Pentraxin 3 Levels in Young Women with and without Polycystic Ovary Syndrome (PCOS) in relation to the Nutritional Status and Systemic Inflammation.
Authors: Wyskida K, Franik G, Choręza P, Pohl N, Markuszewski L, Owczarek A, Madej P, Chudek J, Olszanecka-Glinianowicz M Abstract Objective: The aim of the study was to assess PTX3 levels in PCOS and non-PCOS women in relation to nutritional status and circulating markers of inflammation. Methods: The study enrolled 99 stable body mass PCOS women (17 normal weight, 21 overweight, and 61 obese) and 61 non-PCOS women (24 normal weight, 19 overweight, and 18 obese). Body composition was assessed by bioimpedance, and plasma levels of pentraxin 3 (PTX3), tumor necrosis factor-α (TNF-α), interleukin-6 (...
Source: International Journal of Endocrinology - September 17, 2020 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

High-Normal Preconception TSH Levels Have No Adverse Effects on Reproductive Outcomes in Infertile Women Undergoing the First Single Fresh D5 Blastocyst Transfer.
Conclusion: High-normal TSH levels did not significantly influence reproductive outcomes in infertile women undergoing the first single fresh D5 blastocyst transfer. Further studies are needed to test whether the results might be applicable to a wider population. PMID: 32908501 [PubMed] (Source: International Journal of Endocrinology)
Source: International Journal of Endocrinology - September 13, 2020 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

The Effect of Iodine Status on the Risk of Thyroid Nodules: A Cross-Sectional Study in Zhejiang, China.
Authors: Lou X, Wang X, Wang Z, Mao G, Zhu W, Wang Y, Pan X, Chen Z, Mo Z Abstract Objective: The aim of this study was to explore whether iodine nutrition is associated with the risk of thyroid nodules among adult population in Zhejiang Province, China. Methods: A cross-sectional study was conducted in the general population aged 18 years or older. A total of 2,710 subjects received physical examination, questionnaires, and thyroid ultrasonography. Urinary iodine concentration (UIC) and thyroid hormone levels were measured and documented for each subject. 4 multiple logistic regression models adjusted f...
Source: International Journal of Endocrinology - September 13, 2020 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Risk Factors Related to New-Onset Diabetes after Renal Transplantation in Patients of a High Complexity University Hospital in Colombia, 20 Years of Experience.
Conclusion: We ratify some risk factors for the development of this important disease, which include certain modifiable characteristics. Interventions aimed at changes in lifestyle could be established in a timely manner before transplant surgery. PMID: 32908503 [PubMed] (Source: International Journal of Endocrinology)
Source: International Journal of Endocrinology - September 13, 2020 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

A Novel Homozygous Mutation of Thyroid Peroxidase Gene Abolishes a Disulfide Bond Leading to Congenital Hypothyroidism.
In conclusion, this single disulfide bond loss mutation of a new TPO homozygous mutation, p.Cys655Phe, reduced TPO activity and caused congenital hypothyroidism without affecting subcellular localization of TPO proteins. PMID: 32908504 [PubMed] (Source: International Journal of Endocrinology)
Source: International Journal of Endocrinology - September 13, 2020 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Role and Significance of Circulating Biomarkers: miRNA and E2F1 mRNA Expression and Their Association with Type-2 Diabetic Complications.
Authors: Ali Beg MM, Verma AK, Saleem M, Saud Alreshidi F, Alenazi F, Ahmad H, Joshi PC Abstract Background: Type 2 diabetes mellitus (T2DM) has emerged as an epidemic affecting more than four hundred million people throughout the world. It is a multifactorial disease with range of environmental and genetic factors responsible for its prevalence. In search of novel biomarkers for recording progress of various metabolic diseases, small noncoding RNA in general and microRNAs (miRNAs) in particular have emerged as the most promising biomarkers for diagnosing variety of diseases including diabetes. An increasing number...
Source: International Journal of Endocrinology - September 6, 2020 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Peripheral Spexin Inhibited Food Intake in Mice.
