Hypoxia-inducible factor-2 α promotes fibrosis in non-alcoholic fatty liver disease by enhancing glutamine catabolism and inhibiting yes-associated protein phosphorylation in hepatic stellate cells
This study aimed to investigate the effects of chronic hypoxia on NAFLD progression by examining the role of hypoxia-inducible factor 2α (HIF-2α) activation and that of hepatic stellate cell (HSC)-derived myofibroblasts through glutaminolysis. We hypothesised that hypoxia exacerbates NAFLD by promoting HIF-2α upregulation and inhibiting phosphorylated yes-associated protein (YAP), and that increasing YAP expression enhances HSC-derived myofibroblasts. We studied patients with NAFLD living at high altitudes, as well as animal models and cultured cells. The results revealed significant increases in HSC-derived myofibrobla...
Source: Frontiers in Endocrinology - February 28, 2024 Category: Endocrinology Source Type: research
Development and validation of a cognitive dysfunction risk prediction model for the abdominal obesity population
ConclusionAge, sex, education level, 24-hour total fat intake, red blood cell folate concentration, depression, and moderate work activity were identified as predictive factors for cognitive dysfunction in individuals with abdominal obesity. In conclusion, the nomogram model developed in this study can effectively predict the clinical risk of cognitive dysfunction in individuals with abdominal obesity. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - February 28, 2024 Category: Endocrinology Source Type: research
The effects of behavioral intervention on anthropometric, clinical, and biochemical parameters in patients with polycystic ovary syndrome: a systematic review and meta-analysis
ConclusionBehavioral intervention supplementation contributes to weight loss, reduction in BMI and waist circumference, and improvement in depression among patients with PCOS. However, no significant improvement was observed in the biochemical index and quality of life. The long-term effects of behavioral intervention for PCOS remain unclear due to limitations in the quality of the studies involved and the short duration of treatment.Systematic Review Registrationhttps://www.crd.york.ac.uk/PROSPERO, identifier CRD42023442875. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - February 28, 2024 Category: Endocrinology Source Type: research
Concurrent neoadjuvant endocrine therapy with chemotherapy in HR+HER2- breast cancer: a systematic review and meta-analysis
The role of simultaneous neoadjuvant endocrine therapy in chemotherapy in HR+HER2- breast cancer continues to be controversial. This systematic review and meta-analysis was conducted to further evaluate the effectiveness and safety of this strategy for HR+HER2- breast cancer patients. Trials in which HR+HER2- breast cancer patients were randomly assigned to either single or simultaneous endocrine-assisted neoadjuvant chemotherapy were eligible for inclusion. The prime endpoint was the pathological complete response (pCR) rate. The clinical response (complete clinical response: CR, partial response: PR) and safety were seco...
Source: Frontiers in Endocrinology - February 28, 2024 Category: Endocrinology Source Type: research
Decreased circulating dipeptidyl peptidase-4 activity after short-term intensive insulin therapy predicts clinical outcomes in patients with newly diagnosed type 2 diabetes
ConclusionCirculating DPP-4 activity significantly decreases after SIIT. The change in circulating DPP-4 activity during the 3-month post-treatment phase has the potential to predict long-term remission. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - February 27, 2024 Category: Endocrinology Source Type: research
Predicting the risk of subclinical atherosclerosis based on interpretable machine models in a Chinese T2DM population
ConclusionThe construction of SCAS risk models based on the Chinese T2DM population contributes to its early prevention and intervention, which would reduce the incidence of adverse cardiovascular prognostic events. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - February 27, 2024 Category: Endocrinology Source Type: research
Editorial: Transcriptional regulation of glucose metabolism: gaps and controversies, volume II
(Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - February 27, 2024 Category: Endocrinology Source Type: research
Commentary: Postoperative hypothalamic-pituitary dysfunction and long-term hormone replacement in patients with childhood-onset craniopharyngioma
(Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - February 27, 2024 Category: Endocrinology Source Type: research
The relationship between thyroid peroxidase antibody and differentiated thyroid cancer: a systematic review and meta-analysis
ConclusionThe presence of TPOAb is correlated with an increase prevalence of DTC. However, its effectiveness as a prognostic marker for DTC patients warrants further investigation.Systematic review registrationhttps://www.crd.york.ac.uk/PROSPERO/, identifier CRD42023448824. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - February 27, 2024 Category: Endocrinology Source Type: research
A comparative analysis of energy expenditure and substrate metabolism in male university students with overweight/obesity: Tabata vs HIIT and MICT
ConclusionThe study finds that male college students with overweight/obesity in both exercise and recovery, Tabata group has lower fat and glucose oxidation rates, and energy expenditure compared to HIIT and MICT groups. However, over the entire process, Tabata still exhibits significantly higher rates in these aspects than HIIT and MICT. Despite a shorter exercise duration, Tabata shows a noticeable “time-efficiency” advantage. Tabata can be used as an efficient short-term weight loss exercise program for male college students with overweight/obesity. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - February 27, 2024 Category: Endocrinology Source Type: research
Association between TyG index trajectory and new-onset lean NAFLD: a longitudinal study
ConclusionThe TyG index serves as a promising noninvasive marker for lean NAFLD, with significant implications for clinical practice and public health policy. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - February 27, 2024 Category: Endocrinology Source Type: research
The association between the triglyceride –glucose index and prognosis in postoperative renal cell carcinoma patients: a retrospective cohort study
ConclusionThe TyG index is significantly associated with RCC survival. The mechanisms responsible for these results may contribute toward the improvement of RCC prognosis and immunotherapy efficacy and the development of new immunotherapeutic targets. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - February 27, 2024 Category: Endocrinology Source Type: research
Opioid-induced adrenal insufficiency: diagnostic and management considerations
The dramatic rise in opioid use over the last two decades has led to a surge in their harmful health effects. Lesser known among clinicians is the impact of opioids on the endocrine system, especially with regard to cortisol. Opioids can suppress the hypothalamus-pituitary-adrenal (HPA) axis and may result in clinically significant adrenal insufficiency, especially in those treated at higher doses and for a longer time. A high clinical suspicion is necessary in this population for early diagnosis of opioid-induced adrenal insufficiency (OAI). Diagnosis of OAI is challenging, as the symptoms are often vague and overlap with...
Source: Frontiers in Endocrinology - February 27, 2024 Category: Endocrinology Source Type: research
Tyrosine kinase inhibitors in patients with advanced anaplastic thyroid cancer: an effective analysis based on real-world retrospective studies
ConclusionIn real-world clinical practice, ATC patients could benefit from TKI therapy. In future studies, more basic experiments and clinical explorations are needed to enhance the effects of TKIs in the treatment of patients with ATC. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - February 26, 2024 Category: Endocrinology Source Type: research
Global trends in burden of type 2 diabetes attributable to physical inactivity across 204 countries and territories, 1990-2019
ConclusionBetween 1990 and 2019, there was a marked rise in the worldwide burden of type 2 diabetes associated with physical inactivity, underscoring the role of physical inactivity as a key changeable risk factor in the global landscape of this disease. This necessitates additional research to explore the variables contributing to the varying levels of disease burden across different countries and between sexes. Furthermore, it calls for the formulation of public health policies aimed at guiding prevention tactics, promoting early detection, and enhancing the management of type 2 diabetes. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - February 26, 2024 Category: Endocrinology Source Type: research
