Primary Tumor Site Affects Survival in Patients with Gastroenteropancreatic and Neuroendocrine Liver Metastases.
Authors: Tierney JF, Poirier J, Chivukula S, Pappas SG, Hertl M, Schadde E, Keutgen X Abstract Background: Gastroenteropancreatic neuroendocrine tumors (GEP-NETs) are commonly present with metastatic disease, and the liver is the most frequent metastatic site. Herein, we studied whether primary tumor site affects survival in patients with GEP-NETs and liver metastases (NELM). As a secondary endpoint, we studied whether extrahepatic disease and surgical resection impact survival in this patient population. Methods: Patients with NELM diagnosed from 2006 to 2014 were identified from the National Cancer Database. ...
Source: International Journal of Endocrinology - April 18, 2019 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Gut Microbiota Composition and Structure of the Ob/Ob and Db/Db Mice.
Discussion and conclusion: The high abundance of Bacteroidetes and Firmicutes in microbiota composition and their imbalanced ratio in both model mice reflect the state of metabolic disorders of these mice. Differences in microbiota composition between the two model mice of the same age or in one model mice with different ages were assumed to be closely linked to the fluctuation of their blood glucose levels with age. The data on gut microbiota in ob/ob and db/db mice investigated herein has broad implications for the pathogenesis study and drug discovery on obesity and related complications. PMID: 30984260 [PubMed] (So...
Source: International Journal of Endocrinology - April 17, 2019 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Erratum to "Impact of Long-Acting Somatostatin Analogues on Glucose Metabolism in Acromegaly: A Hospital-Based Study".
Erratum to "Impact of Long-Acting Somatostatin Analogues on Glucose Metabolism in Acromegaly: A Hospital-Based Study". Int J Endocrinol. 2019;2019:1987417 Authors: Shen M, Wang M, He W, He M, Qiao N, Ma Z, Ye Z, Zhang Q, Zhang Y, Yang Y, Cai Y, ABuDuoReYiMu Y, Lu Y, Lu B, Shou X, Wang Y, Ye H, Li Y, Li S, Zhao Y, Cao X, Zhang Z Abstract [This corrects the article DOI: 10.1155/2018/3015854.]. PMID: 30962806 [PubMed - in process] (Source: International Journal of Endocrinology)
Source: International Journal of Endocrinology - April 11, 2019 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Correlation of Serum 1,5-AG with Uric Acid in Type 2 Diabetes Mellitus with Different Renal Functions.
Authors: Zhang K, Xue B, Yuan Y, Wang Y Abstract Aim: Recent studies found that levels of serum uric acid (SUA) were positively associated with serum 1,5-anhydroglucitol (1,5-AG) in subjects with type 2 diabetes mellitus (T2DM). In the current study, we investigated the association between 1,5-AG and UA in T2DM patients with different renal functions. Methods: A total of 405 T2DM patients, 213 men and 192 women, participated in the study. Patients' clinical information was collected, and serum 1,5-AG, SUA, and other clinical characteristics were measured. Correlation analyses were carried out to analyze their c...
Source: International Journal of Endocrinology - April 11, 2019 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Current Progress on MicroRNA-Based Gene Delivery in the Treatment of Osteoporosis and Osteoporotic Fracture.
Authors: Sun X, Guo Q, Wei W, Robertson S, Yuan Y, Luo X Abstract Emerging evidence demonstrates that microRNAs, as important endogenous posttranscriptional regulators, are essential for bone remodeling and regeneration. Undoubtedly, microRNA-based gene therapies show great potential to become novel approaches against bone-related diseases, including osteoporosis and associated fractures. The major obstacles for continued advancement of microRNA-based therapies in clinical application include their poor in vivo stability, nonspecific biodistribution, and unwanted side effects. Appropriate chemical modifications and...
Source: International Journal of Endocrinology - April 11, 2019 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Acute Postexercise Change in Circulating Irisin Is Related to More Favorable Lipid Profile in Pregnant Women Attending a Structured Exercise Program and to Less Favorable Lipid Profile in Controls: An Experimental Study with Two Groups.