This study indicated that acute peripheral injection of spexin inhibited mouse food intake. The anorectic effect may be mediated by GALR3, and inhibiting neuropeptide Y (NPY) via p-CaMK2 and c-Fos in the hypothalamus. PMID: 32831833 [PubMed - as supplied by publisher] (Source: International Journal of Endocrinology)
Source: International Journal of Endocrinology - August 25, 2020 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Quality of Life in Patients with Acromegaly before and after Transsphenoidal Surgical Resection.
Authors: Gu J, Xiang S, He M, Wang M, Gu Y, Li L, Yin Z Abstract Objective: We aimed to determine the perioperative changes in the quality of life (QoL) in patients with acromegaly and to reveal the relationship between biochemical indicators and quality of life change after tumor resection. Methods: Patients with acromegaly were enrolled from a tertiary pituitary center. SF-36 scale and AcroQoL scale were used to determine the QoL before and after surgery. We analyzed changes in QoL using a generalized linear model for repeated measurements. We compared the changes in QoL among three groups (remission, active,...
Source: International Journal of Endocrinology - August 25, 2020 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Eugenol Improves Insulin Secretion and Content of Pancreatic Islets from Male Mouse.
Authors: Oroojan AA Abstract Glucose homeostasis is required for control of insulin secretion. Phenolic compounds improved glucose-stimulated insulin secretion (GSIS). Eugenol is a phenolic compound that may increase GSIS. So, it was decided to investigate the effect of eugenol on the insulin secretion and content of pancreatic islets from the male mice. In this experimental study, 3-month-old NMRI mice (20-25 g) were prepared. The pancreatic islets of Langerhans were isolated using the collagenase digestion method and divided into 12 groups: glucose 2.8, 5.6, and 16.7 mM, glucose 2.8 mM&thinsp...
Source: International Journal of Endocrinology - August 25, 2020 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Relationship between Serum Indirect Bilirubin Level and Insulin Sensitivity: Results from Two Independent Cohorts of Obese Patients with Impaired Glucose Regulation and Type 2 Diabetes Mellitus in China.
Conclusions: The relationships between different types of bilirubin and insulin sensitivity varied. Serum indirect bilirubin might be a protective factor that enhances insulin sensitivity. PMID: 32802055 [PubMed - as supplied by publisher] (Source: International Journal of Endocrinology)
Source: International Journal of Endocrinology - August 18, 2020 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Parathyroid Hormone Reduction Predicts Transient Hypocalcemia after Total Thyroidectomy: A Single-Center Prospective Study.
Authors: Mo K, Shang J, Wang K, Gu J, Wang P, Nie X, Wang W Abstract Objective: We performed this study to investigate the risk factors for postoperative hypocalcemia after total thyroidectomy with central lymph node dissection (CLND). Study Design. This was a single-center prospective study based on 176 consecutive patients who underwent total thyroidectomy for papillary thyroid carcinoma. Setting. Patients were recruited between January 2016 and June 2018. Subjects and Methods. Patients who underwent bilateral (n = 155, bilateral group) and ipsilateral CLND (n = 21) after total thyroid...
Source: International Journal of Endocrinology - August 18, 2020 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Hyperoside Alleviates High Glucose-Induced Proliferation of Mesangial Cells through the Inhibition of the ERK/CREB/miRNA-34a Signaling Pathway.
Conclusion: Our cumulative results suggested that hyperoside inhibits the proliferation of SV40-MES13 cells through the suppression of the ERK/CREB/miRNA-34a signaling pathway, which provides new insight to the current investigation on therapeutic strategies for diabetic nephropathy. PMID: 32774360 [PubMed] (Source: International Journal of Endocrinology)
Source: International Journal of Endocrinology - August 14, 2020 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Quantitative Analysis of the Proteome and the Succinylome in the Thyroid Tissue of High-Fat Diet-Induced Hypothyroxinemia in Rats.
Authors: Hu B, Zhao M, Luo D, Yu C, Shao S, Zhao L, Yang Y, Zhang X, Zhao J, Gao L Abstract Hypothyroidism is a common disease, and its molecular mechanism still needs further investigation. Lysine succinylation is found to be involved in various metabolic processes associated with hypothyroidism. We performed quantitative analysis on lysine succinylome in thyroids of rats with hypothyroxinemia, which was induced through the administration of a high-fat diet. Overall, 129 differentially expressed proteins were quantified. Downregulated proteins were enriched in the thyroid hormone synthesis and thyroid hormone sign...
