Clinical and Experimental Immunology 
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This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.Inflammation in osteoarthritis: is it time to dampen the alarm(in) in this debilitating disease?
Whereas osteoarthritis was historically considered a disease solely of the articular cartilage, it is nowadays broadly accepted that inflammation plays a crucial role in the disease development. Of particular interest in the inflammatory cascade during osteoarthritis are the alarmins, which are released upon cell stress and lie at the basis of the immune reaction. This review gives an overview of the inflammatory processes that are involved in osteoarthritis, with a particular focus on alarmins, and provides possibilities to inhibit these alarmins. SummaryOsteoarthritis (OA) is the most common joint disease that strongly r...
Source: Clinical and Experimental Immunology - November 28, 2018 Category: Allergy & Immunology Authors: M. H. J. van den Bosch Tags: Review Article Source Type: research
CCR6 defines a subset of activated memory T cells of Th17 potential in immune thrombocytopenia
In this study, we aimed to investigate the phenotype and functional char acteristics of circulating CCR6+ T cells in blood from chronic ITP patients and healthy controls. We found that the frequency of CCR6+CD4+cells was higher in ITP patients than in healthy controls. Anti ‐CD3/anti‐CD28 stimulation induced rapid expansion of CCR6+CD4+cells in ITP patients. CCR6+CD4+cells had a phenotype of activated cells and predominantly expressed CD45RO. Forkhead box protein P3 (FoxP3) and CD25 ‐positive cells were exclusively detected within the CCR6+CD4+cells. In ITP patients, CCR6+ regulatory T cells (Treg) were decreased and...
Source: Clinical and Experimental Immunology - November 25, 2018 Category: Allergy & Immunology Authors: M. Lyu,
Y. Li,
Y. Hao,
C. Lyu,
Y. Huang,
B. Sun,
H. Li,
F. Xue,
X. Liu,
R. Yang Tags: Original Article Source Type: research
Beh çet's syndrome as a tool to dissect the mechanisms of thrombo‐inflammation: clinical and pathogenetic aspects
This article is protected by copyright. All rights reserved. (Source: Clinical and Experimental Immunology)
Source: Clinical and Experimental Immunology - November 25, 2018 Category: Allergy & Immunology Authors: Matteo Becatti,
Giacomo Emmi,
Alessandra Bettiol,
Elena Silvestri,
Gerardo Di Scala,
Niccol ò Taddei,
Domenico Prisco,
Claudia Fiorillo Tags: Review Source Type: research
Monocytes show immunoregulatory capacity on CD4+ T cells in a human in ‐vitro model of extracorporeal photopheresis
In this study, we established anin ‐vitro ECP model focusing on ECP ‐treated monocytes in co‐culture with CD4+ T cells as knowledge on the role of monocytes in ECP is particularly controversial and should be further investigated. We found thatin ‐vitro ECP treatment of monocytes (1) significantly induced proinflammatory T cell types dependent on cell ‐contact, whereas anti‐inflammatory T cells were unaffected, (2) significantly reduced proliferation rates of co‐cultured T cells in a cell‐contact‐dependent manner partially due to PD‐L1–PD‐1 interactions as (3) blockade of this interaction by antibodi...
Source: Clinical and Experimental Immunology - November 22, 2018 Category: Allergy & Immunology Authors: F. Wiese,
K. Reinhardt ‐Heller,
M. Volz,
C. Gille,
N. Köstlin,
H. Billing,
R. Handgretinger,
U. Holzer Tags: Original Article Source Type: research
Activation of Toll ‐like receptor 7 signaling in labial salivary glands of primary Sjögren's syndrome patients
ConclusionOur findings suggest that TLR7 is dominantly expressed in both MNCs and ducts with downstream signals for type I IFNs, indicating that TLR7 ‐dominant innate immunity is related to the development of sialadenitis in pSS.This article is protected by copyright. All rights reserved. (Source: Clinical and Experimental Immunology)
Source: Clinical and Experimental Immunology - November 17, 2018 Category: Allergy & Immunology Authors: Toshimasa Shimizu,
Hideki Nakamura,
Ayuko Takatani,
Masataka Umeda,
Yoshiro Horai,
Shota Kurushima,
Toru Michitsuji,
Yoshikazu Nakashima,
Atsushi Kawakami Tags: Original Article Source Type: research
Mechanisms of lymphatic system –specific viral replication and its potential role in autoimmune disease
In conclusion, several mechanisms promote viral replication in secondary lymphatic organs. Identifying such factors in humans is a challenge for future studies.This article is protected by copyright. All rights reserved. (Source: Clinical and Experimental Immunology)
Source: Clinical and Experimental Immunology - November 16, 2018 Category: Allergy & Immunology Authors: Sarah ‐Kim Friedrich,
Philipp A Lang,
Justa Friebus‐Kardash,
Vikas Duhan,
Judith Bezgovsek,
Karl S Lang Tags: Review Source Type: research
Complement component 5 does not interfere with physiologic hemostasis but is essential for Escherichia coli ‐induced coagulation accompanied by Toll‐like receptor 4
