High day-to-day and diurnal variability of oxidative stress and inflammation biomarkers in people with type 2 diabetes mellitus and healthy individuals.
Conclusion:: Oxidative stress and inflammatory biomarkers show considerable variation in both T2D and healthy populations. Trial registration: ClinicalTrials.gov identifier: NCT01206725. PMID: 32693740 [PubMed - in process] (Source: Redox Report : communications in free radical research)
Source: Redox Report : communications in free radical research - July 24, 2020 Category: Biochemistry Authors: Mallard AR, Hollekim-Strand SM, Ingul CB, Coombes JS Tags: Redox Rep Source Type: research

Generation of reactive oxygen species by hydroxypyridone compound/iron complexes.
Conclusion: Biological toxicity of mimosine and deferiprone reported previously can be accounted for by the prooxidant properties of hydroxypyridone compounds: coordination complex with iron generates reactive oxygen species resulting in the disturbance of mitochondrial energy metabolism and DNA damage. PMID: 32615878 [PubMed - in process] (Source: Redox Report : communications in free radical research)
Source: Redox Report : communications in free radical research - July 5, 2020 Category: Biochemistry Authors: Murakami K, Yoshino M Tags: Redox Rep Source Type: research

Renin angiotensin system blockage by losartan neutralize hypercholesterolemia-induced inflammatory and oxidative injuries.
Conclusion: This study confirmed the pathological enrollment of renin-angiotensin system in hypercholesterolemia-associated metabolic alterations. LT had a significant cardiac, hepatic, and renal protective role against these impairments through down-regulation of oxidative damage, inflammation and necrosis. PMID: 32396454 [PubMed - as supplied by publisher] (Source: Redox Report : communications in free radical research)
Source: Redox Report : communications in free radical research - May 13, 2020 Category: Biochemistry Authors: AlSaad AMS, Alasmari F, Abuohashish HM, Mohany M, Ahmed MM, Al-Rejaie SS Tags: Redox Rep Source Type: research

Evidence for NADPH oxidase activation by GPR40 in pancreatic β-cells.
We report for the first time that acute activation of GPR40 leads to NADPH oxidase activation in pancreatic β-cells, without impact on insulin secretion. PMID: 32354273 [PubMed - in process] (Source: Redox Report : communications in free radical research)
Source: Redox Report : communications in free radical research - May 3, 2020 Category: Biochemistry Authors: Nunes Marsiglio-Librais G, Aparecida Vilas-Boas E, Carlein C, Hoffmann MDA, Roma LP, Carpinelli AR Tags: Redox Rep Source Type: research

Codeine-induced sperm DNA damage is mediated predominantly by oxidative stress rather than apoptosis.
Conclusion: This study revealed that chronic codeine exposure causes sperm DNA fragmentation and poor sperm quality primarily via oxidative stress rather than activation of caspase 3-dependent apoptosis. Findings of the present study may explain drug-induced male factor infertility, particularly, those associated with opioid use. PMID: 32290793 [PubMed - in process] (Source: Redox Report : communications in free radical research)
Source: Redox Report : communications in free radical research - April 16, 2020 Category: Biochemistry Authors: Ajayi AF, Akhigbe RE Tags: Redox Rep Source Type: research

Mitochondrial complex II and reactive oxygen species in disease and therapy.
Abstract Increasing evidence points to the respiratory Complex II (CII) as a source and modulator of reactive oxygen species (ROS). Both functional loss of CII as well as its pharmacological inhibition can lead to ROS generation in cells, with a relevant impact on the development of pathophysiological conditions, i.e. cancer and neurodegenerative diseases. While the basic framework of CII involvement in ROS production has been defined, the fine details still await clarification. It is important to resolve these aspects to fully understand the role of CII in pathology and to explore its therapeutic potential in can...
Source: Redox Report : communications in free radical research - April 16, 2020 Category: Biochemistry Authors: Hadrava Vanova K, Kraus M, Neuzil J, Rohlena J Tags: Redox Rep Source Type: research

Selective cytotoxic activity and protective effects of sodium ascorbate against hepatocellular carcinoma through its effect on oxidative stress and apoptosis in vivo and in vitro.
Conclusion: In spite of the antioxidant and anti-inflammatory activity of sodium ascorbate, it produced selective cytotoxic activity via direct activation of the apoptotic pathway in cancer cells without affecting the apoptotic pathway in normal hepatic cells. PMID: 32172678 [PubMed - in process] (Source: Redox Report : communications in free radical research)
Source: Redox Report : communications in free radical research - March 17, 2020 Category: Biochemistry Authors: El-Far YM, Khodir AE, Noor AO, Almasri DM, Bagalagel AA, Diri RM, Kutbi HI, Al-Gayyar MMH Tags: Redox Rep Source Type: research

