Recent Trends in the Clinicopathological Features of Thyroid Nodules in Pediatric Patients: A Single Tertiary Center Experience over 25 Years.
Authors: Rah CS, Kim WW, Lee YM, Kim WG, Song DE, Chung KW, Kim SC, Hong SJ, Sung TY Abstract Background: The trends in pediatric patients having thyroid nodules have not been well evaluated. Here, we analyzed the clinicopathological features of the children who have presented with thyroid nodules at our center over several decades in order to determine a change of trend. Materials and Methods: We analyzed 215 pediatric patients who had undergone a thyroidectomy between 1990 and 2014 at our single tertiary center. The clinicopathological features were analyzed according to age, sex, and the year of diagnosis. ...
Source: International Journal of Endocrinology - January 16, 2020 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Alterations of Bone Metabolism in Patients with Diabetes Mellitus.
Conclusion: In some cases, bone remodeling markers are useful for improving the assessment of the state of bone tissue in early stages of diabetes, while alterations in bone microarchitecture may not always be captured by bone mineral density measurements. PMID: 31933638 [PubMed] (Source: International Journal of Endocrinology)
Source: International Journal of Endocrinology - January 16, 2020 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Delayed Bone Age Might Accelerate the Response to Human Growth Hormone Treatment in Small for Gestational Age Children with Short Stature.
Conclusions: Delayed BA (>2 years) may impact the response to GH treatment in SGA children with short stature. PMID: 31933639 [PubMed] (Source: International Journal of Endocrinology)
Source: International Journal of Endocrinology - January 16, 2020 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

The Impact of Preconceptional Serum TSH Levels between 2.5 and 4.0  mIU/L on Infertile Women Going through Their First IUI Treatment Cycle.
Conclusion: Normal high-serum TSH levels within the reference range (0.4-4.0 mIU/L) measured before treatment seemed to have no adverse impact on the clinical outcomes of patients undergoing their first IUI treatment cycle. PMID: 31933640 [PubMed] (Source: International Journal of Endocrinology)
Source: International Journal of Endocrinology - January 16, 2020 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

The Potential Link between Gut Microbiota and Serum TRAb in Chinese Patients with Severe and Active Graves' Orbitopathy.
Conclusions: Our results revealed the potential relationships between gut microbiota and GO-related traits in the combination of microbial effects. This study may provide a new insight into the interaction between the intestinal microbiota and TRAb-associated immune responses in GO patients. PMID: 31933641 [PubMed] (Source: International Journal of Endocrinology)
Source: International Journal of Endocrinology - January 16, 2020 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Clinical Features, Treatment, and Surveillance of Hyperparathyroidism-Jaw Tumor Syndrome: An Up-to-Date and Review of the Literature.
Authors: Torresan F, Iacobone M Abstract Hyperparathyroidism-jaw tumor (HPT-JT) syndrome is an autosomal dominant disorder characterized by parathyroid tumors in association with fibro-osseous jaw tumors and uterine and renal lesions. HPT-JT syndrome is caused by germline mutations of the cell division cycle 73 (CDC73) gene that encodes the parafibromin, a 531-amino acid protein with antiproliferative activity. Primary hyperparathyroidism is the main finding of HPT-JT syndrome, usually caused by a single-gland parathyroid involvement (80% of cases), at variance with other variants of hereditary hyperparathyroidism,...
Source: International Journal of Endocrinology - January 14, 2020 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Comparative Proteomic Analysis of Visceral Adipose Tissue in Morbidly Obese and Normal Weight Chinese Women.
Conclusion: A number of differentially expressed proteins were identified in VAT between morbidly obese and normal weight Chinese females. These differential proteins could be potential candidates in addressing the role of VAT in the development of obesity. PMID: 31929791 [PubMed] (Source: International Journal of Endocrinology)
Source: International Journal of Endocrinology - January 14, 2020 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Clinical Characteristics of 76 Patients with IgG4-Related Hypophysitis: A Systematic Literature Review.
Authors: Li Y, Gao H, Li Z, Zhang X, Ding Y, Li F Abstract Background: IgG4-related hypophysitis (IgG4-RH) is a rare disease, and its prevalence remains unclear. In recent years, an increasing number of cases have been reported because of the increasing recognition of this disease. We aimed to summarize case reports of IgG4-RH and outline the clinical features and outcomes. Methods: We performed PubMed search of articles using the search terms "hypophysitis [AND] IgG4." Consequently, only 54 English articles (76 cases) met Leporati's diagnostic criteria. Results: Of the 76 cases, the ratio of men ...
Source: International Journal of Endocrinology - January 14, 2020 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