Conclusions: Training and control pregnant women responded differently to a single exercise session, both in the postexercise change in irisin and its relationship to the blood lipids. Only in the training group we observed the postexercise increase in irisin, which was related to more favorable lipid profile. Systematic prenatal physical activity may optimize the postexercise irisin response and lipid metabolism regulated by this hormone. Therefore, exercise programs should be promoted in pregnant women and obstetric care providers. PMID: 30944566 [PubMed] (Source: International Journal of Endocrinology)
Source: International Journal of Endocrinology - April 6, 2019 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Gender- and Age-Specific Differences in the Association of Hyperuricemia and Hypertension: A Cross-Sectional Study.
In this study, we aimed to explore gender- and age-specific differences in this association between hyperuricemia and hypertension in a Chinese population. Methods: A total of 78596 ostensibly healthy subjects (47781 men and 30815 women) were recruited. The association between hyperuricemia and hypertension was analyzed by multivariate logistic regression, and the analyses were stratified by gender and age. Results: Overall prevalence of hypertension and hyperuricemia was significantly higher in males than in females. Increasing trends of hypertension prevalence in both genders as well as hyperuricemia prevalence i...
Source: International Journal of Endocrinology - April 6, 2019 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Genetic, Functional, and Immunological Study of ZnT8 in Diabetes.
Authors: Huang Q, Du J, Merriman C, Gong Z Abstract Zinc level in the body is finely regulated to maintain cellular function. Dysregulation of zinc metabolism may induce a variety of diseases, e.g., diabetes. Zinc participates in insulin synthesis, storage, and secretion by functioning as a "cellular second messenger" in the insulin signaling pathway and glucose homeostasis. The highest zinc concentration is in the pancreas islets. Zinc accumulation in cell granules is manipulated by ZnT8, a zinc transporter expressed predominately in pancreatic α and β cells. A common ZnT8 gene (SLC30A8) polym...
Source: International Journal of Endocrinology - April 4, 2019 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Novel Prognostic Factors Associated with Cell Cycle Control in Sporadic Medullary Thyroid Cancer Patients.
Authors: Pezzani R, Bertazza L, Cavedon E, Censi S, Manso J, Watutantrige-Fernando S, Pennelli G, Galuppini F, Barollo S, Mian C Abstract Background: Medullary thyroid cancer (MTC) is a rare neuroendocrine-derived malignancy. It is represented by sporadic and familiar forms, and both can have RET oncogene mutations. Numerous markers can be used to define MTC; however, none is generally approved for predicting the outcome of sporadic MTC. Aim: The aim of this work was to analyze PTTG1/securin and Aurora kinase A expressions in MTC patients, both at the gene and protein levels, and to define their prognostic role...
Source: International Journal of Endocrinology - March 28, 2019 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Serum Thyroglobulin: Preoperative Levels and Factors Affecting Postoperative Optimal Timing following Total Thyroidectomy.
Authors: Patel A, Shostrom V, Treude K, Lydiatt W, Smith R, Goldner W Abstract Objective: We evaluated if preoperative TG levels affected postoperative levels and if other factors may influence the optimal time to check postoperative TG. Methods: This is a prospective, observational pilot study. We approved and enrolled 50 subjects ≥ 19 years scheduled for total thyroidectomy and measured serum TG, thyroglobulin antibody (TG ab), and TSH preoperatively and post thyroidectomy at 7-14 days, 4 and 6 weeks, and 3 months in subjects with benign pathology, with additional 6- and 12-month measurements in subjects w...
Source: International Journal of Endocrinology - March 28, 2019 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Precise Detection of Gene Mutations in Fine-Needle Aspiration Specimens of the Papillary Thyroid Microcarcinoma Using Next-Generation Sequencing.
Conclusions: This study demonstrated that gene mutations in FNA specimens of PTMC could be successfully analyzed with a higher sensitivity using NGS compared to conventional methods for mutation detection. BRAF mutation of p.V600E was statistically associated with PTMC with a D max larger than 5 mm. PMID: 30915113 [PubMed] (Source: International Journal of Endocrinology)
Source: International Journal of Endocrinology - March 28, 2019 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Demographic Characteristics, Etiology, and Comorbidities of Patients with Cushing's Syndrome: A 10-Year Retrospective Study at a Large General Hospital in China.