Protective effects of 1,25 dihydroxyvitamin D3 and its analogs on ultraviolet radiation-induced oxidative stress: a review.
Abstract The active vitamin D compound, 1,25-dihydroxyvitamin D3 (1,25D) is produced in skin cells following exposure to ultraviolet radiation (UV) from the sun. However, there are many harmful effects of UV which include DNA damage caused by direct absorption of UV, as well as that caused indirectly via UV-induced reactive oxygen species (ROS). Interestingly, 1,25D and analogs have been shown to reduce both direct and indirect UV-induced DNA damage in skin cells. This was accompanied by reductions in ROS and in nitric oxide products with 1,25D following UV. Moreover, following acute UV exposure, 1,25D has been de...
Source: Redox Report : communications in free radical research - February 26, 2020 Category: Biochemistry Authors: Jagoda SV, Dixon KM Tags: Redox Rep Source Type: research

Antioxidant potential of biflavonoid attenuates hyperglycemia by modulating the carbohydrate metabolic enzymes in high fat diet/streptozotocin induced diabetic rats.
Discussion: Oral administration of biflavonoid to diabetic rats significantly ameliorated all the biochemical alterations to near normal levels. The effect produced by the biflavonoid on various parameters was comparable to that of metformin. PMID: 32013797 [PubMed - in process] (Source: Redox Report : communications in free radical research)
Source: Redox Report : communications in free radical research - February 6, 2020 Category: Biochemistry Authors: Ramalingam S, Karuppiah M, Thiruppathi M, Palanivelu S, Panchanatham S Tags: Redox Rep Source Type: research

Salidroside inhibits MAPK, NF- κB, and STAT3 pathways in psoriasis-associated oxidative stress via SIRT1 activation.
Conclusion: Salidroside might inhibit oxidative stress singling pathways via SIRT1 activation, and could be as an ideal candidate for management of psoriasis. PMID: 31495284 [PubMed - in process] (Source: Redox Report : communications in free radical research)
Source: Redox Report : communications in free radical research - September 11, 2019 Category: Biochemistry Authors: Xu F, Xu J, Xiong X, Deng Y Tags: Redox Rep Source Type: research

Resveratrol improves osteogenic differentiation of senescent bone mesenchymal stem cells through inhibiting endogenous reactive oxygen species production via AMPK activation.
Conclusion: These results provide a potential mechanism involving AMPK activation/ROS inhibition signaling pathway in osteogenic differentiation of BMSCs enhanced by resveratrol. It suggests that development of therapy towards ROS is an effective way for osteoporosis treatment. PMID: 31438780 [PubMed - in process] (Source: Redox Report : communications in free radical research)
Source: Redox Report : communications in free radical research - August 25, 2019 Category: Biochemistry Authors: Zhou T, Yan Y, Zhao C, Xu Y, Wang Q, Xu N Tags: Redox Rep Source Type: research

Reaction of endogenous Coenzyme Q10 with nitrogen monoxide and its metabolite nitrogen dioxide.
eci L Abstract Objectives: Coenzyme Q10, incorporated in DOPC lyposomes or naturally present in liver bovine mitochondria or in human blood plasma, was reacted with nitrogen dioxide •NO2 or with a •NO/•NO2 mixture. Methods and Results: The reaction course was monitored by Electron Paramagnetic Resonance (EPR) spectroscopy and in all cases the formation of a di-tert-alkyl nitroxide was observed, deriving from the addition of •NO2 to one of the double bonds, most likely the terminal one, of the isoprenic chain. The rate constant for nitroxide formation was also determined by EPR spectroscopy and ...
Source: Redox Report : communications in free radical research - July 29, 2019 Category: Biochemistry Authors: Astolfi P, Clément JL, Gigmes D, Armeni T, Carloni P, Greci L Tags: Redox Rep Source Type: research

Increased systemic and peritoneal oxidative stress biomarkers in endometriosis are not related to retrograde menstruation.
Discussion: Our results show a peritoneal and systemic oxidative stress biomarkers increase in endometriosis, but not related to each other, and do not support the hypothesis of an increase in hemoglobin-iron supply towards the peritoneal cavity that causes oxidative damage. PMID: 31221043 [PubMed - in process] (Source: Redox Report : communications in free radical research)
Source: Redox Report : communications in free radical research - June 23, 2019 Category: Biochemistry Authors: Montoya-Estrada A, Coria-García CF, Cruz-Orozco OP, Aguayo-González P, Torres-Ramos YD, Flores-Herrera H, Hicks JJ, Medina-Navarro R, Guzmán-Grenfell AM Tags: Redox Rep Source Type: research

