A randomized feasibility trial of the modified Atkins diet in older adults with mild cognitive impairment due to Alzheimer ’s disease
ConclusionsAttrition was greatest between baseline and week 6. All participants retained at week 6 completed the study. Despite low rates of adherence by criteria defined a priori, lipidomic and metabolomic analyses indicate significant changes from baseline in circulating lipids and metabolites between MAD and control participants at 12-week postrandomization, and MAD participants showed greater, albeit nonsignificant, improvement in memory. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - March 4, 2024 Category: Endocrinology Source Type: research
Development and validation of a prediction model for unexpected poor ovarian response during IVF/ICSI
ConclusionThe nomogram can anticipate the probability of unexpected POR in IVF/ICSI treatment, thereby assisting professionals in making appropriate clinical judgments and in helping patients to effectively manage expectations. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - March 4, 2024 Category: Endocrinology Source Type: research
Associations between type 2 diabetes mellitus and chronic liver diseases: evidence from a Mendelian ranldomization study in Europeans and East Asians
ConclusionOur MR analysis revealed varying causal associations between T2DM and CLDs in East Asians and Europeans. Further research is required to investigate the potential mechanisms in various ethnic groups, which could yield new insights into early screening and prevention strategies for CLDs in T2DM patients. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - March 1, 2024 Category: Endocrinology Source Type: research
Early effective intervention can significantly reduce all-cause mortality in prediabetic patients: a systematic review and meta-analysis based on high-quality clinical studies
ConclusionEarly effective intervention, which significantly reduces the incidence of diabetes, can effectively lower all-cause mortality in prediabetic patients without a history of cardiovascular disease (especially those with a 10-year cardiovascular risk >10%), with women and younger individuals benefiting more significantly. Additionally, the duration of follow-up is a key factor influencing outcomes. The conclusions of this study can provide evidence-based guidance for the clinical treatment of prediabetic patients to prevent cardiovascular and microvascular complications.Systematic review registrationhttps://www.c...
Source: Frontiers in Endocrinology - March 1, 2024 Category: Endocrinology Source Type: research
Unveiling peripheral neuropathy and cognitive dysfunction in diabetes: an observational and proof-of-concept study with video games and sensor-equipped insoles
ConclusionsThe video game-based assessment was able to categorize patients with CD and/or PNP with high accuracy. Future studies with larger cohorts are needed to validate these results and potentially enhance the discriminative power of video games. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - March 1, 2024 Category: Endocrinology Source Type: research
Editorial: Changes in extracellular matrix associated with bone disorders
(Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - March 1, 2024 Category: Endocrinology Source Type: research
Editorial: Transgender health: exploring diversity in the endocrine field
(Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - March 1, 2024 Category: Endocrinology Source Type: research
Clinical and laboratory characteristics but not response to treatment can distinguish children with definite growth hormone deficiency from short stature unresponsive to stimulation tests
ConclusionStimulation tests and the equivalent benefit from rhGH therapy, cannot distinguish between dGHD and SUS populations. In addition, lower IGF-1 concentrations at baseline and their higher increase during treatment in dGHD patients, and the lack of pathological retesting upon reaching NAH in SUS patients, are facts that suggest that deficient GH secretion may not be the cause of short stature in the SUS studied population. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - March 1, 2024 Category: Endocrinology Source Type: research
Surgical treatment of cryptorchidism: current insights and future directions
Cryptorchidism presents with an incidence of 1-5% with potential long-term implications on future fertility and overall health. This review focuses on surgical treatment modalities, their impact on testicular development, and function while addressing the Nordic consensus statement as well as current European Association of Urology (EAU) and American Urological Association (AUA) guidelines. Congenital and acquired cryptorchidism present distinctive challenges in surgical management, with different implications for fertility. While congenital cryptorchidism entails a risk to fertility and warrants early intervention, both r...
Source: Frontiers in Endocrinology - March 1, 2024 Category: Endocrinology Source Type: research
A two-sample bidirectional Mendelian randomization analysis investigates associations between gut microbiota and type 2 diabetes mellitus
ConclusionThis study effectively pinpointed specific GM associated with T2DM, potentially paving the way for novel biomarkers in the prevention and treatment of this condition. The findings suggested that probiotics could emerge as a promising avenue for managing T2DM in the future. Furthermore, the analysis indicated that metabolites do not appear to act as mediators in the pathway from GM to T2DM. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - March 1, 2024 Category: Endocrinology Source Type: research
The role of the annexin A protein family at the maternal –fetal interface
Successful pregnancy requires the tolerance of the maternal immune system for the semi-allogeneic embryo, as well as a synchrony between the receptive endometrium and the competent embryo. The annexin family belongs to calcium-regulated phospholipid-binding protein, which functions as a membrane skeleton to stabilize the lipid bilayer and participate in various biological processes in humans. There is an abundance of the annexin family at the maternal–fetal interface, and it exerts a crucial role in embryo implantation and the subsequent development of the placenta. Altered expression of the annexin family and dysfunctio...
Source: Frontiers in Endocrinology - March 1, 2024 Category: Endocrinology Source Type: research
Differences in the clinical and hormonal presentation of patients with familial and sporadic primary aldosteronism
ConclusionIn addition to being younger and having a family history of PA, FH-I and III share other typical characteristics. In this regard, FH-I is characterized by a low prevalence of hypokalemia and FH-III by a severe aldosterone excess causing hypokalemia in more than 85% of patients. The clinical and hormonal phenotype of type II and IV is similar to the sporadic cases. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - March 1, 2024 Category: Endocrinology Source Type: research
Causal relationship of genetically predicted gut microbiota with thyroid cancer: a bidirectional two-sample mendelian randomization study
ConclusionGenetic evidence suggested that bidirectional causal associations of specific bacteria taxa and the risk of TC, highlighting the association of the “gut-thyroid” axis. Further exploration of the potential microbiota-related mechanisms might have profound implications for public health in terms of the early prevention and treatment of TC. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - March 1, 2024 Category: Endocrinology Source Type: research
To diagnose primary and secondary squamous cell carcinoma of the thyroid with ultrasound malignancy risk stratification
ConclusionSCCT is an extremely rare and aggressive malignancy with a male predominance. PSCCT and SSCCT had similar clinical and ultrasound features except for tumor differentiation and the symptom of hoarseness. SCCT showed a high malignancy risk stratification in ACR-TIRADS and C-TIRADS, with a high rate of FNA recommendation. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - March 1, 2024 Category: Endocrinology Source Type: research
Analysis of white matter tract integrity using diffusion kurtosis imaging reveals the correlation of white matter microstructural abnormalities with cognitive impairment in type 2 diabetes mellitus
ConclusionsWMTI is more sensitive than diffusion tensor imaging in detecting T2DM-related WM microstructure abnormalities and can provide novel insights into the possible pathological changes underlying WM degeneration in T2DM. De,⊥ could be a potential imaging marker in monitoring disease progression in the brain and early intervention treatment for the cognitive impairment in T2DM. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - February 29, 2024 Category: Endocrinology Source Type: research