Authors: Zhou J, Zhang M, Bai X, Cui S, Pang C, Lu L, Pang H, Guo X, Wang Y, Xing B Abstract Purpose: To investigate the demographic characteristics, etiology, and comorbidities of Cushing's syndrome (CS) patients at a large medical center in China. Methods: Records on CS patients discharged from 2008 to 2017 were retrieved from the hospital discharge abstract database (DAD) using ICD-10 codes. Demographic characteristics, etiology, and comorbidity data were analyzed. Results: Cushing's disease (CD) accounted for 63.0% of CS patients, followed by adrenocortical adenoma (ACA) (20.9%), primary bilateral macro...
Source: International Journal of Endocrinology - March 28, 2019 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Expression of PAPP-A2 and IGF Pathway-Related Proteins in the Hip Joint of Normal Rat and Those with Developmental Dysplasia of the Hip.
Authors: Chen Y, Lv H, Li L, Wang E, Zhang L, Zhao Q Abstract Developmental dysplasia of the hip (DDH) is one of the major causes of child disability and early osteoarthritis. Genetic factors play an important role, but which still remain unclear. Pregnancy-associated plasma protein-A2 (PAPP-A2), a special hydrolase of insulin-like growth factor binding protein-5 (IGFBP-5), has been confirmed to be associated with DDH by previous studies. The aim of this study was firstly, to investigate the expression of PAPP-A2 and insulin-like growth factor (IGF) pathway-related proteins in normal rat's hip joints; secondly, to ...
Source: International Journal of Endocrinology - March 28, 2019 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

An Update of the Appropriate Treatment Strategies in Anaplastic Thyroid Cancer: A Population-Based Study of 735 Patients.
Authors: Huang NS, Shi X, Lei BW, Wei WJ, Lu ZW, Yu PC, Wang Y, Ji QH, Wang YL Abstract Background: Anaplastic thyroid cancer (ATC) responds poorly to conventional therapies and requires a multidisciplinary approach to manage. The aim of the current study is to explore whether aggressive treatment is beneficial, especially the appropriate extent of surgery in ATC. Methods: Patients diagnosed with ATC from 2004 to 2014 were identified from the Surveillance, Epidemiology, and End Results (SEER) database and included in our study. Results: A total of 735 ATC patients were identified. The two-year overall survi...
Source: International Journal of Endocrinology - March 28, 2019 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Glucocorticoid Receptor Antagonist Administration Prevents Adrenal Gland Atrophy in an ACTH-Independent Cushing's Syndrome Rat Model.
In this study, MIF-treated rats had elevated plasma ACTH levels and increased adrenal weights. In addition, we confirmed that there were fewer atrophic changes, as measured by the pathological findings and mRNA expression levels of corticosterone synthase CYP11B1 in the adrenal glands, in MIF-treated rats. These results indicate that MIF treatment prevents the suppression of the HPA axis and the atrophy of the residual adrenal tissue. Therefore, our study suggests that preoperative GR antagonist administration may improve residual adrenal function and prevent postoperative adrenal insufficiency in ACTH-independent CS. ...
Source: International Journal of Endocrinology - March 28, 2019 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Melatonin in Hypoxic-Ischemic Brain Injury in Term and Preterm Babies.
Authors: Paprocka J, Kijonka M, Rzepka B, Sokół M Abstract Melatonin may serve as a potential therapeutic free radical scavenger and broad-spectrum antioxidant. It shows neuroprotective properties against hypoxic-ischemic brain injury in animal models. The authors review the studies focusing on the neuroprotective potential of melatonin and its possibility of treatment after perinatal asphyxia. Melatonin efficacy, low toxicity, and ability to readily cross through the blood-brain barrier make it a promising molecule. A very interesting thing is the difference between the half-life of melatonin in preterm ne...
Source: International Journal of Endocrinology - March 28, 2019 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Expression of Leptin Receptor and Effects of Leptin on Papillary Thyroid Carcinoma Cells.