New Predictive Equations for Resting Energy Expenditure in Normal to Overweight and Obese Population.
Conclusion: Previous equations likely over- or underpredicted REE. Therefore, the new predictive AA equations developed in this study are recommended for the estimation of REE in young to middle-aged Saudi men and women with different body mass indexes. Future research is also required for further clinical and cross-validation of these new equations. PMID: 31929793 [PubMed] (Source: International Journal of Endocrinology)
Source: International Journal of Endocrinology - January 14, 2020 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

An Overall Glance of Evidence Supportive of One-Hour and Two-Hour Postload Plasma Glucose Levels as Predictors of Long-Term Cardiovascular Events.
Authors: Mann BK, Bhandohal JS, Hong J Abstract This review summarizes the vast literature describing the long-term epidemiological studies with emphasis on postprandial glucose as a stronger predictor of cardiovascular complications as compared to fasting glucose and HbA1c. Many molecular studies also supported this fact by illustrating that postchallenge hyperglycemia is associated with elevated biomarkers of systemic inflammation in the plasma and thus increasing the chances of vascular damage. Large-scale studies have proved that vascular stiffness, brachial-ankle pulse-wave velocity, carotid intima thickness, ...
Source: International Journal of Endocrinology - January 14, 2020 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Gonadotropin-Induced Spermatogenesis in CHH Patients with Cryptorchidism.
This study retrospectively evaluated gonadotropin-induced spermatogenesis outcome in CHH patients with cryptorchidism (n = 40). One hundred and eighty-three CHH patients without cryptorchidism were served as control. All patients received combined gonadotropins therapy (HCG and HMG) and were followed up for at least 6 months. The median follow-up period was 24 (15, 33) months (totally 960 person-months). Sperm (>0/ml) initially appeared in semen at a median of estimated 24 months (95% confidence interval (CI) 17.8-30.2). Twenty (20/40, 50%) patients succeeded in producing sperms, and the average time to pr...
Source: International Journal of Endocrinology - January 14, 2020 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Indicators of Quality of Clinical Care for Type 2 Diabetes Patients in Primary Health Care Centers in Qatar: A Retrospective Analysis.
Authors: Attal S, Mahmoud MH, Aseel MT, Candra A, Amuna P, Elnagmi M, Abdallah M, Ismail N, Abdelrazek A, Albaw D, Albashir A, Elmahdi H Abstract Background: Despite the high prevalence of type 2 diabetes mellitus in Gulf countries, standards of diabetes care at the primary care level have not been widely studied. Aim: To compare the results of diabetes clinical indicators from the American Diabetes Association (ADA) 2017 guidelines to the reference benchmarks in the Behavioral Risk Factor Surveillance System. Materials and Methods: A cross-sectional analysis of electronic medical records in 643 randomly se...
Source: International Journal of Endocrinology - December 31, 2019 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

The Effect of Low Carbohydrate Diet on Polycystic Ovary Syndrome: A Meta-Analysis of Randomized Controlled Trials.
Authors: Zhang X, Zheng Y, Guo Y, Lai Z Abstract Objective: To assess the effect of a low carbohydrate diet (LCD) on women with polycystic ovary syndrome (PCOS). Methods: Data from randomized controlled trials (RCTs) were obtained to perform a meta-analysis of the effects of LCD in PCOS patients. The primary outcomes included the changes in BMI, homeostatic model assessment for insulin resistance (HOMA-IR), and blood lipids, including total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C), follicle-stimulating hormone (FSH), luteotropic hormone (LH)...
Source: International Journal of Endocrinology - December 31, 2019 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Retracted: Sexual Dysfunction in Women with Diabetic Kidney.
Authors: International Journal Of Endocrinology Abstract [This retracts the article DOI: 10.1155/2014/346834.]. PMID: 31885558 [PubMed - in process] (Source: International Journal of Endocrinology)
Source: International Journal of Endocrinology - December 31, 2019 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

