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Condition: Diabetes Mellitus
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Total 263 results found since Jan 2013.
SIRT1 suppresses high glucose and palmitate-induced osteoclast differentiation via deacetylating p66Shc
In conclusion, this study confirms the role of DM in osteoclast differentiation in vitro. SIRT1 suppresses HG- and PA-induced osteoclast differentiation via p66Shc/ROS/NF-κB signaling.
Source: Molecular and Cellular Endocrinology - July 5, 2018 Category: Endocrinology Source Type: research
DNA binding protein HMGB1 secreted by activated microglia promotes the apoptosis of hippocampal neurons in diabetes complicated with OSA
Publication date: Available online 18 June 2018 Source:Brain, Behavior, and Immunity Author(s): Yu Shi, Xiangyu Guo, Jie Zhang, Hanchi Zhou, Bei Sun, Jing Feng Type 2 diabetes mellitus (T2DM) complicated with obstructive sleep apnea (OSA) may cause neuronal apoptosis and cognitive deficits, but the underlying mechanisms remain unclear. We aimed to determine the relationship between the activation of microglia and the apoptosis of hippocampal neurons, specifically in terms of high mobility group box-1 (HMGB1), after high glucose (HG) and intermittent hypoxia (IH) exposure. Diabetic KK-Ay mice and non-diabetic C57BL/6J mice...
Source: Brain, Behavior, and Immunity - June 19, 2018 Category: Neurology Source Type: research
DNA binding protein HMGB1 secreted by activated microglia promotes the apoptosis of hippocampal neurons in diabetes complicated with OSA.
Abstract
Type 2 diabetes mellitus (T2DM) complicated with obstructive sleep apnea (OSA) may cause neuronal apoptosis and cognitive deficits, but the underlying mechanisms remain unclear. We aimed to determine the relationship between the activation of microglia and the apoptosis of hippocampal neurons, specifically in terms of high mobility group box-1 (HMGB1), after high glucose (HG) and intermittent hypoxia (IH) exposure. Diabetic KK-Ay mice and non-diabetic C57BL/6J mice (C57 mice) underwent IH or normoxia (control) exposure for 4 weeks. Cognitive function, microglial activation and hippocampal neuronal apoptos...
Source: Brain, Behavior, and Immunity - June 16, 2018 Category: Neurology Authors: Shi Y, Guo X, Zhang J, Zhou H, Sun B, Feng J Tags: Brain Behav Immun Source Type: research
Anti-inflammatory effect of the extracts from the branch of Taxillus yadoriki being parasitic in Neolitsea sericea in LPS-stimulated RAW264.7 cells
In this study, we evaluated the anti-inflammatory effect of extracts of branch from Taxillus yadoriki being parasitic in Neolitsea sericea (TY-NS-B) using in vitro model. TY-NS-B significantly inhibited LPS-induced secretion of NO and PGE2 in RAW264.7 cells. TY-NS-B was also observed to inhibit LPS-mediated iNOS COX-2 expression. In addition, TY-NS-B attenuated production of inflammatory cytokines such as TNF-α and IL-1β induced by LPS. TY-NS-B blocked LPS-mediated inhibitor of IκB-α, and inhibited p65 translocation to the nucleus and NF-κB activation. Furthermore, TY-NS-B reduced the phosphorylation of MAPKs such as ...
Source: Biomedicine and Pharmacotherapy - May 11, 2018 Category: Drugs & Pharmacology Source Type: research
LncRNA uc.48+ is involved in the diabetic immune and inflammatory responses mediated by P2X7 receptor in RAW264.7 macrophages.
Abstract
High glucose combined with high FFAs can contribute to the unfavorable development of type 2 diabetes mellitus (T2DM) and monocytes/macrophages are important in the occurrence and development of T2DM, which is regarded as a type of low‑grade inflammation. Although our previous study demonstrated that increased expression of P2X7 receptor (P2X7R) in peripheral blood monocytes may alter the innate immune system and that long non‑coding (lnc)RNA uc.48+ was involved in diabetic neuropathic pain, the involvement of uc.48+ mediated by the P2X7R in monocyte/macrophages during T2DM has not been reported. In t...
