Suppressing Effect of Free Triiodothyronine on the Negative Association between Body Mass Index and Serum Osteocalcin Levels in Euthyroid Population
Int J Endocrinol. 2021 Feb 5;2021:6624516. doi: 10.1155/2021/6624516. eCollection 2021.ABSTRACTPrevious studies found that thyroid hormones stimulate osteoblast-like cells to secrete osteocalcin. We aimed to investigate the association between serum thyroid hormone and serum osteocalcin in euthyroid population. The study recruited 1152 community-based euthyroid subjects (average age 59 ± 8 years), among whom 677 were women. Serum free triiodothyronine (FT3), free thyroxine (FT4), thyroid-stimulating hormone (TSH), and osteocalcin were measured by electrochemiluminescence immunoassays. After adjusting for age and gen...
Source: International Journal of Endocrinology - February 25, 2021 Category: Endocrinology Authors: Xiaomin Nie Yiting Xu Yun Shen Yufei Wang Xiaojing Ma Yuqian Bao Source Type: research

Clinical Utility of Preoperative Vitamin D3 Injection for Preventing Transient Hypocalcemia after Total Thyroidectomy
Int J Endocrinol. 2021 Feb 13;2021:6683089. doi: 10.1155/2021/6683089. eCollection 2021.ABSTRACTBACKGROUND: Postoperative transient hypocalcemia (TH) is a common complication of total thyroidectomy. This retrospective study evaluated the clinical utility of preoperative vitamin D3 injection for the prevention of TH after total thyroidectomy.METHODS: We included 2294 patients who underwent total thyroidectomy from January 2015 until October 2018 and retrospectively analyzed their data by complete chart review at our hospital. The patients were divided into two groups: vitamin D3 injection (VDI; n = 342) and vitamin D3 nonin...
Source: International Journal of Endocrinology - February 25, 2021 Category: Endocrinology Authors: Kwangsoon Kim Cho Rok Lee Sang-Wook Kang Jandee Lee Jong Ju Jeong Kee-Hyun Nam Woong Youn Chung Source Type: research

Suppressing Effect of Free Triiodothyronine on the Negative Association between Body Mass Index and Serum Osteocalcin Levels in Euthyroid Population
Int J Endocrinol. 2021 Feb 5;2021:6624516. doi: 10.1155/2021/6624516. eCollection 2021.ABSTRACTPrevious studies found that thyroid hormones stimulate osteoblast-like cells to secrete osteocalcin. We aimed to investigate the association between serum thyroid hormone and serum osteocalcin in euthyroid population. The study recruited 1152 community-based euthyroid subjects (average age 59 ± 8 years), among whom 677 were women. Serum free triiodothyronine (FT3), free thyroxine (FT4), thyroid-stimulating hormone (TSH), and osteocalcin were measured by electrochemiluminescence immunoassays. After adjusting for age and gen...
Source: International Journal of Endocrinology - February 25, 2021 Category: Endocrinology Authors: Xiaomin Nie Yiting Xu Yun Shen Yufei Wang Xiaojing Ma Yuqian Bao Source Type: research

Clinical Utility of Preoperative Vitamin D3 Injection for Preventing Transient Hypocalcemia after Total Thyroidectomy
Int J Endocrinol. 2021 Feb 13;2021:6683089. doi: 10.1155/2021/6683089. eCollection 2021.ABSTRACTBACKGROUND: Postoperative transient hypocalcemia (TH) is a common complication of total thyroidectomy. This retrospective study evaluated the clinical utility of preoperative vitamin D3 injection for the prevention of TH after total thyroidectomy.METHODS: We included 2294 patients who underwent total thyroidectomy from January 2015 until October 2018 and retrospectively analyzed their data by complete chart review at our hospital. The patients were divided into two groups: vitamin D3 injection (VDI; n = 342) and vitamin D3 nonin...
Source: International Journal of Endocrinology - February 25, 2021 Category: Endocrinology Authors: Kwangsoon Kim Cho Rok Lee Sang-Wook Kang Jandee Lee Jong Ju Jeong Kee-Hyun Nam Woong Youn Chung Source Type: research

