SFI, a sex hormone binding globulin based nomogram for predicting non-alcoholic fatty liver disease in the Chinese population
ConclusionThe nomogram SFI has high performance in predicting NAFLD in Chinese population and may be used as a cost-effective screening model to assess NAFLD in the general population. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - June 3, 2023 Category: Endocrinology Source Type: research
Normal glucose tolerant women with low glycemia during the oral glucose tolerance test have a higher risk to deliver a low birth weight infant
ConclusionWomen with a glycemic value <3.9 mmol/L during the OGTT have a higher risk for a neonate with birth weight < 2.5Kg, which remained significant after adjustment for BMI and gestational weight gain. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - June 2, 2023 Category: Endocrinology Source Type: research
NOD mouse dorsal root ganglia display morphological and gene expression defects before and during autoimmune diabetes development
DiscussionTaken together, these results indicate that functional defects are not only seen in beta cells but also in DRG in NOD mice. These results also indicate that these defects are not a consequence of the autoimmune process that takes place in NOD mice and suggest that they may be involved as triggers for its development. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - June 2, 2023 Category: Endocrinology Source Type: research
Association of baseline Life ’s Essential 8 score and trajectories with carotid intima-media thickness
ConclusionsIn summary, our study revealed that high baseline LE8 scores and LE8 score trajectories were associated with lower continuous cIMT and attenuated risk of high cIMT. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - June 2, 2023 Category: Endocrinology Source Type: research
Application of carbon nanoparticles combined with refined extracapsular anatomy in endoscopic thyroidectomy
ConclusionsFine extracapsular anatomy combined with carbon nanoparticle suspension tracing is effective in endoscopic thyroid cancer surgery. It can improve the thoroughness of prophylactic central neck dissection and recognition of the parathyroid gland and avoid parathyroid injury and other complications to effectively protect parathyroid function. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - June 2, 2023 Category: Endocrinology Source Type: research
Causal relationship between nonalcoholic fatty liver disease and different sleep traits: a bidirectional Mendelian randomized study
ConclusionGenetic evidence suggests putative causal relationships between NAFLD and a set of sleep traits, indicating that sleep traits deserves high priority in clinical practice. Not only the confirmed sleep apnea syndrome, but also the sleep duration and sleep state (such as insomnia) deserve clinical attention. Our study proves that the causal relationship between sleep characteristics and NAFLD is the cause of the change of sleep characteristics, while the onset of non-NAFLD is the cause of the change of sleep characteristics, and the causal relationship is one-way. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - June 2, 2023 Category: Endocrinology Source Type: research
Studying trabecular bone samples demonstrates a power law relation between deteriorated structure and mechanical properties - a study combining 3D printing with the finite element method
In this study, we 3D printed structural-identical but BV/TV value-attenuated trabecular bones (scaled up ×20) from the distal femur of healthy and ovariectomized rats and performed compression mechanical tests. Corresponding μFEM models were also established for simulations. The tissue modulus and strength of 3D printed trabecular bones as well as the effective tissue modulus (denoted as Ez) derived from μFEM models were finally corrected by the side-artifact correction factor.ResultsThe results showed that the tissue modulus corrected, strength corrected and Ez corrected exhibited a significant power law function of BV...
Source: Frontiers in Endocrinology - June 2, 2023 Category: Endocrinology Source Type: research
Heritability and circulating concentrations of pregnancy-associated plasma protein-A and stanniocalcin-2 in elderly monozygotic and dizygotic twins
DiscussionThis twin study confirms our hypothesis that the heritability of PAPP-A serum concentrations is substantial, and the same is true for STC2. As regards the age relationship, PAPP-A increases with age, whereas STC2 remains unchanged, thereby supporting the idea that the ability of STC2 to inhibit PAPP-A enzymatic activity decreases with increasing age. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - June 2, 2023 Category: Endocrinology Source Type: research
Changes and related factors of blood CCN1 levels in diabetic patients
ConclusionBlood CCN1 levels are significantly elevated in patients with DR. High and very high levels of plasma CCN1 are risk factors for DR. Blood CCN1 level may be a potential biomarker for diagnosis of DR. The effects of CCN1 on DR may be related to hypoxia, oxidative stress, and dephosphorylation. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - June 2, 2023 Category: Endocrinology Source Type: research
Obesity is associated with impaired postprandial pancreatic polypeptide secretion
ConclusionCompared with normal-weight subjects, overweight and obese subjects had impaired PP secretion after glucose stimulation. In T2DM patients, PP secretion was mainly affected by BMI and GCG.Clinical trial registryThe Ethics Committee of the Affiliated Hospital of Qingdao University.Clinical trial registrationhttp://www.chictr.org.cn, identifier ChiCTR2100047486. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - June 2, 2023 Category: Endocrinology Source Type: research
The therapeutic role and potential mechanism of EGCG in obesity-related precocious puberty as determined by integrated metabolomics and network pharmacology
ConclusionEGCG may contribute to preventing obesity-related precocious puberty through targets such as AKT1, EGFR, ESR1, STAT3, IGF1, and MAPK1 and multiple signaling pathways, including the estrogen, PI3K-Akt, MAPK, and Jak-STAT pathways. This study provided a theoretical foundation for future research. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - June 2, 2023 Category: Endocrinology Source Type: research
Non-severe hypoglycemia in type 1 diabetes: a randomized crossover trial comparing two quantities of oral carbohydrates at different insulin-induced hypoglycemia ranges
ConclusionsNS-H, in the context of hyper-insulinemia, is difficult to treat in PWT1D. Initial consumption of 32 g of CHO revealed some advantages at the 3.0–3.5 mmol/L range. This was not reproduced at lower PG ranges since participants needed additional CHO regardless of the amount of initial consumption.Clinical trial registrationClinicalTrials.gov, identifier NCT03489967. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - June 2, 2023 Category: Endocrinology Source Type: research
Positive correlation between fatty liver index and hyperuricemia in hypertensive Chinese adults: a H-type hypertension registry study
ConclusionThis study demonstrates a positive correlation between FLI and HUA in hypertensive adults, but stronger in females than males. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - June 2, 2023 Category: Endocrinology Source Type: research
Urinary levels of organophosphate flame retardants metabolites in a young population from Southern Taiwan and potential health effects
ConclusionTo our knowledge, this is the first investigation of urinary OPFR metabolite levels in a broad-spectrum young population. There tended to be higher exposure rates in both newborns and pre-schoolers, though little is known about their exposure levels or factors leading to exposure in the young population. Further studies should clarify the exposure levels and factor relationships. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - June 2, 2023 Category: Endocrinology Source Type: research
Association of epilepsy, anti-epileptic drugs (AEDs), and type 2 diabetes mellitus (T2DM): a population-based cohort retrospective study, impact of AEDs on T2DM-related molecular pathway, and via peroxisome proliferator-activated receptor γ transactivation
DiscussionOur study shows epilepsy increases the risk of T2DM development, however, some AEDs such as VPA might yield a protective effect against it. Thus, screening blood glucose levels in patients with epilepsy is required to explore the specific role and impact of AEDs in the development of T2DM. Future in depth research on the possibility to repurpose VPA for the treatment of T2DM, will offer valuable insight regarding the relationship between epilepsy and T2DM. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - June 2, 2023 Category: Endocrinology Source Type: research
