Systems Biology in Reproductive Medicine This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

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Role of preovulatory concentrations of estradiol on timing of conception and regulation of the uterine environment in beef cattle
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Source: Systems Biology in Reproductive Medicine - December 8, 2019 Category: Sexual Medicine Authors: George A. Perry Robert A. Cushman Brandi L. Perry Amanda K. Schiefelbein Emmalee J. Northrop Jerica J.J. Rich Stephanie D. Perkins Source Type: research

Identification of differentially expressed proteins associated with recurrence in ovarian endometriotic cysts
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Source: Systems Biology in Reproductive Medicine - November 12, 2019 Category: Sexual Medicine Authors: Genhai Zhu Jiao Kong Xinhui Fu Fujin Liu Haiyan Huang Lan Hong Kang Wang Source Type: research

Identification of differentially expressed proteins associated with recurrence in ovarian endometriotic cysts.
The objective of this study was to identify proteins that are differentially expressed in the cystic wall tissues of ovarian endometriotic cysts, simple ovarian cysts, and in normal ovarian tissues. Specimens of ovarian endometriotic cyst wall tissue, simple ovarian cyst wall tissue, and normal ovarian tissue (six specimens per group) were collected from patients who received gynecologic surgery, respectively. Differentially expressed proteins related to the ovarian endometriotic cysts were screened by use of isobaric tags for relative and absolute quantitation (iTRAQ) combined with functional annotation and bioinformatics...
Source: Systems Biology in Reproductive Medicine - November 12, 2019 Category: Reproduction Medicine Authors: Zhu G, Kong J, Fu X, Liu F, Huang H, Hong L, Wang K Tags: Syst Biol Reprod Med Source Type: research

Karyotypic abnormalities and molecular analysis of Y chromosome microdeletion in Iranian Azeri Turkish population infertile men.
Abstract Infertility is one of the major health-threatening problems in communities which may lead to psychological problems among couples. Y chromosome abnormalities and microdeletions have recently been considered as one of the male infertility factors. The aim of this study was to evaluate different chromosomal disorders and azoospermia factor b (AZFb), AZFc and AZFd microdeletions in idiopathic non-obstructive oligo or azoospermia infertile men. One hundred infertile (78 azoospermia and 22 oligospermia) and 100 fertile men were included in this study. Luteinizing hormone (LH) and follicle stimulating hormone (...
Source: Systems Biology in Reproductive Medicine - November 5, 2019 Category: Reproduction Medicine Authors: Akbarzadeh Khiavi M, Jalili A, Safary A, Gharedaghchi Z, Mirinezhad SK, Mehdizadeh A, Rahmani SA Tags: Syst Biol Reprod Med Source Type: research

Predictive factors for sperm retrieval from males with azoospermia who are eligible for testicular sperm extraction (TESE).
Abstract The aim of this study was to evaluate the predictive value of factors in infertile male patients to retrieve sperm from their testicles before they undergo testicular sperm extraction (TESE). In total, 64 males were enrolled in this study. Infertility was identified as obstructive azoospermia (OA); non-obstructive azoospermia (NOA); Klinefelter syndrome (KS); and cryptozoospermia (Crypt). Age, body mass index and concomitant conditions were noted. Testicular volumes, serum levels of Follicle-Stimulating Hormone (FSH), Luteinizing Hormone (LH), testosterone (T) and prolactin were investigated. Sperm retrie...
Source: Systems Biology in Reproductive Medicine - November 5, 2019 Category: Reproduction Medicine Authors: Pavan-Jukic D, Stubljar D, Jukic T, Starc A Tags: Syst Biol Reprod Med Source Type: research

Karyotypic abnormalities and molecular analysis of Y chromosome microdeletion in Iranian Azeri Turkish population infertile men
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Source: Systems Biology in Reproductive Medicine - November 5, 2019 Category: Sexual Medicine Authors: Mostafa Akbarzadeh Khiavi Akbar Jalili Azam Safary Ziba Gharedaghchi Seyed Kazem Mirinezhad Amir Mehdizadeh Seyyed Ali Rahmani Source Type: research

Predictive factors for sperm retrieval from males with azoospermia who are eligible for testicular sperm extraction (TESE)
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Source: Systems Biology in Reproductive Medicine - November 5, 2019 Category: Sexual Medicine Authors: Doroteja Pavan-Jukic David Stubljar Tomislav Jukic Andrej Starc Source Type: research

