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Condition: Diabetes Mellitus

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Total 263 results found since Jan 2013.

Repurposed major urinary protein pheromones and adult sensory neurons: Roles in neuron plasticity and experimental diabetes
Am J Physiol Endocrinol Metab. 2022 May 30. doi: 10.1152/ajpendo.00001.2022. Online ahead of print.ABSTRACTMajor urinary proteins (MUPs), members of the broader lipocalin protein family, are classified as pheromones that are excreted in male rodent urine to define conspecific territoriality. In screening for differentially regulated mRNA transcripts in a mouse model of type 1 experimental diabetes mellitus (DM), we identified an unexpected upregulation of several closely related MUP transcripts within diabetic sensory dorsal root ganglia (DRGs). Both sexes expressed overall MUP protein content as identified by an antibody ...
Source: American Journal of Physiology. Endocrinology and Metabolism - May 31, 2022 Category: Physiology Authors: Trevor Poitras Vandana Singh Ramanaguru Piragasam Xiuling Wang Atef Mahmoud Mannaa Ambika Chandrasekhar Jose Martinez Richard Fahlman Douglas W Zochodne Source Type: research

Inhibition of Drp1 ameliorates diabetic retinopathy by regulating mitochondrial homeostasis
Exp Eye Res. 2022 Apr 28:109095. doi: 10.1016/j.exer.2022.109095. Online ahead of print.ABSTRACTDiabetic retinopathy (DR) is a potentially blinding complication resulting from diabetes mellitus (DM). Retinal vascular endothelial cells (RMECs) dysfunction occupies an important position in the pathogenesis of DR, and mitochondrial disorders play a vital role in RMECs dysfunction. However, the detailed mechanisms underlying DR-induced mitochondrial disorders in RMECs remain elusive. In the present study, we used High glucose (HG)-induced RMECs in vitro and streptozotocin (STZ)-induced Sprague-Dawley rats in vivo to explore th...
Source: Experimental Eye Research - May 1, 2022 Category: Opthalmology Authors: Meng-Yuan Zhang Lingpeng Zhu Xun Bao Tian-Hua Xie Jiping Cai Jian Zou Wenjuan Wang Shun Gu Yan Li Hong-Ying Li Yong Yao Ting-Ting Wei Source Type: research

GSE200983 Effect of O-GlcNAc Transferase (OGT) siRNA in trophoblastic BeWo cells
Contributors : Stephanie Olivier-Van Stichelen ; Yiwen CuiSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensEvery year, about 18 million babies are born from mothers with gestational diabetes mellitus (GDM). While diabetic symptoms usually resolve after delivery, lasting complications can occur for both mother and child, including fetal overgrowth, type 2 diabetes (T2D), cardiovascular diseases, and obesity. The rapid progression of GDM is unique to pregnancies, and likely arises from placental dysfunction. Indeed, stress, nutrition and fetal gender are thought to trigger changes in pla...
Source: GEO: Gene Expression Omnibus - April 21, 2022 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research

Aquaporin 9 regulates Leydig cell steroidogenesis in diabetes
Syst Biol Reprod Med. 2022 Mar 30:1-14. doi: 10.1080/19396368.2022.2033350. Online ahead of print.ABSTRACTDiabetes mellitus induced hyperglycemia increases oxidative stress, which contributes to impairment of male reproductive function. Aquaporins (AQPs) belong to a transmembrane protein superfamily containing 13 isoforms (AQP0-12), differentially expressed in various organs, and play a pivotal role in male reproductive function. In the current study, we investigated the relationship between AQPs and testicular steroidogenesis under hyperglycemia in vivo and in vitro. The effect of high glucose on the role of AQPs in Leydi...
Source: Systems Biology in Reproductive Medicine - March 30, 2022 Category: Reproduction Medicine Authors: Arun Kannan Lezy Flora Mariajoseph-Antony Antojenifer Panneerselvam Chithra Loganathan Diwakar Kiduva Jothiraman Kumarasamy Anbarasu Chidambaram Prahalathan Source Type: research

Leveraging Potential of Nanotherapeutics in Management of Diabetic Foot Ulcer
Exp Clin Endocrinol Diabetes DOI: 10.1055/a-1749-4909Diabetic foot ulcers (DFUs) are the most common complications associated with diabetes mellitus. DFUs are displayed as open sores or wounds located on the bottom of the foot as a secondary complication of diabetes mellitus (DM). DFUs are associated with significant morbidity and mortality and can subsequently lead to hospitalization and lower limb amputation if not recognized and treated on time. An immense challenge to conventional treatments is caused by the chronic nature of diabetic foot syndrome and it has led to the emergence of n...
Source: Experimental and Clinical Endocrinology and Diabetes - March 3, 2022 Category: Endocrinology Authors: Pandey, Supriya Shaif, Mohammad Ansari, Tarique M Shamim, Arshiya Kushwaha, Poonam Tags: Mini-Review Source Type: research

TRPV1 Protect against Hyperglycemia and Hyperlipidemia Induced Liver Injury via OPA1 in Diabetes
In conclusion, our study showed that the identified regulation of TRPV1 to OPA1 has important implication to the pathogenesis of T2DM-associated liver injury. Targeting the action of TRPV1 and OPA1 presents a potential therapeutic intervention.PMID:35197406 | DOI:10.1620/tjem.256.131
Source: The Tohoku Journal of Experimental Medicine - February 24, 2022 Category: Research Authors: Ting Wang Yingmei Chen Yong Li Zhen Wang Chenming Qiu Dachun Yang Ken Chen Source Type: research

Novel Nanotechnological Approaches for Targeting Dorsal Root Ganglion (DRG) in Mitigating Diabetic Neuropathic Pain (DNP)
Diabetic neuropathy is the most entrenched complication of diabetes. Usually, it affects the distal foot and toes, which then gradually approaches the lower part of the legs. Diabetic foot ulcer (DFU) could be one of the worst complications of diabetes mellitus. Long-term diabetes leads to hyperglycemia, which is the utmost contributor to neuropathic pain. Hyperglycemia causing an upregulation of voltage-gated sodium channels in the dorsal root ganglion (DRG) was often observed in models of neuropathic pain. DRG opening frequency increases intracellular sodium ion levels, which further causes increased calcium channel open...
Source: Frontiers in Endocrinology - February 8, 2022 Category: Endocrinology Source Type: research

Activation of neutral sphingomyelinase 2 through hyperglycemia contributes to endothelial apoptosis via vesicle-bound intercellular transfer of ceramides
CONCLUSION: lEVs mediate the induction of apoptosis in endothelial cells in response to hyperglycemic injury through intercellular transfer of ceramides.PMID:34951654 | DOI:10.1007/s00018-021-04049-5
Source: Cellular and Molecular Life Sciences : CMLS - December 24, 2021 Category: Cytology Authors: Andreas Zietzer Alina Lisann Jahnel Marko Bulic Katharina Gutbrod Philip D üsing Mohammed Rabiul Hosen Peter D örmann Nikos Werner Georg Nickenig Felix Jansen Source Type: research