Relevance of mutations in protein deubiquitinases genes and TP53 in corticotroph pituitary tumors
ConclusionsWe confirmed high prevalence of USP8 mutations and low incidence of USP48 and TP53 mutations. Changes in protein deubiquitinases genes appear to be favorable prognostic factors in CD. TP53 mutations are rare, occur in both functioning and silent tumors and are related to poor clinical outcome in CD. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - February 29, 2024 Category: Endocrinology Source Type: research
Association between periodontitis and endometriosis: a bidirectional Mendelian randomization study
ConclusionsOur study provided genetic evidence on the causal relationship between periodontitis and endometriosis of the pelvic peritoneum. More studies are necessary to explore the underlying mechanisms. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - February 29, 2024 Category: Endocrinology Source Type: research
Research progress of periostin and osteoporosis
This article reviews the research results and potential applications of periostin in osteoporosis. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - February 29, 2024 Category: Endocrinology Source Type: research
Identification and characterization of a novel CASR mutation causing familial hypocalciuric hypercalcemia
ConclusionThis novel CASR I554N mutation causing FHH attenuates CASR stability, its binding affinity with Ca2+, and the response to eCa2+ corrected by therapeutic calcimimetics. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - February 29, 2024 Category: Endocrinology Source Type: research
Comparison of diagnostic efficacy between 99mTc-methylene diphosphate SPECT/CT and MRI for bone and joint infections: a multicenter retrospective analysis
ConclusionThis represents the largest global study to date evaluating osteomyelitis and bone infection diagnosis using 99mTc-MDP SPECT/CT tomographic fusion imaging. The findings indicate that 99mTc-MDP SPECT/CT fusion imaging offers superior diagnostic accuracy compared to MRI. This is particularly evident in cases involving metallic implants and chronic infections. 99mTc-MDP SPECT/CT fusion imaging emerges as a highly suitable non-invasive diagnostic modality, facilitating enhanced clinical follow-up and treatment. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - February 29, 2024 Category: Endocrinology Source Type: research
Multi-omic analysis of precocious puberty girls: pathway changes and metabolite validation
ConclusionThis study reveals that the metabolomic and transcriptomic changes, along with enriched pathways, are implicated in PP based on clinical and animal analyses. The findings may provide new strategies and research avenues for PP treatment. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - February 29, 2024 Category: Endocrinology Source Type: research
Editorial: Neuropeptide actions in arthropod biology
(Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - February 28, 2024 Category: Endocrinology Source Type: research
Incident comorbidities in patients with chronic hypoparathyroidism after thyroidectomy: a multicenter nationwide study
ConclusionThis study demonstrates that, in the clinical practice of Spanish endocrinologists, a significant increase in the risk of chronic kidney disease, nephrolithiasis and cardiovascular disease, as well as a reduction in the risk of fractures is detected. These results are of interest for the development of new clinical guidelines and monitoring protocols for patients with hypoparathyroidism. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - February 28, 2024 Category: Endocrinology Source Type: research
Editorial: Macromolecular interactions in signaling pathways: from classical approaches to virtual reality
(Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - February 28, 2024 Category: Endocrinology Source Type: research
Evaluating the relationship between the proportion of X-chromosome deletions and clinical manifestations in children with turner syndrome
ConclusionThe mosaicism (XO/XX) is the most common karyotype of TS in screened cases. The phenotypes in children with TS may increase with the proportion of X-chromosome deletions, but the renal disease and comorbidities did not show the same characteristics. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - February 28, 2024 Category: Endocrinology Source Type: research
Effect of mydriasis on macular and peripapillary metrics in swept-source optical coherence tomography angiography
ConclusionsFAZ parameters and retinal VD in the most macular and peripapillary regions are not affected by mydriasis. The thickness of the choroid is decreased after mydriasis, while the thickness of retinal layers in some sectors may be increased after mydriasis. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - February 28, 2024 Category: Endocrinology Source Type: research
Predictive model and risk analysis for peripheral vascular disease in type 2 diabetes mellitus patients using machine learning and shapley additive explanation
ConclusionThe machine learning approach successfully developed a PVD risk prediction model with good performance. The model identified the factors associated with PVD and offered physicians an intuitive understanding on the impact of key features in the model. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - February 28, 2024 Category: Endocrinology Source Type: research
Early changes of bone metabolites and lymphocyte subsets may participate in osteoporosis onset: a preliminary study of a postmenopausal osteoporosis mouse model
ConclusionLipid metabolism was significant at the early stage of the osteoporosis. Bone metabolites may influence bone formation by interfering with bone marrow lymphocyte subsets. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - February 28, 2024 Category: Endocrinology Source Type: research
Case report: Management of pediatric gigantism caused by the TADopathy, X-linked acrogigantism
X-linked acrogigantism (X-LAG) is a rare form of pituitary gigantism that is associated with growth hormone (GH) and prolactin-secreting pituitary adenomas/pituitary neuroendocrine tumors (PitNETs) that develop in infancy. It is caused by a duplication on chromosome Xq26.3 that leads to the misexpression of the gene GPR101, a constitutively active stimulator of pituitary GH and prolactin secretion. GPR101 normally exists within its own topologically associating domain (TAD) and is insulated from surrounding regulatory elements. X-LAG is a TADopathy in which the duplication disrupts a conserved TAD border, leading to a neo-...
Source: Frontiers in Endocrinology - February 28, 2024 Category: Endocrinology Source Type: research
Commentary: Causal effects of specific gut microbiota on bone mineral density: a two-sample Mendelian randomization study
(Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - February 28, 2024 Category: Endocrinology Source Type: research
