Assessment of the severity of diabetic polyneuropathy aids in predicting the risk of developing diabetic complications in patients with untreated diabetes
This study aimed to determine the efficacy of assessing the severity of diabetic polyneuropathy (DPN) in patients with untreated diabetes. Seventy-two patients with untreated type 2 diabetes who were hospitalized for glycemic control were enrolled and divided into the following two groups: patients who had no prior diagnosis and patients who were unattended or had discontinued treatment. Electrophysiological criteria consistent with Baba’s classification were used to diagnose and assess the severity of DPN. The patients were divided into three subgroups: no DPN (stage 0), mild DPN (stage 1), and moderate or more-severe D...
Source: Frontiers in Endocrinology - March 15, 2024 Category: Endocrinology Source Type: research
High-fat diets promote peritoneal inflammation and augment endometriosis-associated abdominal hyperalgesia
Immune dysfunction is one of the central components in the development and progression of endometriosis by establishing a chronic inflammatory environment. Western-style high-fat diets (HFD) have been linked to greater systemic inflammation to cause metabolic and chronic inflammatory diseases, and are also considered an environmental risk factor for gynecologic diseases. Here, we aimed to examine how HFD cause an inflammatory environment in endometriosis and discern their contribution to endometriotic-associated hyperalgesia. Our results showed that HFD-induced obesity enhanced abdominal hyperalgesia that was induced by en...
Source: Frontiers in Endocrinology - March 15, 2024 Category: Endocrinology Source Type: research
Association between cognitive function and skeletal muscle in patients undergoing maintenance hemodialysis
ConclusionSkeletal muscle is a protective predictor of CD in patients undergoing dialysis. BDNF mediates the relationship between cognitive impairment and skeletal muscle function. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - March 15, 2024 Category: Endocrinology Source Type: research
U-shaped relationship between fasting blood glucose and urinary albumin-to-creatinine ratio in the general United States population
ConclusionThe general U.S. population has a U-shaped nonlinear relationship between FBG and UACR. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - March 15, 2024 Category: Endocrinology Source Type: research
Mulberry and Hippophae-based solid beverage promotes weight loss in rats by antagonizing white adipose tissue PPAR γ and FGFR1 signaling
Obesity, a multifactorial disease with many complications, has become a global epidemic. Weight management, including dietary supplementation, has been confirmed to provide relevant health benefits. However, experimental evidence and mechanistic elucidation of dietary supplements in this regard are limited. Here, the weight loss efficacy of MHP, a commercial solid beverage consisting of mulberry leaf aqueous extract and Hippophae protein peptides, was evaluated in a high-fat high-fructose (HFF) diet-induced rat model of obesity. Body component analysis and histopathologic examination confirmed that MHP was effective to fa...
Source: Frontiers in Endocrinology - March 15, 2024 Category: Endocrinology Source Type: research
Blood glucose monitoring devices for type 1 diabetes: a journey from the food and drug administration approval to market availability
Blood glucose monitoring constitutes a pivotal element in the clinical management of Type 1 diabetes (T1D), a globally escalating metabolic disorder. Continuous glucose monitoring (CGM) devices have demonstrated efficacy in optimizing glycemic control, mitigating adverse health outcomes, and augmenting the overall quality of life for individuals afflicted with T1D. Recent progress in the field encompasses the refinement of electrochemical sensors, which enhances the effectiveness of blood glucose monitoring. This progress empowers patients to assume greater control over their health, alleviating the burdens associated with...
Source: Frontiers in Endocrinology - March 15, 2024 Category: Endocrinology Source Type: research
Endocrine and non-endocrine causes of fatigue in adults with Neurofibromatosis type 1
ConclusionsEndocrine and non-endocrine disorders were equally present in our cohort of NF1 adults with and without fatigue. This suggests that the high prevalence of fatigue in NF1 adults is not explained by these somatic disorders. An alternative explanation for fatigue might be deficits in cognitive functioning and other neuropsychological processes in NF1. Based on our results and review of the literature, we provide a clinical algorithm for the approach to fatigue in NF1 adults, including somatic and psychological assessment. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - March 15, 2024 Category: Endocrinology Source Type: research
Corrigendum: Safety issues of tirzepatide (pancreatitis and gallbladder or biliary disease) in type 2 diabetes and obesity: a systematic review and meta-analysis
(Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - March 14, 2024 Category: Endocrinology Source Type: research
Editorial: The interplay between endocrine and immune systems in metabolic diseases
(Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - March 14, 2024 Category: Endocrinology Source Type: research
A Siamese ResNeXt network for predicting carotid intimal thickness of patients with T2DM from fundus images
ConclusionWe provided a Siamese ResNeXt neural network for predicting the carotid intimal thickness of patients with T2DM from fundus images and confirmed the correlation between fundus microvascular lesions and CIMT. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - March 14, 2024 Category: Endocrinology Source Type: research
Rs4862705 in the melatonin receptor 1A gene is associated with renal function decline in type 1 diabetes individuals
ConclusionsThis is the first study showing an association between a variant in a gene belonging to the melatonin system and renal function decline in the diabetic setting. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - March 14, 2024 Category: Endocrinology Source Type: research
Current barriers to initiating insulin therapy in individuals with type 2 diabetes
Insulin is an essential drug in the treatment of diabetes, often necessary for managing hyperglycemia in type 2 diabetes mellitus (T2DM). It should be considered in cases of severe hyperglycemia requiring hospitalization, after the failure of other treatments, in advanced chronic kidney disease, liver cirrhosis, post-transplant diabetes, or during pregnancy. Moreover, in specific patient subgroups, early initiation of insulin is crucial for hyperglycemia control and prevention of chronic complications. Clinical guidelines recommend initiating insulin when other treatments fail, although there are barriers that may delay it...
Source: Frontiers in Endocrinology - March 14, 2024 Category: Endocrinology Source Type: research
Time for micro-RNAs in steatotic liver disease: a case –control study
One of the challenges of modern-day living is to resist the temptation of overfeeding and sedentariness and maintain a healthy body and mind. On a favorable genetic and epigenetic background, a high-fat diet combined with lack of physical exercise constitutes the foundation for severe metabolic disturbances including steatotic liver disease. In our case–control study, we had the aim of establishing the role of selected micro-RNAs—miR-122, miR-192, miR-33a, and miR-33b—as superior biomarkers for the diagnosis and prognosis of steatotic liver in a 36-patient cohort compared to 12 healthy controls. Initial results confi...
Source: Frontiers in Endocrinology - March 14, 2024 Category: Endocrinology Source Type: research
Development and validation of nomograms to predict clinical outcomes of preeclampsia
ConclusionBased on the clinical features and peripheral blood laboratory indicators, we identified significant factors and developed models to predict early-onset PE, severe PE, and the gestation duration of pregnant women with PE, which could help clinicians assess the clinical outcomes early and design appropriate strategies for patients. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - March 14, 2024 Category: Endocrinology Source Type: research
Chemotherapy combined with endocrine neoadjuvant therapy for hormone receptor-positive local advanced breast cancer: a case report and literature review
ConclusionsA novel approach involving concurrent neoadjuvant therapy with CT and endocrine therapy may offer a potentially effective treatment avenue for some cases with HR+ LABC. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - March 13, 2024 Category: Endocrinology Source Type: research