miR-98-5p Alleviated Epithelial-to-Mesenchymal Transition and Renal Fibrosis via Targeting Hmga2 in Diabetic Nephropathy.
Authors: Zhu Y, Xu J, Liang W, Li J, Feng L, Zheng P, Ji T, Bai S Abstract Recently, microRNAs have been recognized as crucial regulators of diabetic nephropathy (DN) development. Epithelial-to-mesenchymal transition (EMT) can play a significant role in tubulointerstitial fibrosis, and it is a hallmark of diabetic nephropathy progression. Nevertheless, the function of miR-98-5p in the modulation of EMT and renal fibrosis during DN remains barely investigated. Hence, identifying the mechanisms of miR-98-5p in regulating EMT and fibrosis is of huge significance. In our present research, decreased miR-98-5p was demons...
Source: International Journal of Endocrinology - December 31, 2019 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Characterising SRD5A2 Gene Variants in 37 Indonesian Patients with 5-Alpha-Reductase Type 2 Deficiency.
We examined results from testosterone/dihydrotestosterone (T/DHT) and urinary etiocholanolone/androsterone (Et/An) ratios, as well as from molecular and clinical analyses. Twelve variants in the SRD5A2 gene were identified, and 6 of which were novel, namely, c.34-38delGinsCCAGC, p.Arg50His, p.Tyr136 ∗ , p.Gly191Arg, p.Phe194Ile, and p.Ile253Val variants. Moreover, we determined that 20 individuals contained harmful mutations, while the remaining 17 variants were benign. Those containing harmful mutations exhibited more severe phenotypes with median external genitalia masculinisation scores (EMS) of 3 (1.5-9) and wer...
Source: International Journal of Endocrinology - December 31, 2019 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

The Cerebellum Posterior Lobe Associates with the Exophthalmos of Primary Hyperthyroidism: A Resting-State fMRI Study.
Conclusions: Our study was the first, to our knowledge, to explore changes in the brains of patients with EOPH using the DC method. The DC value was significantly different in the cerebellum posterior lobe in patients with EOPH, indicating that the cerebellum posterior lobe is associated with EOPH. PMID: 31885561 [PubMed] (Source: International Journal of Endocrinology)
Source: International Journal of Endocrinology - December 31, 2019 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

TG  : HDL-C Ratio Is a Good Marker to Identify Children Affected by Obesity with Increased Cardiometabolic Risk and Insulin Resistance.
This study aims to examine the clinical utility of triglyceride to high-density lipoprotein ratio (TG : HDL-C) in identifying cardiometabolic risk and insulin resistance (IR) among children with obesity, in comparison with MetS as defined by the International Diabetes Federation (IDF). Data of 232 children with obesity aged 10-16 years were obtained from our study, MyBFF@school study, conducted between January and December 2014. Children were divided into tertiles of TG : HDL-C ratio. The minimum value of the highest tertile was 1.11. Thus, elevated TG : HDL-C ratio was defined as ...
Source: International Journal of Endocrinology - December 31, 2019 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

The Role of MicroRNAs in the Pathogenesis of Diabetic Nephropathy.
Authors: Tang J, Yao D, Yan H, Chen X, Wang L, Zhan H Abstract Diabetic nephropathy (DN) is one of the most common microvascular complications in diabetic patients; it is also an important cause of renal dysfunction, renal fibrosis, and end-stage renal disease. Unfortunately, the pathogenesis of DN is complex and has not yet been fully elucidated; hence, the pathogenesis of DN to determine effective treatments of crucial importance is deeply explored. Early DN research focuses on hemodynamic changes and metabolic disorders, and recent studies have shown the regulatory role of microRNAs (miRNAs) in genes, which may ...
Source: International Journal of Endocrinology - December 31, 2019 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Comparison of Robotic Posterior Retroperitoneal Adrenalectomy over Laparoscopic Posterior Retroperitoneal Adrenalectomy: A Single Tertiary Center Experience.
Conclusions: RPRA is a feasible and technically safe approach for benign adrenal diseases. The use of RPRA could benefit patients and provide comfort by overcoming the factors contributing to a longer operation time in the laparoscopic technique, such as male gender and high BMI. PMID: 31885564 [PubMed] (Source: International Journal of Endocrinology)
Source: International Journal of Endocrinology - December 31, 2019 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

