Elevated extracellular inorganic phosphate inhibits ecto-phosphatase activity in breast cancer cells: Regulation by hydrogen peroxide
In this study, we show that increased Pi levels in the extracellular environment promote a decrease in ecto-phosphatase activity, which is associated with Pi-induced oxidative stress. High levels of Pi inhibit ecto-phosphatase because Pi generates H2 O2 . Ecto-phosphatase activity is inhibited by H2 O2 , and this inhibition is selective for phospho-tyrosine hydrolysis. Additionally, it is shown that the mechanism of inhibition of ecto-phosphatase activity involves lipid peroxidation. In addition, the inhibition of ecto-phosphatase activity by H2 O2 is irreversible. These findings have new implications for understanding ect...
Source: Cell Biology International - October 11, 2023 Category: Cytology Authors: Marco A Lacerda-Abreu Jos é R Meyer-Fernandes Source Type: research
Methods used to achieve different levels of the neuronal differentiation process in SH-SY5Y and Neuro2a cell lines: An integrative review
Cell Biol Int. 2023 Oct 10. doi: 10.1002/cbin.12093. Online ahead of print.ABSTRACTTo study the process of neuronal differentiation, the human neuroblastoma (SH-SY5Y) and the murine neuroblastoma (Neuro2a) cell lines have proven to be effective models. For this approach, different protocols involving known neurotrophic factors and other molecules, such as retinoic acid (RA), have been assessed to better understand the neuronal differentiation process. Thus, the goal of this manuscript was to provide a brief overview of recent studies that have used protocols to promote neurodifferentiation in SH-SY5Y and Neuro2a cell lines...
Source: Cell Biology International - October 11, 2023 Category: Cytology Authors: M ônica G Dos Santos Jos é R Gomes Michele D M Costa Source Type: research
Elevated extracellular inorganic phosphate inhibits ecto-phosphatase activity in breast cancer cells: Regulation by hydrogen peroxide
In this study, we show that increased Pi levels in the extracellular environment promote a decrease in ecto-phosphatase activity, which is associated with Pi-induced oxidative stress. High levels of Pi inhibit ecto-phosphatase because Pi generates H2 O2 . Ecto-phosphatase activity is inhibited by H2 O2 , and this inhibition is selective for phospho-tyrosine hydrolysis. Additionally, it is shown that the mechanism of inhibition of ecto-phosphatase activity involves lipid peroxidation. In addition, the inhibition of ecto-phosphatase activity by H2 O2 is irreversible. These findings have new implications for understanding ect...
Source: Cell Biology International - October 11, 2023 Category: Cytology Authors: Marco A Lacerda-Abreu Jos é R Meyer-Fernandes Source Type: research
Methods used to achieve different levels of the neuronal differentiation process in SH-SY5Y and Neuro2a cell lines: An integrative review
Cell Biol Int. 2023 Oct 10. doi: 10.1002/cbin.12093. Online ahead of print.ABSTRACTTo study the process of neuronal differentiation, the human neuroblastoma (SH-SY5Y) and the murine neuroblastoma (Neuro2a) cell lines have proven to be effective models. For this approach, different protocols involving known neurotrophic factors and other molecules, such as retinoic acid (RA), have been assessed to better understand the neuronal differentiation process. Thus, the goal of this manuscript was to provide a brief overview of recent studies that have used protocols to promote neurodifferentiation in SH-SY5Y and Neuro2a cell lines...
Source: Cell Biology International - October 11, 2023 Category: Cytology Authors: M ônica G Dos Santos Jos é R Gomes Michele D M Costa Source Type: research
Elevated extracellular inorganic phosphate inhibits ecto-phosphatase activity in breast cancer cells: Regulation by hydrogen peroxide
In this study, we show that increased Pi levels in the extracellular environment promote a decrease in ecto-phosphatase activity, which is associated with Pi-induced oxidative stress. High levels of Pi inhibit ecto-phosphatase because Pi generates H2 O2 . Ecto-phosphatase activity is inhibited by H2 O2 , and this inhibition is selective for phospho-tyrosine hydrolysis. Additionally, it is shown that the mechanism of inhibition of ecto-phosphatase activity involves lipid peroxidation. In addition, the inhibition of ecto-phosphatase activity by H2 O2 is irreversible. These findings have new implications for understanding ect...
