Fertility and sexual activity in patients with Triple A syndrome
ConclusionOur results contribute to still scarce knowledge on fertility in patients with Triple A syndrome and as well represents a foundation for further research on causes of infertility and possible treatment options. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - March 13, 2024 Category: Endocrinology Source Type: research
The emerging role and clinical significance of circRNAs in papillary thyroid cancer
In conclusion, circRNAs play a critical role in PTC, and dysregulated circRNAs influence multiple signaling pathways and cellular processes involved in tumorigenesis and metastasis. It represents a promising avenue for advancing the diagnosis, management, and treatment of PTC. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - March 13, 2024 Category: Endocrinology Source Type: research
Motilin fluctuations in healthy volunteers determined by liquid chromatography mass spectrometry
This study highlights the utility of LC-MS/MS for parallel measurement of motilin alongside other peptide hormones, and supports previous reports of the cyclical nature of motilin levels in the fasting state and interruption with feeding. This analytical method has utility for further clinical studies into motilin and gut hormone physiology in human volunteers. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - March 13, 2024 Category: Endocrinology Source Type: research
Predictive value of ultrasonic artificial intelligence in placental characteristics of early pregnancy for gestational diabetes mellitus
ConclusionsThe study emphasized the intrinsic relationship between early pregnancy placental USI and the development of GDM. The use of nomogram holds potential for clinical applications in predicting the development of GDM. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - March 13, 2024 Category: Endocrinology Source Type: research
Age differences in the association of body mass index-defined obesity with abdominal aortic calcification
ConclusionsIn US, adults aged 52 years or older, obesity was associated with decreased AAC risk. Older age may be one potential reason for the obesity paradox. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - March 13, 2024 Category: Endocrinology Source Type: research
Comparative study between poorly differentiated thyroid cancer and anaplastic thyroid cancer: real-world pathological distribution, death attribution, and prognostic factor estimation
ConclusionThe populational analysis of the PDTC/ATC cohort has provided reliable support for better understanding of the difference between PDTC and ATC cases and the guidance of clinical practice and further studies. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - March 13, 2024 Category: Endocrinology Source Type: research
Case report: A novel splice-site mutation of MTX2 gene caused mandibuloacral dysplasia progeroid syndrome: the first report from China and literature review
ConclusionThis is the first case of MAD syndrome caused by mutations in MTX2 gene reported in the Chinese population. MTX2 gene c.378 + 1G > A homozygous mutation has not been previously reported and the report of this patient expands the spectrum of MTX2 mutations. In addition, we summarized the genotypes and clinical characteristics of patients with progeroid syndromes in China. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - March 13, 2024 Category: Endocrinology Source Type: research
Interleukin-16 is increased in obesity and alters adipogenesis and inflammation in vitro
DiscussionOur results suggest a potential role of IL-16 in adipogenesis, lipid and glucose homeostasis, fibrosis, and inflammation in an obesity context. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - March 13, 2024 Category: Endocrinology Source Type: research
Phenotype of early-onset fetal growth restriction in sheep
This study aimed to identify the temporal nature of reduced developmental trajectory in fetuses with FGR, and to examine the effects of common factors that may mediate differential growth such as glucocorticoid treatment. We hypothesised that the trajectory of growth would be adversely impacted by FGR.MethodsFGR was induced via surgical placental insufficiency in fetal sheep (89 days gestation/0.6 gestation; n=135) and compared to age-matched controls over the last third of gestation and into neonatal life (n=153).ResultsBody weight of FGR fetuses/lambs was significantly reduced compared to controls (p<0.0001) from 127 ...
Source: Frontiers in Endocrinology - March 13, 2024 Category: Endocrinology Source Type: research
Causal relationship between Alzheimer ’s disease and prostate cancer: a bidirectional Mendelian randomization analysis
ConclusionThe results of this study demonstrated an absence of bidirectional causality between AD and PCa among the European population, suggested that a genetically predicted possibility of decreased PCa risk in AD patients, and no significant genetically predicted causal effect of PCa on AD. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - March 13, 2024 Category: Endocrinology Source Type: research
Developmental potential of non- and mono-pronuclear zygotes and associated clinical outcomes in IVF cycles
ConclusionsOur findings suggest that 0PN and 2PN zygotes have comparable developmental potential, while 1PN embryos exhibit lower developmental potential. Blastocyst FET outcomes appear similar among 0PN, 1PN, and 2PN zygotes. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - March 12, 2024 Category: Endocrinology Source Type: research
Cushing ’s syndrome during pregnancy - two case reports
ConclusionDue to the associated risks of laparoscopic adrenalectomy,it is uncertain whether this treatment significantly decreases overall maternal mortality. Additional observational research and validation through randomized controlled trials (RCTs) are required. We advise that CS in pregnant women be diagnosed and treated by experienced teams in relevant departments and medical centers. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - March 12, 2024 Category: Endocrinology Source Type: research
Investigating the impact of elevated urinary trace elements on non-alcoholic fatty liver disease using vibration-controlled transient elastography
ConclusionThese findings suggest a positive association between exposure to trace elements in the urine and the risk of NAFLD. Specifically, urinary barium and cesium appeared to have the greatest impact on the risk of NAFLD. These results provide novel insights into the diagnosis and treatment of NAFLD. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - March 12, 2024 Category: Endocrinology Source Type: research
Roles of organokines in intervertebral disc homeostasis and degeneration
The intervertebral disc is not isolated from other tissues. Recently, abundant research has linked intervertebral disc homeostasis and degeneration to various systemic diseases, including obesity, metabolic syndrome, and diabetes. Organokines are a group of diverse factors named for the tissue of origin, including adipokines, osteokines, myokines, cardiokines, gastrointestinal hormones, and hepatokines. Through endocrine, paracrine, and autocrine mechanisms, organokines modulate energy homeostasis, oxidative stress, and metabolic balance in various tissues to mediate cross-organ communication. These molecules are involved ...
Source: Frontiers in Endocrinology - March 12, 2024 Category: Endocrinology Source Type: research
Cryptorchidism and puberty
Cryptorchidism is the condition in which one or both testes have not descended adequately into the scrotum. The congenital form of cryptorchidism is one of the most prevalent urogenital anomalies in male newborns. In the acquired form of cryptorchidism, the testis that was previously descended normally is no longer located in the scrotum. Cryptorchidism is associated with an increased risk of infertility and testicular germ cell tumors. However, data on pubertal progression are less well-established because of the limited number of studies. Here, we aim to review the currently available data on pubertal development in boys...
Source: Frontiers in Endocrinology - March 12, 2024 Category: Endocrinology Source Type: research