The Association of Autoantibodies in Hyperthyroid Heart Disease Combined with Pulmonary Hypertension.
Authors: Zhang X, Chen L, Sheng J, Li C, He Y, Han W Abstract Hyperthyroidism is a clinical state that results from increased thyroid hormone levels which has a significant impact on cardiac function and structure. Graves' disease is the most common cause of hyperthyroidism in iodine-replete areas. Hyperthyroid heart disease may be associated with pulmonary hypertension in patients who have overt hyperthyroidism. To investigate the association of pulmonary hypertension induced by hyperthyroid heart disease and autoantibody, one hundred and one cases with hyperthyroid heart disease who were consecutively admitted to...
Source: International Journal of Endocrinology - December 31, 2019 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

A Mechanism Exploration of Metabolic Syndrome Causing Nodular Thyroid Disease.
Conclusions: Patients with MS have a higher prevalence of TNs, probably due to the elevated TSH and inflammatory levels in vivo. Among the components of MS, glucose intolerance contributes most to the development of TNs. PMID: 31885566 [PubMed] (Source: International Journal of Endocrinology)
Source: International Journal of Endocrinology - December 31, 2019 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Contributions of Fasting and Postprandial Glucose Concentrations to Haemoglobin A1c in Drug-Na ïve Mal-Glucose Metabolism in Chinese Population Using Continuous Glucose Monitoring System.
Conclusions: In drug-naïve patients with T2D or IGT/IFG, PG contributed more in patients with HbA1c 
Source: International Journal of Endocrinology - December 25, 2019 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Dysregulation of Kisspeptin and Leptin, as Anorexigenic Agents, Plays Role in the Development of Obesity in Postmenopausal Women.
Authors: Hestiantoro A, Astuti BPK, Muharam R, Pratama G, Witjaksono F, Wiweko B Abstract During the menopausal period, women have a higher tendency to develop obesity and any other metabolic syndromes. Dysregulation of leptin and kisspeptin signaling as anorexigenic agents is believed to be the connection between metabolic disorders and altered reproductive function. Therefore, this study aimed at investigating the association between leptin, soluble leptin receptor (sOBR), free leptin index, kisspeptin concentrations, and body mass index (BMI) in postmenopausal women. A cross-sectional study was carried out among...
Source: International Journal of Endocrinology - December 25, 2019 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Etiology and Clinical Presentation of Disorders of Sex Development in Kenyan Children and Adolescents.
Conclusion: The commonest presumed cause of DSD was ovotesticular DSD in contrast to western studies, which found CAH to be more common. Investigation of DSD cases is expensive and needs to be supported. We would have liked to do molecular genetic analysis outside the country but financial challenges made it impossible. A network for detailed diagnostics in resource-limited countries would be highly desirable. There is a need to train health care workers and medical students for early diagnosis. Psychological evaluation should be carried out for all patients at diagnosis and support given for families. PMID: 31871452 [...
Source: International Journal of Endocrinology - December 25, 2019 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Metabolic Effects of Testosterone Hormone Therapy in Normal and Orchiectomized Male Rats: From Indirect Calorimetry to Lipolytic Enzymes.
This study measured respiratory quotient (RQ), TEE, ghrelin, insulin, and key lipolysis enzyme concentrations in relation to body weight (wt) and food intake (FI) in both normal and bilaterally orchiectomized rats with/without T treatment. Methods: In total, thirty-two male Wistar rats (300-400 g) were divided into four groups (n = 8/group), including (a) sham-operated and vehicle-injected group (Sham), (b) T-treated sham group (T-Sham) for which sham-operated rats were injected with IM testosterone undecanoate (100 mg/kg, for one week), (c) orchiectomy and vehicle-injected group (Orch), and...
Source: International Journal of Endocrinology - December 25, 2019 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Intrapartum Results on Differing Degrees of Ketonuria in Nulliparous Women with Gestational Diabetes Mellitus during Spontaneous Labor.
