Comparison of Efficacy and Safety of Lispro and Aspart Evaluated by Continuous Glucose Monitoring System in Patients with Newly Diagnosed Type 2 Diabetes.
Conclusions: Lispro and aspart had the similar ability to control the glycemic variations in patients with newly diagnosed T2DM. This study was registered with ClinicalTrials.gov, number ChiCTR-IPR-17010338. PMID: 29780415 [PubMed] (Source: International Journal of Endocrinology)
Source: International Journal of Endocrinology - May 24, 2018 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Physiological Aldosterone Concentrations Are Associated with Alterations of Lipid Metabolism: Observations from the General Population.
Conclusions: The present data show that plasma aldosterone is positively associated with LDL-C and non-HDL-C and inversely associated with HDL-C in the general population. Our data thus suggests that aldosterone concentrations within the physiological range may be related to alterations of lipid metabolism. PMID: 29780416 [PubMed] (Source: International Journal of Endocrinology)
Source: International Journal of Endocrinology - May 24, 2018 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Osteoporosis Is Associated with Deteriorating Clinical Status in Adults with Cystic Fibrosis.
Conclusions: Osteoporosis in CF occurs with deteriorating clinical status while the role of calcium metabolism seems minor. Gender specific and dysglycemic impact on bone status should be investigated further. PMID: 29780417 [PubMed] (Source: International Journal of Endocrinology)
Source: International Journal of Endocrinology - May 24, 2018 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Biological and Clinical Effects of Calciprotein Particles on Chronic Kidney Disease-Mineral and Bone Disorder.
Authors: Akiyama K, Kimura T, Shiizaki K Abstract Calciprotein particles (CPPs) are a new biological marker of chronic kidney disease-mineral and bone disorder (CKD-MBD). CPPs consist of phosphate, calcium, and some proteins, with phosphate being the major contributor to the level and biological activity of CPPs. Recent studies have shown the physiological and pathological significance of CPPs, including contributions to bone and mineral metabolism, and to tissue and organ impairments such as cardiovascular damage and inflammatory responses. These actions are well known as important aspects of CKD-MBD. Fibroblast g...
Source: International Journal of Endocrinology - May 24, 2018 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Elevated Serum Total Bilirubin Concentrations Are Negatively Associated with Diabetic Retinopathy among the Chinese Northeastern Population.
Conclusion: Our results demonstrate that a significant negative association was found between STBC and DR. STBC might be an early clinical marker for predicting the occurrence of DR. PMID: 29780419 [PubMed] (Source: International Journal of Endocrinology)
Source: International Journal of Endocrinology - May 24, 2018 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Clinical Characteristics of Aldosterone- and Cortisol-Coproducing Adrenal Adenoma in Primary Aldosteronism.
This study investigated the incidence, clinical characteristics, and molecular biological features of patients with A/CPAs. We retrospectively identified 22 A/CPA patients from 555 PA patients who visited the Chinese People's Liberation Army General Hospital between 2004 and 2015. Analysis of clinical parameters revealed that patients with A/CPAs had larger tumors than those with pure APAs (P
Source: International Journal of Endocrinology - May 19, 2018 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Meta-Analysis of the Association between Vitamin D Receptor Polymorphisms and the Risk of Autoimmune Thyroid Disease.
In conclusion, the present study suggested that VDR rs731236, rs1544410, rs2228570, and rs7975232 polymorphisms were significantly associated with AITD risk. However, more well-designed studies should be performed to verify the current results. PMID: 29765404 [PubMed] (Source: International Journal of Endocrinology)
Source: International Journal of Endocrinology - May 17, 2018 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Simulated Cholinergic Reinnervation of β (INS-1) Cells: Antidiabetic Utility of Heterotypic Pseudoislets Containing β Cell and Cholinergic Cell.
In this study, the cholinergic reinnervation of beta cells was simulated by 2D and 3D coculture of INS-1 and NG108-15 cells. In 2D culture conditions, 20 mM glucose induced a 1.24-fold increase (p
Source: International Journal of Endocrinology - May 16, 2018 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Efficacy, Safety, and Quality of Treatment Satisfaction of Premixed Human and Analogue Insulin Regimens in a Large Cohort of Type 2 Diabetic Patients: PROGENS BENEFIT Observational Study.
