The role of targeting glucose metabolism in chondrocytes in the pathogenesis and therapeutic mechanisms of osteoarthritis: a narrative review
This article systematically summarizes the regulatory effects of different enzymes and factors related to glucose metabolism in OA, as well as the mechanism and potential of various substances in the treatment of OA by affecting glucose metabolism. This provides a theoretical basis for a better understanding of the mechanism of OA progression and the development of optimal prevention and treatment strategies. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - March 6, 2024 Category: Endocrinology Source Type: research
A call for a US National Institute of Women ’s Health and Human Development
(Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - March 6, 2024 Category: Endocrinology Source Type: research
Causal relationship between PCSK9 inhibitor and primary glomerular disease: a drug target Mendelian randomization study
ConclusionsPCSK9i markedly decreased the risk of IgAN, suggesting a potential mechanism beyond their primary effect on LDL-C. However, these inhibitors were also associated with an increased risk of NS. On the other hand, HMGCRi appears to serve as a protective factor against IgAN. Conversely, PCSK9i may pose a risk factor for NS, suggesting the necessity for cautious application and further research into their impacts on various glomerular diseases. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - March 6, 2024 Category: Endocrinology Source Type: research
Establishment and validation of a nomogram for subsequent first-cycle live births in patients diagnosed with recurrent implantation failure: a population-based analysis
ConclusionWe have developed and validated a novel predictive model that estimates a woman’s chances of having a live birth after a diagnosis of RIF and provides clinicians with a personalized clinical decision-making tool. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - March 5, 2024 Category: Endocrinology Source Type: research
Effect of maternal serum albumin level on birthweight and gestational age: an analysis of 39200 singleton newborns
ConclusionsA higher maternal serum albumin level during early pregnancy was associated with poor fetal growth, with the detrimental effects becoming apparent as early as the mid-gestation period. These findings provided vital information for clinicians to predict fetal growth status and identify cases with a high risk of adverse neonatal outcomes early on. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - March 5, 2024 Category: Endocrinology Source Type: research
Assessment of hepatic fibrosis with non-invasive indices in subjects with diabetes before and after liver transplantation
DiscussionThus, persistence of diabetes after surgery is a possible risk factor for an evolution to fibrosis in the transplanted liver, potentially leading to worsened long-term outcomes in this population. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - March 5, 2024 Category: Endocrinology Source Type: research
Revisiting the mechanisms linking blood glucose to cognitive impairment: new evidence for the potential important role of klotho
ConclusionHigher blood glucose levels are associated with poorer cognitive performance in non-diabetic older adults, partially mediated through lower klotho levels. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - March 5, 2024 Category: Endocrinology Source Type: research
Double somatic mutations in CTNNB1 and GNA11 in an aldosterone-producing adenoma
In conclusion, our study indicated that CTNNB1 and GNA11-mutated APA has characteristics of the ZG. The disease could occur in adults with no clear association with pregnancy or menopause. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - March 5, 2024 Category: Endocrinology Source Type: research
Independent associations of serum calcium with or without albumin adjustment and serum phosphorus with nonalcoholic fatty liver disease: results from NHANES 1999-2018
ConclusionSerum calcium and phosphorus were significantly associated with the development of NAFLD. These findings suggest the potential clinical significance of serum calcium/phosphorus and albumin levels in individuals at high risk for NAFLD. Our study supports the potential role of serum calcium/phosphorus homeostasis in the pathophysiology of NAFLD and could serve as NAFLD-related biomarkers. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - March 5, 2024 Category: Endocrinology Source Type: research
The MQRG score: a novel prognostic tool for adrenocortical carcinoma patients based on mitochondrial quality
ConclusionsMultilayer alterations in MQRGs are associated with patient prognosis and immune cell infiltration characteristics. This comprehensive analysis of MQRGs can contribute to a deeper understanding of potential differences in ACC patients' tumor microenvironment. This can influence clinical decision-making and advanced prognosis prediction, thereby offering new insights into personalized treatments in ACC. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - March 5, 2024 Category: Endocrinology Source Type: research
Long-term risk of neoplastic events after childhood growth hormone treatment: a population-based cohort study in Sweden
ConclusionNo association was found between rhGH treatment during childhood for GHD, SGA, or ISS and malignant neoplastic events in early to mid-adulthood. A moderate increase in overall neoplastic events was observed due to an increased number of events in male patients. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - March 5, 2024 Category: Endocrinology Source Type: research
Worldwide productivity and research trend of publications concerning SIAD: a bibliometric study
ConclusionBased on bibliometric analysis and knowledge mapping, this study summarises development trends in the field of SIAD research, providing references for current and future research into SIAD. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - March 5, 2024 Category: Endocrinology Source Type: research
The relationship between daytime napping and glycemic control in people with type 2 diabetes
ConclusionDaytime napping (e.g., duration and type) is an important modifiable factor for glycemic control in people with type 2 diabetes. This study provides new insights into the relationship between napping and glucose management among people with diabetes. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - March 5, 2024 Category: Endocrinology Source Type: research
Association between fatigue, peripheral serotonin, and L-carnitine in hypothyroidism and in chronic fatigue syndrome
ConclusionsThese findings suggest a new link between low peripheral serotonin, L-carnitine, and fatigue. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - March 5, 2024 Category: Endocrinology Source Type: research
Reprogramming of the developing heart by Hif1a-deficient sympathetic system and maternal diabetes exposure
In conclusion, our findings indicate that the interplay between deficiencies in the cardiac sympathetic system and subtle structural alternations in the vasculature, microvasculature, and myocardium during heart development not only increases the risk of cardiovascular disease but also diminishes the adaptability to the stress associated with the transition to extrauterine life, thus increasing the risk of neonatal death. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - March 5, 2024 Category: Endocrinology Source Type: research
