Thyroid stimulating immunoglobulin concentration is associated with disease activity and predicts response to treatment with intravenous methylprednisolone in patients with Graves ’ orbitopathy
ConclusionsHigh TSI levels are associated with active disease (cut-off 2.62 IU/L) and predict poor response to IVMP treatment (cut-off 19.4 IU/L) in GO. While sIL-2R correlates with disease activity, it is also related to thyroid function, making it less useful as an additional biomarker in GO. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - March 21, 2024 Category: Endocrinology Source Type: research
Corrigendum: Dose-dependent stimulation of human follicular steroidogenesis by a novel rhCG during ovarian stimulation with fixed rFSH dosing
(Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - March 21, 2024 Category: Endocrinology Source Type: research
Efficacy and safety of basal insulins in people with type 2 diabetes mellitus: a systematic review and network meta-analysis of randomized clinical trials
ConclusionThe efficacy of various basal insulin regimens is comparable. However, they have different safety profiles. IGlar-300 may be the best choice when weight gain is a concern. In contrast, IDeg-100, IDeg-200, IDet, and IGlar-300 may be preferred when hypoglycemia is the primary concern. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - March 21, 2024 Category: Endocrinology Source Type: research
Predictive factors and the management of hyperglycemia in patients with acromegaly and Cushing ’s disease receiving pasireotide treatment: post hoc analyses from the SOM230B2219 study
ConclusionIncreasing age, HbA1c, and FPG and pre-diabetes/diabetes were associated with increased likelihood of requiring antihyperglycemic medication during pasireotide treatment. These risk factors may be used to identify those who need more vigilant monitoring to optimize outcomes during pasireotide treatment. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - March 21, 2024 Category: Endocrinology Source Type: research
Develop prediction model to help forecast advanced prostate cancer patients ’ prognosis after surgery using neural network
ConclusionPatients with advanced prostate cancer may benefit from surgery. In order to forecast their overall survival, we first build a clinical features-based prognostic model. This model is accuracy and may offer some reference on clinical decision making. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - March 21, 2024 Category: Endocrinology Source Type: research
Relationship between blood cadmium levels and bone mineral density in adults: a cross-sectional study
ConclusionOur findings demonstrated a significant negative association between blood cadmium levels and bone mineral density in a population of U.S. adults. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - March 21, 2024 Category: Endocrinology Source Type: research
Association of adiposity indicators with cardiometabolic multimorbidity risk in hypertensive patients: a large cross-sectional study
ConclusionThis study indicated the significant positive association of CMI, LAP, VAI, and CVAI with the risk of CMM in hypertensive patients. Among these indicators, CVAI demonstrated the most robust performance in predicting CMM risk and may serve as a valuable tool for identifying CMM risk in Chinese hypertensive patients. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - March 21, 2024 Category: Endocrinology Source Type: research
Amide proton transfer weighted contrast has diagnostic capacity in detecting diabetic foot: an MRI-based case –control study
ConclusionNormalized MTRasym (3.5 ppm) and the BF in lesion may be treated as a safer and more convenient new indicator to evaluate the tissue infection without using a contrast agent, which may be useful in monitoring and preoperatively assessing DF patients with renal insufficiency. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - March 21, 2024 Category: Endocrinology Source Type: research
The association between rapid growth and lipid profile: a systematic review and meta-analysis
ConclusionRapid growth is associated with lipid profiles, particularly during early childhood, and this relationship is influenced by factors such as the duration of growth, the level of national development, and birth weight. These findings are significant for the development of strategies to prevent metabolic diseases.This review was registered in PROSPERO International Prospective Register of Systematic Reviews (www.crd.york.ac.uk/prospero/) with the registration number CRD42020154240. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - March 21, 2024 Category: Endocrinology Source Type: research
Tumor growth manifested in two-fifths of low-risk papillary thyroid microcarcinoma patients during active surveillance: data from a tertiary center in China
ConclusionTDR may be a better metric for evaluating tumor growth in observational PTMCs. A certain proportion of PTMCs grow during the period of AS and tumor growth was associated with age and volume of PTMC at initial diagnosis. Therefore, how to block tumor growth during the AS period, especially for young patients and patients with early-stage PTMC (size ≤ 5 mm), will be a new challenge. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - March 21, 2024 Category: Endocrinology Source Type: research
Micronized natural progesterone (Seidigestan ®) vs GnRH antagonists for preventing the LH surge during controlled ovarian stimulation (PRO_NAT study): study protocol of a randomized clinical trial
DiscussionThe outcomes of this trial have the potential to inform evidence-based adjustments in the management of ovarian stimulation protocols for oocyte donors.Clinical trial registrationClinicalTrials.gov, identifier, NCT05954962. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - March 21, 2024 Category: Endocrinology Source Type: research
Population-enriched innate immune variants may identify candidate gene targets at the intersection of cancer and cardio-metabolic disease
Both cancer and cardio-metabolic disease disparities exist among specific populations in the US. For example, African Americans experience the highest rates of breast and prostate cancer mortality and the highest incidence of obesity. Native and Hispanic Americans experience the highest rates of liver cancer mortality. At the same time, Pacific Islanders have the highest death rate attributed to type 2 diabetes (T2D), and Asian Americans experience the highest incidence of non-alcoholic fatty liver disease (NAFLD) and cancers induced by infectious agents. Notably, the pathologic progression of both cancer and cardio-metabo...
Source: Frontiers in Endocrinology - March 21, 2024 Category: Endocrinology Source Type: research
Prognostic nomograms for predicting long ‐term overall survival in spindle cell melanoma: a population‐based study
ConclusionThe nomogram developed in this study is sufficiently reliable for forecasting the risk and prognosis of SCM, which may facilitate personalized treatment recommendations in upcoming clinical trials. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - March 20, 2024 Category: Endocrinology Source Type: research
Comparison of ultrasound risk stratification systems for pediatric thyroid nodules
ConclusionThe ACR-TIRADS, C-TIRADS, and ATA guidelines showed high missed malignancy rates when using their original recommended FNA criteria. When nodules < 1 cm with the highest category in each RSS biopsied, the missed malignancy rate of each RSS was decreased. Decreasing the FNA thresholds for highly suspicious malignant nodules may therefore be an effective means of managing malignant thyroid nodules in pediatric patients. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - March 20, 2024 Category: Endocrinology Source Type: research
Corrigendum: Cysteine residues in signal transduction and its relevance in pancreatic beta cells
(Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - March 20, 2024 Category: Endocrinology Source Type: research