Authors: Nabrdalik K, Kwiendacz H, Sawczyn T, Tomasik A, Kukla M, Masierek M, Gumprecht J Abstract Diabetes is a lifelong course disease, so insulin treatment has to be effective and safe, and patients should be satisfied with it. We aimed to compare efficacy, safety, and quality of treatment satisfaction of human and premixed analogue insulin among 3264 patients (53.58% women) with type 2 diabetes mellitus (T2DM) in a real-life environment. 2493 patients (62.77%) had been assigned to group I where before the inclusion into the study the treatment regimen has been changed from analogue to human premixed insulin and...
Source: International Journal of Endocrinology - May 16, 2018 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Cataract as Early Ocular Complication in Children and Adolescents with Type 1 Diabetes Mellitus.
Authors: Šimunović M, Paradžik M, Škrabić R, Unić I, Bućan K, Škrabić V Abstract Cataract is a rare manifestation of ocular complication at an early phase of T1DM in the pediatric population. The pathophysiological mechanism of early diabetic cataract has not been fully understood; however, there are many theories about the possible etiology including osmotic damage, polyol pathway, and oxidative stress. The prevalence of early diabetic cataract in the population varies between 0.7 and 3.4% of children and adolescents with T1DM. The occurrence of diabetic cataract in most pediatric patien...
Source: International Journal of Endocrinology - May 16, 2018 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

In Situ Preservation Fraction of Parathyroid Gland in Thyroidectomy: A Cohort Retrospective Study.
Conclusion: In situ preservation of parathyroid gland is crucial for parathyroid function. Less preserved is the independent risk factor for postoperative hypoparathyroidism and hypocalcemia, resulting in a worse function of parathyroid gland in the long term. PMID: 29755522 [PubMed] (Source: International Journal of Endocrinology)
Source: International Journal of Endocrinology - May 16, 2018 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Hypophyseal Involvement in Immunoglobulin G4-Related Disease: A Retrospective Study from a Single Tertiary Center.
Conclusions. IgG4-RD is a broad disease, and all physicians involved have to be aware of the possibility of pituitary dysfunction. Younger patients should be expected. The histopathological feature of pituitary gland biopsy could be atypical. For patients with a longer history, the combination of GC and immunosuppressive agents is favorable. Early and adequate courses of treatment are crucial for the management of IgG4-RH. With GC and/or immunosuppressant treatment, however, pituitary function or diabetes insipidus did not improve considerably. PMID: 29755523 [PubMed] (Source: International Journal of Endocrinology)
Source: International Journal of Endocrinology - May 16, 2018 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

A Clinical Roadmap to Investigate the Genetic Basis of Pediatric Pheochromocytoma: Which Genes Should Physicians Think About?
We describe epidemiological data on the prevalence of pheochromocytoma susceptibility genes, including new genes that are expanding the genetic etiology of this neuroendocrine tumor in pediatric patients. The clinical phenotypes associated with a higher pretest probability for hereditary pheochromocytoma are presented, focusing on differences between pediatric and adult patients. We also describe new syndromes, as well as rates of malignancy and multifocal disease associated with these syndromes and pheochromocytoma susceptibility genes published more recently. Finally, we discuss new tools for genetic screening of patient...
Source: International Journal of Endocrinology - May 16, 2018 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Incidence and Risk Factors of Diabetic Foot Ulcer: A Population-Based Diabetic Foot Cohort (ADFC Study)-Two-Year Follow-Up Study.
This study was carried out to assess the incidence and risk factors of diabetic foot ulcer (DFU). Materials and Methods: In this prospective cohort study in a university hospital, all the participants were examined and followed up for new DFU as final outcome for two years. To analyze the data, the variables were first evaluated with a univariate analysis. Then variables with P value
Source: International Journal of Endocrinology - May 9, 2018 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Susceptible and Prognostic Genetic Factors Associated with Diabetic Peripheral Neuropathy: A Comprehensive Literature Review.
Authors: Prabodha LBL, Sirisena ND, Dissanayake VHW Abstract Type 2 diabetes mellitus (T2D) is a disorder of glucose metabolism. It is a complex process involving the regulation of insulin secretion, insulin sensitivity, gluconeogenesis, and glucose uptake at the cellular level. Diabetic peripheral neuropathy (DPN) is one of the debilitating complications that is present in approximately 50% of diabetic patients. It is the primary cause of diabetes-related hospital admissions and nontraumatic foot amputations. The pathogenesis of diabetic neuropathy is a complex process that involves hyperglycemia-induced oxidative...