Clinical Analysis of Cervical Lymph Node Metastasis Risk Factors and the Feasibility of Prophylactic Central Lymph Node Dissection in Papillary Thyroid Carcinoma.
Authors: Chen Y, Chen S, Lin X, Huang X, Yu X, Chen J Abstract Objective: To identify the risk factors for cervical lymph node metastasis (CLNM) and the feasibility of prophylactic central lymph node dissection. Methods: The characteristics of 1107 patients were extracted and analyzed. Univariate and multivariate analyses were used to identify risk factors associated with lymph node metastasis. The relationship between the central lymph node dissection (CLND) and lateral lymph node metastasis (LLNM) was analyzed using the correlation analysis. Results: The probability of CLNM was closely related to the male gender, age
Source: International Journal of Endocrinology - February 21, 2021 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

The Effect of Vitamin D Supplementation on Blood Lipids in Patients with Polycystic Ovary Syndrome: A Meta-Analysis of Randomized Controlled Trials.
Authors: Gao H, Li Y, Yan W, Gao F Abstract Purpose: Studies have found that vitamin D supplementation may improve blood lipids in patients with polycystic ovary syndrome, but the results are controversial, so this study will further analyze the effect of vitamin D supplementation on blood lipids in patients with polycystic ovary syndrome. Methods: PubMed, Embase, Cochrane Library, CNKI, and Wanfang databases were searched up to May 2020, to identify randomized controlled trials of the effect of vitamin D supplementation on blood lipids in patients with polycystic ovary syndrome. The Cochrane risk of bias tool ...
Source: International Journal of Endocrinology - February 21, 2021 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Evaluation of Different Anthropometric Indicators for Screening for Nonalcoholic Fatty Liver Disease in Elderly Individuals.
Conclusion: LAP is closely related to the occurrence of NAFLD and could be an efficient screening and treatment tool for NAFLD in the elderly people. Lay Summary. We conducted a screening and study of nonalcoholic fatty liver disease in the elderly population by determining the association between obesity indexes and nonalcoholic fatty liver disease. We found that LAP is practical, easy-to-measure tool for screening and studying NAFLD in the high-risk community elderly population, making it a valuable indicator in research. PMID: 33574841 [PubMed] (Source: International Journal of Endocrinology)
Source: International Journal of Endocrinology - February 14, 2021 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

TNRC6C Functions as a Tumor Suppressor and Is Frequently Downregulated in Papillary Thyroid Cancer.
In this study, we aimed to confirm the effect of TNRC6C on PTC and investigate the underlying molecular mechanism. The difference of mRNA level of TNRC6C between PTC tissue and noncancerous thyroid tissue and the association of expression level of TNRC6C with clinicopathological features of PTC were analyzed using TCGA data. Immunohistochemical assay was performed to detect the protein expression of TNRC6C in PTC and its adjacent noncancerous tissue. Cell proliferation, migration, invasion, and apoptosis were analyzed after knockdown or overexpression of TNRC6C in BCPAP cells. RNA-sequencing was performed to find the targe...
Source: International Journal of Endocrinology - February 11, 2021 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Identification of Three Significant Genes Associated with Immune Cells Infiltration in Dysfunctional Adipose Tissue-Induced Insulin-Resistance of Obese Patients via Comprehensive Bioinformatics Analysis.
Conclusions: This article revealed that CSF1R, C1QC, and TYROBP were potential hub genes associated with immune cells' infiltration and the function of proinflammation, especially adipose tissue macrophages, in the progression of obesity-induced diabetes or insulin-resistance. PMID: 33564304 [PubMed] (Source: International Journal of Endocrinology)
Source: International Journal of Endocrinology - February 11, 2021 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Serum Irisin Level Is Positively Associated with Bone Mineral Density in Patients on Maintenance Hemodialysis.
Authors: Lu CW, Wang CH, Lin YL, Kuo CH, Lai YH, Hsu BG, Tsai JP Abstract Background: Irisin is a circulating hormone-like myokine that plays an important role in bone metabolism. We performed a cross-sectional study to investigate whether serum irisin levels correlated with bone mineral density (BMD) in patients on maintenance hemodialysis (MHD). Methods: Blood samples were obtained from 80 patients on MHD, and serum irisin concentrations were determined using a commercially available enzyme-linked immunosorbent assay. BMD was measured by dual-energy X-ray absorptiometry of the L2-L4 vertebrae. Results: In...
Source: International Journal of Endocrinology - February 11, 2021 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