Authors: Celano M, Maggisano V, Lepore SM, Sponziello M, Pecce V, Verrienti A, Durante C, Maranghi M, Lucia P, Bulotta S, Damante G, Russo D Abstract Background: Obesity has been hypothesized to contribute to the aggressiveness of thyroid cancer through the production of abnormal levels of serum adipokines. Leptin receptor (OB-R) expression has also been documented in papillary thyroid cancer (PTC). Aim: In this translational study, we analyzed in vitro the effects of leptin on the growth and migration of thyroid cancer cells (TPC-1 and K1), the molecular mechanisms underlying leptin's action, and the influence...
Source: International Journal of Endocrinology - March 27, 2019 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Hypertriglyceridemia and Its Association with HbA1c Test: A Prospective In Vivo Controlled Study.
Conclusion: Triglycerides do not impair the interpretation of HbA1c assay. Patients and clinicians can now be confident that hypertriglyceridemia is not an important factor when interpreting HbA1c results. PMID: 30891069 [PubMed] (Source: International Journal of Endocrinology)
Source: International Journal of Endocrinology - March 22, 2019 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Study of the Potential Endocrine-Disrupting Effects of Phenylurea Compounds on Neurohypophysis Cells In Vitro.
Authors: Sepp K, Molnár Z, László AM, Alapi T, Tóth L, Serester A, Valkusz Z, Gálfi M, Radács M Abstract Homeostatic disruptor agents, and endocrine disruptor compounds (EDC) specifically, can originate from agricultural and industrial chemicals. If they modify the adaptation of living organisms as direct (e.g., by altering hormone regulation, membrane functions) and/or indirect (e.g., cell transformation mechanisms) factors, they are classified as EDC. We aimed to examine the potential endocrine-disrupting effects of phenylurea herbicides (phenuron, monuron, and diuron) on...
Source: International Journal of Endocrinology - March 19, 2019 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Monthly Intramuscular Neridronate for the Treatment of Postmenopausal Osteoporosis: Results of a 6-Year Prospective Italian Study.
Conclusion: The monthly administration of IM NE represents a manageable and effective option, in terms of BMD and bone BM improvement, for the long-term treatment of postmenopausal OP women with gastric intolerance to BPs. This trial is registered with ClinicalTrials.gov Identifier: NCT03699150. PMID: 30881452 [PubMed] (Source: International Journal of Endocrinology)
Source: International Journal of Endocrinology - March 19, 2019 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

A Novel Pentapeptide Inhibitor Reduces Amyloid Deposit Formation by Direct Interaction with hIAPP.
Conclusions: The novel pentapeptide inhibitor FLPNF was constructed and inhibited the aggregation through direct binding to hIAPP. It is considered a suitable inhibitor for hIAPP amyloid deposit formation. PMID: 30838043 [PubMed] (Source: International Journal of Endocrinology)
Source: International Journal of Endocrinology - March 8, 2019 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Corrigendum to "Factors Associated with the Prevalence of Thyroid Nodules and Goiter in Middle-Aged Euthyroid Subjects".
Corrigendum to "Factors Associated with the Prevalence of Thyroid Nodules and Goiter in Middle-Aged Euthyroid Subjects". Int J Endocrinol. 2019;2019:9131406 Authors: Dauksiene D, Petkeviciene J, Klumbiene J, Verkauskiene R, Vainikonyte-Kristapone J, Seibokaite A, Ceponis J, Sidlauskas V, Daugintyte-Petrusiene L, Norkus A, Zilaitiene B Abstract [This corrects the article DOI: 10.1155/2017/8401518.]. PMID: 30838044 [PubMed - in process] (Source: International Journal of Endocrinology)
Source: International Journal of Endocrinology - March 8, 2019 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Association between the Number of Childbirths and the Progress of Atherosclerosis among Women with Diabetes: A Cohort Study Based on Chinese Population.