Source: International Journal of Endocrinology - August 14, 2020 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Effect of Preoperative Vitamin D Deficiency on Hypocalcemia in Patients with Acute Hypoparathyroidism after Thyroidectomy.
Authors: Vibhatavata P, Pisarnturakit P, Boonsripitayanon M, Pithuksurachai P, Plengvidhya N, Sirinvaravong S Abstract Postoperative hypoparathyroidism is a common complication of total or completion thyroidectomy. The association between preoperative vitamin D deficiency (VDD) and the development of more severe postoperative hypocalcemia is still unclear. Objectives. To evaluate the effect of preoperative VDD on severity of hypocalcemia in patients with hypoparathyroidism following thyroidectomy. Methods. Patients who developed acute hypoparathyroidism after total or completion thyroidectomy, defined as postoperat...
Source: International Journal of Endocrinology - August 14, 2020 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Function of Dicer with regard to Energy Homeostasis Regulation, Structural Modification, and Cellular Distribution.
Authors: Tong X, Yu N, Han R, Wang T Abstract As a type III ribonuclease (RNase III) specifically cleaving double-stranded RNA substrates into short fragments, Dicer is indispensable in a range of physi/pathologic processes, e.g., nutrient deprivation, hypoxia, or DNA damage. Therefore, much interest has been paid to the research of this protein as well as its products like microRNAs (miRNAs). The close relationship between Dicer levels and fluctuations of nutrient availability suggests that the protein participates in the regulation of systemic energy homeostasis. Through miRNAs, Dicer regulates the hypothalamic m...
Source: International Journal of Endocrinology - August 14, 2020 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Advantages of Phosphodiesterase Type 5 Inhibitors in the Management of Glucose Metabolism Disorders: A Clinical and Translational Issue.
Authors: Antinozzi C, Sgrò P, Di Luigi L Abstract Among metabolic diseases, carbohydrate metabolism disorders are the most widespread. The most common glucose pathological conditions are acquired and may increase the risk of type 2 diabetes, obesity, heart diseases, stroke, and kidney insufficiency. Phosphodiesterase type 5 inhibitors (PDE5i) have long been used as an effective therapeutic option for the treatment of erectile dysfunction (ED). Different studies have demonstrated that PDE5i, by sensitizing insulin target tissues to insulin, play an important role in controlling the action of insulin and gluco...
Source: International Journal of Endocrinology - August 14, 2020 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Clinical Efficacy Evaluation of Sirolimus in Congenital Hyperinsulinism.
Conclusion: This study suggested that sirolimus therapy needs further evaluation to determine which patients will benefit the most. The genetic basis of CHI may have possible implications for determining the patient's response. PMID: 32774365 [PubMed] (Source: International Journal of Endocrinology)
Source: International Journal of Endocrinology - August 14, 2020 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Epigenetic Modifications due to Environment, Ageing, Nutrition, and Endocrine Disrupting Chemicals and Their Effects on the Endocrine System.
Authors: Plunk EC, Richards SM Abstract The epigenome of an individual can be altered by endogenous hormones, environment, age, diet, and exposure to endocrine disrupting chemicals (EDCs), and the effects of these modifications can be seen across generations. Epigenetic modifications to the genome can alter the phenotype of the individual without altering the DNA sequence itself. Epigenetic modifications include DNA methylation, histone modification, and aberrant microRNA (miRNA) expression; they begin during germ cell development and embryogenesis and continue until death. Hormone modulation occurs during the agei...
Source: International Journal of Endocrinology - August 14, 2020 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Clinical Characteristics and Prevalence of Comorbidities according to Metformin Use in Korean Patients with Type 2 Diabetes.
Conclusions: There were significant differences with respect to clinical characteristics and comorbidity prevalence according to metformin use among Korean type 2 diabetes patients. Long-term follow-up of these patients is necessary to observe how this difference will affect clinical outcomes for these patients. PMID: 32774367 [PubMed] (Source: International Journal of Endocrinology)
Source: International Journal of Endocrinology - August 14, 2020 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Mitochondrial DNA: A New Predictor of Diabetic Kidney Disease.