The Safety and Efficacy of the Repeated PRRT with [90Y]Y/[177Lu]Lu-DOTATATE in Patients with NET.
Conclusions: The repeated therapy with [90Y]Y/[177Lu]Lu-DOTATATE is safe and effective for patients with disseminated, inoperable G1 and G2 neuroendocrine tumours. PMID: 33552155 [PubMed] (Source: International Journal of Endocrinology)
Source: International Journal of Endocrinology - February 10, 2021 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Development of a New Equation for the Prediction of Resting Metabolic Rate in Sri Lankan Adults.
Authors: Fairoosa P, Lanerolle P, De Lanerolle-Dias M, Wickramasinghe VP, Waidyatilaka I Abstract Resting metabolic rate (RMR) is the key determinant of the energy requirement of an individual. Measurement of RMR by indirect calorimetry is not feasible in field settings and therefore equation-based calculations are used. Since a valid equation is not available for Sri Lankans, it is important to develop a new population-specific equation for field use. The study objective was to develop a new equation for the prediction of RMR in healthy Sri Lankans using a reference method, indirect calorimetry. RMR data were coll...
Source: International Journal of Endocrinology - February 7, 2021 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

The Association of Mean Plasma Glucose and In hospital Death Proportion: A Retrospective, Cohort Study of 162,169 In-Patient Data.
Authors: Chen P, Chen L, Zhao X, Sun Q Abstract Aims: To investigate the association between mean plasma glucose and inhospital death proportion. Methods: We retrospectively collected 162,169 inpatient data in Huashan Hospital from January 2012 to December 2015. Mean plasma glucose was calculated and considered as the average glycemia control during hospitalization. Patients were stratified into six groups according to mean plasma glucose. Nonlinear regression was performed to determine the associations between mean plasma glucose and inhospital death proportion, medical cost, and length of stay. Multivariate l...
Source: International Journal of Endocrinology - February 4, 2021 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Osteocalcin Alleviates Nonalcoholic Fatty Liver Disease in Mice through GPRC6A.
In conclusion, this study found that uncarboxylated osteocalcin alleviates NAFLD in mice through the GPRC6A signaling pathway. Our study suggests that liver GPRC6A may be a potential target for treating NAFLD. PMID: 33531899 [PubMed] (Source: International Journal of Endocrinology)
Source: International Journal of Endocrinology - February 4, 2021 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Proton Pump Inhibitors and Fractures in Adults: A Critical Appraisal and Review of the Literature.
Authors: Briganti SI, Naciu AM, Tabacco G, Cesareo R, Napoli N, Trimboli P, Castellana M, Manfrini S, Palermo A Abstract Despite the large number of patients worldwide being on proton pump inhibitors (PPIs) for acid-related gastrointestinal disorders, uncertainty remains over their long-term safety. Particularly, the potential side effects of these drugs on bone health have been evaluated in the last years. The purpose of our narrative review is to gather and discuss results of clinical studies focusing on the interactions between PPIs and fracture risk. Data generated mainly from nested case-control studies and me...
Source: International Journal of Endocrinology - January 31, 2021 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Genotype-Phenotype Correlation in Patients with Congenital Adrenal Hyperplasia due to 21-Hydroxylase Deficiency in Cuba.
Conclusions: The correlation between the detected molecular defect and the clinical expression of 21OHD was reasonable in the Cuban population, which could allow phenotypic predictions to be made from the genotype. PMID: 33505466 [PubMed] (Source: International Journal of Endocrinology)
Source: International Journal of Endocrinology - January 29, 2021 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Predictive Model of Type 2 Diabetes Remission after Metabolic Surgery in Chinese Patients.
Conclusion: Presurgery age, C-peptide AUC, and FPG are independent predictors of T2D remission after metabolic surgery. Among these, C-peptide AUC plays a decisive role in both short- and long-term remission prediction, and the optimal cutoff value for C-peptide AUC in predicting T2D remission was 30.93 ng/ml, with moderate predictive values. The ACF score is a simple reliable system that can predict T2D remission among Chinese patients. PMID: 33488705 [PubMed] (Source: International Journal of Endocrinology)
Source: International Journal of Endocrinology - January 27, 2021 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Liraglutide Promotes Osteoblastic Differentiation in MC3T3-E1 Cells by ERK5 Pathway.
