Identification and validation of NAD+ metabolism-related biomarkers in patients with diabetic peripheral neuropathy
ConclusionENPP3 and NUDT12 might play key roles in DPN, which provides reference for further research on DPN. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - February 23, 2024 Category: Endocrinology Source Type: research
Discussion on the mechanism of Danggui Sini decoction in treating diabetic foot based on network pharmacology and molecular docking and verification of the curative effect by meta-analysis
ConclusionsDSD may treat DF by participating in biological processes such as cell proliferation regulation, inflammatory reaction, oxidative stress reaction, and promotion of angiogenesis. DSD treats DF through AKT1, TP53, IL6, TNF, VEGFA, and other targets. DSD plays a role in treating DF mainly through the AGE-RAGE signaling pathway and PI3K-AKT signaling pathway. The molecular docking results of AKT1, TP53, IL-6, TNF, and VEGFA with the active substances of DSD show that they all have a high docking activity; among them, VEGFA has a higher docking activity. Compared with conventional treatment, DSD has a high effective ...
Source: Frontiers in Endocrinology - February 23, 2024 Category: Endocrinology Source Type: research
Children with idiopathic short stature have significantly different gut microbiota than their normal height siblings: a case-control study
DiscussionOur findings suggest that different characteristics in the GM may explain variations in linear growth. The varying levels of Methanobrevibacter demonstrated within the ISS group reflect the multifactorial nature of ISS and the potential ability of the GM to partially explain growth variations. The targeting of specific microbiota could provide personalized therapies to improve growth in children with ISS. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - February 23, 2024 Category: Endocrinology Source Type: research
Unveiling the pathogenesis and therapeutic approaches for diabetic nephropathy: insights from panvascular diseases
Diabetic nephropathy (DN) represents a significant microvascular complication in diabetes, entailing intricate molecular pathways and mechanisms associated with cardiorenal vascular diseases. Prolonged hyperglycemia induces renal endothelial dysfunction and damage via metabolic abnormalities, inflammation, and oxidative stress, thereby compromising hemodynamics. Concurrently, fibrotic and sclerotic alterations exacerbate glomerular and tubular injuries. At a macro level, reciprocal communication between the renal microvasculature and systemic circulation establishes a pernicious cycle propelling disease progression. The cu...
Source: Frontiers in Endocrinology - February 22, 2024 Category: Endocrinology Source Type: research
Editorial: Exploring the optimal endometrial preparation protocol for frozen-thawed embryo transfer
(Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - February 22, 2024 Category: Endocrinology Source Type: research
