Serum fetuin-a and risk of thoracic aortic aneurysms: a two-sample mendelian randomization study
ConclusionsSerum fetuin-A level was negatively associated with risk of TTAs and correlated with the decreased descending thoracic aortic diameter. Mendelian randomization provides support for the potential causal relationship between fetuin-A and thoracic aortic aneurysm. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - February 26, 2024 Category: Endocrinology Source Type: research
Advances in the role and mechanism of fibroblasts in fracture healing
With the development of social population ageing, bone fracture has become a global public health problem due to its high morbidity, disability and mortality. Fracture healing is a complex phenomenon involving the coordinated participation of immigration, differentiation and proliferation of inflammatory cells, angioblasts, fibroblasts, chondroblasts and osteoblasts which synthesize and release bioactive substances of extracellular matrix components, Mortality caused by age-related bone fractures or osteoporosis is steadily increasing worldwide as the population ages. Fibroblasts play an important role in the process of fr...
Source: Frontiers in Endocrinology - February 26, 2024 Category: Endocrinology Source Type: research
Effects of flaxseed oil supplementation on metaphase II oocyte rates in IVF cycles with decreased ovarian reserve: a randomized controlled trial
ConclusionFlaxseed oil improved ovarian response and the quality of oocytes and embryos, thereby increasing the fertilization rate and high-quality embryo rate in DOR patients. The use of flaxseed oil was positively correlated with MII oocyte rate in women with DOR.Clinical trial numberhttps://www.chictr.org.cn/, identifier ChiCTR2300073785 (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - February 26, 2024 Category: Endocrinology Source Type: research
Transcriptome profiling reveals superovulation with the gonadotropin-releasing hormone agonist trigger impaired embryo implantation in mice
ConclusionOur findings suggest that a combination of PMSG and GnRHa trigger impaired embryo implantation in mice, as the excessive uterine response to superphysiological estrogen levels can lead to the change of gene expression related to endometrial remodeling, abnormal expression of uterine ion transport genes and excessive immune-related genes. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - February 26, 2024 Category: Endocrinology Source Type: research
Incidence of microvascular dysfunction is increased in hyperlipidemic mice, reducing cerebral blood flow and impairing remote memory
DiscussionWe conclude that the hyperlipidemic PCSK9DY mouse model can serve as an appropriate approach to induce microvascular dysfunction that leads to reduced blood flow in the hippocampus, which could explain the cognitive dysfunction in these mice. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - February 26, 2024 Category: Endocrinology Source Type: research
Key genes involved in nonalcoholic steatohepatitis improvement after bariatric surgery
ConclusionIn summary, this study contributes to our understanding of the mechanisms by which bariatric surgery improves NASH, and to the development of potential biomarkers for the treatment of NASH. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - February 26, 2024 Category: Endocrinology Source Type: research
A strategic study of acupuncture for diabetic kidney disease based on meta-analysis and data mining
ConclusionAcupuncture improved clinical symptoms, renal function indices such as uALB, umALB, uβ2-MG, and SCR, as well as blood glucose and blood lipid in patients with DKD, and has a favorable safety profile. CV12, SP8, SP10, ST36, SP6, BL20, BL23, and SP9 are the core acupoints for acupuncture in DKD, and this program is expected to become a supplementary treatment for DKD. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - February 26, 2024 Category: Endocrinology Source Type: research
Brain-derived neuerotrophic factor and related mechanisms that mediate and influence progesterone-induced neuroprotection
Historically, progesterone has been studied significantly within the context of reproductive biology. However, there is now an abundance of evidence for its role in regions of the central nervous system (CNS) associated with such non-reproductive functions that include cognition and affect. Here, we describe mechanisms of progesterone action that support its brain-protective effects, and focus particularly on the role of neurotrophins (such as brain-derived neurotrophic factor, BDNF), the receptors that are critical for their regulation, and the role of certain microRNA in influencing the brain-protective effects of proges...