Source: International Journal of Endocrinology - May 9, 2018 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Direct Photocoagulation Guided by Merged Retinal Images for the Treatment of Focal Diabetic Macular Edema.
Conclusion: MIG-PC contributed to the improvement in BCVA and reduction in RT, number of laser shots required, and retreatment rates. Based on our data, MIG-PC can be recommended for the treatment of focal DME. This trial is registered with ID UMIN000030390. PMID: 29721014 [PubMed] (Source: International Journal of Endocrinology)
Source: International Journal of Endocrinology - May 4, 2018 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

A Comparative Assessment of Cardiovascular Autonomic Reflex Testing and Cardiac 123I-Metaiodobenzylguanidine Imaging in Patients with Type 1 Diabetes Mellitus without Complications or Cardiovascular Risk Factors.
Authors: Didangelos T, Moralidis E, Karlafti E, Tziomalos K, Margaritidis C, Kontoninas Z, Stergiou I, Boulbou M, Papagianni M, Papanastasiou E, Hatzitolios AI Abstract Aim: To compare the cardiovascular autonomic reflex tests (CARTs) with cardiac sympathetic innervation imaging with 123I-metaiodobenzylguanidine (MIBG) in patients with type 1 diabetes mellitus (T1DM). Patients and Methods: Forty-nine patients (29 males, mean age 36 ± 10 years, mean T1DM duration 19 ± 6 years) without cardiovascular risk factors were prospectively enrolled. Participants were evaluated for autonomic dysfunction by a...
Source: International Journal of Endocrinology - May 4, 2018 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

The Association of Thyroid Nodules with Metabolic Status: A Cross-Sectional SPECT-China Study.
Authors: Chen Y, Zhu C, Chen Y, Wang N, Li Q, Han B, Zhao L, Chen C, Zhai H, Lu Y Abstract Purpose: The aim of this study was to investigate the association of thyroid nodules (TNs) and their ultrasound (US) characteristics related to malignancy with metabolic status. Methods: The data were obtained from a cross-sectional study (SPECT-China, 2014-2015). The study included 9898 participants older than 18 years. Participants underwent several checkups, which included the measurement of anthropometric parameters, blood pressure, TSH levels, glucose, and lipid profiles. TN and nonalcoholic fatty liver disease (NAFL...
Source: International Journal of Endocrinology - May 4, 2018 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Elevated and Correlated Expressions of miR-24, miR-30d, miR-146a, and SFRP-4 in Human Abdominal Adipose Tissue Play a Role in Adiposity and Insulin Resistance.
Authors: Nunez Lopez YO, Garufi G, Pasarica M, Seyhan AA Abstract Objective: We explored the relationships among microRNAs (miRNAs) and SFRP4, as they relate to adipose tissue functions including lipolysis, glucose and glycerol turnover, and insulin sensitivity. Methods: Abdominal adipose tissue (AbdAT) levels of thirteen microRNAs (miRNAs), SFRP4, and VEGF in lean nondiabetic subjects (n = 7), subjects with obesity (n = 5), and subjects with obesity and type 2 diabetes (T2DM) (n = 5) were measured by qPCR. Insulin sensitivity was measured by the euglycemic-hyperinsulinemic clamp. Osmium fixation and Coulter co...
Source: International Journal of Endocrinology - May 4, 2018 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Efficacy and Safety of Insulin Degludec versus Insulin Glargine: A Systematic Review and Meta-Analysis of Fifteen Clinical Trials.
This study aimed to assess the effects and safety of IDeg versus IGlar. Methods: A systematic literature search was conducted using the PubMed, EMBASE, and Cochrane Library electronic databases to identify all randomized controlled trials (RCTs). Results: Fifteen RCTs were identified. The combined data showed that the decrease in the glycosylated hemoglobin (HbA1c) level was slightly different, and the proportion of patients who achieved HbA1c 
Source: International Journal of Endocrinology - May 4, 2018 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Establishing Differences in Thermographic Patterns between the Various Complications in Diabetic Foot Disease.