Antioxidant potential of theaflavin ameliorates the activities of key enzymes of glucose metabolism in high fat diet and streptozotocin - induced diabetic rats.
Discussion: Oral administration of theaflavin to diabetic rats significantly ameliorated all the biochemical alterations to near normal levels. The results of the present study suggest that theaflavin exhibits antidiabetic effect through its antioxidant activity. PMID: 31142215 [PubMed - in process] (Source: Redox Report : communications in free radical research)
Source: Redox Report : communications in free radical research - May 31, 2019 Category: Biochemistry Authors: Gothandam K, Ganesan VS, Ayyasamy T, Ramalingam S Tags: Redox Rep Source Type: research

Protection of cholinergic and antioxidant system contributes to the effect of Vitamin D3 ameliorating memory dysfunction in sporadic dementia of Alzheimer's type.
Abstract OBJECTIVE: Investigate Vitamin D3 (VD3) effect on the Acetylcholinesterase (AChE), oxidative damage and behavioral tests in animals subjected to Intracerebroventicular injection of Streptozotocin (ICV-STZ) simulating a Sporadic Dementia of Alzheimer's Type (SDAT) and treated with VD3 (21 days). METHODS: Animals were divided into eight groups: Vehicle, VD12.5 μg/kg, VD42 μg/kg, VD125 μg/kg, STZ, STZ+VD12.5 μg/kg, STZ+VD42 μg/kg, STZ+VD125 μg/kg. RESULTS: VD3 prevented the increase in AChE in groups of VD42 µg/kg and VD125 µg/kg; in AChE of synaptossom...
Source: Redox Report : communications in free radical research - May 20, 2019 Category: Biochemistry Authors: Rodrigues MV, Gutierres JM, Carvalho F, Lopes TF, Antunes V, da Costa P, Pereira ME, Schetinger MRC, Morsch VM, de Andrade CM Tags: Redox Rep Source Type: research

Cigarette smoke exposure induces ROS-mediated autophagy by regulating sestrin, AMPK, and mTOR level in mice.
In conclusion, these results suggest the involvement of ROS, SESN2, AMPK, and mTOR in the CS-induced autophagic process in the lung. PMID: 30957679 [PubMed - in process] (Source: Redox Report : communications in free radical research)
Source: Redox Report : communications in free radical research - April 10, 2019 Category: Biochemistry Authors: Morsch ALBC, Wisniewski E, Luciano TF, Comin VH, Silveira GB, Marques SO, Thirupathi A, Silveira Lock PC, De Souza CT Tags: Redox Rep Source Type: research

Hepatitis C virus core or NS3/4A protein expression preconditions hepatocytes against oxidative stress and endoplasmic reticulum stress.
In conclusion, hepatocytes exposed to direct and indirect oxidative stress inducers are able to cope with cellular stress associated with viral hepatitis and thus promote cell survival. PMID: 30909829 [PubMed - in process] (Source: Redox Report : communications in free radical research)
Source: Redox Report : communications in free radical research - March 28, 2019 Category: Biochemistry Authors: Ríos-Ocampo WA, Daemen T, Buist-Homan M, Faber KN, Navas MC, Moshage H Tags: Redox Rep Source Type: research

Early onset of renal oxidative stress in small for gestational age newborn pigs.
CONCLUSION: Early induction of oxidative stress may contribute to the onset of kidney injury in growth-restricted infants. PMID: 30907266 [PubMed - in process] (Source: Redox Report : communications in free radical research)
Source: Redox Report : communications in free radical research - March 27, 2019 Category: Biochemistry Authors: Soni H, Yakimkova T, Matthews AT, Amartey PK, Read RW, Buddington RK, Adebiyi A Tags: Redox Rep Source Type: research

Proteomics and phosphoproteomics study of LCMT1 overexpression and oxidative stress: overexpression of LCMT1 arrests H2O2-induced lose of cells viability.
DISCUSSION: These data provide proteomics and phosphoproteomics insights into the association of LCMT1-dependent PP2Ac methylation and oxidative stress and indirectly indicate that the methylation of PP2A plays an important role against oxidative stress. PMID: 30898057 [PubMed - in process] (Source: Redox Report : communications in free radical research)
Source: Redox Report : communications in free radical research - March 24, 2019 Category: Biochemistry Authors: Wang X, Tang S, Qin F, Liu Y, Liang Z, Cai H, Mo L, Xiao D, Guo S, Ouyang Y, Sun B, Lu C, Li X Tags: Redox Rep Source Type: research