Authors: Sun Y, Liang Y, Li Z, Xia N Abstract Liraglutide is a glucagon-like peptide-1 analogue widely used in the treatment of type 2 diabetes mellitus. However, the effects of liraglutide on osteoblast proliferation and differentiation in MC3T3-E1 cells have not been fully elucidated. In the present study, the promoting effects of liraglutide were investigated in MC3T3-E1 cells. The results indicated that cell viability was affected following the treatment of the cells with different concentrations of liraglutide (0, 10, 100, and 1000 nM) at different time periods of culture (24, 48, and 72 h). More...
Source: International Journal of Endocrinology - January 27, 2021 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Development and Validation of a Nomogram to Predict Type 2 Diabetes Mellitus in Overweight and Obese Adults: A Prospective Cohort Study from 82938 Adults in China.
Conclusions: The nomogram showed accurate prediction for T2DM among Chinese population with overweight and obese and might aid in assessment risk of T2DM. PMID: 33488707 [PubMed] (Source: International Journal of Endocrinology)
Source: International Journal of Endocrinology - January 27, 2021 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Classification of Thyroid Nodules with Stacked Denoising Sparse Autoencoder.
Conclusion: The classifier developed in this study has the superb discriminative ability for thyroid nodules. However, it needs validation in cytologically indeterminate thyroid nodules before clinical use. PMID: 33488708 [PubMed] (Source: International Journal of Endocrinology)
Source: International Journal of Endocrinology - January 27, 2021 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Retracted: Glycolipid Metabolism Disorder in the Liver of Obese Mice Is Improved by TUDCA via the Restoration of Defective Hepatic Autophagy.
Authors: Of Endocrinology IJ Abstract [This retracts the article DOI: 10.1155/2015/687938.]. PMID: 33424967 [PubMed] (Source: International Journal of Endocrinology)
Source: International Journal of Endocrinology - January 12, 2021 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Vitamin D Supplementation Ameliorates Metabolic Dysfunction in Patients with PCOS: A SystematicReview of RCTs and Insight into the Underlying Mechanism.
Authors: Guo S, Tal R, Jiang H, Yuan T, Liu Y Abstract Objective: Evidence suggests that vitamin D deficiency correlated with metabolic disorders in women with polycystic ovary syndrome (PCOS). We conducted this systematic review and meta-analysis to evaluate the impact of vitamin D supplementation alone on glucose, lipid, and androgen parameters and inflammation biomarkers in women with PCOS. Methods: Literature research was conducted in Pubmed, Embase, Web of Science, Clinical Trials, and Cochrane Library to identify relevant randomized controlled trials (RCTs) up to March 2020. The effect of vitamin D supple...
Source: International Journal of Endocrinology - January 12, 2021 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Study of Health-Related Quality of Life and Healthcare Utilization among Type 2 Diabetic Population in an Urban Area of Eastern Nepal.
Conclusion: People with diabetes in this study were more affected in the domain anxiety and worry. The frequency of healthcare access and utilization in patients with type 2 diabetes was high. The quality of life among them could be improved by taking care on healthy behavior, comorbid conditions, and complications. PMID: 33424969 [PubMed] (Source: International Journal of Endocrinology)
Source: International Journal of Endocrinology - January 12, 2021 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Neuromuscular Blockade Correlates with Hormones and Body Composition in Acromegaly.
Authors: Zhang Y, Guo X, Tan G, Zhao M, Huang Y, Chen W, Shi X, Pei L, Xing B Abstract Tumor resection is the first-line therapy for acromegaly patients. In some cases, unsatisfactory intraoperative neuromuscular blockades (NMBs) lead to failed operations. The purpose of this study was to investigate and quantify the NMB status of acromegaly patients and explore the relationship between NMB status and hormone levels and body composition. Twenty patients with untreated acromegaly and seventeen patients with nonfunctioning pituitary adenomas as controls were enrolled in this study. NMB was assessed using the train-of...
Source: International Journal of Endocrinology - January 9, 2021 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Serum Levels of Asprosin, a Novel Adipokine, Are Significantly Lowered in Patients with Acromegaly.
Authors: Ke X, Duan L, Gong F, Zhang Y, Deng K, Yao Y, Wang L, Pan H, Zhu H Abstract Background: Asprosin is a novel identified adipokine secreted mainly by white adipose tissue, which is elevated in metabolic diseases such as diabetes and obesity. Acromegaly is a syndrome caused by pituitary growth hormone (GH) cell adenoma with excessive GH secretion. Serum adipocytokines levels may be involved in abnormal glycolipid metabolism in acromegaly patients. Objectives: To investigate serum asprosin levels in acromegaly patients and its correlation with high GH levels and glucolipid metabolic parameters. Methods...
Source: International Journal of Endocrinology - January 9, 2021 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