Source: Cell Biology International - October 11, 2023 Category: Cytology Authors: Marco A Lacerda-Abreu Jos é R Meyer-Fernandes Source Type: research
Methods used to achieve different levels of the neuronal differentiation process in SH-SY5Y and Neuro2a cell lines: An integrative review
Cell Biol Int. 2023 Oct 10. doi: 10.1002/cbin.12093. Online ahead of print.ABSTRACTTo study the process of neuronal differentiation, the human neuroblastoma (SH-SY5Y) and the murine neuroblastoma (Neuro2a) cell lines have proven to be effective models. For this approach, different protocols involving known neurotrophic factors and other molecules, such as retinoic acid (RA), have been assessed to better understand the neuronal differentiation process. Thus, the goal of this manuscript was to provide a brief overview of recent studies that have used protocols to promote neurodifferentiation in SH-SY5Y and Neuro2a cell lines...
Source: Cell Biology International - October 11, 2023 Category: Cytology Authors: M ônica G Dos Santos Jos é R Gomes Michele D M Costa Source Type: research
Elevated extracellular inorganic phosphate inhibits ecto-phosphatase activity in breast cancer cells: Regulation by hydrogen peroxide
In this study, we show that increased Pi levels in the extracellular environment promote a decrease in ecto-phosphatase activity, which is associated with Pi-induced oxidative stress. High levels of Pi inhibit ecto-phosphatase because Pi generates H2 O2 . Ecto-phosphatase activity is inhibited by H2 O2 , and this inhibition is selective for phospho-tyrosine hydrolysis. Additionally, it is shown that the mechanism of inhibition of ecto-phosphatase activity involves lipid peroxidation. In addition, the inhibition of ecto-phosphatase activity by H2 O2 is irreversible. These findings have new implications for understanding ect...
Source: Cell Biology International - October 11, 2023 Category: Cytology Authors: Marco A Lacerda-Abreu Jos é R Meyer-Fernandes Source Type: research
Methods used to achieve different levels of the neuronal differentiation process in SH-SY5Y and Neuro2a cell lines: An integrative review
Cell Biol Int. 2023 Oct 10. doi: 10.1002/cbin.12093. Online ahead of print.ABSTRACTTo study the process of neuronal differentiation, the human neuroblastoma (SH-SY5Y) and the murine neuroblastoma (Neuro2a) cell lines have proven to be effective models. For this approach, different protocols involving known neurotrophic factors and other molecules, such as retinoic acid (RA), have been assessed to better understand the neuronal differentiation process. Thus, the goal of this manuscript was to provide a brief overview of recent studies that have used protocols to promote neurodifferentiation in SH-SY5Y and Neuro2a cell lines...
Source: Cell Biology International - October 11, 2023 Category: Cytology Authors: M ônica G Dos Santos Jos é R Gomes Michele D M Costa Source Type: research
Elevated extracellular inorganic phosphate inhibits ecto-phosphatase activity in breast cancer cells: Regulation by hydrogen peroxide
In this study, we show that increased Pi levels in the extracellular environment promote a decrease in ecto-phosphatase activity, which is associated with Pi-induced oxidative stress. High levels of Pi inhibit ecto-phosphatase because Pi generates H2 O2 . Ecto-phosphatase activity is inhibited by H2 O2 , and this inhibition is selective for phospho-tyrosine hydrolysis. Additionally, it is shown that the mechanism of inhibition of ecto-phosphatase activity involves lipid peroxidation. In addition, the inhibition of ecto-phosphatase activity by H2 O2 is irreversible. These findings have new implications for understanding ect...