Peroxisome Proliferator-Activated Receptors (PPARs) levels in spermatozoa of normozoospermic and asthenozoospermic men
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Source: Systems Biology in Reproductive Medicine - November 1, 2019 Category: Sexual Medicine Authors: Motahareh Sadat Mousavi Abdolhossein Shahverdi Jo ël Drevet Vahid Akbarinejad Vahid Esmaeili Forough Azam Sayahpour Tohid Rezaei Topraggaleh Pegah Rahimizadeh AliReza Alizadeh Source Type: research

Peroxisome Proliferator-Activated Receptors (PPARs) levels in spermatozoa of normozoospermic and asthenozoospermic men.
This study was designed to determine and compare PPARα, PPARβ and PPARγ mRNA expression in sperm cells of normozoospermic and asthenozoospermic men. In addition, flow cytometric analyses, immunofluorescence and western blot were used to evaluate PPARγ protein levels in spermatozoa. We have compared the sperm PPARs mRNA relative expression in 27 normozoospermic and 28 asthenozoospermic samples and monitored sperm PPARγ protein levels in 39 normozoospermic and 40 asthenozoospermic samples using flow cytometry. We have also assessed in a sub-group of seven normozoospermic and eight asthenozoosperm...
Source: Systems Biology in Reproductive Medicine - November 1, 2019 Category: Reproduction Medicine Authors: Mousavi MS, Shahverdi A, Drevet J, Akbarinejad V, Esmaeili V, Sayahpour FA, Topraggaleh TR, Rahimizadeh P, Alizadeh A Tags: Syst Biol Reprod Med Source Type: research

Pelvic Radiation-Induced Testicular Damage: An Experimental Study at 1 Gray
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Source: Systems Biology in Reproductive Medicine - October 26, 2019 Category: Sexual Medicine Authors: Sema Yilmaz Rakici Ali Irfan Guzel Levent Tumkaya Hatice Sevim Nalkiran Tolga Mercantepe Source Type: research

Pelvic Radiation-Induced Testicular Damage: An Experimental Study at 1 Gray.
In this study we aimed to evaluate the effects of a low therapeutic dose of 1 Gy on the induction of cellular and histological damage in early-stage testicular germ cells and the impact of this radiation on offspring sex ratio. Unirradiated and irradiated male rats were mated with unirradiated female rats. Female rats were followed and the sex of the offspring was determined. The male rats were sacrificed at the end of the second week, and the testicular germ cells were subjected to genetic analysis along with cytological and histopathological examination. Sperm DNA was amplified with primers specific to testis-specif...
Source: Systems Biology in Reproductive Medicine - October 26, 2019 Category: Reproduction Medicine Authors: Rakici SY, Guzel AI, Tumkaya L, Sevim Nalkiran H, Mercantepe T Tags: Syst Biol Reprod Med Source Type: research

H3K4me2 accompanies chromatin immaturity in human spermatozoa: an epigenetic marker for sperm quality assessment
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Source: Systems Biology in Reproductive Medicine - October 3, 2019 Category: Sexual Medicine Authors: Miriama Štiavnická Olga Garc ía-Álvarez Zd ěnka Ulčová-Gallová Peter Sutovsky Laura Abril-Parre ño Martina Dolej šová Hedvika Řimnáčová Ji ří Moravec Petr Ho šek Petr Lo šan Luk áš Gold Tereza Fenclov á Milena Kr álíčková Jan Nev Source Type: research

H3K4me2 accompanies chromatin immaturity in human spermatozoa: an epigenetic marker for sperm quality assessment.
In this study, 99 semen samples, including 22 normozoospermic (N), 63 asthenozoospermic (A), and 14 oligoasthenozoospermic (OA) samples, were comprehensively analyzed with respect to H3K4me2 levels, DNA damage (DNA fragmentation index, DFI), and sperm immaturity (high DNA stainability, %HDS), as determined by a sperm chromatin structure assay using flow cytometry. We detected a significant relationship between H3K4me2 and %HDS (r = 0.47; p OA) indicates the importance of chromatin immaturity and histone code deviations in sperm evaluations. Using various approaches, our study elucidated H3K4me2 as a molecular ma...
Source: Systems Biology in Reproductive Medicine - October 3, 2019 Category: Reproduction Medicine Authors: Štiavnická M, García-Álvarez O, Ulčová-Gallová Z, Sutovsky P, Abril-Parreño L, Dolejšová M, Řimnáčová H, Moravec J, Hošek P, Lošan P, Gold L, Fenclová T, Králíčková M, Nevoral J Tags: Syst Biol Reprod Med Source Type: research