The Correlation between Time in Range and Diabetic Microvascular Complications Utilizing Information Management Platform.
Authors: Sheng X, Xiong GH, Yu PF, Liu JP Abstract Background: In recent years, the time of blood glucose within the target range is a new research hotspot in blood glucose management. TIR is expected to be a novel indicator for evaluating the efficacy of glycemic control and predicting diabetic complications. However, its relationship with diabetic complications has not been fully elucidated. Objective: To explore the relationship between time in range (TIR) and glycosylated hemoglobin (HbA1C) through the information big data management platform. Possible association between TIR and diabetic microvascular comp...
Source: International Journal of Endocrinology - January 2, 2021 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

The Association of Obesity with Autoimmune Thyroiditis and Thyroid Function-Possible Mechanisms of Bilateral Interaction.
Authors: Baranowska-Bik A, Bik W Abstract A growing number of patients suffer from autoimmune diseases, including autoimmune thyroid disease. There has simultaneously been a significant increase in the prevalence of obesity worldwide. It is still an open question whether adiposity can directly influence activation of inflammatory processes affecting the thyroid in genetically predisposed individuals. Adipokines, biologically active substances derived from the adipocytes, belong to a heterogenic group of compounds involved in numerous physiological functions, including the maintenance of metabolism, hormonal balance...
Source: International Journal of Endocrinology - January 2, 2021 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Gengnianchun Recipe Protects Ovarian Reserve of Rats Treated by 4-Vinylcyclohexene Diepoxide via the AKT Pathway.
Authors: Zhao F, Wang W Abstract Diminished ovarian reserve (DOR) refers to a decrease in the number and quality of oocytes. Western treatment of DOR does not improve the ovarian reserve fundamentally, and the effect is limited. Gengnianchun recipe (GNC) is a traditional Chinese medicine formula originally applied to treat menopausal syndrome but is also found to be effective in treating clinical DOR patients. Here we aim to examine the effect of GNC in a DOR rat model induced by 4-vinylcyclohexene diepoxide (VCD), a chemical that selectively destroys ovarian small preantral follicles, and further investigate the p...
Source: International Journal of Endocrinology - January 2, 2021 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

TIR-Domain-Containing Adaptor-Inducing Interferon- β (TRIF) Is Involved in Glucose Metabolism in Adipose Tissue through the Insulin/AKT Signaling Pathway.
In this study, we have determined the effects of genetic deficiency of toll/interleukin-1 receptor-domain-containing adaptor-inducing interferon-β (TRIF) on food intake, bodyweight, glucose metabolism, adipose tissue macrophage polarization, and insulin signaling in normal chow diet-fed mice to investigate the role of the TRIF-dependent TLR signaling in adipose tissue metabolism and inflammation. TRIF deficiency (TRIF-/-) increased food intake and bodyweight. The significant increase in bodyweight in TRIF-/- mice was discernible as early as 24 weeks of age and sustained thereafter. TRIF-/- mice showed impaired glucose...
Source: International Journal of Endocrinology - January 1, 2021 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Visceral Adiposity Index in Breast Cancer Survivors: A Case-Control Study.
Authors: Cardoso-Peña E, Soto Pina AE, Villanueva ÁG, López Chavez GE, Ramírez Martínez P, Ramírez Montoya H, Berumen Lechuga MG, Benitez Arciniega AD, Alarcón Fortepiani ML, Valdés Ramos R, Garduño García JJ Abstract Background: Breast cancer (BC) is the first cause of cancer morbidity and mortality in women. This disease has been linked to obesity; however, it is not clear how fat accumulation affects women who survive breast cancer. Although the visceral adiposity index (VAI) is a marker of cardiometabolic risk and adipose tissue dysfunction, ...
Source: International Journal of Endocrinology - January 1, 2021 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

