotoxicity of morphine, paynantheine and speciociliatine for EPG85.257RDB and MCF7MX cells was determined and ABCB1 and ABCG2 gene and protein expression were determined. The binding score of paynantheine to ABCB1 was higher in the docking studies. Paynantheine and speciociliatin...
Source: Cell Biology International - March 14, 2024 Category: Cytology Authors: Nayereh Abdali Mohammad Nadipour Borujeni Sayedeh Azimeh Hosseini Rahim Malekzadeh Marzieh Abolhasani Seyed Abbas Mirzaei Fatemeh Elahian Source Type: research
Curcumin relieves oxaliplatin-induced neuropathic pain via reducing inflammation and activating antioxidant response
In conclusion, our findings suggest that CUR treatment inhibits GSK-3β activation, increases Nrf2 mediated antioxidant responses, inhibits oxidative damage and inflammatory reaction, and alleviates OXA-induced neuropathic pain.PMID:38480956 | DOI:10.1002/cbin.12153 (Source: Cell Biology International)
Source: Cell Biology International - March 14, 2024 Category: Cytology Authors: Meng-Wei Zhang Xu Sun Yi-Wen Xu Wei Meng Qiong Tang Hui Gao Ling Liu Shao-Hui Chen Source Type: research
Paynantheine more effectively reverses multidrug resistance in malignant EPG85.257RDB and MCF7MX cells than morphine and speciociliatine
Cell Biol Int. 2024 Mar 13. doi: 10.1002/cbin.12152. Online ahead of print.ABSTRACTThe possible interactions of morphine, paynantheine and speciociliatine alkaloids with ATP-binding cassette (ABC) transporters was investigated. The compounds were docked against ABCG2 and ABCB1 to predict the binding mode of alkaloids in active binding sites. The cytotoxicity of morphine, paynantheine and speciociliatine for EPG85.257RDB and MCF7MX cells was determined and ABCB1 and ABCG2 gene and protein expression were determined. The binding score of paynantheine to ABCB1 was higher in the docking studies. Paynantheine and speciociliatin...
Source: Cell Biology International - March 14, 2024 Category: Cytology Authors: Nayereh Abdali Mohammad Nadipour Borujeni Sayedeh Azimeh Hosseini Rahim Malekzadeh Marzieh Abolhasani Seyed Abbas Mirzaei Fatemeh Elahian Source Type: research
Curcumin relieves oxaliplatin-induced neuropathic pain via reducing inflammation and activating antioxidant response
In conclusion, our findings suggest that CUR treatment inhibits GSK-3β activation, increases Nrf2 mediated antioxidant responses, inhibits oxidative damage and inflammatory reaction, and alleviates OXA-induced neuropathic pain.PMID:38480956 | DOI:10.1002/cbin.12153 (Source: Cell Biology International)
Source: Cell Biology International - March 14, 2024 Category: Cytology Authors: Meng-Wei Zhang Xu Sun Yi-Wen Xu Wei Meng Qiong Tang Hui Gao Ling Liu Shao-Hui Chen Source Type: research
Paynantheine more effectively reverses multidrug resistance in malignant EPG85.257RDB and MCF7MX cells than morphine and speciociliatine
Cell Biol Int. 2024 Mar 13. doi: 10.1002/cbin.12152. Online ahead of print.ABSTRACTThe possible interactions of morphine, paynantheine and speciociliatine alkaloids with ATP-binding cassette (ABC) transporters was investigated. The compounds were docked against ABCG2 and ABCB1 to predict the binding mode of alkaloids in active binding sites. The cytotoxicity of morphine, paynantheine and speciociliatine for EPG85.257RDB and MCF7MX cells was determined and ABCB1 and ABCG2 gene and protein expression were determined. The binding score of paynantheine to ABCB1 was higher in the docking studies. Paynantheine and speciociliatin...