Conclusions: Significant differences in mean temperatures exist between participants who were healthy and those with DM with no known complications when compared to participants with neuroischaemia, neuropathy, or PAD. As foot temperature rises, so does the probability of the presence of complications of neuropathy, neuroischaemia, or peripheral arterial disease. PMID: 29721019 [PubMed] (Source: International Journal of Endocrinology)
Source: International Journal of Endocrinology - May 4, 2018 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Copy Number Variation of Immune-Related Genes and Their Association with Iodine in Adults with Autoimmune Thyroid Diseases.
Conclusion: SIRPB1 CNV and an excess of iodine were risk factors for AITD, but an association with the occurrence of AITD was not found. PMID: 29713342 [PubMed] (Source: International Journal of Endocrinology)
Source: International Journal of Endocrinology - May 3, 2018 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Elevated Serum IL-17 Expression at Cessation Associated with Graves' Disease Relapse.
Conclusions: This present study indicated elevated serum IL-17 expression at cessation to be a predictor for GD relapse within 12 months. PMID: 29713343 [PubMed] (Source: International Journal of Endocrinology)
Source: International Journal of Endocrinology - May 3, 2018 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Gender-Specific Risk of Central Compartment Lymph Node Metastasis in Papillary Thyroid Carcinoma.
Authors: Sun Y, Lv H, Zhang S, Bai Y, Shi B Abstract Our aim was to evaluate the impact of gender on the predictive factors of central compartment lymph node metastasis (CLNM) in papillary thyroid carcinoma (PTC). A retrospective study of 590 patients treated for PTC was performed. Univariate and multivariate analyses showed that gender (female; P = 0.001), age (≥45 y; P 1 cm; P
Source: International Journal of Endocrinology - May 3, 2018 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Melatonin Treatment Improves Insulin Resistance and Pigmentation in Obese Patients with Acanthosis Nigricans.
This study aimed to determine the effects of melatonin on insulin resistance in obese patients with acanthosis nigricans (AN). Methods: A total of 17 obese patients with acanthosis nigricans were recruited in a 12-week pilot open trial. Insulin sensitivity, glucose metabolism, inflammatory factors, and other biochemical parameters before and after the administration of melatonin were measured. Results: After 12 weeks of treatment with melatonin (3 mg/day), homeostasis model assessment insulin resistance index (HOMA-IR) (8.99 ± 5.10 versus 7.77 ± 5.21, p
Source: International Journal of Endocrinology - May 1, 2018 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

The Association between Serum Bilirubin Level and Electrochemical Skin Conductance in Chinese Patients with Type 2 Diabetes.
Authors: Mao F, Zhu X, Lu B, Li Y Abstract Bilirubin is an antioxidant and plays a protective role against cardiovascular and microvascular disease. The aim of this study is to explore the possible protective effect of bilirubin on small nerve function. A total of 265 Chinese patients with type 2 diabetes mellitus (T2DM) were enrolled in the study. Both SUDOSCAN and other traditional diabetic neuropathy examinations including neuropathy symptom score (NSS), the neuropathy disability score (NDS) and Michigan Neuropathy Screening Instrument (MNSI) scores were performed in all patients with T2DM. Blood bilirubin level...
Source: International Journal of Endocrinology - May 1, 2018 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

MicroRNA and Microvascular Complications of Diabetes.
Authors: Barutta F, Bellini S, Mastrocola R, Bruno G, Gruden G Abstract In the last decade, miRNAs have received substantial attention as potential players of diabetes microvascular complications, affecting the kidney, the retina, and the peripheral neurons. Compelling evidence indicates that abnormally expressed miRNAs have pivotal roles in key pathogenic processes of microvascular complications, such as fibrosis, apoptosis, inflammation, and angiogenesis. Moreover, clinical research into innovative both diagnostic and prognostic tools suggests circulating miRNAs as possible novel noninvasive markers of diabetes m...
Source: International Journal of Endocrinology - May 1, 2018 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Sexual Dimorphism for the Association between Vitamin D and Insulin Resistance in Chinese People.
Conclusion: We found an inverse association between 25(OH)D and HOMA-IR in Chinese overweight males. Vitamin D supplementation might be beneficial in this population. However, further clinical trials are needed to confirm this association. PMID: 29692809 [PubMed] (Source: International Journal of Endocrinology)
Source: International Journal of Endocrinology - April 27, 2018 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Predictive Factors of Secondary Normocalcemic Hyperparathyroidism after Roux-en-Y Gastric Bypass.