Authors: Huang SY, Yu B, He X, Chen Y Abstract To compare intrapartum results associated with differing degrees of ketonuria in nulliparous women with gestational diabetes mellitus (GDM), we implemented a retrospective cohort study comparing clinical characteristics among differing degrees of ketonuria and the duration and distribution of ketonuria at different stages of labor. We also analyzed adverse maternal and neonatal outcomes for each group. A total of 570 GDM deliveries were included; of these, 238 had negative ketonuria (41.8%), 180 had moderate ketonuria (31.6%), and 152 had ketosis (26.6%). The proportio...
Source: International Journal of Endocrinology - December 14, 2019 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Regulatory Effect of 1,25(OH)2D3 on TGF- β1 and miR-130b Expression in Streptozotocin-Induced Diabetic Nephropathy in Rats.
Regulatory Effect of 1,25(OH)2D3 on TGF-β1 and miR-130b Expression in Streptozotocin-Induced Diabetic Nephropathy in Rats. Int J Endocrinol. 2019;2019:1231346 Authors: Liu Y, Yang Y, Wang Q, Kahaer A, Zhang J, Liao J, Abudureyimu M, Yahefu R, Qi J, Zhao L, Zhu J Abstract Objective: To investigate the role of microRNA-130b in 1,25(OH)2D3 mediated improvement of renal fibrosis via transforming growth factor-beta 1 in a rat model of diabetic nephropathy (DN). Methods: DN was induced in 30 rats by intraperitoneal injection of streptozotocin. These rats were randomly allocated to the DN group, TGF-...
Source: International Journal of Endocrinology - December 1, 2019 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Preoperative and Postoperative Bone Mineral Density Change and Risk Factor Analysis in Patients with a GH-Secreting Pituitary Adenoma.
This study analysed changes in bone mineral density (BMD) at different sites in patients with acromegaly and postoperative BMD changes and explored risk factors associated with BMD. Methods: Clinical data of 39 patients with growth hormone- (GH-) secreting pituitary adenomas and 29 patients with nonfunctioning pituitary adenomas who were newly diagnosed in neurosurgery from January 2016 to December 2018 were retrospectively analysed, including measurements of preoperative and postoperative BMD, serum GH glucose inhibition, random GH and IGF-1, and other anterior pituitary hormones. Results: The average patient age ...
Source: International Journal of Endocrinology - December 1, 2019 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Pituitary Involvement in Granulomatosis with Polyangiitis: A Retrospective Analysis in a Single Chinese Hospital and a Literature Review.
Conclusions: GPA should be carefully considered as a potential cause of pituitary dysfunction (PD), especially when multisystem dysfunction exists. Conventional treatment with corticosteroids and/or immunosuppressive agents improves systemic symptoms, but pituitary disorders persisted in most patients. PMID: 31781205 [PubMed] (Source: International Journal of Endocrinology)
Source: International Journal of Endocrinology - December 1, 2019 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

The Testosterone Effect on Metabolic and Urologic Outcomes in Patients with Nonfunctioning Pituitary Macroadenomas and Hypogonadotropic Hypogonadism.
Conclusion: TTh in young men with NFPMA improves LUTS, sexual function, and some metabolic parameters, and it is relatively safe in the prostatic context. PMID: 31781206 [PubMed] (Source: International Journal of Endocrinology)
Source: International Journal of Endocrinology - December 1, 2019 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Gonadal and Cortisol Hormone Profile among Male Chronic Khat, Marijuana, and Heroin Abuses.
Authors: Yibrah M, Negesso AE, Gebregziabher A, Challa F, Mudi K, Tesfay F, Gebretsadkan M, Kinde S, Asmelash D Abstract Background: Drugs of abuse could interfere with the hypothalamic-pituitary-gonadal axis, causing impaired functions of the gland and associated functions of target organs. Drugs of abuse tend to cause changes in the endocrine system, and these changes could be physiological, molecular, biochemical, genetic, and cellular. Method: A case-control study design was conducted from a total of 171 male consented study participants (148 drug abusers and 23 controls). The serum gonadal and cortisol hor...
Source: International Journal of Endocrinology - December 1, 2019 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

