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Condition: Diabetes Mellitus
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Total 263 results found since Jan 2013.
AGE-Induced Suppression of EZH2 Mediates Injury of Podocytes by Reducing H3K27me3.
CONCLUSIONS: Our studies provide a novel pathway how AGEs contribute to podocyte injury and the formation of the so-called metabolic memory in DKD.
PMID: 32854097 [PubMed - as supplied by publisher]
Source: American Journal of Nephrology - August 26, 2020 Category: Urology & Nephrology Authors: Liebisch M, Wolf G Tags: Am J Nephrol Source Type: research
Sirtuin 3 deficiency exacerbates diabetic cardiomyopathy via necroptosis enhancement and NLRP3 activation.
In this study, we investigated the role of SIRT3 in diabetic cardiomyopathy (DCM). Mice were injected with streptozotocin (STZ, 60 mg/kg, ip) to induce diabetes mellitus. Our proteomics analysis revealed that SIRT3 expression in the myocardium of diabetic mice was lower than that of control mice, as subsequently confirmed by real-time PCR and Western blotting. To explore the role of SIRT3 in DCM, SIRT3-knockout mice and 129S1/SvImJ wild-type mice were injected with STZ. We found that diabetic mice with SIRT3 deficiency exhibited aggravated cardiac dysfunction, increased lactate dehydrogenase (LDH) level in the serum, de...
Source: Acta Pharmacologica Sinica - August 6, 2020 Category: Drugs & Pharmacology Authors: Song S, Ding Y, Dai GL, Zhang Y, Xu MT, Shen JR, Chen TT, Chen Y, Meng GL Tags: Acta Pharmacol Sin Source Type: research
Diabetes mellitus exacerbates post ‐myocardial infarction heart failure by reducing sarcolipin promoter methylation
ConclusionsDiabetes increases the vulnerability of STEMI patients to post ‐MI HF by down‐regulating SLN promoter methylation, which further regulates SERCA2a activity via increasing cardiac SLN expression.
Source: ESC Heart Failure - June 10, 2020 Category: Cardiology Authors: Zhongwei Liu,
Yong Zhang,
Chuan Qiu,
Haitao Zhu,
Shuo Pan,
Hao Jia,
Hongyan Kang,
Gongchang Guan,
Rutai Hui,
Ling Zhu,
Junkui Wang Tags: Original Research Article Source Type: research
Long Non-Coding RNA (lncRNA) SNHG5 Participates in Vertical Sleeve Gastrectomy for Type II Diabetes Mellitus by Regulating TGR5.
CONCLUSIONS By downregulating expression of the SNHG5 gene and then altering expression of the TGR5 gene, the damage to colorectal cells induced by high glucose was alleviated. This may be one of the mechanisms underlying the effect of sleeve gastric surgery in treatment of diabetes mellitus.
PMID: 32242546 [PubMed - in process]
Source: Medical Science Monitor - April 4, 2020 Category: Research Tags: Med Sci Monit Source Type: research
Knockout of AKAP150 improves impaired BK channel-mediated vascular dysfunction through the Akt/GSK3 β signalling pathway in diabetes mellitus.
In this study, we investigated the regulation of impaired BK channel-mediated vascular dysfunction in diabetes mellitus. Using AKAP150 null mice (AKAP150-/- ) and wild-type (WT) control mice (C57BL/6J), diabetes was induced by intraperitoneal injection of streptozotocin. We found that knockout of AKAP150 reversed vascular remodelling and fibrosis in mice with diabetes and in AKAP150-/- diabetic mice. Impaired Akt/GSK3β signalling contributed to decreased BK-β1 expression in aortas from diabetic mice, and the silencing of AKAP150 increased Akt phosphorylation and BK-β1 expression in MOVAS cells treated with HG medium. Th...
Source: J Cell Mol Med - March 11, 2020 Category: Molecular Biology Authors: Zhu YR, Jiang XX, Ye P, Wang ZM, Zheng Y, Liu Z, Chen SL, Zhang DM Tags: J Cell Mol Med Source Type: research
Dysregulation of microRNA-770-5p influences pancreatic- β-cell function by targeting TP53 regulated inhibitor of apoptosis 1 in gestational diabetes mellitus.
CONCLUSIONS: The data demonstrated that miR-770-5p was a vital regulator in pancreatic β-cell proliferation, apoptosis and insulin secretion by targeting TRIAP1, and dysregulation of miR-770-5p resulted in the development of GDM via APAF1 signaling pathway.
PMID: 32016984 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - February 6, 2020 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
Thioredoxin-Interacting Protein (TXNIP) Regulates Parkin/PINK1-mediated Mitophagy in Dopaminergic Neurons Under High-glucose Conditions: Implications for Molecular Links Between Parkinson ’s Disease and Diabetes
In this study, we investigated the roles of thioredoxin-interacting protein (TXNIP) in Parkin/PINK1-mediated mitophagy in dopaminergic (DA) cells under high-glucose (HG) conditions. In streptozotocin-induced diab etic mice, TXNIP was upregulated and autophagy was inhibited in the midbrain, while the loss of DA neurons was accelerated by hyperglycemia. In cultured PC12 cells under HG, TXNIP expression was upregulated and the intracellular reactive oxygen species (ROS) levels increased, leading to cell death. Autophagic flux was further blocked and PINK1 expression was decreased under HG conditions. Parkin expression in the ...
Source: Neuroscience Bulletin - January 13, 2020 Category: Neuroscience Source Type: research
Down-regulation of microRNA-873 attenuates insulin resistance and myocardial injury in rats with gestational diabetes mellitus by up-regulating IGFBP2.
