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Hesperidin activates Nrf2 to protect cochlear hair cells from cisplatin-induced damage
This study employs both in vivo and in vitro models of cisplatin ototoxicity to explore this possibility. Our results reveal that hesperidin mitigates cisplatin-induced ototoxicity by activating the Nrf2/NQO1 pathway in sensory hair cells, thereby reducing ROS accumulation, preventing hair cell apoptosis, and alleviating hearing loss.PMID:38629504 | DOI:10.1080/13510002.2024.2341470 (Source: Redox Report : communications in free radical research)
Source: Redox Report : communications in free radical research - April 17, 2024 Category: Biochemistry Authors: Jintao Lou Fan Wu Wuhui He Rui Hu Ziyi Cai Guisheng Chen Wenji Zhao Zhigang Zhang Yu Si Source Type: research

Zinc ameliorates acrylamide-induced oxidative stress and apoptosis in testicular cells via Nrf2/HO-1/NfkB and Bax/Bcl2 signaling pathway
CONCLUSION: In conclusion, zinc may protect against acrylamide-induced testicular toxicity, mediated by its antioxidant, anti-inflammatory, and antiapoptotic effects.PMID:38629506 | DOI:10.1080/13510002.2024.2341537 (Source: Redox Report : communications in free radical research)
Source: Redox Report : communications in free radical research - April 17, 2024 Category: Biochemistry Authors: Ayodeji Johnson Ajibare Adeyemi Fatai Odetayo Olabode Oluwadare Akintoye Luqman Aribidesi Olayaki Source Type: research

Astaxanthin prevents bone loss in osteoporotic rats with palmitic acid through suppressing oxidative stress
CONCLUSION: Summarizing, ATX may inhibit PA-induced bone loss through its antioxidant properties via the SIRT1 signaling pathway.PMID:38623993 | DOI:10.1080/13510002.2024.2333096 (Source: Redox Report : communications in free radical research)
Source: Redox Report : communications in free radical research - April 16, 2024 Category: Biochemistry Authors: Zhou-Shan Tao Xing-Jing Wu Min Yang Cai-Liang Shen Source Type: research

Enhancing the bioavailability and activity of natural antioxidants with nanobubbles and nanoparticles
Redox Rep. 2024 Dec;29(1):2333619. doi: 10.1080/13510002.2024.2333619. Epub 2024 Apr 5.ABSTRACTKEY POLICY HIGHLIGHTSNanobubbles and nanoparticles may enhance the polyphenols' bioavailabilityNanobubbles may stimulate the activation of Nrf2 and detox enzymesArmoured oxygen nanobubbles may enhance radiotherapy or chemotherapy effects.PMID:38577911 | PMC:PMC11000614 | DOI:10.1080/13510002.2024.2333619 (Source: Redox Report : communications in free radical research)
Source: Redox Report : communications in free radical research - April 5, 2024 Category: Biochemistry Authors: Miroslav Čolić Sandra Kraljevi ć Pavelić Željka Peršurić Andrea Agaj Aleksandar Bulog Kre šimir Pavelić Source Type: research

Enhancing the bioavailability and activity of natural antioxidants with nanobubbles and nanoparticles
Redox Rep. 2024 Dec;29(1):2333619. doi: 10.1080/13510002.2024.2333619. Epub 2024 Apr 5.ABSTRACTKEY POLICY HIGHLIGHTSNanobubbles and nanoparticles may enhance the polyphenols' bioavailabilityNanobubbles may stimulate the activation of Nrf2 and detox enzymesArmoured oxygen nanobubbles may enhance radiotherapy or chemotherapy effects.PMID:38577911 | DOI:10.1080/13510002.2024.2333619 (Source: Redox Report : communications in free radical research)
Source: Redox Report : communications in free radical research - April 5, 2024 Category: Biochemistry Authors: Miroslav Čolić Sandra Kraljevi ć Pavelić Željka Peršurić Andrea Agaj Aleksandar Bulog Kre šimir Pavelić Source Type: research

Correction
Redox Rep. 2024 Dec;29(1):2327255. doi: 10.1080/13510002.2024.2327255. Epub 2024 Apr 2.NO ABSTRACTPMID:38563331 | PMC:PMC10993761 | DOI:10.1080/13510002.2024.2327255 (Source: Redox Report : communications in free radical research)
Source: Redox Report : communications in free radical research - April 2, 2024 Category: Biochemistry Source Type: research

Ivacaftor attenuates gentamicin-induced ototoxicity through the CFTR-Nrf2-HO1/NQO1 pathway
The objective of this study was to estimate the effect of the CFTR activator ivacaftor on gentamicin-induced ototoxicity and determine its mechanism.METHODS: The hair cell count was analyzed by Myosin 7a staining. Apoptosis was analyzed by TUNEL Apoptosis Kit. Cellular reactive oxygen species (ROS) level was detected by DCFH-DA probes. The Nrf2 related proteins expression levels were analyzed by western blot.RESULTS: An in vitro cochlear explant model showed that gentamicin caused ROS accumulation in sensory hair cells and induced apoptosis, and this effect was alleviated by pretreatment with ivacaftor. Western blotting sh...
Source: Redox Report : communications in free radical research - April 2, 2024 Category: Biochemistry Authors: Rui Hu Fan Wu Yi-Qing Zheng Source Type: research

Correction
Redox Rep. 2024 Dec;29(1):2327255. doi: 10.1080/13510002.2024.2327255. Epub 2024 Apr 2.NO ABSTRACTPMID:38563331 | DOI:10.1080/13510002.2024.2327255 (Source: Redox Report : communications in free radical research)
Source: Redox Report : communications in free radical research - April 2, 2024 Category: Biochemistry Source Type: research