MC4R Single Nucleotide Polymorphisms Were Associated with Metabolically Healthy and Unhealthy Obesity in Chinese Northern Han Populations.
Authors: Gao L, Wang L, Yang H, Pan H, Gong F, Zhu H Abstract Melanocortin-4 receptor (MC4R) has been reported to be associated with the risk of obesity, and metabolically unhealthy obese (MUHO) patients tend to have a greater risk of cardiovascular complications than metabolically healthy obese (MHO) patients. Therefore, we aimed to study single nucleotide polymorphisms (SNPs) in the MC4R gene associated with metabolically healthy and unhealthy obesity in Chinese Northern Han populations. A total of 1100 Chinese Northern Han subjects were recruited and divided into four groups according to the criteria of the Adul...
Source: International Journal of Endocrinology - December 1, 2019 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Use of FreeStyle Libre Flash Monitor Register in the Netherlands (FLARE-NL1): Patient Experiences, Satisfaction, and Cost Analysis.
Authors: Fokkert MJ, Damman A, van Dijk PR, Edens MA, Abbes S, Braakman J, Slingerland RJ, Dikkeschei LD, Dille J, Bilo HJG Abstract In patients with diabetes mellitus (DM), adequate glucose control is of major importance. When treatment schemes become more complicated, proper self-management through intermittent self-measurement of blood glucose (SMBG), among others, becomes crucial in achieving this goal. In the last decade, continuous glucose monitoring (CGM) has been on the rise, providing not only intermittent information but also information on continuous glucose trends. The FreeStyle Libre (FSL) Flash CGM sy...
Source: International Journal of Endocrinology - December 1, 2019 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

miR-129-5p Inhibits Adipogenesis through Autophagy and May Be a Potential Biomarker for Obesity.
This study aimed to identify how miR-129-5p (a specific miRNA) regulates adipogenesis in vitro and explore its possible role in the pathogenesis of obesity in humans. Materials and Methods: The miR-129-5p expression was detected in obese mouse models. The effect of miR-129-5p on adipocyte differentiation was observed, and the adipose markers were analyzed. Bioinformatics and dual-luciferase reporter assay were applied to predict and confirm the target genes of miR-129-5p. The human serum samples were detected and analyzed. Results: miR-129-5p is highly expressed in adipose tissues of db/db mice. Gain- and loss-of-f...
Source: International Journal of Endocrinology - December 1, 2019 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Benign Adrenocortical Tumors and the Detection of Nonadrenal Neoplasia.
Conclusions: Patients with benign adrenocortical tumors had higher odds of detected pancreatic IPMN, as well as thyroid nodules, parathyroid tumors, benign breast masses, and prostate hyperplasia compared with patients with normal adrenal glands. These associations may have important implications for patient care and healthcare economics, regardless of whether they reflect incidental discoveries due to imaging detection or frequency bias, or a common risk for developing multiple neoplasia. PMID: 31781211 [PubMed] (Source: International Journal of Endocrinology)
Source: International Journal of Endocrinology - December 1, 2019 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Risedronate Attenuates Podocyte Injury in Phosphate Transporter-Overexpressing Rats.
In conclusion, our findings suggest that risedronate could maintain glomerular barrier function by rescuing Pi-induced podocyte injury. PMID: 31772574 [PubMed] (Source: International Journal of Endocrinology)
Source: International Journal of Endocrinology - November 28, 2019 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