Conclusion: The increasing number of childbirths is associated with the progression of atherosclerotic stiffness among Chinese women with diabetes, independent of a variety of confounding factors. PMID: 30809258 [PubMed] (Source: International Journal of Endocrinology)
Source: International Journal of Endocrinology - March 1, 2019 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Relation of Different Components of Climate with Human Pituitary-Thyroid Axis and FT3/FT4 Ratio: A Study on Euthyroid and SCH Subjects in Two Different Seasons.
This study aims at finding the effect of temperate climate on the seasonal variations of TSH and TH in euthyroid and subclinical hypothyroidism (SCH) subjects and at evaluating if the test season has an effect on the number of subjects diagnosed as SCH. It basically focuses on the relation of different components of climate with TH and TSH. Method: In a prospective study on 152 healthy (euthyroid) volunteers and 25 SCH subjects, the serum hormone levels (TSH, FT4, and FT3) were measured in both the summer and winter seasons and correlated with all the climate components using Pearson's correlation coefficient. The effe...
Source: International Journal of Endocrinology - February 26, 2019 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

PDE5A Suppresses Proteasome Activity Leading to Insulin Resistance in C2C12 Myotubes.
Conclusions: These results suggest that PDE5A suppresses proteasome activity, which results in ER stress and subsequent insulin resistance in C2C12 myotubes. PMID: 30774657 [PubMed] (Source: International Journal of Endocrinology)
Source: International Journal of Endocrinology - February 19, 2019 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

IRF7 Gene Variations Confer Susceptibility to Autoimmune Thyroid Diseases and Graves' Ophthalmopathy.
The objective of this study was to investigate whether IRF7 polymorphisms are associated with autoimmune thyroid diseases (AITDs). We selected three single nucleotide polymorphisms (SNPs) of IRF7, namely, rs1061501, rs1131665, and rs1061502 for genotyping using PCR-based ligase detection reaction (LDR) method in a total of 1659 participants (592 with Graves' disease, 297 with Hashimoto's thyroiditis, and 770 healthy controls). Gene-disease and genotype-clinical phenotype associations were evaluated for the three SNPs. Our results showed that the AG genotype and the minor allele G frequency of rs1131665 and rs1061502 in AIT...
Source: International Journal of Endocrinology - February 19, 2019 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Metformin Counteracts HCC Progression and Metastasis Enhancing KLF6/p21 Expression and Downregulating the IGF Axis.
Conclusion: Our data show that METF could suppress HepG2 proliferation, through induction of cell cycle arrest at the G0/G1 phase. In addition, METF effect on the cancer microenvironment and on the IGF axis leads to the development of new METF therapeutic use in HCC treatment. PMID: 30774659 [PubMed] (Source: International Journal of Endocrinology)
Source: International Journal of Endocrinology - February 19, 2019 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Risk Factors for Cervical Lymph Node Metastasis of Papillary Thyroid Microcarcinoma: A Single-Center Retrospective Study.
Conclusions: Identification of risk factors for cervical LNM could assist individualization of clinical management for PTMC. PMID: 30774660 [PubMed] (Source: International Journal of Endocrinology)
Source: International Journal of Endocrinology - February 19, 2019 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Clinical Usefulness of Bioavailable Vitamin D and Impact of GC Genotyping on the Determination of Bioavailable Vitamin D in a Korean Population.
Authors: Kim HY, Kim JH, Jung MH, Cho IA, Kim Y, Cho MC Abstract Background: Bioavailable 25-hydroxy vitamin D (25(OH)D) has been suggested for the accurate determination of vitamin D status. The purpose of this study was to determine the utility of bioavailable 25(OH)D in assessing vitamin D status when vitamin D-binding protein (VDBP) was significantly altered by pregnancy and liver cirrhosis (LC). The role of genotyping of GC, a gene encoding VDBP, in the determination of bioavailable 25(OH)D concentration in a Korean population was also evaluated. Methods: This prospective study enrolled a total of 136 subj...
Source: International Journal of Endocrinology - February 19, 2019 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Integrated Bioinformatics Analysis of Hub Genes and Pathways in Anaplastic Thyroid Carcinomas.