The Search of miRNA Related to Invasive Growth of Nonfunctioning Gonadotropic Pituitary Tumors.
Conclusion: Differences in miRNAs expression profiles in invasive and noninvasive gonadotropic PitNETs are slight and the level of miRNA expression seems not to be applicable as useful classifier of tumor invasiveness. PMID: 33354213 [PubMed] (Source: International Journal of Endocrinology)
Source: International Journal of Endocrinology - December 29, 2020 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Clinical Characteristics and Spermatogenesis in Patients with Congenital Hypogonadotropic Hypogonadism Caused by FGFR1 Mutations.
Conclusion: Patients with FGFR1 mutations have a higher prevalence of cryptorchidism and smaller testicular volume. Although patients with FGFR1 mutations have a similar rate of success for spermatogenesis compared to that of the mutation-negative patients, a longer treatment period was required and a lower sperm concentration was achieved. PMID: 33354214 [PubMed] (Source: International Journal of Endocrinology)
Source: International Journal of Endocrinology - December 29, 2020 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

The ANGPTL8 rs2278426 (C/T) Polymorphism Is Associated with Prediabetes and Type 2 Diabetes in a Han Chinese Population in Hebei Province.
Conclusion: ANGPTL8 rs2278426 may be involved in the mechanism of insulin secretion and could lead to an increased risk of pre-DM and T2DM. PMID: 33343659 [PubMed] (Source: International Journal of Endocrinology)
Source: International Journal of Endocrinology - December 23, 2020 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Characterization of Mineral and Bone Metabolism Biomarkers in a Chinese Consanguineous Twin Family with Primary Hypertrophic Osteoarthropathy.
Conclusion: The patients with PHO displayed an active state of bone reconstruction. There may be a lack of vitamin D, accompanied by an increase in BGP and β-CTX levels. Heterozygous mutations of SLCO2A1 might lead to mild PHO. PMID: 33343660 [PubMed] (Source: International Journal of Endocrinology)
Source: International Journal of Endocrinology - December 23, 2020 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

A Significant Association of Upper Limb Muscle Strength with Thyroid Function in Overweight and Obese Population: A Study of the Sixth Korea National Health and Nutrition Examination Survey (KNHANES 2014-2015).
Authors: Lee J, Jo K, Ha J, Lim DJ, Lee JM, Chang SA, Kang MI, Kim MH Abstract Background. As skeletal muscle is one of main targets of thyroid hormone signalling, an association of thyroid function and muscle strength could be expected. The aim of study is to evaluate the association of free thyroxine (FT4) and thyrotropin (TSH) with upper limb muscle strength, measured by hand grip strength, in subjects with normal FT4 from national representative data. The study utilized the sixth edition of the Korea National Health and Nutrition Examination Survey. After exclusion of subjects with FT4 level out of normal range...
Source: International Journal of Endocrinology - December 23, 2020 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Analysis of the Relationships between Multiple Endocrine Hormones and Return of Spontaneous Circulation (ROSC) in Cardiac Arrest Patients: Possible Association of the Serum Free T4 Level with ROSC.
Conclusions: The present findings suggest a possible relationship between the serum F-T4 level and ROSC in OHCA patients. A higher serum F-T4 level might cause an increase in the β-adrenergic response in cardiomyocytes and increased responsiveness to catecholamines and was possibly associated with ROSC. PMID: 33312195 [PubMed] (Source: International Journal of Endocrinology)
Source: International Journal of Endocrinology - December 16, 2020 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Real-World Data for Lenvatinib in Radioiodine-Refractory Differentiated Thyroid Cancer (RELEVANT): A Retrospective Multicentric Analysis of Clinical Practice in Austria.
Conclusion: Lenvatinib showed sustained clinical efficacy in patients with metastatic RAI-refractory TC even with reduced maintenance dosages over years. The effects were comparable to the registration trial, although patients had a higher median age and, more commonly, dose reductions. PMID: 33312196 [PubMed] (Source: International Journal of Endocrinology)
Source: International Journal of Endocrinology - December 16, 2020 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