Authors: Huang Y, Chi J, Wei F, Zhou Y, Cao Y, Wang Y Abstract Diabetic kidney disease (DKD) is a common cause of end-stage renal disease, and diagnosis and treatment in time can help delay its progress. At present, there are more and more studies on the pathogenesis of DKD; mitochondrial dysfunction plays an important role in DKD. The occurrence and development of DKD is closely related to epigenetic changes and the interaction between mtDNA, ROS, inflammatory factors, and endothelial damage, which continuously aggravates kidney. The change of mtDNA is both the cause of DKD and the result of DKD. It is of great si...
Source: International Journal of Endocrinology - August 1, 2020 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

NBPF9 Gene May Be Involved in Congenital Hypopituitarism: A Whole-Genome Study of a Boy with Pituitary Stalk Interruption Syndrome and His Family.
Authors: Wang CZ, Guo LL, Guo QH, Mu YM Abstract Pituitary stalk interruption syndrome (PSIS) is a rare congenital defect manifesting as various degrees of anterior pituitary hormone deficiency. Scattered familial cases have been found, revealing some genetic variants. However, most of the previous research studies involved an affected sibling, and the gene spectra of the patients' entire family have rarely been reported. We conducted a study of a family consisting of a PSIS patient with his unaffected sibling and healthy parents of Han Chinese background using whole-genome sequencing. Bioinformatic analysis was ca...
Source: International Journal of Endocrinology - August 1, 2020 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Corrigendum to "Angiogenesis in Pituitary Adenomas: Human Studies and New Mutant Mouse Models".
Corrigendum to "Angiogenesis in Pituitary Adenomas: Human Studies and New Mutant Mouse Models". Int J Endocrinol. 2020;2020:8978014 Authors: Cristina C, Luque GM, Demarchi G, Vicchi FL, Zubeldia-Brenner L, Perez Millan MI, Perrone S, Ornstein AM, Lacau-Mengido IM, Berner SI, Becu-Villalobos D Abstract [This corrects the article DOI: 10.1155/2014/608497.]. PMID: 32733555 [PubMed - in process] (Source: International Journal of Endocrinology)
Source: International Journal of Endocrinology - August 1, 2020 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Stress Hyperglycaemia Indicates Embolus Size and Localization in Patients with Acute Pulmonary Embolism.
Authors: Altabas V, Pukec L, Mlinarić S, Pintarić H, Šikić A Abstract Objective: Acute pulmonary embolism is a life-threatening form of venous thromboembolism often causing stress hyperglycaemia. The aim of this study was to determine the prognostic value of stress hyperglycaemia in acute pulmonary embolism, providing new insights into the presumed embolus size and localization, clinical parameters (Pulmonary Embolism Severity Index, PESI), and in-hospital mortality. Design and Methods. Among a total of 95,454 patients referred to the Emergency Department of the Sestre Milosrdnice University Hospital Cent...
Source: International Journal of Endocrinology - July 31, 2020 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Heightened ACE Activity and Unfavorable Consequences in COVID-19 Diabetic Subjects.
Authors: Sandooja R, Vura NVRK, Morocco M Abstract Coronavirus disease-19 (COVID-19) can manifest as fever, cough, and shortness of breath and is caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Occasionally, these patients may present with diabetic ketoacidosis (DKA). Patients with comorbidities such as diabetes mellitus and hypertension, as well as older age groups, are known to have a more severe disease progression and poor prognosis. In this review article, we attempt to better understand the disease process in diabetics and also discuss potential mechanisms by which diabetes may play a ...
Source: International Journal of Endocrinology - July 31, 2020 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Clinical Associations of Thyroid Hormone Levels with the Risk of Atherosclerosis in Euthyroid Type 2 Diabetic Patients in Central China.
Conclusion: T2D patients with low but clinically normal FT3 level are more likely to develop macrovascular complications comparing with those with mid- and high-normal FT3 level. PMID: 32714391 [PubMed] (Source: International Journal of Endocrinology)
Source: International Journal of Endocrinology - July 29, 2020 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

p.Gln318X and p.Val281Leu as the Major Variants of CYP21A2 Gene in Children with Idiopathic Premature Pubarche.