3-Deoxyglucosone Induces Glucagon-Like Peptide-1 Secretion from STC-1 Cells via Upregulating Sweet Taste Receptor Expression under Basal Conditions.
In this study, we determined the acute effect of 3DG on GLP-1 secretion under basal conditions and investigated the possible mechanisms. Normal fasting rats were given a single acute intragastric administration of 50 mg/kg 3DG. Plasma basal GLP-1 levels and duodenum 3DG content and sweet taste receptor expression were measured. STC-1 cells were acutely exposed to 3DG (80, 300, and 1000 ng/ml) for 1 h under basal conditions (5.6 mM glucose), and GLP-1 secretion, intracellular concentrations of cyclic adenosine monophosphate (cAMP) and Ca2+, and molecular expression of STR signaling pathway were m...
Source: International Journal of Endocrinology - November 28, 2019 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Corrigendum to "Wingless-Type MMTV Integration Site Family Member 5a Is a Key Secreted Islet Stellate Cell-Derived Product that Regulates Islet Function".
Corrigendum to "Wingless-Type MMTV Integration Site Family Member 5a Is a Key Secreted Islet Stellate Cell-Derived Product that Regulates Islet Function". Int J Endocrinol. 2019;2019:6762534 Authors: Xu W, Liang J, Geng HF, Lu J, Li R, Wang XL, Lv Q, Liu Y, Wang J, Liu XK, Jones PM, Sun Z Abstract [This corrects the article DOI: 10.1155/2019/7870109.]. PMID: 31772576 [PubMed - in process] (Source: International Journal of Endocrinology)
Source: International Journal of Endocrinology - November 28, 2019 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Treating Clinically Node-Negative Insular Thyroid Carcinoma without Prophylactic Central Compartment Neck Dissection Is Associated with Decreased Survival Regardless of T Staging and Administration of Radioactive Iodine Therapy: The First Evidence.
This study provides the first evidence that treating cN0 ITC without prophylactic CCND is associated with decreased survival regardless of T staging and administration of RAI therapy. Background. Regarding the rare but aggressive insular thyroid carcinoma (ITC), the value of prophylactic central compartment neck dissection (CCND) for clinically node-negative (cN0) disease is unclear. We aimed to provide the first evidence. Methods. N0 and pN1a ITC patients were identified from the Surveillance, Epidemiology, and End Results database. These patients were divided into thyroid-surgery + CCND group (pN0/pN1a pati...
Source: International Journal of Endocrinology - November 20, 2019 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

A Possible Mechanism of Metformin in Improving Insulin Resistance in Diabetic Rat Models.
Conclusion: Changes in CA synthesis after metformin treatment may be associated with inhibition of CYP8B1. These results may play an important role in improving insulin sensitivity after metformin treatment. PMID: 31737069 [PubMed] (Source: International Journal of Endocrinology)
Source: International Journal of Endocrinology - November 20, 2019 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Effects of Uric Acid on Diabetes Mellitus and Its Chronic Complications.
Authors: Xiong Q, Liu J, Xu Y Abstract With the deepening of the researches on uric acid, especially in the study of metabolic diseases, uric acid has been found to be closely related to obesity, metabolic syndrome, nonalcoholic fatty liver disease, diabetes, and other metabolic diseases. Uric acid causes a series of pathophysiological changes through inflammation, oxidative stress, vascular endothelial injury, and so on and thus subsequently promotes the occurrence and development of diseases. This review confirmed the positive correlation between uric acid and diabetes mellitus and its chronic complications throu...
Source: International Journal of Endocrinology - November 20, 2019 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Assessment of Iodine Status among Pregnant Women and Neonates Using Neonatal Thyrotropin (TSH) in Mainland China after the Introduction of New Revised Universal Salt Iodisation (USI) in 2012: A Re-Emergence of Iodine Deficiency?
In conclusion, our results indicated iodine deficiency in the region, according to the neonatal TSH cutoff recommended by WHO/UNICEF/IGD. More efforts are urgently required to improve iodine status of pregnant women in the region in order to prevent a re-emergence of iodine deficiency. PMID: 31687019 [PubMed] (Source: International Journal of Endocrinology)
Source: International Journal of Endocrinology - November 8, 2019 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Causes and Metabolic Consequences of Gynecomastia in Adult Patients.
Conclusion: The development of GM in adults might be an important symptom of an underlying gonadal disease. Moreover, it could be associated with an increased risk of metabolic disturbances. Our results support the need of detailed laboratory and hormonal investigations in patients with GM including targeted screening for metabolic disturbances. Further longitudinal studies are needed to evaluate the long-term consequences of sex hormones imbalance on cardiovascular morbidity and mortality in adults with GM. PMID: 31687020 [PubMed] (Source: International Journal of Endocrinology)
Source: International Journal of Endocrinology - November 8, 2019 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Co-Occurrence of Multiple Endocrine Abnormalities Induced by the DIHS/DRESS.
Conclusions: Patients require careful long-term follow-up after DIHS/DRESS. Involvement of endocrine glands, especially FT1DM, should always be monitored in patients with a history of DIHS/DRESS. This study indicated that DIHS/DRESS could lead to APS, especially APS III, providing novel insights into the etiological factors of APS. PMID: 31687021 [PubMed] (Source: International Journal of Endocrinology)
Source: International Journal of Endocrinology - November 8, 2019 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Low Frequency of MKRN3 and DLK1 Variants in Chinese Children with Central Precocious Puberty.
Conclusions: In this study, we report four novel MKRN3 variants in patients with ICPP. Moreover, we did not find any variants of DLK1 gene. Variants of MKRN3 are relatively uncommon in Chinese ICPP patients. PMID: 31687022 [PubMed] (Source: International Journal of Endocrinology)
Source: International Journal of Endocrinology - November 8, 2019 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Intraoperative Near-Infrared Autofluorescence and Indocyanine Green Imaging to Identify Parathyroid Glands: A Comparison.
Authors: Lerchenberger M, Al Arabi N, Gallwas JKS, Stepp H, Hallfeldt KKJ, Ladurner R Abstract Objective: To investigate the feasibility of near-infrared autofluorescence (AF) and indocyanine green (ICG) fluorescence to identify parathyroid glands intraoperatively. Methods: Fluorescence imaging was carried out during open parathyroid and thyroid surgery. After visual identification, parathyroid glands were exposed to near-infrared (NIR) light with a wavelength between 690 and 770 nm. The camera of the Storz® NIR/ICG endoscopic system used detects NIR light as a blue signal. Therefore, parathyroid AF ...
Source: International Journal of Endocrinology - November 1, 2019 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