Age-associated changes in GSH S-transferase gene/proteins in livers of rats.
This study characterized three expression patterns of 10 GSTs during development and aging in rat liver, adding to our understanding of anti-aging role of GSTs. PMID: 30444463 [PubMed - in process] (Source: Redox Report : communications in free radical research)
Source: Redox Report : communications in free radical research - November 19, 2018 Category: Biochemistry Authors: Xu S, Hou D, Liu J, Ji L Tags: Redox Rep Source Type: research

Sicyos angulatus ameliorates acute liver injury by inhibiting oxidative stress via upregulation of anti-oxidant enzymes.
CONCLUSION: SA ameliorated liver injury and might be a good strategy for the treatment of liver injury. PMID: 30426855 [PubMed - in process] (Source: Redox Report : communications in free radical research)
Source: Redox Report : communications in free radical research - November 16, 2018 Category: Biochemistry Authors: Kim HY, Noh JR, Moon SJ, Choi DH, Kim YH, Kim KS, Yook HS, An JP, Oh WK, Hwang JH, Lee CH Tags: Redox Rep Source Type: research

Alteration in sperm characteristics, endocrine balance and redox status in rats rendered diabetic by streptozotocin treatment: attenuating role of Loranthus micranthus.
CONCLUSION: The anti-diabetic and aphrodisiac properties exhibited by L. micranthus could be contingent on its ability to restore a balance to the compromised redox status that characterizes male reproductive dysfunction in diabetes. PMID: 30376784 [PubMed - in process] (Source: Redox Report : communications in free radical research)
Source: Redox Report : communications in free radical research - November 2, 2018 Category: Biochemistry Authors: Ebokaiwe AP, Ijomone OM, Osawe SO, Chukwu CJ, Ejike CECC, Zhang G, Wang F Tags: Redox Rep Source Type: research

Hesperetin mitigates acrolein-induced apoptosis in lung cells in vitro and in vivo.
CONCLUSION: In the present report, we demonstrate that hesperetin exhibits a protective effect against acrolein-induced apoptosis of lung cells in both in vitro and in vivo models. Our study provides a useful model to investigate the potential application of hesperetin for the prevention of lung diseases associated with acrolein toxicity. PMID: 30325253 [PubMed - in process] (Source: Redox Report : communications in free radical research)
Source: Redox Report : communications in free radical research - October 18, 2018 Category: Biochemistry Authors: Park JH, Ku HJ, Park JW Tags: Redox Rep Source Type: research

Oxidative insults disrupt OPA1-mediated mitochondrial dynamics in cultured mammalian cells.
DISCUSSION: Taken together, these findings indicate that oxidative insults damage OPA1-mediated mitochondrial dynamics in mammalian cells via activation of OMA1, consistent with an emerging role for mitochondrial dynamics as an early indicator of cellular stress signaling. PMID: 29961397 [PubMed - in process] (Source: Redox Report : communications in free radical research)
Source: Redox Report : communications in free radical research - July 3, 2018 Category: Biochemistry Authors: Garcia I, Innis-Whitehouse W, Lopez A, Keniry M, Gilkerson R Tags: Redox Rep Source Type: research

Rosuvastatin alleviates high-salt and cholesterol diet-induced cognitive impairment in rats via Nrf2-ARE pathway.
The objectives of our study were to investigate the possible effect of rosuvastatin in ameliorating high salt and cholesterol diet (HSCD)-induced cognitive impairment and to also investigate its possible action via the Nrf2-ARE pathway. METHODS: In silico studies were performed to check the theoretical binding of rosuvastatin to the Nrf2 target. HSCD was used to induce cognitive impairment in rats and neurobehavioral studies were performed to evaluate the efficacy of rosuvastatin in enhancing cognition. Biochemical analyses were used to estimate changes in oxidative markers. Western blot and immunohistochemical analys...
Source: Redox Report : communications in free radical research - July 3, 2018 Category: Biochemistry Authors: Husain I, Akhtar M, Madaan T, Abdin MZ, Islamuddin M, Najmi AK Tags: Redox Rep Source Type: research

Does hypothyroidism augment sun-induced skin damage?
DISCUSSION: The hypothyroid state could be a risk factor for enhanced oxidative skin damage in chronic photo-exposed skin due to oxidative stress. The lipid peroxidation is one of the major pathways by which photo-oxidative stress promotes photocarcinogenesis and photo-aging. PMID: 29962323 [PubMed - in process] (Source: Redox Report : communications in free radical research)
Source: Redox Report : communications in free radical research - July 3, 2018 Category: Biochemistry Authors: Bocheva G, Valcheva-Traykova M, Landzhov B Tags: Redox Rep Source Type: research