In conclusion, CYP21A2 variant detection has implications in the genetic diagnosis of PP phenotype. The genetic characterization of the CYP21A2 gene is important for characterizing the variable phenotype of carriers and genetic counseling of PP and NC-CAH patients. PMID: 32714392 [PubMed] (Source: International Journal of Endocrinology)
Source: International Journal of Endocrinology - July 29, 2020 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Haptoglobin Phenotypes Are Associated with the Postload Glucose and Insulin Levels in Pediatric Obesity.
Conclusion: To our knowledge, this is the first study on Hp phenotypes conducted in a pediatric population with obesity. We showed that the presence of Hp2 allele is associated with a worse response of glucose load in terms of both glucose and insulin levels. Thus, the Hp2-2 phenotype could predispose in pediatrics, at the same degree of obesity, to a worse glycemic and insulinemic compensation. PMID: 32695161 [PubMed] (Source: International Journal of Endocrinology)
Source: International Journal of Endocrinology - July 24, 2020 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

The Effect of Inflammation on the Formation of Thyroid Nodules.
Conclusion: Inflammation promotes the development of TNs disease, probably due to its indirect effect through inhibiting the synthesis of thyroid hormone, which results in the elevation of TSH. PMID: 32695162 [PubMed] (Source: International Journal of Endocrinology)
Source: International Journal of Endocrinology - July 24, 2020 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

The Association between Serum Uric Acid and Bone Mineral Density in Older Adults.
Conclusions: Our study revealed a positive relationship between sUA and lumbar BMD among most old adults. This association followed an inverted U-shaped curve among blacks. PMID: 32676109 [PubMed] (Source: International Journal of Endocrinology)
Source: International Journal of Endocrinology - July 19, 2020 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Selenium Supplementation May Decrease Thyroid Peroxidase Antibody Titer via Reducing Oxidative Stress in Euthyroid Patients with Autoimmune Thyroiditis.
Authors: Tian X, Li N, Su R, Dai C, Zhang R Abstract Objective: Selenium, as an antioxidant, has been implicated in the development of autoimmune thyroiditis (AIT). Many studies showed selenium supplementation could decrease thyroid autoantibodies in patients with AIT. However, the underlying mechanisms have not been well determined. Therefore, we performed a clinical study to investigate the possible mechanism of beneficial effects of selenium treatment on AIT patients. Methods: Forty euthyroid patients with AIT were randomized into two groups. Group I was treated with 200 μg/day selenium supplementa...
Source: International Journal of Endocrinology - July 19, 2020 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

GLP-1/GLP-1R Signaling Regulates Ovarian PCOS-Associated Granulosa Cells Proliferation and Antiapoptosis by Modification of Forkhead Box Protein O1 Phosphorylation Sites.
Authors: Sun Z, Li P, Wang X, Lai S, Qiu H, Chen Z, Hu S, Yao J, Shen J Abstract As the major cause of female anovulatory infertility, polycystic ovary syndrome (PCOS) affects a great proportion of women at childbearing age. Although glucagon-like peptide 1 receptor agonists (GLP-IRAs) show therapeutic effects for PCOS, its target and underlying mechanism remains elusive. In the present study, we identified that, both in vivo and in vitro, GLP-1 functioned as the regulator of proliferation and antiapoptosis of MGCs of follicle in PCOS mouse ovary. Furthermore, forkhead box protein O1 (FoxO1) plays an important role...
Source: International Journal of Endocrinology - July 15, 2020 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

The Late-Gestational Triglyceride to High-Density Lipoprotein Cholesterol Ratio Is Associated with Neonatal Macrosomia in Women without Diabetes Mellitus.
Conclusions: Maternal serum TG/HDL levels at late gestation are positively associated with neonatal body weight and the risk of macrosomia in women without DM. Maintaining maternal lipid levels in an appropriate range is important in the context of fetal overgrowth and primary prevention of macrosomia. PMID: 32655633 [PubMed] (Source: International Journal of Endocrinology)
Source: International Journal of Endocrinology - July 15, 2020 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Erratum to "Gastroenteropancreatic Neuroendocrine Neoplasia Characterization in Portugal: Results from the NETs Study Group of the Portuguese Society of Endocrinology, Diabetes and Metabolism".