Authors: Casella C, Molfino S, Mittempergher F, Cappelli C, Portolani N Abstract Objective: Aim of this study is to evaluate determinants of secondary normocalcemic hyperparathyroidism (SNHPT) persistence in patients who have undergone Roux-en-Y gastric bypass on vertical-banded gastroplasty. Methods: 226 consecutive patients submitted to bariatric surgery were prospectively enrolled and divided in two groups on the basis of preoperative presence of SNHPT. For each patient, we evaluated anthropometric and laboratory parameters. Calcium metabolism (calcemia, PTH, and 25-hydroxy vitamin D serum levels) was studie...
Source: International Journal of Endocrinology - April 27, 2018 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Vesicle-Associated Membrane Protein-Associated Protein A Is Involved in Androgen Receptor Trafficking in Mouse Sertoli Cells.
This study was conducted to the underlying molecular mechanism mediating AR trafficking. Data from mass spectrometry using membrane coimmunoprecipitation sample by anti-AR antibody indicated VAPA is a candidate protein. Knockdown of VAPA by shRNA decreased the amount of AR localized to membrane and nuclear fraction and prevented AR trafficking after being exposed to testosterone. Further studies indicated AR trafficking in Sertoli cells might be mediated by VAPA via association with vesicle transport protein OSBP. This study can enrich the mechanism of the androgen actions and will be helpful for further clarifying the non...
Source: International Journal of Endocrinology - April 26, 2018 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

The Change of Left Ventricular Function in Rats with Subclinical Hypothyroid and the Effects of Thyroxine Replacement.
Conclusions: TSH can impair left ventricular function by regulating several factors, and L-T4 treatment ameliorates it in sHT rats. PMID: 29686704 [PubMed] (Source: International Journal of Endocrinology)
Source: International Journal of Endocrinology - April 26, 2018 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Higher Income and Integration into the Workforce Are the Main Factors Associated with Quality of Life in Acromegalic Patients in Northeastern Brazil.
Authors: GuimarãesSá AM, Ferreira PAM, Souza MT, Nascimento GC, da Silva Pereira Damianse S, de Carvalho Rocha VC, Dos Santos Faria M, de Souza Paiva Ferreira A Abstract Objective: To identify the factors associated with quality of life in patients with acromegaly with follow-up at the referral service in neuroendocrinology of the state of Maranhão, northeast Brazil. Methods: The Acromegaly Quality of Life Questionnaire (Acro-QoL) was used. Factors independently associated with quality of life were identified using multivariate linear regression, with p values 
Source: International Journal of Endocrinology - April 24, 2018 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Metformin Regulating miR-34a Pathway to Inhibit Egr1 in Rat Mesangial Cells Cultured with High Glucose.
Conclusion: We enriched the effects of miR-34a pathway regulating Egr1 in high glucose-cultured MCs. It provides a foundation for future researches considering Egr1 as a therapeutic target and a new direction for the clinical application of metformin in early DKD. PMID: 29681936 [PubMed] (Source: International Journal of Endocrinology)
Source: International Journal of Endocrinology - April 24, 2018 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Sheehan's Syndrome Revisited: Underlying Autoimmunity or Hypoperfusion?
Authors: González-González JG, Borjas-Almaguer OD, Salcido-Montenegro A, Rodríguez-Guajardo R, Elizondo-Plazas A, Montes-de-Oca-Luna R, Rodríguez-Gutiérrez R Abstract Sheehan's syndrome remains a frequent obstetric complication with an uncertain pathophysiology. We aimed to assess the incidence of hypopituitarism (≥2 hormonal axis impairment) within the first six postchildbirth months and to determine the existence of anti-pituitary antibodies. From 2015 to 2017, adult pregnant women, who developed moderate to severe postpartum hemorrhage (PPH), were consecutively included in t...
Source: International Journal of Endocrinology - April 24, 2018 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

The Bone-Cardiovascular Axis: Mechanisms and Clinical Relevance.
Authors: Verheyen N, Grübler MR, Catena C, Fahrleitner-Pammer A, van Ballegooijen AJ PMID: 29681938 [PubMed] (Source: International Journal of Endocrinology)
Source: International Journal of Endocrinology - April 24, 2018 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Genetic Variability in eIF2 α Gene Is Associated with Islet β-Cell Function in the Development of Diabetes in a Chinese Han Population.