In conclusion, C5 showed no impact on physiological hemostasis, but substantially contributed toE.coli‐induced procoagulant events, which were abolished by the combined inhibition of C5 and CD14 or TLR4.This article is protected by copyright. All rights reserved. (Source: Clinical and Experimental Immunology)
Source: Clinical and Experimental Immunology - November 16, 2018 Category: Allergy & Immunology Authors: Anne Landsem,
Hilde Fure,
Judith Krey Ludviksen,
Dorte Christiansen,
Corinna Lau,
Monica Mathisen,
Grethe Bergseth,
Stig Nymo,
Knut Tore Lappeg ård,
Trent Martin Woodruff,
Terje Espevik,
Tom Eirik Mollnes,
Ole‐Lars Brekke Tags: Original Article Source Type: research
The immunopathogenesis of fibrosis in systemic sclerosis
This article is protected by copyright. All rights reserved. (Source: Clinical and Experimental Immunology)
Source: Clinical and Experimental Immunology - November 14, 2018 Category: Allergy & Immunology Authors: Max Brown,
Steven O'Reilly Tags: Review Source Type: research
AID and TET2 co ‐operation modulates FANCA expression by active demethylation in diffuse large B cell lymphoma
(i) AID recruits TET2 to bind FANCA promoter; (ii) AID ‐TET2 complex demethylate FANCA and increase its expression in DLBCL; (iii) A combination of proteasome inhibitor bortezomib with AID and TET2 depletion significantly inhibits DLBCL cell growth. SummaryDiffuse large B cell lymphoma (DLBCL) is traced to a mature B malignance carrying abnormal activation ‐induced cytidine deaminase (AID) expression. AID activity initially focuses on deamination of cytidine to uracil to generate somatic hypermutation and class‐switch recombination of the immunoglobulin (Ig), but recently it has been implicated in DNA demethylation o...
Source: Clinical and Experimental Immunology - November 13, 2018 Category: Allergy & Immunology Authors: J. Jiao,
Y. Jin,
M. Zheng,
H. Zhang,
M. Yuan,
Z. Lv,
W. Odhiambo,
X. Yu,
P. Zhang,
C. Li,
Y. Ma,
Y. Ji Tags: Original Article Source Type: research
Enterovirus infection and type 1 diabetes: unraveling the crime scene
Enteroviruses (EV) have been historically associated to type 1 diabetes. Definitive proof for their implication in disease development is lacking, but growing evidence suggests that they could be involved in beta cell destruction either directly by killing beta cells or indirectly by creating an exacerbated inflammatory response in the islets, capable of attracting autoreactive T cells to the ‘scene of the crime’. Increasing evidence in the field shows that a ‘viral signature’ exists in type 1 diabetes and involves interferon responses that could be sustained during prolonged periods. These include the up‐regulat...
Source: Clinical and Experimental Immunology - November 13, 2018 Category: Allergy & Immunology Authors: T. Rodriguez ‐Calvo Tags: Review Article Source Type: research
Inflammation in osteoarthritis: is it time to dampen the alarm ‐in this debilitating disease?
This article is protected by copyright. All rights reserved. (Source: Clinical and Experimental Immunology)
Source: Clinical and Experimental Immunology - November 13, 2018 Category: Allergy & Immunology Authors: Martijn H.J. van den Bosch Tags: Review Source Type: research
Autoantibodies to Killer Cell Immunoglobulin ‐Like Receptor 3DL1 in Patients with Systemic Lupus Erythematosus
This article is protected by copyright. All rights reserved. (Source: Clinical and Experimental Immunology)
Source: Clinical and Experimental Immunology - November 13, 2018 Category: Allergy & Immunology Authors: Akihiro Doi,
Shigeyuki Kano,
Mai Asano,
Yuko Takahashi,
Takahiro Mimori,
Akio Mimori,
Hiroshi Kaneko Tags: Original Article Source Type: research
The impact of timing of maternal influenza immunisation on infant antibody levels at birth
This article is protected by copyright. All rights reserved. (Source: Clinical and Experimental Immunology)
Source: Clinical and Experimental Immunology - November 13, 2018 Category: Allergy & Immunology Authors: Z. Zhong,
M. Haltalli,
B. Holder,
T. Rice,
B. Donaldson,
M. O'Driscoll,
K. Le ‐Doare,
B. Kampmann,
J.S. Tregoning Tags: Original Article Source Type: research
Colonization of preterm gnotobiotic piglets with probiotic Lactobacillus rhamnosus GG & its interference with Salmonella Typhimurium
This article is protected by copyright. All rights reserved. (Source: Clinical and Experimental Immunology)
Source: Clinical and Experimental Immunology - November 13, 2018 Category: Allergy & Immunology Authors: Alla Splichalova,
Vera Jenistova,
Zdislava Splichalova,
Igor Splichal Tags: Original Article Source Type: research
Issue Information
Clinical&Experimental Immunology, Volume 194, Issue 3, December 2018. (Source: Clinical and Experimental Immunology)
Source: Clinical and Experimental Immunology - November 12, 2018 Category: Allergy & Immunology Tags: Issue Information Source Type: research