In conclusion, the present study identified several hub genes and pathways, which will contribute to elucidating the pathogenesis of ATC and providing therapeutic targets for ATC. PMID: 30774662 [PubMed] (Source: International Journal of Endocrinology)
Source: International Journal of Endocrinology - February 19, 2019 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Early Effects of Hyperbaric Oxygen on Inducible Nitric Oxide Synthase Activity/Expression in Lymphocytes of Type 1 Diabetes Patients: A Prospective Pilot Study.
This study aimed at examining the early effects of hyperbaric oxygen therapy (HBOT) on inducible nitric oxide synthase (iNOS) activity/expression in lymphocytes of type 1 diabetes mellitus (T1DM) patients. A group of 19 patients (mean age: 63 ± 2.1) with T1DM and with the peripheral arterial disease were included in this study. Patients were exposed to 10 sessions of HBOT in the duration of 1 h to 100% oxygen inhalation at 2.4 ATA. Blood samples were collected for the plasma C-reactive protein (CRP), plasma free fatty acid (FFA), serum nitrite/nitrate, and serum arginase activity measurem...
Source: International Journal of Endocrinology - February 15, 2019 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Animal Models of Diabetes and Related Metabolic Diseases.
Authors: Sasase T, Fatchiyah F, Miyajima K, Koide M PMID: 30723499 [PubMed] (Source: International Journal of Endocrinology)
Source: International Journal of Endocrinology - February 8, 2019 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Aerobic Training Associated with Arginine Supplementation Reduces Collagen-Induced Platelet Hyperaggregability in Rats under High Risk to Develop Metabolic Syndrome.
Authors: Motta NAV, Fumian MM, Medeiros RF, Lima GF, Scaramello CBV, Oliveira KJ, Nóbrega ACL, Brito FCF Abstract Background: Increased platelet response is seen in individuals with metabolic syndrome. Previous reports have shown that arginine supplementation and aerobic exercise training enhance vascular nitric oxide (NO) activity and inhibit platelet hyperaggregability; however, the effects of their association remain unknown. Aim: To investigate whether arginine supplementation and aerobic exercise association may exert beneficial effects, reducing platelet hyperaggregability in rats under high risk t...
Source: International Journal of Endocrinology - February 8, 2019 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Is a Combination of a GnRH Agonist and Recombinant Growth Hormone an Effective Treatment to Increase the Final Adult Height of Girls with Precocious or Early Puberty?
Authors: Song W, Zhao F, Liang S, Li G, Xue J Abstract The aim of treatment for idiopathic central precocious puberty (ICPP) is to increase final adult stature, for which gonadotropin-releasing hormone agonist (GnRHa) is the gold standard. Early puberty is frequently similar to ICPP, with pubertal onset only slightly advanced. Short stature may result from early pubertal onset. Some studies have suggested that recombinant human growth hormone (rhGH) should be combined with a GnRHa to improve adult height, while others have not. Here, the aim was to compare the efficacy of combined GnRHa and rhGH treatment with GnRH...
Source: International Journal of Endocrinology - January 30, 2019 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

The Association between Glucose Control and Functional Indices in Older People with Diabetes.
Conclusion. In this cohort of older people with diabetes, there was an association between A1C and measures of functional indices. Future studies of glucose-lowering medication should include physical and functional assessment. PMID: 30675156 [PubMed] (Source: International Journal of Endocrinology)
Source: International Journal of Endocrinology - January 26, 2019 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Thyroid Dysfunction in Patients with Metabolic Syndrome: A Cross-Sectional, Epidemiological, Pan-India Study.
Conclusion: Hypothyroidism was the most common TD in Indian patients with MetS. A large proportion of TD cases diagnosed during the study highlight the need for vigilant thyroid screening in patients with MetS in a real-life setting. PMID: 30675157 [PubMed] (Source: International Journal of Endocrinology)
Source: International Journal of Endocrinology - January 26, 2019 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Response to: Comment #2 on "Differences in Ventilatory Threshold for Exercise Prescription in Outpatient Diabetic and Sarcopenic Obese Subjects".