Conclusion: The eIF2α polymorphism is associated with islet β-cell function in a Chinese population. PMID: 29675042 [PubMed] (Source: International Journal of Endocrinology)
Source: International Journal of Endocrinology - April 21, 2018 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Cardiovascular Risk Factors after Childhood Cancer Treatment Are Independent of the FTO Gene Polymorphism?
Authors: Sawicka-Żukowska M, Krawczuk-Rybak M, Bernatowicz P, Muszyńska-Rosłan K, Konstantynowicz J, Łuczyński W Abstract The study objective was to assess the prevalence of cardiovascular disease risk factors in patients treated for childhood cancer (N = 101) and to determine the involvement of clinical (cancer type and therapy) and/or genetic (FTO gene rs9939609 polymorphism) factors. Anthropometric features, laboratory findings, and standardized osteodensitometric indices (fat and lean mass) were considered. Overweight/obesity was found in 17.82% of the patients; however, central adiposity was found in as m...
Source: International Journal of Endocrinology - April 21, 2018 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Investigating the Interactive Effects of Sex Steroid Hormones and Brain-Derived Neurotrophic Factor during Adolescence on Hippocampal NMDA Receptor Expression.
This study sought to determine the interactive effects of preadolescent hormone manipulation and BDNF heterozygosity (+/-) on hippocampal NMDA-R expression. Wild-type and BDNF+/- mice were gonadectomised, and females received either 17β-estradiol or progesterone treatment, while males received either testosterone or dihydrotestosterone (DHT) treatment. Dorsal (DHP) and ventral hippocampus (VHP) were dissected, and protein expression of GluN1, GluN2A, GluN2B, and PSD-95 was assessed by Western blot analysis. Significant genotype × OVX interactions were found for GluN1 and GluN2 expression within the...
Source: International Journal of Endocrinology - April 20, 2018 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Brief Overview of a Decade of Genome-Wide Association Studies on Primary Hypertension.
Authors: Azam AB, Azizan EAB Abstract Primary hypertension is widely believed to be a complex polygenic disorder with the manifestation influenced by the interactions of genomic and environmental factors making identification of susceptibility genes a major challenge. With major advancement in high-throughput genotyping technology, genome-wide association study (GWAS) has become a powerful tool for researchers studying genetically complex diseases. GWASs work through revealing links between DNA sequence variation and a disease or trait with biomedical importance. The human genome is a very long DNA sequence which c...
Source: International Journal of Endocrinology - April 20, 2018 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Positive Association of Metabolic Syndrome with a Single Nucleotide Polymorphism of Syndecan-3 (rs2282440) in the Taiwanese Population.
Conclusion: SDC3 rs2282440 polymorphism is positively associated with MetS in the Taiwanese population. Further investigation is needed to see if this association is mediated by mere adiposity or SDC3 polymorphism is also linked with other components of MetS such as lipid metabolism. PMID: 29666642 [PubMed] (Source: International Journal of Endocrinology)
Source: International Journal of Endocrinology - April 20, 2018 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Drugs Involved in Dyslipidemia and Obesity Treatment: Focus on Adipose Tissue.
Authors: Dias S, Paredes S, Ribeiro L Abstract Metabolic syndrome can be defined as a state of disturbed metabolic homeostasis characterized by visceral obesity, atherogenic dyslipidemia, arterial hypertension, and insulin resistance. The growing prevalence of metabolic syndrome will certainly contribute to the burden of cardiovascular disease. Obesity and dyslipidemia are main features of metabolic syndrome, and both can present with adipose tissue dysfunction, involved in the pathogenic mechanisms underlying this syndrome. We revised the effects, and underlying mechanisms, of the current approved drugs for dyslip...
Source: International Journal of Endocrinology - March 31, 2018 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Association between Dietary Patterns and Precocious Puberty in Children: A Population-Based Study.
Conclusions: Dietary patterns were found to be related to precocious puberty among Shanghai children. PMID: 29593790 [PubMed] (Source: International Journal of Endocrinology)
Source: International Journal of Endocrinology - March 31, 2018 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Histopathological Characterization and Whole Exome Sequencing of Ectopic Thyroid: Fetal Architecture in a Functional Ectopic Gland from Adult Patient.