Erratum to "Gastroenteropancreatic Neuroendocrine Neoplasia Characterization in Portugal: Results from the NETs Study Group of the Portuguese Society of Endocrinology, Diabetes and Metabolism". Int J Endocrinol. 2020;2020:9184324 Authors: Santos AP, Vinagre J, Soares P, Claro I, Sanches AC, Gomes L, Fernandes I, Catarino AL, Preto J, Pereira BD, Marques AP, Rodrigues F, Amaral C, Rocha G, Mellidez JC, Simões H, Lopes JM, Bugalho MJ, On Behalf Of The NETs Study Group Of The Portuguese Society Of Endocrinology Diabetes And Metabolism Abstract [This corrects the article DOI: 10.1155/2019/...
Source: International Journal of Endocrinology - July 15, 2020 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Relationship between Prolactin, Chronic Kidney Disease, and Cardiovascular Risk.
Authors: Dourado M, Cavalcanti F, Vilar L, Cantilino A Abstract CKD has a high prevalence worldwide, mainly due to its main etiologies-diabetes and hypertension. It has high cardiovascular morbidity and mortality, with traditional risk factors such as atherosclerosis, hypertension, diabetes, smoking, and left ventricular hypertrophy being common. Nontraditional cardiovascular risk factors, such as anemia, hyperparathyroidism, chronic inflammation, and microalbuminuria, are also well studied. Prolactin is a hormone not only related to lactation but also being considered a uremic toxin by some authors. It accumulates...
Source: International Journal of Endocrinology - July 15, 2020 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Differentiation of Rat Adipose-Derived Stem Cells into Parathyroid-Like Cells.
Conclusion: We successfully differentiated rat adipose-derived stem cells into parathyroid-like cells, which will pave a new route to curing hypoparathyroidism. PMID: 32612651 [PubMed] (Source: International Journal of Endocrinology)
Source: International Journal of Endocrinology - July 4, 2020 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

TSH Levels in Subclinical Hypothyroidism in the 97.5th Percentile of the Population.
Authors: Pérez-Campos Mayoral L, Hernández-Huerta MT, Mayoral-Andrade G, Pérez-Campos Mayoral E, Zenteno E, Martínez-Cruz R, Martínez Ruíz H, Martínez Cruz M, Pérez Santiago AD, Pérez-Campos E Abstract The debate regarding the cutoff point in the treatment of patients with subclinical hypothyroidism (Shypo) is ongoing. Generally, two different groups are identified for treatment by levels of 10 and 20 mIU/L. Nevertheless, the question remains, "what cutoff point should be chosen?" We have written a selective nonsystematic review focused...
Source: International Journal of Endocrinology - July 4, 2020 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

From Prediabetes to Type 2 Diabetes Mellitus in Women with Polycystic Ovary Syndrome: Lifestyle and Pharmacological Management.
Conclusions: The use of insulin-sensitizing agents, such as metformin and inositols, along with lifestyle interventions may improve the metabolic profile in PCOS women. PMID: 32587614 [PubMed] (Source: International Journal of Endocrinology)
Source: International Journal of Endocrinology - June 28, 2020 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Hypocalcemia with Immune Checkpoint Inhibitors: The Disparity among Various Reports.
Authors: Nalluru SS, Piranavan P, Ning Y, Ackula H, Siddiqui AD, Trivedi N Abstract Immune-related adverse events affecting parathyroid function are rarely reported with immune checkpoint inhibitors (ICPIs). Activating calcium-sensing receptor antibodies causing autoimmune hypoparathyroidism with nivolumab was recently reported. KEYNOTE-189 and CHECKMATE-067 trials reported a 21-29% hypocalcemia event rate, but the etiology of hypocalcemia was not reported. A chart review was performed to study patients receiving ICPI from 2015 to 2018 at multiple sites affiliated with Saint Vincent Hospital. The study population w...
Source: International Journal of Endocrinology - June 28, 2020 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Physiological Effect of Ghrelin on Body Systems.