miR-29a Negatively Affects Glucose-Stimulated Insulin Secretion and MIN6 Cell Proliferation via Cdc42/ β-Catenin Signaling.
miR-29a Negatively Affects Glucose-Stimulated Insulin Secretion and MIN6 Cell Proliferation via Cdc42/β-Catenin Signaling. Int J Endocrinol. 2019;2019:5219782 Authors: Duan J, Qian XL, Li J, Xiao XH, Lu XT, Lv LC, Huang QY, Ding W, Zhang HY, Xiong LX Abstract Background: Diabetes is a progressive metabolic disease characterized by hyperglycemia. Functional impairment of islet β cells can occur to varying degrees. This impairment can initially be compensated for by proliferation and metabolic changes of β cells. Cell division control protein 42 (Cdc42) and the microRNA (miRNA) miR-29 have...
Source: International Journal of Endocrinology - November 1, 2019 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Use of PEGylated Recombinant Human Growth Hormone in Chinese Children with Growth Hormone Deficiency: A 24-Month Follow-Up Study.
Conclusion: PEGylated rhGH replacement therapy is effective and safe in pediatric patients with GHD. The adherence to once-weekly PEGylated rhGH therapy is superior to daily rhGH in children with GHD. PMID: 31641350 [PubMed] (Source: International Journal of Endocrinology)
Source: International Journal of Endocrinology - October 25, 2019 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

RAGE is a Potential Cause of Onset and Progression of Nonalcoholic Fatty Liver Disease.
Conclusion: Soluble form of RAGE (sRAGE) has the capability to reduce inflammation by blocking the interaction of AGE with RAGE. However, sRAGE has some limitations, and the best method of usage is probably autotransplantation of transfected stem cells or monocytes, as a precursor of macrophages and Kupffer cells, with a virus that carries sRAGE to alleviate the harmful effects of AGE-RAGE signaling in the settings of fatty liver disease. PMID: 31641351 [PubMed] (Source: International Journal of Endocrinology)
Source: International Journal of Endocrinology - October 25, 2019 Category: Endocrinology Tags: Int J Endocrinol Source Type: research