DPP4 Activities Are Associated with Osteopenia/Osteoporosis and Fracture Risk in Newly Diagnosed Type 2 Diabetes.
Conclusions: Elevated plasma DPP4 activity tended to be associated with a higher proportion of osteoporosis/osteopenia and increased the fracture risk in newly diagnosed type 2 diabetes. PMID: 33312197 [PubMed] (Source: International Journal of Endocrinology)
Source: International Journal of Endocrinology - December 16, 2020 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Reference Intervals of Total Testosterone in Adult Filipino Men.
Conclusion: The present study derived reference ranges of total testosterone using data from apparently healthy, young adult men to support clinical services. PMID: 33312198 [PubMed] (Source: International Journal of Endocrinology)
Source: International Journal of Endocrinology - December 16, 2020 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Metabolic Perturbations and Severe COVID-19 Disease: Implication of Molecular Pathways.
Authors: Nigro E, Perrotta F, Polito R, D'Agnano V, Scialò F, Bianco A, Daniele A Abstract Coronavirus disease (COVID-19) is caused by SARS-CoV-2 virus, which can result in serious respiratory illnesses such as pneumonia leading to respiratory failure. It was first reported in Wuhan, Hubei, China, in December 2019 and rapidly spread globally, becoming a pandemic in March 2020. Among comorbidities observed in SARS-CoV-2 positive patients, hypertension (68.3%) and type 2-diabetes (30.1%) are the most frequent conditions. Although symptoms are highly heterogeneous (ranging from absence of symptoms to severe acu...
Source: International Journal of Endocrinology - December 16, 2020 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Would Cortisol Measurements Be a Better Gauge of Hydrocortisone Replacement Therapy? Congenital Adrenal Hyperplasia as an Exemplar.
Authors: Hindmarsh PC, Honour JW Abstract There is an increase in mortality and morbidity as well as poor quality of life in patients with congenital adrenal hyperplasia (CAH) and other causes of adrenal insufficiency. Glucocorticoid replacement therapy should aim to replace the missing cortisol as close as possible to the normal circadian rhythm using hydrocortisone. Dosing should be based on the individual's absorption and clearance of the drug. Adequacy of dosing should be checked using 24-hour profiles of plasma cortisol with samples drawn preferably every hour or at least every 2 hours. Measurement of cortisol...
Source: International Journal of Endocrinology - December 12, 2020 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Postoperative Nomogram for Predicting Cancer-Specific and Overall Survival among Patients with Medullary Thyroid Cancer.
Authors: Chen L, Wang Y, Zhao K, Wang Y, He X Abstract Background: Medullary thyroid carcinoma (MTC) accounts for 1%-2% of thyroid cancer in the United States based on the latest Surveillance, Epidemiology, and End Results (SEER) data, and this study aimed to construct a comprehensive predictive nomogram based on various clinical variables in MTC patients who underwent total thyroidectomy and neck lymph nodes dissection. Methods: Data regarding 1,237 MTC patients who underwent total thyroidectomy and neck lymph nodes dissection from 2004 to 2015 were obtained from the SEER database. Univariate and multivariate ...
Source: International Journal of Endocrinology - December 12, 2020 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Prevalence of Diabetes, Prediabetes, and Associated Factors in an Adult Chinese Population: Baseline of a Prediabetes Cohort Study.
Conclusion: The prevalence of DM and PDM is relatively high in this wealthy East China village population. Many modifiable risk factors exist for DM and PDM, which will be closely monitored during our longitudinal observation. PMID: 33299413 [PubMed] (Source: International Journal of Endocrinology)
Source: International Journal of Endocrinology - December 12, 2020 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Corrigendum to "Indicators of Quality of Clinical Care for Type 2 Diabetes Patients in Primary Health Care Centers in Qatar: A Retrospective Analysis".
Corrigendum to "Indicators of Quality of Clinical Care for Type 2 Diabetes Patients in Primary Health Care Centers in Qatar: A Retrospective Analysis". Int J Endocrinol. 2020;2020:2901538 Authors: Attal S, Mahmoud MH, Aseel MT, Candra A, Amuna P, Elnagmy M, Abdallah M, Ismail N, Hanfy A, Albaw D, Albashir A, Elmahdi H Abstract [This corrects the article DOI: 10.1155/2019/3519093.]. PMID: 33293953 [PubMed] (Source: International Journal of Endocrinology)
Source: International Journal of Endocrinology - December 10, 2020 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Serum Kisspeptin and AMH Levels Are Good References for Precocious Puberty Progression.
Conclusions: Kisspeptin and AMH have a unique significance in the auxiliary diagnosis, the differential diagnosis, the treatment, and prognosis of sexual puberty disorder. PMID: 33293954 [PubMed] (Source: International Journal of Endocrinology)
Source: International Journal of Endocrinology - December 10, 2020 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Recovery of Prenatal Baicalein Exposure Perturbed Reproduction by Postnatal Exposure of Testosterone in Male Mice.
Authors: Vaadala S, Ponneri N, Karanam VS, Sainath SB, Reddy PS, Pamuru RR, Mohammed A Abstract Baicalein (BC), a flavonoid, which lacks the qualities of reproductive health and shows adverse effects, is tested in this study. Inseminated mice were injected with 30, 60, and 90 mg BC/Kg body weight on gestation days 11, 13, 15, and 17. The F1 BC-exposed males of each dosage were divided into six groups. First three groups (n = 6 from each BC dosage) were used for assessment of reproductive performance, the others (n = 4 from each BC dosage) were administered with testosterone 4.16&t...
Source: International Journal of Endocrinology - December 10, 2020 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Follicle-Stimulating Hormone Positively Associates with Metabolic Factors in Perimenopausal Women.
Conclusions: The risk of Mets increased in perimenopausal females than in premenopausal women. And a higher FSH level was associated with higher WC, TG, BPs, and the risk of Mets in perimenopausal women. Elevated FSH level appears to be a risk factor of MetS biomarkers in perimenopausal women. PMID: 33273916 [PubMed] (Source: International Journal of Endocrinology)
Source: International Journal of Endocrinology - December 6, 2020 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

