The causal association between circulating cytokines with the risk of frailty and sarcopenia under the perspective of geroscience
ConclusionGenetic predisposition to assess IL-10, IL-12, and VEGF levels was associated with a higher risk of low hand grip strength and M-CSF with the presence of appendicular lean mass. The high levels of TNF-β and MIG were associated with a higher risk of frailty. More studies will be required to explore the molecular biological mechanisms underlying the action of inflammatory factors. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - March 5, 2024 Category: Endocrinology Source Type: research
The effect of β-cell dysfunction on reproductive outcomes of PCOS undergoing IVF or ICSI embryo transfer cycles: a retrospective cohort study
Conclusionsβ-cell dysfunction is independently associated with increased miscarriage rate and decreased live birth rate in women with PCOS. It also plays a synergistic role with IR in terms of the reproductive outcomes, while the influence of IR overweighs that of β-cell dysfunction. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - March 5, 2024 Category: Endocrinology Source Type: research
Early detection of myocardial involvement by non-contrast T1 ρ mapping of cardiac magnetic resonance in type 2 diabetes mellitus
ConclusionIn T2DM patients, T1ρ may be a new non-contrast cardiac magnetic resonance technique for identifying myocardial diffuse fibrosis, and T1ρ may be more sensitive than native T1 in the detection of myocardial diffuse fibrosis. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - March 5, 2024 Category: Endocrinology Source Type: research
Serum FT3/FT4, but not TSH is associated with handgrip strength in euthyroid U.S. population: evidence from NHANES
ConclusionsThis study demonstrated FT3/FT4, but not TSH, was positively associated with HGS in middle age group, and the different association was observed in men in middle age group when participants were stratified by sex. Future longitudinal cohort study should be conducted to reveal the causal relationship between thyroid function and muscle strength. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - March 4, 2024 Category: Endocrinology Source Type: research
Comparison of the effects of monounsaturated fatty acids and polyunsaturated fatty acids on the lipotoxicity of islets
ConclusionsBoth MUFAs and PUFAs can effectively protect islet β cells from SFA-induced cellular lipotoxicity. In particular, both OA in vitro and OO in vivo showed superior activities on protecting islets function and enhance insulin sensitivity, suggesting that MUFAs might have greater potential for nutritional intervention on diabetes. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - March 4, 2024 Category: Endocrinology Source Type: research
Preoperative glucose-to-lymphocyte ratio predicts survival in cancer
ConclusionElevated preoperative GLR was remarkably associated with a poorer prognosis in patients with NSCLC, CRC, breast cancer, gastric cancer, kidney cancer, liver cancer, esophageal cancer, and melanoma. Preoperative GLR promises to be an essential predictor of survival for cancer patients. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - March 4, 2024 Category: Endocrinology Source Type: research
Serum klotho as a novel biomarker for metabolic syndrome: findings from a large national cohort
ConclusionSerum klotho levels were found to be inversely associated with the prevalence of metabolic syndrome, independent of potential confounding factors such as demographics, socioeconomic status, and lifestyle factors. Furthermore, higher klotho levels strongly indicated a lower risk of all-cause mortality in individuals with metabolic syndrome. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - March 4, 2024 Category: Endocrinology Source Type: research
Anti-M üllerian hormone, testicular descent and cryptorchidism
Anti-Müllerian hormone (AMH) is a Sertoli cell-secreted glycoprotein involved in male fetal sex differentiation: it provokes the regression of Müllerian ducts, which otherwise give rise to the Fallopian tubes, the uterus and the upper part of the vagina. In the first trimester of fetal life, AMH is expressed independently of gonadotropins, whereas from the second trimester onwards AMH testicular production is stimulated by FSH and oestrogens; at puberty, AMH expression is inhibited by androgens. AMH has also been suggested to participate in testicular descent during fetal life, but its role remains unclear. Serum AMH is ...
Source: Frontiers in Endocrinology - March 4, 2024 Category: Endocrinology Source Type: research
Establishment and verification of a nomogram that predicts the risk for coronary slow flow
ConclusionThe constructed nomogram accurately and individually predicts the risk of CSF for patients with suspected CSF and may be considered for use in clinical care. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - March 4, 2024 Category: Endocrinology Source Type: research
PANoptosis-related genes function as efficient prognostic biomarkers in colon adenocarcinoma
ConclusionThis study enhances our understanding of COAD’s genetic framework, emphasizing the synergy between cell death pathways and the immune system. The development of a prognostic model based on these insights offers a promising tool for personalized treatment strategies. Future research should focus on validating and refining this model in clinical settings to optimize therapeutic interventions in COAD. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - March 4, 2024 Category: Endocrinology Source Type: research
Advances in targeted therapy and biomarker research in thyroid cancer
Driven by the intricacy of the illness and the need for individualized treatments, targeted therapy and biomarker research in thyroid cancer represent an important frontier in oncology. The variety of genetic changes associated with thyroid cancer demand more investigation to elucidate molecular details. This research is clinically significant since it can be used to develop customized treatment plans. A more focused approach is provided by targeted therapies, which target certain molecular targets such as mutant BRAF or RET proteins. This strategy minimizes collateral harm to healthy tissues and may also reduce adverse ef...
Source: Frontiers in Endocrinology - March 4, 2024 Category: Endocrinology Source Type: research
Systematic review and meta-analysis of the effects of menopause hormone therapy on cognition
DiscussionThese findings suggest time-dependent effects of MHT on certain aspects of cognition, with variations based on formulation and timing of initiation, underscoring the need for further research with larger samples and more homogeneous study designs. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - March 4, 2024 Category: Endocrinology Source Type: research
Symptom and comorbidity burden in hypertensive patients with obstructive sleep apnea
ConclusionCompared to OSA patients with normal blood pressure, OSA patients with hypertension had more significant daytime sleepiness, more frequent nocturnal urination, and a higher risk of diabetes, coronary heart disease, and cerebrovascular disease. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - March 4, 2024 Category: Endocrinology Source Type: research
Secretory leukocyte protease inhibitor as a novel predictive biomarker in patients with diabetic kidney disease
ConclusionsSerum SLPI levels increased with DKD progression and were associated with clinical parameters of DKD. Moreover, elevated SLPI levels showed potential prognostic value for renal endpoint events in individuals with DKD. These findings validate the results of previous studies on SLPI in patients with DKD and provide new insights into the role of SLPI as a biomarker for the diagnosis and prognosis of DKD that require validation. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - March 4, 2024 Category: Endocrinology Source Type: research
Modified versus three-level technique of retroperitoneal laparoscopic adrenalectomy for all patients with adrenal lesions ≤ 6cm: a retrospective, case-controlled study
ConclusionMT retroperitoneal laparoscopic adrenalectomy has demonstrated its benefits in the treatment of adrenal lesions across all patients with adrenal lesions ≤ 6cm, serving as a valuable point of reference for the surgical management of adrenal diseases.Patient summaryWe have made modifications to the classic retroperitoneal laparoscopic adrenalectomy and achieved superior surgical outcomes, resulting in a procedure known as modified retroperitoneal laparoscopic adrenalectomy. This technique is suitable for both obese individuals and the general population with adrenal lesions ≤ 6cm. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - March 4, 2024 Category: Endocrinology Source Type: research