Authors: Akalu Y, Molla MD, Dessie G, Ayelign B Abstract Ghrelin is a relatively novel multifaceted hormone that has been found to exert a plethora of physiological effects. In this review, we found/confirmed that ghrelin has effect on all body systems. It induces appetite; promotes the use of carbohydrates as a source of fuel while sparing fat; inhibits lipid oxidation and promotes lipogenesis; stimulates the gastric acid secretion and motility; improves cardiac performance; decreases blood pressure; and protects the kidneys, heart, and brain. Ghrelin is important for learning, memory, cognition, reward, sleep, ta...
Source: International Journal of Endocrinology - June 24, 2020 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Germline Mutation in KIF1B β Gene Associated with Loss of Heterozygosity: Usefulness of Next-Generation Sequencing in the Genetic Screening of Patients with Pheochromocytoma.
We reported a case presentation and next-generation sequencing analysis supported by in silico studies and evaluation of mitochondrial status in KIF1Bβ tissue. A 46-year-old male affected by a left secreting pheochromocytoma underwent surgery in 2017. After surgery, the normetanephrine levels decreased very slowly and a suspected abdominal lymph node was detected. We found a novel germline KIF1Bβ gene mutation, c.4052C > T, p. Pro1351Leu associated with tumor loss of heterozygosity, and resulted likely-pathogenetic by in silico studies. This mutation was also associated with an increased number o...
Source: International Journal of Endocrinology - June 24, 2020 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Selenium Supplementation, Body Mass Composition, and Leptin Levels in Patients with Obesity on a Balanced Mildly Hypocaloric Diet: A Pilot Study.
Conclusion: Se could reinforce the effects of diet for overweight and obesity. This work was registered in the ISRCTN registry with study ID ISRCTN6106073. PMID: 32565792 [PubMed] (Source: International Journal of Endocrinology)
Source: International Journal of Endocrinology - June 24, 2020 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Complicated Relationship between Genetic Mutations and Phenotypic Characteristics in Transient and Permanent Congenital Hypothyroidism: Analysis of Pooled Literature Data.
Authors: Long W, Zhou L, Wang Y, Liu J, Wang H, Yu B Abstract Purpose: Mutations and phenotypic characteristics remain unclear in patients with congenital hypothyroidism (CH), and no study concerning whether the outcome of transient CH (TCH) or permanent CH (PCH) is determined by mutations has been reported. Methods: We searched the literature up to April 2019. Eligible studies and data extraction were performed. We estimated the relationship between mutations and phenotypic characteristics in pooled patients with CH. Results: Two hundred forty-one cases were pooled from 41 eligible studies. The thyroid mor...
Source: International Journal of Endocrinology - June 24, 2020 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Increased Serum Leptin Level Predicts Bone Mineral Density in Hemodialysis Patients.
This study evaluated the relationship between BMD and serum leptin levels in patients on hemodialysis. Methods: In this cross-sectional study including 98 hemodialysis patients, BMD was measured using dual energy X-ray absorptiometry of the lumbar vertebrae (L2-L4), and serum leptin levels were determined using an enzyme immunoassay. Results: There were 25 (25.5%), 13 (13.3%), and 60 (61.2%) patients with osteopenia, osteoporosis, and normal BMD, respectively. Advanced age (P=0.017); decreased body mass index (BMI, P
Source: International Journal of Endocrinology - June 24, 2020 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Sex-Specific Association between Serum 25-Hydroxyvitamin D and Metabolic Risk Factors in T2DM Patients.
Authors: Sun X, Zhou S, He X, Wang Y, Cui W Abstract Objective: To evaluate the relationship between serum 25-hydroxyvitamin (25(OH)D) levels and metabolic risk factor levels in patients with type 2 diabetes mellitus (T2DM) on a sex-specific basis. Methods: Our study comprised 507 patients with T2DM (321 men, 186 women; median age, 59 years). The metabolic risk factors examined included lipoprotein(a), glycated albumin (GA-L), and random blood glucose (RBG); the levels of these parameters were determined enzymatically. Serum 25(OH)D levels were measured by commercial ELISA kits. Participants were divided into l...
Source: International Journal of Endocrinology - June 24, 2020 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Neck Circumference is an Effective Supplement for Nonalcoholic Fatty Liver Disease Screening in a Community-Based Population.