Source: International Journal of Molecular Medicine - May 9, 2018 Category: Molecular Biology Authors: Wu H, Wen F, Jiang M, Liu Q, Nie Y Tags: Int J Mol Med Source Type: research
HDAC11 deletion reduces fructose-induced cardiac dyslipidemia, apoptosis and inflammation by attenuating oxidative stress injury.
Abstract
Diabetes mellitus (DM) is a risk factor for abnormal heart development, but the molecular mechanism remains obscure. Histone deacetylase 11 (HDAC11), the most recently identified histone deacetylase, is the sole member of class IV HDACs. However, its role in diabetic cardiac injury is still poorly understood. In the present study, we attempted to explore the effects of HDAC11 on fructose (Fru)-induced cardiac injury using the wild type (HDAC11+/+) and knockout (HDAC11-/-) mice. The results indicated that HDAC11 was significantly expressed in human and mouse diabetic heart failure (DHF) hearts. HDAC11-/- r...
Source: Biochemical and Biophysical Research communications - April 12, 2018 Category: Biochemistry Authors: Fan XD, Wan LL, Duan M, Lu S Tags: Biochem Biophys Res Commun Source Type: research
Apoptosis signal regulating kinase-1 and NADPH oxidase mediate human amylin evoked redox stress and apoptosis in pancreatic beta-cells
Publication date: Available online 6 April 2018 Source:Biochimica et Biophysica Acta (BBA) - Biomembranes Author(s): Sanghamitra Singh, Diti Chatterjee Bhowmick, Satyabrata Pany, Myungkuk Joe, Noor Zaghlula, Aleksandar M. Jeremic Misfolded toxic human islet amyloid polypeptide or amylin (hA) and plasma membrane-associated redox complex, NADPH oxidase (NOX), have been implicated in the islet β-cell demise associated with type-2 diabetes mellitus (T2DM). Studies show that hA accumulation is stressful to β-cells and that misfolding of human amylin evokes redox stress and activates mitogen activated protein (MAP) kinases, p...
Source: Biochimica et Biophysica Acta (BBA) Biomembranes - April 6, 2018 Category: Biochemistry Source Type: research
Apoptosis signal regulating kinase-1 and NADPH oxidase mediate human amylin evoked redox stress and apoptosis in pancreatic beta-cells.
Abstract
Misfolded toxic human islet amyloid polypeptide or amylin (hA) and plasma membrane-associated redox complex, NADPH oxidase (NOX), have been implicated in the islet β-cell demise associated with type-2 diabetes mellitus (T2DM). Studies show that hA accumulation is stressful to β-cells and that misfolding of human amylin evokes redox stress and activates mitogen activated protein (MAP) kinases, p38 MAPK and c-Jun N-terminal (JNK) kinase. However, the molecular link and causality between hA-evoked redox stress, NOX activity and MAP kinases signaling in pancreatic β-cells is incompletely understood. Here, ...
Source: Biochimica et Biophysica Acta - April 5, 2018 Category: Biochemistry Authors: Singh S, Bhowmick DC, Pany S, Joe M, Zaghlula N, Jeremic AM Tags: Biochim Biophys Acta Source Type: research
Nicotine Enhances Mesangial Cell Proliferation and Fibronectin Production in High Glucose Milieu via Activation of Wnt/ β-catenin Pathway.
In this study, we examined the involvement of Wnt/β-catenin pathway in nicotine-mediated mesangial cell growth in high glucose milieu. Primary human renal mesangial cells were treated with nicotine in the presence of normal (5 mM) or high glucose (30 mM) followed by evaluation for cell growth. In the presence of normal glucose, nicotine increased both the total cell numbers and Ki-67 positive cell ratio, indicating that nicotine stimulated mesangial cell proliferation. Although high glucose itself also stimulated mesangial cell proliferation, nicotine further enhanced the mitogenic effect of high glucose. Similarly, nicot...
