Correlation between seminal plasma biochemical markers and semen parameters in idiopathic oligoasthenoteratospermia: identification of biomarkers for L-carnitine therapy
ConclusionSeminal plasma biochemical markers, particularly fructose and neutral glycosidase, may serve as valuable indicators for determining the eligibility of patients with idiopathic sperm abnormalities for L-carnitine therapy. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - March 12, 2024 Category: Endocrinology Source Type: research
Characterization of sensory and motor dysfunction and morphological alterations in late stages of type 2 diabetic mice
This study contributes to our understanding of mechanisms underlying neurological dysfunction during diabetes progression and helps to identify novel therapeutic interventions for patients with diabetic neuropathy. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - March 11, 2024 Category: Endocrinology Source Type: research
Editorial: New advances on hypothalamus-pituitary stem cell biology
(Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - March 11, 2024 Category: Endocrinology Source Type: research
Independent association of general and central adiposity with risk of gallstone disease: observational and genetic analyses
ConclusionBoth observational and genetic analyses consistently provide evidence on an association of central obesity with an increased risk of GSD, independent of general obesity. Our work highlights the need of considering both general and central obesity in the clinical management of GSD. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - March 11, 2024 Category: Endocrinology Source Type: research
Ultrasound-guided fine needle aspiration thyroglobulin in the diagnosis of lymph node metastasis of differentiated papillary thyroid carcinoma and its influencing factors
ConclusionThe findings of this study indicate that the utilization of FNA in conjunction with FNA-Tg is a crucial approach for detecting LNM in DTC. TNM stage indicated N1b, the presence of HVLNM, the presence of HT, lymph node L/S ratio, liquefaction, calcification, tumor diameter, sTg and sTgAb are factors that can impact FNA-Tg levels.In the context of clinical application, it is imperative to individualize the use of FNA-Tg. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - March 11, 2024 Category: Endocrinology Source Type: research
Editorial: Circadian rhythm in obesity
(Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - March 11, 2024 Category: Endocrinology Source Type: research
Causal relationship between genetically predicted type 2 diabetes mellitus and male infertility
ConclusionsThis research furnishes evidence supporting a causal association between T2DM and male infertility. These insights offer a foundation for future investigations aiming to establish the association between genetically predicted T2DM and male infertility. These outcomes suggest the significance of active monitoring and proactive measures for preventing infertility in male individuals with T2DM. Furthermore, careful consideration is required for individuals of reproductive age to prevent and treat T2DM. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - March 11, 2024 Category: Endocrinology Source Type: research
Cost-effective prognostic evaluation of breast cancer: using a STAR nomogram model based on routine blood tests
ConclusionCombining appropriate RT parameters, STAR nomogram could help in the detection of patient anemia, coagulation function, inflammation and immune status. Practical implementation of the STAR nomogram in a clinical setting is feasible, and its potential clinical impact lies in its ability to provide an early, economical and reliable tool for survival prediction and surveillance strategy management. However, our model still has limitations and requires external data validation. In subsequent studies, we plan to mitigate the potential impact on model robustness by further updating and adjusting the data and model. (So...
Source: Frontiers in Endocrinology - March 11, 2024 Category: Endocrinology Source Type: research
Exploring the potential of pheophorbide A, a chlorophyll-derived compound in modulating GLUT for maintaining glucose homeostasis
ConclusionThe current study’s findings were validated by in-silico and cellular analyses, suggesting that pheophorbide A may regulate GLUT1 and might be regarded as a potential lead for boosting the GSIS pathway, thus maintaining glucose homeostasis. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - March 11, 2024 Category: Endocrinology Source Type: research
Total weight loss rather than preoperative body mass index correlates with remission of irregular menstruation after sleeve gastrectomy in patients with polycystic ovary syndrome
ConclusionsSG had a significant effect on the remission of irregular menstruation in patients with obesity and PCOS. Preoperative BMI did not emerge as a decisive factor correlated with remission; instead, TWL% showed potential as a key factor. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - March 11, 2024 Category: Endocrinology Source Type: research
Sirtuin 1 serum concentration in healthy children - dependence on sex, age, stage of puberty, body weight and diet
This study aimed to evaluate fasting serum SIRT1 levels in healthy children, and to analyse the influence of age, sex, puberty, body weight, height, and diet on its concentration.Methods47 healthy children aged 4-14 with weight and height within normal range and no chronic disease were included into the study. Fasting serum SIRT1 concentrations were estimated by Enzyme Linked Immunosorbent Assay (ELISA).ResultsResults showed that serum SIRT1 concentrations in healthy children did not differ with respect to sex, age, height, weight and puberty. Whereas, it appeared that a higher frequency of fruits, vegetables and dairy pro...
Source: Frontiers in Endocrinology - March 11, 2024 Category: Endocrinology Source Type: research
Safety, tolerability, pharmacokinetics and pharmacokinetic-pharmacodynamic modeling of cetagliptin in patients with type 2 diabetes mellitus
ConclusionsCetagliptin was well tolerated, inhibited plasma DPP-4 activity, increased plasma active GLP-1 levels, and exhibited a certain trend of glucose-lowering effect in patients with T2DM. The established population PK/PD model adequately described the PK and PD characteristics of cetagliptin. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - March 11, 2024 Category: Endocrinology Source Type: research
Overlapping action of T3 and T4 during Xenopus laevis development
Thyroid hormones are involved in many biological processes such as neurogenesis, metabolism, and development. However, compounds called endocrine disruptors can alter thyroid hormone signaling and induce unwanted effects on human and ecosystems health. Regulatory tests have been developed to detect these compounds but need to be significantly improved by proposing novel endpoints and key events. The Xenopus Eleutheroembryonic Thyroid Assay (XETA, OECD test guideline no. 248) is one such test. It is based on Xenopus laevis tadpoles, a particularly sensitive model system for studying the physiology and disruption of thyroid ...
Source: Frontiers in Endocrinology - March 11, 2024 Category: Endocrinology Source Type: research
A lactate metabolism-related signature predicting patient prognosis and immune microenvironment in ovarian cancer
This study investigated the potential role of LMRGs in tumor microenvironment diversity and prognosis in OV, suggesting that LMRGs play a crucial role in OV progression and the tumor microenvironment, thus serving as novel indicators for prognosis, immune microenvironment status, and response to immunotherapy. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - March 11, 2024 Category: Endocrinology Source Type: research
The thrombotic risk in Cushing ’s syndrome—questions, answers, and the algorithm to consider in its assessment: part I—thrombotic risk not related to surgery
IntroductionRecently, it has been reported that there is a great diversity in strategies used for thromboprophylaxis in patients with Cushing’s syndrome (CS). An aim of this review was to discuss these practices in light of the existing data on the thrombotic risk in patients with CS and guidelines for medically ill patients.MethodsThe four relevant topics and questions on thrombotic risk in CS were identified. The current guidelines on prevention and diagnosis of venous thromboembolism (VTE) were reviewed for the answers. An algorithm to consider in the assessment of the thrombotic risk in patients with CS was proposed....
Source: Frontiers in Endocrinology - March 11, 2024 Category: Endocrinology Source Type: research
