Five percent weight loss is a significant 1-year predictor and an optimal 5-year cut-off for reducing the number of obesity-related cardiovascular disease risk components: the Japan Obesity and Metabolic Syndrome Study
ConclusionsA weight loss of ≥5.0% at 1 year and ≥7.5% at 5 years could reduce the number of obesity-related CVD risk components in patients with obesity. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - March 27, 2024 Category: Endocrinology Source Type: research
Global, regional, and national burden of chronic kidney disease attributable to high fasting plasma glucose from 1990 to 2019: a systematic analysis from the global burden of disease study 2019
ConclusionWith an increasing population and changing dietary patterns, the burden of CKD attributed to HFPG is expected to worsen. From 1990 to 2019, males and developing regions have experienced a more significant burden. Notably, the EAPC values for both ASMR and ASDR were higher in males and regions with lower SDI (excluding high-income North America). This emphasizes the pressing requirement for effective interventions to reduce the burden of CKD attributable to HFPG. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - March 27, 2024 Category: Endocrinology Source Type: research
The association between Chinese visceral adiposity index and cardiometabolic multimorbidity among Chinese middle-aged and older adults: a national cohort study
ConclusionThe CVAI is a valid biomarker with good predictive capability for cardiometabolic multimorbidity and can be used by primary healthcare organizations in the future for early warning, prevention, and intervention with regard to cardiometabolic multimorbidity. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - March 27, 2024 Category: Endocrinology Source Type: research
Comparing surgical and endoscopic resection approaches for colorectal neuroendocrine tumors within the diameter range of 10-20mm: an inverse probability weighting analysis based on the SEER database
ConclusionFor patients with mucosal-limited lesions and without local lymph node or distant metastasis, ER is the preferred surgical approach. However, for patients with muscular invasion or positive lymph nodes/distant metastasis, SR offers a better prognosis. The choice of surgical approach should be based on the specific clinical characteristics of patients within different subgroups. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - March 27, 2024 Category: Endocrinology Source Type: research
Research progress on the mechanism of TCM regulating intestinal microbiota in the treatment of DM mellitus
This article reviews the relationship between intestinal microbiota and DM, as well as the mechanism of TCM intervention in DM by regulating intestinal microbiota. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - March 27, 2024 Category: Endocrinology Source Type: research
Analysis of clinical evidence on traditional Chinese medicine for the treatment of diabetic nephropathy: a comprehensive review with evidence mapping
ConclusionDN represents a significant health challenge, particularly for the elderly, with TCM showing promise in symptom alleviation and renal protection. Yet, the field is marred by research inconsistencies and methodological shortcomings. Future investigations should prioritize the development of standardized outcome sets tailored to DN, carefully select evaluation indicators that reflect TCM’s unique intervention strategies, and aim to improve the robustness of clinical evidence. Emphasizing TCM’s foundational theories while incorporating advanced scientific technologies will be essential for innovating research me...
Source: Frontiers in Endocrinology - March 27, 2024 Category: Endocrinology Source Type: research
Feature selection and risk prediction for diabetic patients with ketoacidosis based on MIMIC-IV
ConclusionThe study found that hematocrit, hemoglobin, anion gap, age, and Charlson comorbidity index are closely associated with ketoacidosis. In clinical practice, these five baseline characteristics should be given with the special attention to achieve early detection and treatment, thus reducing the incidence of the disease. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - March 27, 2024 Category: Endocrinology Source Type: research
Editorial: New insights into the metabolic processes of immune-related diseases by multi-omics technologies
(Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - March 26, 2024 Category: Endocrinology Source Type: research
Editorial: Equity in type 1 diabetes technology and beyond: where are we in 2022?
(Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - March 26, 2024 Category: Endocrinology Source Type: research
Practice effects of personalized interventions with interdisciplinary teamwork in type 2 diabetes remission: a retrospective study
ConclusionsThrough an interdisciplinary team intervention strategy, we significantly optimized the glucose metabolism, lipid metabolism, and BMI status of patients with T2DM, making diabetes remission an achievable goal, which provides valuable experience for further optimization of diabetes prevention and control protocols. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - March 26, 2024 Category: Endocrinology Source Type: research
Case report: Long term response to growth hormone in a child with Silver-Russell syndrome-like phenotype due to a novel paternally inherited IGF2 variant
We report a novel IGF2 variant c.[-6-2A>G] (NM_000612) in a child with severe IUGR and clinical features of SRS and confirm the utility of targeted exome sequencing in patients with negative results to common genetic analyses. In addition, we report that long-term growth hormone treatment improves height SDS in this patient. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - March 26, 2024 Category: Endocrinology Source Type: research
The effect of exercise on flow-mediated dilation in people with type 2 diabetes mellitus: a systematic review and meta-analysis of randomized controlled trials
ConclusionThis meta-analysis provides clinicians with evidence to recommended that T2DM patients participate in exercise, especially HIIT, more than 3 times per week for less than 60 min, with a target of 180 min per week being reached by increasing the frequency of exercise.Systematic review registrationhttps://www.crd.york.ac.uk/prospero, identifier CRD42023466575. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - March 26, 2024 Category: Endocrinology Source Type: research
Association of adrenal steroids with metabolomic profiles in patients with primary and endocrine hypertension
DiscussionsOur study indicates cortisol, cortisone, and catecholamine excess are significantly associated with metabolomic variances in EHT versus PHT patients. Notably, catecholamine excess is key to PPGL’s metabolomic changes, whereas in PA, other non-defining adrenal steroids mainly account for metabolomic differences. In CS, cortisol, alongside other non-defining adrenal hormones, contributes to these differences, suggesting that metabolic disorders and cardiovascular morbidity in these conditions could also be affected by various adrenal steroids. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - March 26, 2024 Category: Endocrinology Source Type: research
Association of metabolic syndrome and sarcopenia with all-cause and cardiovascular mortality: a prospective cohort study based on the NHANES
ConclusionThe coexistence of MetS and SP increased the risk of all-cause and cardiovascular mortality, particularly in males and in nonelderly populations. Individuals with either MetS or SP may require more careful management to prevent the development of other diseases and thereby reduce mortality. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - March 26, 2024 Category: Endocrinology Source Type: research
Gene expression analyses of GH/IGF axis in triploid crucian carp with growth heterosis
Hybridization and polyploid breeding are the main approaches used to obtain new aquaculture varieties. Allotriploid crucian carp (3n) with rapid growth performance was generated by mating red crucian carp (RCC) with allotetraploids (4n). Fish growth is controlled by the growth hormone (GH)/insulin-like growth factor (IGF) axis. In the present study, we examined the expression characteristics of GH/IGF axis genes in hybrids F1, 4n, 3n, RCC and common carp (CC). The results showed that GHRa, GHRb, IGF1, IGF2, and IGF-1Ra were highly expressed in 3n compared with RCC and CC, whereas IGF3 was undetectable in the liver in RCC, ...
Source: Frontiers in Endocrinology - March 26, 2024 Category: Endocrinology Source Type: research