Source: Bioscience Reports - March 23, 2018 Category: Biomedical Science Authors: Lan X, Wen H, Aslam R, Marashi Shoshtari SS, Mishra A, Kumar V, Wang H, Wu G, Luo H, Malhotra A, Singhal PC Tags: Biosci Rep Source Type: research
The induced RNA ‐binding protein, HuR, targets 3′‐UTR region of IL‐6 mRNA and enhances its stabilization in periodontitis
Summary
RNA‐binding proteins (RBPs) regulate mRNA stability by binding to the 3′‐untranslated region (UTR) region of mRNA. Human antigen‐R (HuR), one of the RBPs, is involved in the progression of diseases, such as rheumatoid arthritis, diabetes mellitus and some inflammatory diseases. Interleukin (IL)‐6 is a major inflammatory cytokine regulated by HuR binding to mRNA. Periodontal disease (PD) is also an inflammatory disease caused by elevations in IL‐6 following an infection by periodontopathogenic bacteria. The involvement of HuR in the progression of PD was assessed using in‐vitro and in‐vivo experiment...
Source: Clinical and Experimental Immunology - March 8, 2018 Category: Allergy & Immunology Authors: K. Ouhara, S. Munenaga, M. Kajiya, K. Takeda, S. Matsuda, Y. Sato, Y. Hamamoto, T. Iwata, S. Yamasaki, K. Akutagawa, N. Mizuno, T. Fujita, E. Sugiyama, H. Kurihara Tags: Original Article Source Type: research
Mdia1 is Crucial for Advanced Glycation End Product-Induced Endothelial Hyperpermeability
Conclusion: Our study revealed that mDia1 plays a critical role in AGE-induced microvascular hyperpermeability through binding to RAGE.Cell Physiol Biochem 2018;45:1717 –1730
Source: Cellular Physiology and Biochemistry - February 28, 2018 Category: Cytology Source Type: research
Notch1 regulates PTEN expression to exacerbate renal tubulointerstitial fibrosis in diabetic nephropathy by inhibiting autophagy via interactions with Hes1.
In conclusion, the inhibition of PTEN by Notch1/Hes1 in response to high glucose concentration inhibits autophagy, which is associated with the progression of fibrosis. Therefore, these signaling molecules may represent novel therapeutic targets in diabetic nephropathy.
PMID: 29496446 [PubMed - as supplied by publisher]
Source: Biochemical and Biophysical Research communications - February 26, 2018 Category: Biochemistry Authors: Liu X, Zhang Y, Shi M, Wang Y, Zhang F, Yan R, Liu L, Xiao Y, Guo B Tags: Biochem Biophys Res Commun Source Type: research
SIRT1 suppresses high glucose and palmitate-induced osteoclast differentiation via deacetylating p66Shc
In conclusion, this study confirms the role of DM in osteoclast differentiation in vitro. SIRT1 suppresses HG- and PA-induced osteoclast differentiation via p66Shc/ROS/NF-κB signaling.
Source: Molecular and Cellular Endocrinology - February 25, 2018 Category: Endocrinology Source Type: research
The induced RNA-binding protein, HuR targets 3'-UTR region of IL-6 mRNA and enhances its stabilization in periodontitis.
This article is protected by copyright. All rights reserved.
PMID: 29393507 [PubMed - as supplied by publisher]
Source: Clinical and Developmental Immunology - February 2, 2018 Category: Allergy & Immunology Authors: Ouhara K, Munenaga S, Kajiya M, Takeda K, Matsuda S, Sato Y, Hamamoto Y, Iwata T, Yamasaki S, Akutagawa K, Mizuno N, Fujita T, Sugiyama E, Kurihara H Tags: Clin Exp Immunol Source Type: research
The induced RNA ‐binding protein, HuR targets 3'‐UTR region of IL‐6 mRNA and enhances its stabilization in periodontitis
This article is protected by copyright. All rights reserved.
Source: Clinical and Experimental Immunology - February 2, 2018 Category: Allergy & Immunology Authors: Kazuhisa Ouhara, Syuichi Munenaga, Mikihito Kajiya, Katsuhiro Takeda, Shinji Matsuda, Yoko Sato, Yuta Hamamoto, Tomoyuki Iwata, Satoshi Yamasaki, Keiichi Akutagawa, Noriyoshi Mizuno, Tsuyoshi Fujita, Eiji Sugiyama, Hidemi Kurihara Tags: Original Article Source Type: research