Source: Cell Biology International - October 11, 2023 Category: Cytology Authors: Marco A Lacerda-Abreu Jos é R Meyer-Fernandes Source Type: research
Methods used to achieve different levels of the neuronal differentiation process in SH-SY5Y and Neuro2a cell lines: An integrative review
Cell Biol Int. 2023 Oct 10. doi: 10.1002/cbin.12093. Online ahead of print.ABSTRACTTo study the process of neuronal differentiation, the human neuroblastoma (SH-SY5Y) and the murine neuroblastoma (Neuro2a) cell lines have proven to be effective models. For this approach, different protocols involving known neurotrophic factors and other molecules, such as retinoic acid (RA), have been assessed to better understand the neuronal differentiation process. Thus, the goal of this manuscript was to provide a brief overview of recent studies that have used protocols to promote neurodifferentiation in SH-SY5Y and Neuro2a cell lines...
Source: Cell Biology International - October 11, 2023 Category: Cytology Authors: M ônica G Dos Santos Jos é R Gomes Michele D M Costa Source Type: research
Elevated extracellular inorganic phosphate inhibits ecto-phosphatase activity in breast cancer cells: Regulation by hydrogen peroxide
In this study, we show that increased Pi levels in the extracellular environment promote a decrease in ecto-phosphatase activity, which is associated with Pi-induced oxidative stress. High levels of Pi inhibit ecto-phosphatase because Pi generates H2 O2 . Ecto-phosphatase activity is inhibited by H2 O2 , and this inhibition is selective for phospho-tyrosine hydrolysis. Additionally, it is shown that the mechanism of inhibition of ecto-phosphatase activity involves lipid peroxidation. In addition, the inhibition of ecto-phosphatase activity by H2 O2 is irreversible. These findings have new implications for understanding ect...
Source: Cell Biology International - October 11, 2023 Category: Cytology Authors: Marco A Lacerda-Abreu Jos é R Meyer-Fernandes Source Type: research
The role of NFATc1 in the progression and metastasis of prostate cancer: A review on the molecular mechanisms and signaling pathways
Cell Biol Int. 2023 Oct 9. doi: 10.1002/cbin.12094. Online ahead of print.ABSTRACTA common type of cancer among men is the prostate cancer that kills many people every year. The multistage of this disease and the involvement of the vital organs of the body have reduced the life span and quality of life of the people involved and turned the treatment process into a complex one. NFATc1 biomarker contributes significantly in the diagnosis and treatment of this disease by increasing its expression in prostate cancer and helping the proliferation, differentiation, and invasion of cancer cells through different signaling pathway...
Source: Cell Biology International - October 10, 2023 Category: Cytology Authors: Samaneh Hasani Farshid Fathabadi Saman Saeidi Pouya Mohajernoei Zahra Hesari Source Type: research
Overexpression of PPM1B inhibited chemoresistance to temozolomide and proliferation in glioma cells
In conclusion, PPM1B suppressed glioma cell proliferation and the IKKβ-NF-κB signaling pathway, and enhanced temozolomide sensitivity of glioma cells.PMID:37798941 | DOI:10.1002/cbin.12092 (Source: Cell Biology International)
Source: Cell Biology International - October 6, 2023 Category: Cytology Authors: Yunhu Yu Qian Liu Qishan Ran Fang Cao Source Type: research
Overexpression of PPM1B inhibited chemoresistance to temozolomide and proliferation in glioma cells
In conclusion, PPM1B suppressed glioma cell proliferation and the IKKβ-NF-κB signaling pathway, and enhanced temozolomide sensitivity of glioma cells.PMID:37798941 | DOI:10.1002/cbin.12092 (Source: Cell Biology International)
Source: Cell Biology International - October 6, 2023 Category: Cytology Authors: Yunhu Yu Qian Liu Qishan Ran Fang Cao Source Type: research
Overexpression of PPM1B inhibited chemoresistance to temozolomide and proliferation in glioma cells
In conclusion, PPM1B suppressed glioma cell proliferation and the IKKβ-NF-κB signaling pathway, and enhanced temozolomide sensitivity of glioma cells.PMID:37798941 | DOI:10.1002/cbin.12092 (Source: Cell Biology International)
Source: Cell Biology International - October 6, 2023 Category: Cytology Authors: Yunhu Yu Qian Liu Qishan Ran Fang Cao Source Type: research