Nur77 promotes embryo adhesion by transcriptionally regulating HOXA10 expression
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Source: Systems Biology in Reproductive Medicine - October 1, 2019 Category: Sexual Medicine Authors: Jingtao Shen Xudong Zhu Mei Zhang Yue Jiang Guijun Yan Zhilong Wang Lihua Sun Qun Zhang Source Type: research

Nur77 promotes embryo adhesion by transcriptionally regulating HOXA10 expression.
This study is the first to show that Nur77 promotes embryo adhesion by transcriptionally regulating HOXA10 expression. Nur77 and 6-MP may provide a basis to develop a new treatment for patients who suffer from embryo adhesion dysfunction. Abbreviations: HB-EGF: heparin-binding epidermal growth factor-like growth factor; HOXA10: homeobox A10; NGFI-B: nerve growth factor-induced gene B; RIF: recurrent implantation failure; RPL: recurrent pregnancy loss; 6-MP: 6-mercaptopurine; IGFBP-1: insulin-like growth factor binding protein-1; LIF: leukemia inhibitory factor; IL-1β: Interleukin - 1β; CRISPR/Cas9: Clustered Regu...
Source: Systems Biology in Reproductive Medicine - October 1, 2019 Category: Reproduction Medicine Authors: Shen J, Zhu X, Zhang M, Jiang Y, Yan G, Wang Z, Sun L, Zhang Q Tags: Syst Biol Reprod Med Source Type: research

Incidence of high sperm DNA fragmentation in a targeted population of subfertile men
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Source: Systems Biology in Reproductive Medicine - September 24, 2019 Category: Sexual Medicine Authors: Chitra Vinnakota Lynsey Cree John Peek Dean E. Morbeck Source Type: research

Incidence of high sperm DNA fragmentation in a targeted population of subfertile men.
This study shows that SDF testing can be targeted based on age and sperm motility, thereby reducing unnecessary testing. Furthermore, we provide evidence that lifestyle modifications can reduce DNA fragmentation in men with high DFI. PMID: 31550174 [PubMed - as supplied by publisher] (Source: Systems Biology in Reproductive Medicine)
Source: Systems Biology in Reproductive Medicine - September 24, 2019 Category: Reproduction Medicine Authors: Vinnakota C, Cree L, Peek J, Morbeck DE Tags: Syst Biol Reprod Med Source Type: research

Characterization of DNA cleavage produced by seminal plasma using leukocytes as a cell target
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Source: Systems Biology in Reproductive Medicine - September 20, 2019 Category: Sexual Medicine Authors: Elva I. Cort és-Gutiérrez Carlos Garc ía De La Vega Javier Bartolom é-Nebreda Jaime Gos álvez Source Type: research

Characterization of DNA cleavage produced by seminal plasma using leukocytes as a cell target.
In conclusion, capacity of seminal plasma for producing DNA cleavage represents a solid contribution to expand the analysis of the standard seminal profile and could constitute a putative diagnostic tool for evaluating male infertility. Abbreviations: ALS: alkali labile sites; ART: Assisted Reproduction Technologies; DBD-FISH: DNA Breakage Detection-Fluorescence In Situ Hybridization; DNA: deoxyribonucleic acid; DSBs-DNA: double-strand DNA; FITC: Fluorescein IsoThioCyanate; GEDA: Gravity Enforced Diffusion Assays; PBS: phosphate-buffered saline; ROS: Reactive Oxigen Species; SSBs-DNA: single-strand DNA; SSC: saline-sodium ...
Source: Systems Biology in Reproductive Medicine - September 20, 2019 Category: Reproduction Medicine Authors: Cortés-Gutiérrez EI, De La Vega CG, Bartolomé-Nebreda J, Gosálvez J Tags: Syst Biol Reprod Med Source Type: research

Conventional IVF improves blastocyst rate and quality compared to ICSI when used in patients with mild or moderate teratozoospermia
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Source: Systems Biology in Reproductive Medicine - September 15, 2019 Category: Sexual Medicine Authors: Martin Stimpfel Nina Jancar Eda Vrtacnik-Bokal Irma Virant-Klun Source Type: research