Abstract
Gestational diabetes mellitus (GDM) is a metabolic disorder characterized by insulin resistance, and patients with GDM have a higher risk of cardiovascular disease. Multiple microRNAs (miRNAs) are reported to be involved in the regulation of myocardial injury. Moreover, miR-873 was predicted to target insulin-like growth factor binding protein 2 (IGFBP2) through bioinformatic analysis, which was further confirmed using a luciferase assay. Thus, our objective was to assess whether microRNA-873 (miR-873) affects insulin resistance and myocardial injury in an established GDM rat model. The GDM rats were trea...
Source: Am J Physiol Endocri... - January 6, 2020 Category: Endocrinology Authors: Han N, Fang HY, Jiang JX, Xu Q Tags: Am J Physiol Endocrinol Metab Source Type: research
Inhibition of brain-type glycogen phosphorylase ameliorates high glucose-induced cardiomyocyte apoptosis via Akt-HIF-1 α activation.
In conclusion, the present study suggested that inhibition of pygb prevents HG-induced cardiomyocyte apoptosis via Akt-HIF-α activation.
PMID: 31905009 [PubMed - as supplied by publisher]
Source: Biochemistry and Cell Biology - January 5, 2020 Category: Biochemistry Authors: Wu X, Huang W, Quan M, Chen Y, Tu J, Zhou J, Xin HB, Qian Y Tags: Biochem Cell Biol Source Type: research
GSE133264 Loss of ER and nuclear envelope-associated neutral sphingomyelinase SMPD4 causes a severe neurodevelopmental disorder with microcephaly and congenital arthrogryposis
This study provides a link between sphingolipid membrane homeostasis, cell fate and mitotic decisions indicating novel pathway in the pathogenesis of microcephaly.
Source: GEO: Gene Expression Omnibus - December 31, 2019 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
HMGB1 upregulates NF-kB by inhibiting IKB-α and associates with diabetic retinopathy
This study aimed to investigate the effect of high-mobility group box 1 (HMGB1) protein and its mechanism in diabetic retinopathy (DR) were investigated.Main methodsHuman retinal endothelial cells (HREC) were uesd for chip-seq. Sprague Dawley (SD) rats were randomly divided into control group, HMGB1 group, diabetes mellitus (DM) combined with HMGB1 siRNA group, and DM group. Next, eyeballs were removed and retinas were detached for western blot. The DM model of cell was built by increasing the glucose concentration in cell culture medium. The regulation of HMGB1 was achieved by short hairpin (sh)-HMGB1 transfection, then, ...
Source: Life Sciences - December 7, 2019 Category: Biology Source Type: research
SGLT2 inhibitor ipragliflozin attenuates breast cancer cell proliferation.
Authors: Komatsu S, Nomiyama T, Numata T, Kawanami T, Hamaguchi Y, Iwaya C, Horikawa T, Fujimura-Tanaka Y, Hamanoue N, Motonaga R, Tanabe M, Inoue R, Yanase T, Kawanami D
Abstract
Cancer is currently one of the major causes of death in patients with type 2 diabetes mellitus. We previously reported the beneficial effects of the glucagon-like peptide-1 receptor agonist exendin-4 against prostate and breast cancer. In the present study, we examined the anti-cancer effect of the sodium-glucose cotransporter 2 (SGLT2) inhibitor ipragliflozin using a breast cancer model. In human breast cancer MCF-7 cells, SGLT2 expressi...
Source: Endocrine Journal - November 30, 2019 Category: Endocrinology Tags: Endocr J Source Type: research
Molecules, Vol. 24, Pages 4208: Deficiency of Urokinase Plasminogen Activator May Impair β Cells Regeneration and Insulin Secretion in Type 2 Diabetes Mellitus
Conclusion: uPA may play a substantial role in insulin secretion, β cell regeneration, and progressive development of T2DM. Supplementation of uPA might be a novel approach for prevention and treatment of T2DM in the future.
Source: Molecules - November 19, 2019 Category: Chemistry Authors: Wu Ou Chang Lin Pei Chen Tags: Article Source Type: research
Newer therapeutic approaches towards the management of diabetes mellitus: an update.
This article focused on the emerging therapeutic approaches other than the conventional pharmacological therapies, which include stem cell therapy, gene therapy, siRNA, nanotechnology and theranostics.
PMID: 31663302 [PubMed - as supplied by publisher]
Source: Panminerva Medica - November 1, 2019 Category: General Medicine Tags: Panminerva Med Source Type: research
Berberine improves insulin resistance in adipocyte models by regulating the methylation of hypoxia-inducible factor-3 α.
Berberine improves insulin resistance in adipocyte models by regulating the methylation of hypoxia-inducible factor-3α.
Biosci Rep. 2019 Oct 30;39(10):
Authors: Wang Y, Gong W, Lv S, Qu H, He Y
Abstract
Methylation of hypoxia-inducible factor-3α (HIF3A) was previously demonstrated to be highly associated with insulin resistance (IR) in patients with gestational diabetes mellitus (GDM). We aimed to study the therapeutic effects of Berberine (BBR) on GDM and the possible mechanisms. The expressions and methylated states of HIF3A in pregnant women with GDM were compared with that in healthy controls. T...
Source: Bioscience Reports - October 29, 2019 Category: Biomedical Science Authors: Wang Y, Gong W, Lv S, Qu H, He Y Tags: Biosci Rep Source Type: research