Response to: Comment #2 on "Differences in Ventilatory Threshold for Exercise Prescription in Outpatient Diabetic and Sarcopenic Obese Subjects". Int J Endocrinol. 2018;2018:3093208 Authors: Emerenziani GP, Gallotta MC, Migliaccio S, Greco EA, Marocco C, di Lazzaro L, Fornari R, Lenzi A, Baldari C, Guidetti L PMID: 30675158 [PubMed] (Source: International Journal of Endocrinology)
Source: International Journal of Endocrinology - January 26, 2019 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Characterization of Follicular Atresia Responsive to BPA in Zebrafish by Morphometric Analysis of Follicular Stage Progression.
Authors: Migliaccio M, Chioccarelli T, Ambrosino C, Suglia A, Manfrevola F, Carnevali O, Fasano S, Pierantoni R, Cobellis G Abstract Bisphenol A is an industrial chemical compound, pervasively polluting the environment and diet, classified as an endocrine disruptor because of its interference effects on the endocrine system. In zebrafish, BPA exposure induces follicular atresia. To acquire knowledge on this atretic effect, using a qualitative and quantitative histomorphological approach, we studied zebrafish ovarian follicular stage development in response to low BPA concentrations. Results show that BPA interferes...
Source: International Journal of Endocrinology - January 26, 2019 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Vanadyl Sulfate Effects on Systemic Profiles of Metabolic Syndrome in Old Rats with Fructose-Induced Obesity.
Conclusion: VS could play an important role in the treatment of metabolic syndrome, contributing to a decrease in obesity and T2DM, through different ways, such as euglycemia, satiety, weight loss, and lipid profile optimization, among others. However, more research is needed to confirm this suggestion. PMID: 30675160 [PubMed] (Source: International Journal of Endocrinology)
Source: International Journal of Endocrinology - January 26, 2019 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Nerve Growth Factor Levels in Term Human Infants: Relationship to Prenatal Growth and Early Postnatal Feeding.
Conclusions: Circulating NGF is related to both prenatal growth and early postnatal nutrition. The maintenance of increased NGF concentrations in SGA-breastfed infants at age 4 months might be a potential mechanism to counterbalance potential risks for developing cognitive and psychomotor disadvantages. PMID: 30675161 [PubMed] (Source: International Journal of Endocrinology)
Source: International Journal of Endocrinology - January 26, 2019 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Relationship of Circulating Fetuin-A Levels with Body Size and Metabolic Phenotypes.
Conclusions: This study demonstrates that fetuin-A levels are significantly associated with metabolic health phenotypes, such as MHO and MANW, in Korean adults. PMID: 30675162 [PubMed] (Source: International Journal of Endocrinology)
Source: International Journal of Endocrinology - January 26, 2019 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Response to: Comment on "The Gut Microbiome Profile in Obesity: A Systematic Review".
Response to: Comment on "The Gut Microbiome Profile in Obesity: A Systematic Review". Int J Endocrinol. 2018;2018:9109451 Authors: Castañer O, Schröder H PMID: 30671094 [PubMed] (Source: International Journal of Endocrinology)
Source: International Journal of Endocrinology - January 25, 2019 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Autoimmune Diseases in Patients with Cushing's Syndrome after Resolution of Hypercortisolism: Case Reports and Literature Review.
Conclusions: Our results demonstrate that patients successfully treated for CS could develop autoimmune diseases. Therefore, after treatment, CS patients need to be strictly monitored in order to evaluate the possible onset of autoimmune diseases. PMID: 30662460 [PubMed] (Source: International Journal of Endocrinology)
Source: International Journal of Endocrinology - January 23, 2019 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Hepatic Steatosis Index in Acromegaly: Correlation with Insulin Resistance Regardless of the Disease Control.
Authors: Ciresi A, Guarnotta V, Campo D, Giordano C Abstract Objective: In acromegaly, both lipotoxicity secondary to GH excess and insulin resistance have a significant impact on the liver. Ultrasonography has shown poor sensitivity in detecting hepatic steatosis and noninvasive methods have been proposed. We evaluated the hepatic steatosis index (HSI), a validated surrogate index of hepatic steatosis, and we correlated it with disease activity and insulin resistance. Design: Thirty-one patients with newly diagnosed acromegaly were studied at diagnosis and after 12 months of treatment with somatostatin recepto...