Conventional IVF improves blastocyst rate and quality compared to ICSI when used in patients with mild or moderate teratozoospermia.
Abstract The ICSI procedure was invented to treat severe male infertility but is often used even if the sperm quality parameters are normal. This practice has recently been called into question, but there is still no clear answer especially in terms of sperm morphology, regarding when it is necessary to perform ICSI and when conventional IVF is indeed more beneficial. In borderline cases it seems logical to fertilize oocytes using ICSI and conventional IVF at the same time. Since we also use this approach we performed a retrospective analysis of such cycles to elucidate, which procedure results in a better clinica...
Source: Systems Biology in Reproductive Medicine - September 15, 2019 Category: Reproduction Medicine Authors: Stimpfel M, Jancar N, Vrtacnik-Bokal E, Virant-Klun I Tags: Syst Biol Reprod Med Source Type: research

CCDC9 is identified as a novel candidate gene of severe asthenozoospermia
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Source: Systems Biology in Reproductive Medicine - September 10, 2019 Category: Sexual Medicine Authors: Yanwei Sha Yankai Xu Xiaoli Wei Wensheng Liu Libin Mei Shaobin Lin Zhiyong Ji Xu Wang Zhiying Su Pingping Qiu Jing Chen Xiong Wang Source Type: research

Outcome of varicocelectomy on different degrees of total motile sperm count: A systematic review and meta-analysis
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Source: Systems Biology in Reproductive Medicine - August 22, 2019 Category: Sexual Medicine Authors: Qun Wang Yang Yu Yanhong Liu Libo Wang Source Type: research

Outcome of varicocelectomy on different degrees of total motile sperm count: A systematic review and meta-analysis.
Abstract It is crucial to identify the subfertile men with varicocele who will benefit the most from varicocelectomy, and the factors which help in predicting the response to varicocelectomy. We aimed to evaluate the impact of varicocelectomy on total motile sperm count (TMSC) and spontaneous pregnancy (SP) rates. A comprehensive literature search was performed using Medline/PubMed and Google Scholar up to December 26, 2018, with no restriction on language and year of publication. Published articles reporting different degrees of TMSC before and after varicocelectomy in infertile men with varicocele (palpable and/...
Source: Systems Biology in Reproductive Medicine - August 21, 2019 Category: Reproduction Medicine Authors: Wang Q, Yu Y, Liu Y, Wang L Tags: Syst Biol Reprod Med Source Type: research

Mimicking the cauda epididymal plasma-like osmolality in extender improves liquid preservation of ram semen at 3 –5°C
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Source: Systems Biology in Reproductive Medicine - July 24, 2019 Category: Sexual Medicine Authors: Rajani Kumar Paul Krishnappa Balaganur Davendra Kumar Raghvendar Singh Source Type: research

Mimicking the cauda epididymal plasma-like osmolality in extender improves liquid preservation of ram semen at 3-5 °C.
Mimicking the cauda epididymal plasma-like osmolality in extender improves liquid preservation of ram semen at 3-5°C. Syst Biol Reprod Med. 2019 Jul 24;:1-9 Authors: Paul RK, Balaganur K, Kumar D, Singh R Abstract Cauda epididymis in mammals is known to store mature sperm largely in quiescent state for several weeks without significantly affecting fertility. Hence, the aim of this study was to evaluate the effects of mimicking cauda epididymal plasma (CEP)-like conditions in extender on liquid preservation of ram semen at 3-5°C. Four experiments were conducted in this study: (1) evaluation of ...
Source: Systems Biology in Reproductive Medicine - July 24, 2019 Category: Reproduction Medicine Authors: Paul RK, Balaganur K, Kumar D, Singh R Tags: Syst Biol Reprod Med Source Type: research

Thymoquinone ameliorates obesity-induced metabolic dysfunction, improves reproductive efficiency exhibiting a dose-organ relationship
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Source: Systems Biology in Reproductive Medicine - July 2, 2019 Category: Sexual Medicine Authors: Seba Harphoush Guoqing Wu Gao Qiuli Margaret Zaitoun Maissam Ghanem Yonghui Shi Guowei Le Source Type: research

