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Condition: Diabetes Mellitus
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Total 263 results found since Jan 2013.
Elevated galectin-3 levels detected in women with hyperglycemia during early and mid-pregnancy antagonizes high glucose - induced trophoblast cells apoptosis via galectin-3/foxc1 pathway
CONCLUSION: Future studies were required to validate whether plasma galectin-3 might become a potential biomarker for hyperglycemia during pregnancy. Elevated galectin-3 levels might be a vital protective mechanism among those exposed to hyperglycemia during pregnancy.PMID:37626284 | DOI:10.1186/s10020-023-00707-5
Source: Molecular Medicine - August 25, 2023 Category: Molecular Biology Authors: Yu Deng Hongyan Jin Jie Ning Dong Cui Muqiu Zhang Huixia Yang Source Type: research
SGLT2 inhibitor canagliflozin alleviates vascular calcification through suppression of NLRP3 inflammasome
CONCLUSIONS: Our study for the first time demonstrates that CANA exerts a protective effect on vascular calcification at least partially via suppressing NLRP3 signaling pathway. Therefore, supplementation of CANA as well as inhibition of NLRP3 inflammasome presents a potential therapy for vascular calcification.PMID:37523743 | DOI:10.1093/cvr/cvad119
Source: Atherosclerosis - July 31, 2023 Category: Cardiology Authors: An Chen Zirong Lan Li Li Luting Xie Xiaoyu Liu Xiulin Yang Siyi Wang Qingchun Liang Qianqian Dong Liyun Feng Yining Li Yuanzhi Ye Mingwei Fu Lihe Lu Jianyun Yan Source Type: research
Kaempferol attenuates nonalcoholic fatty liver disease in type 2 diabetic mice via the Sirt1/AMPK signaling pathway
Biomed Pharmacother. 2023 Jul 5;165:115113. doi: 10.1016/j.biopha.2023.115113. Online ahead of print.ABSTRACTNonalcoholic fatty liver disease (NAFLD) is one of the most common liver diseases with limited treatment options. Moreover, its prevalence is doubled in type 2 diabetes mellitus (T2DM). Kaempferol (KAP) is a flavonoid compound that has been suggested to have beneficial effects on NAFLD, but studies on the mechanism are lacking, especially in the diabetic state. Herein, we investigated the effect of KAP on NAFLD associated with T2DM and its underlying mechanism in vitro and in vivo. The results of in vitro studies in...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - July 7, 2023 Category: Drugs & Pharmacology Authors: Na Li Lin Yin Jiamin Shang Meidai Liang Zhaoyu Liu Haiguang Yang Guifen Qiang Guanhua Du Xiuying Yang Source Type: research
Hydroxysafflor yellow A inhibits endothelial cell ferroptosis in diabetic atherosclerosis mice by regulating miR-429/SLC7A11
CONCLUSIONS: HSYA is expected to become an important health drug to prevent the occurrence and development of T2DM/AS.PMID:37410531 | DOI:10.1080/13880209.2023.2225543
Source: Atherosclerosis - July 6, 2023 Category: Cardiology Authors: Jianjie Rong Chuanyong Li Qiang Zhang Guangfeng Zheng Weijian Fan Zhichang Pan Shuming Shi Source Type: research
Nicotine exacerbates diabetic nephropathy through upregulation of Grem1 expression
CONCLUSION: Grem1 plays a vital role in nicotine-exacerbated DN. Grem1 may be a potential therapeutic target for chronic smokers with DN.PMID:37415117 | DOI:10.1186/s10020-023-00692-9
Source: Molecular Medicine - July 6, 2023 Category: Molecular Biology Authors: Jianning Chen Haiting Xiao Rui Xue Vinod Kumar Rukhsana Aslam Syed Faizan Mehdi Huairong Luo Ashwani Malhotra Xiqian Lan Pravin Singhal Source Type: research
Diabetes is accompanied by secretion of pro-atherosclerotic exosomes from vascular smooth muscle cells
CONCLUSION: These data identify a novel paracrine signaling pathway that promotes the cardiovascular complications of diabetes mellitus.PMID:37179303 | DOI:10.1186/s12933-023-01833-4
Source: Atherosclerosis - May 13, 2023 Category: Cardiology Authors: Heng Yu Hunter F Douglas Donald Wathieu Ryan A Braun Christine Edomwande Daniel J Lightell Thaidan Pham Natasha C Klingenberg Shelia Pugh Bishop Damir B Khismatullin T Cooper Woods Source Type: research
LncRNA DANCR deficiency promotes high glucose-induced endothelial to mesenchymal transition in cardiac microvascular cells via the FoxO1/DDAH1/ADMA signaling pathway
This study aims to evaluate underlying mechanisms of ADMA in DCM especially for EndMT under diabetic conditions. A diabetic rat model was induced by streptozotocin (STZ) injection, and human cardiac microvascular endothelial cells (HCMECs) were stimulated with high glucose to induce EndMT. Subsequently, the role of ADMA in EndMT was detected either by exogenous ADMA or by over-expressing dimethylarginine dimethylaminohydrolase 1 (DDAH1, degradation enzyme for ADMA) before high glucose stimulation. Furthermore, the relationships among forkhead box protein O1 (FoxO1), DDAH1 and ADMA were evaluated by FoxO1 over-expression or...
Source: European Journal of Pharmacology - April 28, 2023 Category: Drugs & Pharmacology Authors: Meiting Wu Ting Li Ge Li Bingxuan Niu Tian Wu Li Yan Shiming Wang Shuangyi He Chuyi Huang Weiqiang Tong Niansheng Li Junlin Jiang Source Type: research
Periostin acts as a bridge between gestational diabetes mellitus (GDM) and chronic inflammation to modulate insulin resistance by modulating PPAR α/NF-κB/TNF-α signaling pathway
CONCLUSION: POSTN levels were significantly higher in pregnant women with GDM and were associated with chronic inflammation and PPARα expression. POSTN may act as a bridge between GDM and chronic inflammation to modulate insulin resistance by modulating PPARα/NF-κB/TNF-α signaling pathway.PMID:37106515 | DOI:10.2174/1871530323666230427104724
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - April 28, 2023 Category: Endocrinology Authors: Qun Ji Xinying Li Yan Wang Haiwei Liu Kaining Chen Huibiao Quan Huachuan Zhang Jianmin Ran Source Type: research
