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Condition: Diabetes Mellitus
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Total 263 results found since Jan 2013.
Swinhoeic acid from < em > Potentilla fragarioides < /em > ameliorates high glucose-induced oxidative stress and accumulation of ECM in mesangial cells via Keap1-dependent activation of Nrf2
CONCLUSION: Swinhoeic acid ameliorates oxidative stress and accumulation of ECM resulting from high glucose in mesangial cells via activating Nrf2 in Keap1-dependent manner.PMID:36259553 | PMC:PMC9590439 | DOI:10.1080/13510002.2022.2134755
Source: Redox Report : communications in free radical research - October 19, 2022 Category: Biochemistry Authors: Huankai Yao Min Kong Dan Du Fengwei Ai Jindong Li Yan Li Source Type: research
Blocking REDD1/TXNIP Complex Ameliorates HG-Induced Renal Tubular Epithelial Cell Apoptosis and EMT through Repressing Oxidative Stress
Int J Endocrinol. 2022 Sep 21;2022:6073911. doi: 10.1155/2022/6073911. eCollection 2022.ABSTRACTDiabetic nephropathy (DN) has become the most common secondary kidney disease causing end-stage renal disease (ESRD). Nevertheless, the underlying mechanisms responsible for DN remain largely unknown. Regulated in development and DNA damage response 1 (REDD1) is a prooxidative molecule known to contribute to diabetes mellitus and its complications. However, it has not been previously examined whether and how REDD1 can further drive renal tubular epithelial cell (RTEC) apoptosis and epithelial-to-mesenchymal transition in DN. The...
Source: International Journal of Endocrinology - October 3, 2022 Category: Endocrinology Authors: Lin Mu Nan Chen Yakun Chen Zhifen Yang Huandi Zhou Shan Song Yonghong Shi Source Type: research
miR-351 promotes atherosclerosis in diabetes by inhibiting the ITGB3/PIK3R1/Akt pathway and induces endothelial cell injury and lipid accumulation
CONCLUSION: Silencing miR-351 upregulates ITGB3 and activates the PIK3R1/Akt pathway, thereby exerting anti-apoptosis and protective effects on endothelial cells.PMID:36180828 | DOI:10.1186/s10020-022-00547-9
Source: Molecular Medicine - September 30, 2022 Category: Molecular Biology Authors: Hong Li Dan Song Qihui Liu Linlin Li Xiaoshi Sun Jiamei Guo Dianlian Li Ping Li Source Type: research
ABCG1 is Expressed in a LXR-Independent Manner in Patients with Type 2 Diabetes Mellitus
CONCLUSION: The study suggested that the expression of ATP-binding cassette G1 and high density lipoprotein-induced cholesterol efflux in macrophages were reduced in type 2 diabetes mellitus. Impairment of cholesterol efflux and ATP-binding cassette G1 gene expression in type 2 diabetes mellitus might be regulated by a Liver X receptor-independent pathway.PMID:36017862 | DOI:10.2174/1566524023666220822150820
Source: Molecular Medicine - August 26, 2022 Category: Molecular Biology Authors: Hui-Juan Wang Ji-Hong Wang Xin-Na Xu Xing-Shan Zhao Wei Liu Source Type: research