Renal mitochondrial oxidative stress is enhanced by the reduction of Sirt3 activity, in Zucker diabetic fatty rats.
CONCLUSIONS: Enhancement of mitochondrial oxidative stress in the diabetic kidney was mediated by the reduction of Sirt3 activity. CD38 overexpression may be related to a reduction in the NAD+/NADH ratio in the diabetic kidney. PMID: 29897845 [PubMed - in process] (Source: Redox Report : communications in free radical research)
Source: Redox Report : communications in free radical research - June 15, 2018 Category: Biochemistry Authors: Ogura Y, Kitada M, Monno I, Kanasaki K, Watanabe A, Koya D Tags: Redox Rep Source Type: research

Aerobic training reduces oxidative stress in skeletal muscle of rats exposed to air pollution and supplemented with chromium picolinate.
Abstract OBJECTIVE: The purpose of this study was to investigate the effects of chromium picolinate (CrPic) supplementation associated with aerobic exercise using measures of oxidative stress in rats exposed to air pollution. METHODS: Sixty-one male Wistar rats were divided into eight groups: residual oil fly ash (ROFA) exposure and sedentary (ROFA-SED); ROFA exposure, sedentary and supplemented (ROFA-SED-CrPic); ROFA exposure and trained (ROFA-AT); ROFA exposure, supplemented and trained (ROFA-AT-CrPic); sedentary (Sal-SED); sedentary and supplemented (Sal-SED-CrPic); trained (Sal-AT); and supplemented and t...
Source: Redox Report : communications in free radical research - May 20, 2018 Category: Biochemistry Authors: Marmett B, Nunes RB, de Souza KS, Lago PD, Rhoden CR Tags: Redox Rep Source Type: research

Effect of ubiquinol supplementation on biochemical and oxidative stress indexes after intense exercise in young athletes.
DISCUSSION: Data highlights a very rapid dynamic of CoQ depletion following intense exercise underlying an increased demand by the organism. Ubiquinol supplementation minimized exercise-induced depletion and enhanced plasma and cellular antioxidant levels but it was not able to improve physical performance indexes or markers of muscular damage. PMID: 29734881 [PubMed - in process] (Source: Redox Report : communications in free radical research)
Source: Redox Report : communications in free radical research - May 9, 2018 Category: Biochemistry Authors: Orlando P, Silvestri S, Galeazzi R, Antonicelli R, Marcheggiani F, Cirilli I, Bacchetti T, Tiano L Tags: Redox Rep Source Type: research

Proanthocyanidins: novel treatment for psoriasis that reduces oxidative stress and modulates Th17 and Treg cells.
Abstract Psoriasis is a common, chronic, inflammatory skin disease that affects 2%-4% of the global population. Recent studies have shown that increased oxidative stress (OS) and T-cell abnormalities are central to the pathogenesis of this disease. The resulting reactive oxygen species (ROS) induces proliferation and differentiation of Th17/Th1/Th22 cells and inhibits the anti-inflammatory activities of regulatory T lymphocytes (Treg). Subsequent secretions of inflammatory cytokines, such as interleukin (IL)-17, IL-22, tumor necrosis factor alpha (TNF-α), and interferon-gamma (IFN-γ), and vascular endo...
Source: Redox Report : communications in free radical research - April 10, 2018 Category: Biochemistry Authors: Lai R, Xian D, Xiong X, Yang L, Song J, Zhong J Tags: Redox Rep Source Type: research

Optimization of a diagnostic platform for oxidation-reduction potential (ORP) measurement in human plasma.
DISCUSSION: We confirm that ORP detects oxidative stress in plasma samples. Optimal measurement of plasma ORP requires blood collection in heparin anticoagulant tubes and immediate analysis without a freeze-thaw cycle. PMID: 29606080 [PubMed - in process] (Source: Redox Report : communications in free radical research)
Source: Redox Report : communications in free radical research - April 3, 2018 Category: Biochemistry Authors: Polson D, Villalba N, Freeman K Tags: Redox Rep Source Type: research

Taurine alleviates endoplasmic reticulum stress in the chondrocytes from patients with osteoarthritis.
Abstract Osteoarthritis (OA), characterized by pain and stiffness, swelling, deformity and dysfunction of joints, affects large numbers of population. The purpose of this study was to discover the effects of taurine in human OA chondrocytes and explore the underlying mechanisms. 46 patients with different grades of OA were recruited. Of these patients, 24 underwent total knee replacement and cartilages were harvested. The mRNA expressions of type II collagen (Collagen II) and endoplasmic reticulum (ER) stress markers (GRP78, GADD153 and Caspase-12) in cartilages were quantified by qRT-PCR. Cell viability and apopt...
Source: Redox Report : communications in free radical research - March 3, 2018 Category: Biochemistry Authors: Bian Y, Wang H, Sun S Tags: Redox Rep Source Type: research