This study aimed to investigate the histopathological, functional, and genetic features of human ectopic thyroids. Six samples were histologically examined, and the expression of the specific thyroid proteins was assessed by immunohistochemistry. Two samples were submitted to whole exome sequencing. An oropharynx sample showed immature fetal architecture tissue with clusters or cords of oval thyrocytes and small follicles; one sample exhibited a normal thyroid pattern while four showed colloid goiter. All ectopic thyroids expressed the specific thyroid genes and T4 at similar locations to those observed in normal thyroid. ...
Source: International Journal of Endocrinology - March 31, 2018 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

GH, IGF-1, and Age Are Important Contributors to Thyroid Abnormalities in Patients with Acromegaly.
Conclusions: Both benign and malignant thyroid abnormalities are increased in the acromegalic population compared to those in the general population. Age at diagnosis is an independent risk factor for thyroid abnormalities, and GH burden may be a partial contributor. Early diagnosis, early treatment, and monitoring of postoperational endocrine levels are important for acromegalic patients. PMID: 29593792 [PubMed] (Source: International Journal of Endocrinology)
Source: International Journal of Endocrinology - March 31, 2018 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Favorable Effect of Anti-TNF Therapy on Insulin Sensitivity in Nonobese, Nondiabetic Patients with Inflammatory Bowel Disease.
Conclusion: Anti-TNF therapy exerts a favorable effect on insulin sensitivity, while it has no effect on lipid levels in nondiabetic, nonobese patients with inflammatory bowel disease. PMID: 29576769 [PubMed] (Source: International Journal of Endocrinology)
Source: International Journal of Endocrinology - March 28, 2018 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Effects of Cholecalciferol on Key Components of Vitamin D-Endo/Para/Autocrine System in Experimental Type 1 Diabetes.
Conclusions: T1D-induced vitamin D deficiency is associated with impairments of renal and extrarenal CYP27B1 and VDR expression. Cholecalciferol can be effective in the amelioration of diabetes-associated abnormalities in the vitamin D-endo/para/autocrine system. PMID: 29552033 [PubMed] (Source: International Journal of Endocrinology)
Source: International Journal of Endocrinology - March 21, 2018 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Different Associations of Trunk and Lower-Body Fat Mass Distribution with Cardiometabolic Risk Factors between Healthy Middle-Aged Men and Women.
Authors: Wu B, Huang J, Fukuo K, Suzuki K, Yoshino G, Kazumi T Abstract The aim of this study was to assess whether the gender-specific pattern of fat mass (FM) distribution is related to gender differences in cardiometabolic risk factors. 207 healthy middle-aged Japanese were included in the study. We measured FM in the total body, trunk, and lower-body with dual-energy X-ray absorptiometry (DXA). The percentage of trunk FM (TFM) and lower-body FM (LFM) is noted as %TFM and %LFM, respectively. Other measurements included glucose and insulin during oral glucose tolerance test (OGTT), leptin, adiponectin, plasminoge...
Source: International Journal of Endocrinology - March 14, 2018 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Vitamin D and Male Sexual Function: A Transversal and Longitudinal Study.
Conclusions: Vitamin D is important for the wellness of male sexual function, and vitamin D administration improves sexual function. PMID: 29531528 [PubMed] (Source: International Journal of Endocrinology)
Source: International Journal of Endocrinology - March 14, 2018 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Pre- and Postoperative Body Composition and Metabolic Characteristics in Patients with Acromegaly: A Prospective Study.
Conclusions: Body composition and metabolism in acromegaly patients changed after surgery, and gender and age influenced these changes. PMID: 29531529 [PubMed] (Source: International Journal of Endocrinology)
Source: International Journal of Endocrinology - March 14, 2018 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Exploring the Role of Estrogens in Lizard Spermatogenesis through the Study of Clomiphene and FSH Effects.
Authors: Verderame M, Scudiero R, Limatola E Abstract Spermatogenesis is a fascinating biological process aiming to generate haploid spermatozoa from diploid spermatogonia through a specific hormonal network between gonadotropins and steroids. Increasing evidence suggests that the primary female sex hormone estrogen plays an active role in this process. This research points out on the role of estrogen during lizard spermatogenesis by using three experimental approaches: (1) exposure to an analogue of nonsteroidal estrogen as Clomiphene citrate that acts both as estrogen agonist and antagonist; (2) exposure to the g...
Source: International Journal of Endocrinology - February 23, 2018 Category: Endocrinology Tags: Int J Endocrinol Source Type: research