Source: International Journal of Endocrinology - January 23, 2019 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Clinical Diagnosis of X-Linked Spondyloepiphyseal Dysplasia Tarda and a Novel Missense Mutation in the Sedlin Gene (SEDL).
Conclusion: SEDT in this family was caused by a G/C missense mutation in exon 6 of the SEDL gene, previously not shown to be associated with X-linked SEDT. PMID: 30647738 [PubMed] (Source: International Journal of Endocrinology)
Source: International Journal of Endocrinology - January 17, 2019 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Metabolic Syndrome and Its Components Predict the Risk of Type 2 Diabetes Mellitus in the Mainland Chinese: A 3-Year Cohort Study.
Conclusions: MetS predicts the risk of T2DM. The quantitative MetS-based prediction model for T2DM risk may improve preventive strategies for T2DM and present considerable public health benefits for the people in mainland China. PMID: 30647739 [PubMed] (Source: International Journal of Endocrinology)
Source: International Journal of Endocrinology - January 17, 2019 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

The Value of Peripheral Enhancement Pattern for Diagnosing Thyroid Cancer Using Contrast-Enhanced Ultrasound.
The objective of this study was to investigate the diagnostic accuracy of the peripheral enhancement patterns during CEUS scanning of thyroid nodules. Material and Methods: 120 nodules with peripheral rings during CEUS and definite pathology confirmed by surgery were included in this study. The internal and peripheral CEUS enhancement patterns of these nodules were assessed, and the diagnostic value of CEUS was compared with the conventional ultrasound. The relationship of types of peripheral rings and sizes of nodules was analyzed, respectively. Results: There were 78 benign and 42 malignant nodules. Peripheral ir...
Source: International Journal of Endocrinology - January 12, 2019 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

High Expression of Somatostatin Receptors 2A, 3, and 5 in Corticotroph Pituitary Adenoma.
Authors: Behling F, Honegger J, Skardelly M, Gepfner-Tuma I, Tabatabai G, Tatagiba M, Schittenhelm J Abstract The development of somatostatin analogs for the treatment of pituitary Cushing's disease has been based on somatostatin receptor expression analyses of small cohorts of pituitary adenomas. Additionally, the classification of pituitary adenomas has recently changed. To enable progress with this treatment option, we assessed somatostatin receptors in a large cohort of corticotroph and other pituitary adenomas according to the new WHO classification of endocrine tumors. Paraffin-embedded tumor samples of 88 co...
Source: International Journal of Endocrinology - January 12, 2019 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Atherogenic Index in Type 2 Diabetes and Its Relationship with Chronic Microvascular Complications.
This study was designed to investigate risk factors related to atherogenic index of plasma (AIP), as well as the relationship between AIP and chronic microvascular complications in patients with type 2 diabetes (T2DM). Methods: This study included 2523 patients with T2DM who had not been treated with lipid-lowering drugs and were admitted to the Department of Endocrinology at Zhongnan Hospital, Wuhan University, during the period from January 2015 to February 2018. Anthropometric indicators were measured after overnight fasting. Low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), ...
Source: International Journal of Endocrinology - January 12, 2019 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Concentrations of Selected Adipokines, Interleukin-6, and Vitamin D in Patients with Papillary Thyroid Carcinoma in Respect to Thyroid Cancer Stages.
In this study, we estimated serum concentrations of leptin, adiponectin, chemerin, interleukin-6 (IL-6), and vitamin D in patients with papillary thyroid cancer (PTC). We searched for associations between the adipokines, IL-6, vitamin D, anthropometric parameters, and TNM AJCC/UICC 2017 classification in 177 patients diagnosed with PTC (151 women and 26 men). Normal weight patients were predominantly classified as clinical stage I. The prevalence of stages higher than I was significantly higher in PTC patients with BMI ≥ 25 or with metabolic syndrome. Using logistic regression waist circumference &g...
Source: International Journal of Endocrinology - January 12, 2019 Category: Endocrinology Tags: Int J Endocrinol Source Type: research