A systematic review of p53 regulation of oxidative stress in skeletal muscle.
CONCLUSION: Current evidence confirms that p53 acts as a threshold regulator of cellular homeostasis. Therefore, within each modality, the intensity and duration are parameters of the oxidative stressor that must be analyzed to determine the role p53 plays in regulating signaling pathways to maintain cellular health and function in skeletal muscle. ABBREVIATIONS: Acadl: acyl-CoA dehydrogenase, long chain; Acadm: acyl-CoA dehydrogenase, C-4 to C-12 straight chain; AIF: apoptosis-inducing factor; Akt: protein kinase B (PKB); AMPK: AMP-activated protein kinase; ATF-4: activating transcription factor 4; ATM: ATM serine/th...
Source: Redox Report : communications in free radical research - January 3, 2018 Category: Biochemistry Authors: Beyfuss K, Hood DA Tags: Redox Rep Source Type: research

Exercise through a cardiac rehabilitation program attenuates oxidative stress in patients submitted to coronary artery bypass grafting.
CONCLUSIONS: The results suggest that regular exercise through a cardiac rehabilitation program can attenuate oxidative stress in chronic coronary artery disease patients submitted to coronary artery bypass grafting. PMID: 29279041 [PubMed - as supplied by publisher] (Source: Redox Report : communications in free radical research)
Source: Redox Report : communications in free radical research - December 27, 2017 Category: Biochemistry Authors: Taty Zau JF, Costa Zeferino R, Sandrine Mota N, Fernandes Martins G, Manoel Serra S, Bonates da Cunha T, Medeiros Lima D, Bragança Pereira B, Matos do Nascimento E, Filho DW, Curi Pedrosa R, Pedrosa RC Tags: Redox Rep Source Type: research

Redox status of patients before cardiac surgery.
DISCUSSION: In this prospective study we determined multiple correlations between redox markers and parameters linked to cardiovascular diseases. The data point towards so far unknown interdependencies, particularly between antihypertensive drugs and redox metabolism. A thorough follow-up to these data has the potential to improve patient management. ABBREVIATIONS: A: absorption; ΔA: absorption difference; ABTS: 2,2'-azino-di(3-ethylbenzothiazoline sulfonate); ACE: angiotensin-converting enzyme; AO: antioxidant; ARB: angiotensin receptor blocker; BMI: body mass index; CAD: coronary artery disease; CCB: calcium c...
Source: Redox Report : communications in free radical research - December 19, 2017 Category: Biochemistry Authors: Schuh AK, Sheybani B, Jortzik E, Niemann B, Wilhelm J, Boening A, Becker K Tags: Redox Rep Source Type: research

A high-caloric diet rich in soy oil alleviates oxidative damage of skeletal muscles induced by dexamethasone in chickens.
Discussion Oxidative damage in skeletal muscles and mitochondria was the result of GC-induced suppression of the activity of mitochondrial complex I. A HC diet improved the antioxidative capacity and reduced the oxidative damage induced by the GC. PMID: 29157186 [PubMed - as supplied by publisher] (Source: Redox Report : communications in free radical research)
Source: Redox Report : communications in free radical research - November 20, 2017 Category: Biochemistry Authors: Jiao H, Zhou K, Zhao J, Wang X, Lin H Tags: Redox Rep Source Type: research

Influence of gestational diabetes on the activity of δ-aminolevulinate dehydratase and oxidative stress biomarkers.
This study aimed to evaluate the activity of delta-aminolevulinate dehydratase (δ-ALA-D) and oxidative stress biomarkers in pregnant women with gestational diabetes mellitus (GDM), in order to demonstrate the involvement of oxidative stress in this condition, which presents pathophysiology still undetermined. METHODS: δ-ALA-D activity, lipid peroxidation estimated as the levels of thiobarbituric acid reactive substances (TBARS), protein (P-SH) and non-protein thiol (NP-SH) content, catalase (CAT) activity and concentration of vitamin C (VIT C) in samples of pregnant women with GDM (n = 48) an...
Source: Redox Report : communications in free radical research - November 17, 2017 Category: Biochemistry Authors: Rodrigues F, de Lucca L, Neme WS, Gonçalves TL Tags: Redox Rep Source Type: research

Spectrophotometric assays for measuring redox biomarkers in blood and tissues: the NADPH network.
Abstract Nicotinamide adenine dinucleotide (NAD(+)/NADH) along with its phosphorylated form (NADP(+)/NADPH) are two molecules ubiquitously present in all organisms, and they play key roles as cofactors in fundamental catabolic and anabolic processes, respectively. The oxidation of NADPH to NADP(+) initiates a cascade of reactions, where a network of molecules is implicated. The molecules of this cascade form a network with eminent translational potential in redox metabolism. A special point of interest is that spectrophotometric assays have been developed both for NADH/NADPH and the molecules directly regulated by...
Source: Redox Report : communications in free radical research - October 31, 2017 Category: Biochemistry Authors: Veskoukis AS, Margaritelis NV, Kyparos A, Paschalis V, Nikolaidis MG Tags: Redox Rep Source Type: research