Source: Frontiers in Endocrinology - February 26, 2024 Category: Endocrinology Source Type: research
Whole-exome sequencing combined with postoperative data identify c.1614dup (CAMKK2) as a novel candidate monogenic obesity variant
In conclusion, our data confirm the efficacy of WES combined with postoperative data in detecting novel candidate MOVs and c.1614dup (CAMKK2) might be a promising MOV, which needs further confirmation. This study enriches the human monogenic obesity mutation database and provides a scientific basis for clinically accurate diagnosis and treatment. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - February 26, 2024 Category: Endocrinology Source Type: research
Updates in the pathophysiology of COVID-19 infection in male reproductive and sexual health: a literature review
This extensive comprehensive review explores the impact of the Coronavirus disease 2019 (COVID-19) pandemic on men’s sexual and reproductive health. We conducted a literature review focusing on the possible pathophysiology by which severe acute respiratory syndrome corona virus 2 (SARS-CoV-2) affects men’s sexual and reproductive systems. We reviewed most of the studies that reported the impact of SARS-CoV-2 infection on the Testicular, Epididymal, Prostatic, and Penile tissue. Also, we focused on evaluating the SARS-CoV-2 infection on semen parameters and male reproductive hormones. Finally, we reviewed the COVID-19 v...
Source: Frontiers in Endocrinology - February 26, 2024 Category: Endocrinology Source Type: research
L −shaped association of triglyceride glucose index and sensorineural hearing loss: results from a cross-sectional study and Mendelian randomization analysis
ConclusionsAn L-shaped association was identified among the TyG index, fasting blood glucose, and SNHL in the American population. TyG index of more than 9.07 and blood glucose of more than 94 mg/dL were significantly and positively associated with SNHL risk, respectively. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - February 23, 2024 Category: Endocrinology Source Type: research
Re-analysis of gene mutations found in pituitary stalk interruption syndrome and a new hypothesis on the etiology
ConclusionBased on our summary and analyses, we propose a new hypothesis: disruptions in normal embryonic development, partially stemming from the genetic background and/or specific gene mutations in individuals, may increase the likelihood of abnormal fetal deliveries, where different degrees of traction during delivery may lead to different levels of pituitary stalk interruption and posterior lobe ectopia. The clinical diversity observed in PSIS patients may result from a combination of genetic background, specific mutations, and variable degrees of traction during delivery. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - February 23, 2024 Category: Endocrinology Source Type: research
Vascular changes of the choroid and their correlations with visual acuity in diabetic retinopathy
ConclusionChoroidal vascular alterations, especially decreased CVI, occurred in patients with DR. The CVI decreased with duration of DM and was correlated with visual impairment, indicating that the CVI might be a reliable imaging biomarker to monitor the progression of DR. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - February 23, 2024 Category: Endocrinology Source Type: research
Ovaries of estrogen receptor 1-deficient mice show iron overload and signs of aging
IntroductionEstrogens are crucial regulators of ovarian function, mediating their signaling through binding to estrogen receptors. The disruption of the estrogen receptor 1 (Esr1) provokes infertility associated with a hemorrhagic, cystic phenotype similar to that seen in diseased or aged ovaries. Our previous study indicated the possibility of altered iron metabolism in Esr1-deficient ovaries showing massive expression of lipocalin 2, a regulator of iron homeostasis.MethodsTherefore, we examined the consequences of depleting Esr1 in mouse ovaries, focusing on iron metabolism. For that reason, we compared ovaries of adult ...
Source: Frontiers in Endocrinology - February 23, 2024 Category: Endocrinology Source Type: research
Stress hyperglycemia is associated with poor outcome in critically ill patients with pulmonary hypertension
ConclusionStress hyperglycemia assessed by the GAR was associated with increased 90-day mortality in ICU patients with PH. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - February 23, 2024 Category: Endocrinology Source Type: research
