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Condition: Diabetes Mellitus
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Total 263 results found since Jan 2013.
Advanced glycation end products induce skeletal muscle atrophy and insulin resistance via activating ROS-mediated ER stress PERK/FOXO1 signaling
In this study, we investigated whether AGEs could exacerbate skeletal muscle atrophy and its related insulin resistance. Mice were exposed to AGEs. Forkhead box O1 (FOXO1) was silenced by a constructed viral vector carrying siRNA. Skeletal muscle atrophy was evaluated by H&E, oil red O, myosin skeletal heavy chain (MHC) and laminin immunofluorescent stains. Reactive oxygen species (ROS) generation was assessed by DHE stain. Western blotting was used to evaluate protein expression and phosphorylation. Insulin resistance was monitored by insulin tolerance test (ITT) and glucose infusion rate (GIR). Mice exposed to AGEs s...
Source: American Journal of Physiology. Endocrinology and Metabolism - February 1, 2023 Category: Physiology Authors: Haixia Du Yanpeng Ma Xiqiang Wang Yong Zhang Ling Zhu Shuang Shi Shuo Pan Zhongwei Liu Source Type: research
Swinhoeic acid from < em > Potentilla fragarioides < /em > ameliorates high glucose-induced oxidative stress and accumulation of ECM in mesangial cells via Keap1-dependent activation of Nrf2
CONCLUSION: Swinhoeic acid ameliorates oxidative stress and accumulation of ECM resulting from high glucose in mesangial cells via activating Nrf2 in Keap1-dependent manner.PMID:36259553 | DOI:10.1080/13510002.2022.2134755
Source: Redox Report : communications in free radical research - October 19, 2022 Category: Biochemistry Authors: Huankai Yao Min Kong Dan Du Fengwei Ai Jindong Li Yan Li Source Type: research