A comparison of native and non-urate Total Antioxidant Capacity of fasting plasma and saliva among middle-aged and older subjects.
Abstract OBJECTIVES: As plasma and salivary total antioxidant capacity (TAC) is mainly contributed by uric acid (UA), the present study measures non-urate TAC (Nu-TAC). The aim of the study was to correlate plasma native TAC, Nu-TAC and UA with their salivary analogues, and compare the UA contribution in both body fluids using two different methods. METHODS: The study involved 55 middle-aged and older subjects (66.7 ± 4.5 years). TAC was determined simultaneously with two methods (ferric reducing ability of plasma - FRAP, 2.2-diphenyl-1-picryl-hydrazyl - DPPH and countertypes for saliva -...
Source: Redox Report : communications in free radical research - October 31, 2017 Category: Biochemistry Authors: Gawron-Skarbek A, Prymont-Przymińska A, Sobczak A, Guligowska A, Kostka T, Nowak D, Szatko F Tags: Redox Rep Source Type: research

Antioxidant, antihyperglycemic, and antidyslipidemic effects of Brazilian-native fruit extracts in an animal model of insulin resistance.
CONCLUSION: Fruit extracts of E. uniflora and P. cattleianum exhibited considerable antihyperglycemic, antidyslipidemic, and antioxidant effects, and may be useful in the therapeutic management of alterations due to IR. PMID: 29088999 [PubMed - as supplied by publisher] (Source: Redox Report : communications in free radical research)
Source: Redox Report : communications in free radical research - October 31, 2017 Category: Biochemistry Authors: de Souza Cardoso J, Oliveira PS, Bona NP, Vasconcellos FA, Baldissarelli J, Vizzotto M, Soares MSP, Ramos VP, Spanevello RM, Lencina CL, Tavares RG, Stefanello FM Tags: Redox Rep Source Type: research

Biomarkers of antioxidant status and lipid peroxidation in elderly patients with hypertension.
The objective of the present study was to examine selected parameters of the blood redox system in elderly patients with hypertension.examine selected parameters of the blood redox system in elderly patients with hypertension. METHODS: We analyzed differences in redox-associated molecules and enzymes among elderly hypertensive subjects (age above 65 years, n = 49) and two groups of normotensive subjects (65 - Control group II; n = 30). RESULTS: Decreased activity of antioxidant enzymes, increased lipid peroxidation and reduced production of nitric oxide were observed in hypertensive ...
Source: Redox Report : communications in free radical research - September 5, 2017 Category: Biochemistry Authors: Pawluk H, Pawluk R, Robaczewska J, Kędziora-Kornatowska K, Kędziora J Tags: Redox Rep Source Type: research

Activity of the antioxidant enzyme paraoxonase in Argentinean children living at high altitude.
CONCLUSION: SAC showed an unfavorable lipoprotein profile, lower PON and higher ARE activities compared with BA children, suggesting the presence of altered HDL metabolism and antioxidant capacity. PMID: 28853330 [PubMed - as supplied by publisher] (Source: Redox Report : communications in free radical research)
Source: Redox Report : communications in free radical research - August 30, 2017 Category: Biochemistry Authors: Hirschler V, Martín M, Oestreicher K, Molinari C, Tetzlaff W, Botta E, Boero L, Brites F, San Antonio de los Cobres Study Group Tags: Redox Rep Source Type: research

Poor acute outcome in congestive heart failure is associated with increases in the plasma static oxidation-reduction potentials (sORP) in men but not in women.
We examined whether sex modified the relationship between ORP and hospital discharge disposition (poor outcome: death, hospice), along with other demographics, medications, and diagnostic parameters. RESULTS: Males with poor outcomes had higher sORP and icORP values than females (P  0.05). Males were younger and more likely to have HF-rEF and diabetes. Controlling for these variables did not account for the sex differences in ORP measures. Regardless of sex, higher creatinine was related to higher sORP and icORP, while lower magnesium and potassium were related to higher sORP and icORP, respectively. ...
Source: Redox Report : communications in free radical research - August 28, 2017 Category: Biochemistry Authors: Bjugstad KB, Lalama J, Rael LT, Salottolo K, Dauber I, Bar-Or D Tags: Redox Rep Source Type: research