Thymoquinone ameliorates obesity-induced metabolic dysfunction, improves reproductive efficiency exhibiting a dose-organ relationship.
Abstract Women with obesity are more likely to have a complicated reproductive life. Insulin resistance and metabolic dysfunction are associated with obesity. Thymoquinone (TQ) is a well-known antioxidant, considered to be an AMPK-activator. The goal of this work was to investigate the ability of TQ to improve fertility and lactation and clarify the possible mechanism. Female C57BL/6 mice were subjected to High Fat Diet (HFD) supplemented with TQ (10% pmm) and TQ (20% pmm). Histopathological examination was conducted on mammary and ovarian samples. Metabolic and oxidant status was evaluated, and qRT-PCR analysis w...
Source: Systems Biology in Reproductive Medicine - July 1, 2019 Category: Reproduction Medicine Authors: Harphoush S, Wu G, Qiuli G, Zaitoun M, Ghanem M, Shi Y, Le G Tags: Syst Biol Reprod Med Source Type: research

Can trophectoderm RNA analysis predict human blastocyst competency?
Abstract A systematic review of the literature showed that trophectoderm biopsy could assist in the selection of healthy embryos for uterine transfer without affecting implantation rates. However, previous studies attempting to establish the relationship between trophectoderm gene expression profiles and implantation competency using either microarrays or RNA sequencing strategies, were not sufficiently optimized to handle the exceptionally low RNA inputs available from biopsied material. In this pilot study, we report that differential gene expression in human trophectoderm biopsies assayed by an ultra-sensitive ...
Source: Systems Biology in Reproductive Medicine - June 27, 2019 Category: Reproduction Medicine Authors: Ntostis P, Kokkali G, Iles D, Huntriss J, Tzetis M, Picton H, Pantos K, Miller D Tags: Syst Biol Reprod Med Source Type: research

Can trophectoderm RNA analysis predict human blastocyst competency?
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Source: Systems Biology in Reproductive Medicine - June 27, 2019 Category: Sexual Medicine Authors: Panagiotis Ntostis Georgia Kokkali David Iles John Huntriss Maria Tzetis Helen Picton Konstantinos Pantos David Miller Source Type: research

Monocyte-derived extracellular trap (MET) formation induces aggregation and affects motility of human spermatozoa in vitro
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Source: Systems Biology in Reproductive Medicine - June 18, 2019 Category: Sexual Medicine Authors: Mabel Schulz Fabiola Zambrano Hans-Christian Schuppe Florian Wagenlehner Anja Taubert Ulrich Gaertner R ául Sánchez Carlos Hermosilla Source Type: research

Monocyte-derived extracellular trap (MET) formation induces aggregation and affects motility of human spermatozoa in vitro.
lla C Abstract The presence of bacteria and/or leukocytes can alter semen quality resulting in low sperm quality and infertility. Inflammation or infection increases the numbers of PMN or macrophages/monocytes in male genital tract. Release of extracellular traps (ETs) by leukocytes has been recognized as a novel mechanism of early host innate immunity, in response to invasive pathogens. This is the first work that evaluated the mechanism of triggered ETs in monocytes co-incubated with spermatozoa or bacteria and the effect on sperm function. Selected spermatozoa and human monocytes isolated from peripheral blood ...
Source: Systems Biology in Reproductive Medicine - June 18, 2019 Category: Reproduction Medicine Authors: Schulz M, Zambrano F, Schuppe HC, Wagenlehner F, Taubert A, Gaertner U, Sánchez R, Hermosilla C Tags: Syst Biol Reprod Med Source Type: research

New insights into sperm with total globozoospermia: Increased fatty acid oxidation and centrin1 alteration
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Source: Systems Biology in Reproductive Medicine - June 17, 2019 Category: Sexual Medicine Authors: Elena Moretti Giulia Collodel Maria Cristina Salvatici Giuseppe Belmonte Cinzia Signorini Source Type: research

New insights into sperm with total globozoospermia: Increased fatty acid oxidation and centrin1 alteration.
Abstract Sperm morphology and lipid profile have a relevant role in male fertility. We explore the status of the sperm centriole, essential structure for human fertilization and the role of fatty acid oxidation in globozoospermia, a rare sperm pathology causing infertility. A case of globozoospermia was characterized by light and electron microscopy, sperm immunolocalization was performed for centrin1, 8-iso-PGF2α and peroxisome proliferator γ activated receptor gamma (PPARγ). In semen and sperm pellet, F2-isoprostanes (F2-IsoPs) levels were determined. Finally, the cytosolic phospholipase A2 (cP...
Source: Systems Biology in Reproductive Medicine - June 17, 2019 Category: Reproduction Medicine Authors: Moretti E, Collodel G, Salvatici MC, Belmonte G, Signorini C Tags: Syst Biol Reprod Med Source Type: research