The Impact of Preconception TSH on the Reproductive Outcomes of Infertile Women Undergoing the First Fresh D3 Embryo Transfer Cycle.
Conclusion: High-normal TSH levels did not significantly influence reproductive outcomes in infertile women undergoing the first fresh D3 embryo transfer. Further studies are needed to test whether the results might be applicable to a wider population. PMID: 33273917 [PubMed] (Source: International Journal of Endocrinology)
Source: International Journal of Endocrinology - December 6, 2020 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Androgen Effects on the Adrenergic System of the Vascular, Airway, and Cardiac Myocytes and Their Relevance in Pathological Processes.
Conclusions: Androgens play an essential role in the adrenergic system of vascular, airway, and cardiac myocytes, favoring either a state of health or disease. While the use of androgens as a therapeutic tool for treating asthma symptoms or heart disease is proposed, the vascular system is warmly affected. PMID: 33273918 [PubMed] (Source: International Journal of Endocrinology)
Source: International Journal of Endocrinology - December 6, 2020 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

The Composition of Gut Microbiota in Patients Bearing Hashimoto's Thyroiditis with Euthyroidism and Hypothyroidism.
Conclusion: In summary, our study demonstrated the altered composition of gut microbiota in HT patients with different thyroid function status. Moreover, Phascolarctobacterium may be involved in the development of HT. PMID: 33224194 [PubMed] (Source: International Journal of Endocrinology)
Source: International Journal of Endocrinology - November 25, 2020 Category: Endocrinology Tags: Int J Endocrinol Source Type: research