Biologically important hydrazide-containing fused azaisocytosines as antioxidant agents.
DISCUSSION: Hydrazides 3, 6 and 9 with an antioxidant potential better or comparable to that of the well-known antioxidants are proposed as new antioxidant candidates. PMID: 28812524 [PubMed - as supplied by publisher] (Source: Redox Report : communications in free radical research)
Source: Redox Report : communications in free radical research - August 16, 2017 Category: Biochemistry Authors: Sztanke M, Sztanke K Tags: Redox Rep Source Type: research

Galangin, a natural flavonoid reduces mitochondrial oxidative damage in streptozotocin-induced diabetic rats.
Abstract OBJECTIVE: We designed this study to observe the effect of galangin on damaged mitochondria in the liver of diabetic rats. METHODS: Male albino Wistar rats were made diabetic by injecting streptozotocin (STZ) intraperitoneally (40 mg kg(-1) body weight (BW)). Galangin (8 mg kg(-1) BW) or glibenclamide (600 µg kg(-1) BW) was given orally daily once for 45 days to both healthy and diabetic rats. RESULTS: Diabetic rats showed significant (P 
Source: Redox Report : communications in free radical research - August 16, 2017 Category: Biochemistry Authors: Aloud AA, Veeramani C, Govindasamy C, Alsaif MA, Al-Numair KS Tags: Redox Rep Source Type: research

Hesperidin attenuates inflammation and oxidative damage in pleural exudates and liver of rat model of pleurisy.
CONCLUSION: Our results suggest that hesperidin can elicit its anti-inflammatory action by blocking exudate and leukocyte influx into pleural cavity, inhibiting MPO activity and preventing oxidative damage. PMID: 28657497 [PubMed - as supplied by publisher] (Source: Redox Report : communications in free radical research)
Source: Redox Report : communications in free radical research - June 28, 2017 Category: Biochemistry Authors: Adefegha SA, Rosa Leal DB, Olabiyi AA, Oboh G, Castilhos LG Tags: Redox Rep Source Type: research

Phytochemical treatments target kynurenine pathway induced oxidative stress.
CONCLUSION: These results suggest that phenolic compounds, a class of phytochemicals, including flavonoids and diarylheptanoids, should be further studied to develop new treatments for oxidative stress related neurological disorders. PMID: 28651456 [PubMed - as supplied by publisher] (Source: Redox Report : communications in free radical research)
Source: Redox Report : communications in free radical research - June 26, 2017 Category: Biochemistry Authors: Parasram K Tags: Redox Rep Source Type: research

Pterostilbene protects against UVB-induced photo-damage through a phosphatidylinositol-3-kinase-dependent Nrf2/ARE pathway in human keratinocytes.
CONCLUSION: The present study indicated that Pter effectively protected against UVB-induced photodamage by increasing endogenous defense mechanisms, scavenging UVB-induced ROS, and aiding in damaged DNA repair through a PI3K-dependent activation of Nrf2/ARE pathway. PMID: 28532341 [PubMed - as supplied by publisher] (Source: Redox Report : communications in free radical research)
Source: Redox Report : communications in free radical research - May 22, 2017 Category: Biochemistry Authors: Li H, Jiang N, Liang B, Liu Q, Zhang E, Peng L, Deng H, Li R, Li Z, Zhu H Tags: Redox Rep Source Type: research

Markers of oxidative/nitrative damage of plasma proteins correlated with EDSS and BDI scores in patients with secondary progressive multiple sclerosis.
The objective of the present study was to evaluate oxidative/nitrative stress in the plasma of 50 patients suffering from the secondary progressive course of multiple sclerosis (MS), and to verify its correlation with physical and mental disability as assessed by the Expanded Disability Status Scale (EDSS), and the Beck Depression Inventory (BDI). Methods Oxidative and nitrative damage to proteins was determined by the level of carbonyl groups and 3-nitrotyrosine using ELISA test. Based on the reaction with Ellman's reagent, we estimated the concentration of oxidized thiol groups. Additionally, we measured the level of lip...
Source: Redox Report : communications in free radical research - May 19, 2017 Category: Biochemistry Authors: Morel A, Bijak M, Niwald M, Miller E, Saluk J Tags: Redox Rep Source Type: research

Antioxidant properties of drugs used in Type 2 diabetes management: could they contribute to, confound or conceal effects of antioxidant therapy?
CONCLUSION: Pharmaceutical agents used in the treatment of type 2 diabetes has been shown to exert an antioxidant effect.. PMID: 28514939 [PubMed - as supplied by publisher] (Source: Redox Report : communications in free radical research)
Source: Redox Report : communications in free radical research - May 17, 2017 Category: Biochemistry Authors: Choi SW, Ho CK Tags: Redox Rep Source Type: research