Source: Cell Biology International - March 14, 2024 Category: Cytology Authors: Nayereh Abdali Mohammad Nadipour Borujeni Sayedeh Azimeh Hosseini Rahim Malekzadeh Marzieh Abolhasani Seyed Abbas Mirzaei Fatemeh Elahian Source Type: research
Curcumin relieves oxaliplatin-induced neuropathic pain via reducing inflammation and activating antioxidant response
In conclusion, our findings suggest that CUR treatment inhibits GSK-3β activation, increases Nrf2 mediated antioxidant responses, inhibits oxidative damage and inflammatory reaction, and alleviates OXA-induced neuropathic pain.PMID:38480956 | DOI:10.1002/cbin.12153 (Source: Cell Biology International)
Source: Cell Biology International - March 14, 2024 Category: Cytology Authors: Meng-Wei Zhang Xu Sun Yi-Wen Xu Wei Meng Qiong Tang Hui Gao Ling Liu Shao-Hui Chen Source Type: research
Correction to "Autophagy regulates the apoptosis of bone marrow-derived mesenchymal stem cells under hypoxic condition via AMP-activated protein kinase/mammalian target of rapamycin pathway"
Cell Biol Int. 2024 Mar 11. doi: 10.1002/cbin.12142. Online ahead of print.NO ABSTRACTPMID:38468368 | DOI:10.1002/cbin.12142 (Source: Cell Biology International)
Source: Cell Biology International - March 12, 2024 Category: Cytology Source Type: research
Correction to "Autophagy regulates the apoptosis of bone marrow-derived mesenchymal stem cells under hypoxic condition via AMP-activated protein kinase/mammalian target of rapamycin pathway"
Cell Biol Int. 2024 Mar 11. doi: 10.1002/cbin.12142. Online ahead of print.NO ABSTRACTPMID:38468368 | DOI:10.1002/cbin.12142 (Source: Cell Biology International)
Source: Cell Biology International - March 12, 2024 Category: Cytology Source Type: research
OxLDL enhances procoagulant activity of endothelial cells by TMEM16F-mediated phosphatidylserine exposure
In this study, we used oxLDL-induced human aortic endothelial cells (HAECs) and high-fat diet (HFD)-fed mice as a hyperlipidemia model. Phosphatidylserine (PS) exposure, cytosolic Ca2+ , reactive oxygen species (ROS), and lipid peroxidation were measured by flow cytometer. TMEM16F expression was detected by immunofluorescence, western blot, and reverse transcription polymerase chain reaction. Procoagulant activity (PCA) was measured by coagulation time, intrinsic/extrinsic factor Xase, and thrombin generation. We found that oxLDL-induced PS exposure and the corresponding PCA of HAECs were increased significantly compared w...
Source: Cell Biology International - March 6, 2024 Category: Cytology Authors: Meishan Yan Zelong Wang Yao An Zhanni Li Yun Li Hongyu Zhang Caixia Li Lifeng Wang Li Chen Chao Gao Dongsheng Wang Chunyan Gao Source Type: research
OxLDL enhances procoagulant activity of endothelial cells by TMEM16F-mediated phosphatidylserine exposure
In this study, we used oxLDL-induced human aortic endothelial cells (HAECs) and high-fat diet (HFD)-fed mice as a hyperlipidemia model. Phosphatidylserine (PS) exposure, cytosolic Ca2+ , reactive oxygen species (ROS), and lipid peroxidation were measured by flow cytometer. TMEM16F expression was detected by immunofluorescence, western blot, and reverse transcription polymerase chain reaction. Procoagulant activity (PCA) was measured by coagulation time, intrinsic/extrinsic factor Xase, and thrombin generation. We found that oxLDL-induced PS exposure and the corresponding PCA of HAECs were increased significantly compared w...
Source: Cell Biology International - March 6, 2024 Category: Cytology Authors: Meishan Yan Zelong Wang Yao An Zhanni Li Yun Li Hongyu Zhang Caixia Li Lifeng Wang Li Chen Chao Gao Dongsheng Wang Chunyan Gao Source Type: research
OxLDL enhances procoagulant activity of endothelial cells by TMEM16F-mediated phosphatidylserine exposure
In this study, we used oxLDL-induced human aortic endothelial cells (HAECs) and high-fat diet (HFD)-fed mice as a hyperlipidemia model. Phosphatidylserine (PS) exposure, cytosolic Ca2+ , reactive oxygen species (ROS), and lipid peroxidation were measured by flow cytometer. TMEM16F expression was detected by immunofluorescence, western blot, and reverse transcription polymerase chain reaction. Procoagulant activity (PCA) was measured by coagulation time, intrinsic/extrinsic factor Xase, and thrombin generation. We found that oxLDL-induced PS exposure and the corresponding PCA of HAECs were increased significantly compared w...
Source: Cell Biology International - March 6, 2024 Category: Cytology Authors: Meishan Yan Zelong Wang Yao An Zhanni Li Yun Li Hongyu Zhang Caixia Li Lifeng Wang Li Chen Chao Gao Dongsheng Wang Chunyan Gao Source Type: research
OxLDL enhances procoagulant activity of endothelial cells by TMEM16F-mediated phosphatidylserine exposure
In this study, we used oxLDL-induced human aortic endothelial cells (HAECs) and high-fat diet (HFD)-fed mice as a hyperlipidemia model. Phosphatidylserine (PS) exposure, cytosolic Ca2+ , reactive oxygen species (ROS), and lipid peroxidation were measured by flow cytometer. TMEM16F expression was detected by immunofluorescence, western blot, and reverse transcription polymerase chain reaction. Procoagulant activity (PCA) was measured by coagulation time, intrinsic/extrinsic factor Xase, and thrombin generation. We found that oxLDL-induced PS exposure and the corresponding PCA of HAECs were increased significantly compared w...
Source: Cell Biology International - March 6, 2024 Category: Cytology Authors: Meishan Yan Zelong Wang Yao An Zhanni Li Yun Li Hongyu Zhang Caixia Li Lifeng Wang Li Chen Chao Gao Dongsheng Wang Chunyan Gao Source Type: research