This study aimed to investigate the relationship between NC and liver fat content (LFC) and NAFLD. Methods: A total of 1698 subjects (577 men and 1121 women) from the Shanghai community were enrolled. All the subjects underwent NC measurement and biochemical measurements. LFC was calculated using the parameters from abdominal ultrasound images. Elevated NC was defined as NC ≥38.5 cm in men and NC ≥34.5 cm in women. Results: Subjects with NAFLD based on the LFC measurement had higher values of NC, liver enzyme profiles, homoeostasis model assessment-insulin resistance index, and LFC than those without NAFLD (all P
Source: International Journal of Endocrinology - June 9, 2020 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Resistin Activates p65 Pathway and Reduces Glycogen Content through Keratin 8.
In this study, we found that resistin upregulated expression of the p65 subunit of NF-κB, which led to the promotion of K8 transcriptional expression; in turn, the expression of K8 inhibited glycogen accumulation in HepG2 cells. PMID: 32508919 [PubMed] (Source: International Journal of Endocrinology)
Source: International Journal of Endocrinology - June 9, 2020 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

SLC22A1 rs622342 Polymorphism Predicts Insulin Resistance Improvement in Patients with Type 2 Diabetes Mellitus Treated with Metformin: A Cross-Sectional Study.
Authors: Wu K, Li X, Xu Y, Zhang X, Guan Z, Zhang S, Li Y Abstract Background: Metformin is the most widely used oral antidiabetic agent and can reduce insulin resistance (IR) effectively. Organic cation transporter 1 (encoded by SLC22A1) is responsible for the transport of metformin, and ataxia-telangiectasia-mutated (ATM) is a gene relating to the DNA repair and cell cycle control. The aim of this study was to evaluate if the genetic variants in SLC22A1 rs622342 and ATM rs11212617 could be effective predictors of islet function improvement in patients with type 2 diabetes mellitus (T2DM) on metformin treatment. ...
Source: International Journal of Endocrinology - May 27, 2020 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

gp91phox, a Novel Biomarker Evaluating Oxidative Stress, Is Elevated in Subclinical Hypothyroidism.
In this study, the levels of serum soluble gp91phox were measured to assess the oxidative stress in patients with SH. And the relationship among gp91phox, low-density lipoprotein-C (LDL-C), and TSH was also investigated. Methods: A total of 51 subjects were enrolled and categorized into four groups: the healthy controls subjects (n = 13), controls with high level of LDL-C alone (n = 12), SH with normal level of LDL-C (n = 11), and SH with high level of LDL-C (n = 15). The related clinical and laboratory data were collected for statistical analysis. All the patient...
Source: International Journal of Endocrinology - May 27, 2020 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Effect of Denosumab on Bone Mineral Density of Hematopoietic Stem Cell Transplantation Recipients.
Authors: Jeong C, Kim HJ, Lee S, Kang MI, Ha J Abstract Purpose: Denosumab is a monoclonal antibody that prevents the development of osteoclasts. The effect of denosumab in solid organ transplant recipients has been elucidated, but its effect in haematopoietic stem cell transplantation recipients has not been studied yet. The aim of this study was to determine the effectiveness and safety of denosumab in haematopoietic stem cell transplantation recipients. Methods: We retrospectively evaluated 33 female patients with osteoporosis (mean age 52.6 ± 9.8 years) following allogeneic haematopoiet...
Source: International Journal of Endocrinology - May 27, 2020 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Localization of Parathyroid Disease in Reoperative Patients with Primary Hyperparathyroidism.
Authors: Parikh AM, Grogan RH, Morón FE Abstract The localization of persistent or recurrent disease in reoperative patients with primary hyperparathyroidism presents challenges for radiologists and surgeons alike. In this article, we summarize the relevant imaging modalities, compare their accuracy in identifying reoperative disease, and outline their advantages and disadvantages. Accurate localization by preoperative imaging is a predictor of operative success, whereas negative or discordant preoperative imaging is a risk factor for operative failure. Ultrasound is a common first-line modality because it i...
Source: International Journal of Endocrinology - May 27, 2020 Category: Endocrinology Tags: Int J Endocrinol Source Type: research