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Condition: Diabetes Mellitus
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Total 263 results found since Jan 2013.
ABCG1 is Expressed in a LXR-Independent Manner in Patients with Type 2 Diabetes Mellitus
CONCLUSION: The study suggested that the expression of ATP-binding cassette G1 and high density lipoprotein-induced cholesterol efflux in macrophages were reduced in type 2 diabetes mellitus. Impairment of cholesterol efflux and ATP-binding cassette G1 gene expression in type 2 diabetes mellitus might be regulated by a Liver X receptor-independent pathway.PMID:36017862 | DOI:10.2174/1566524023666220822150820
Source: Current Molecular Medicine - August 26, 2022 Category: Molecular Biology Authors: Hui-Juan Wang Ji-Hong Wang Xin-Na Xu Xing-Shan Zhao Wei Liu Source Type: research
Melatonin ameliorates diabetic hyperglycaemia-induced impairment of Leydig cell steroidogenic function through activation of SIRT1 pathway
CONCLUSIONS: These findings suggest that SIRT1 pathway plays essential roles in the pleiotropic actions of melatonin on Leydig cells and in the prevention of hyperglycaemia-induced steroidogenic dysfunction. The stimulatory action of melatonin on SIRT1 pathway is related to oxidative stress and its antioxidant property. Our data provide new evidence for the relationship of melatonin and SIRT1 pathway in the context of hyperglycaemia, and melatonin as a combination therapy may be useful to combat DM-related complications, especially male reproductive system injury.PMID:35962432 | DOI:10.1186/s12958-022-00991-6
Source: Reproductive Biology - August 12, 2022 Category: Reproduction Medicine Authors: Ping Wang Shoubing Zhang Shuai Lin Zhengmei Lv Source Type: research
MicroRNA-223-3p promotes pyroptosis of cardiomyocyte and release of inflammasome factors via downregulating the expression level of SPI1 (PU.1)
Toxicology. 2022 Jul 2:153252. doi: 10.1016/j.tox.2022.153252. Online ahead of print.ABSTRACTDiabetic cardiomyopathy (DCM) is a common heart disease in patients with diabetes mellitus (DM), and is sometimes its main cause of death. Among all the causes of DCM, myocardial cell death is considered to be the most basic pathological change. Furthermore, studies have shown that pyroptosis, the pro-inflammatory programmed cell death, contributes to the progress of DCM. MicroRNAs (miRNAs) also have been proved to take part in the formation of DCM. However, it is not clear whether and how miRNAs regulate myocardial cell pyroptosis...
Source: Toxicology - July 6, 2022 Category: Toxicology Authors: Simin Zhao Yao Tan Jianning Qin Haiqiang Xu Lingyun Liu Hengquan Wan Chi Zhang Wenjing Fan Shunlin Qu Source Type: research
SIRT3 attenuates coronary atherosclerosis in diabetic patients by regulating endothelial cell function
CONCLUSION: SIRT3 was associated with the progression of atherosclerosis in T2DM patients through upregulation of PPAR-α and eNOS and downregulation of iNOS, which are involved in endothelial dysfunction under hyperglycemic conditions.PMID:35791925 | DOI:10.1002/jcla.24586
Source: Atherosclerosis - July 6, 2022 Category: Cardiology Authors: Huiping Gong Jing Liu Zhiwei Xue Wenwen Wang Cuicui Li Fanfan Xu Yimeng Du Xiaona Lyu Source Type: research
MicroRNA-223-3p promotes pyroptosis of cardiomyocyte and release of inflammasome factors via downregulating the expression level of SPI1 (PU.1)
Toxicology. 2022 Jul 2:153252. doi: 10.1016/j.tox.2022.153252. Online ahead of print.ABSTRACTDiabetic cardiomyopathy (DCM) is a common heart disease in patients with diabetes mellitus (DM), and is sometimes its main cause of death. Among all the causes of DCM, myocardial cell death is considered to be the most basic pathological change. Furthermore, studies have shown that pyroptosis, the pro-inflammatory programmed cell death, contributes to the progress of DCM. MicroRNAs (miRNAs) also have been proved to take part in the formation of DCM. However, it is not clear whether and how miRNAs regulate myocardial cell pyroptosis...
Source: Toxicology - July 6, 2022 Category: Toxicology Authors: Simin Zhao Yao Tan Jianning Qin Haiqiang Xu Lingyun Liu Hengquan Wan Chi Zhang Wenjing Fan Shunlin Qu Source Type: research
Repurposed major urinary protein pheromones and adult sensory neurons: Roles in neuron plasticity and experimental diabetes
Am J Physiol Endocrinol Metab. 2022 May 30. doi: 10.1152/ajpendo.00001.2022. Online ahead of print.ABSTRACTMajor urinary proteins (MUPs), members of the broader lipocalin protein family, are classified as pheromones that are excreted in male rodent urine to define conspecific territoriality. In screening for differentially regulated mRNA transcripts in a mouse model of type 1 experimental diabetes mellitus (DM), we identified an unexpected upregulation of several closely related MUP transcripts within diabetic sensory dorsal root ganglia (DRGs). Both sexes expressed overall MUP protein content as identified by an antibody ...
Source: Am J Physiol Endocri... - May 31, 2022 Category: Endocrinology Authors: Trevor Poitras Vandana Singh Ramanaguru Piragasam Xiuling Wang Atef Mahmoud Mannaa Ambika Chandrasekhar Jose Martinez Richard Fahlman Douglas W Zochodne Source Type: research
