Prevention of Elevation in Plasma Triacylglycerol with High-Dose Bezafibrate Treatment Abolishes Insulin Resistance and Attenuates Glucose Intolerance Induced by Short-Term Treatment with Dexamethasone in Rats.
Conclusion: High-dose bezafibrate treatment prevents the increase in plasma triacylglycerol and the development of insulin resistance and attenuates glucose intolerance in rats caused by GC treatment, indicating the involvement of dyslipidemia in the GC-induced insulin resistance. PMID: 30532777 [PubMed] (Source: International Journal of Endocrinology)
Source: International Journal of Endocrinology - December 13, 2018 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Peripheral Arterial Disease in Type 2 Diabetes Is Associated with an Increase in Fibrinogen Levels.
Authors: Chen QF, Cao D, Ye TT, Deng HH, Zhu H Abstract Background: The present study is undertaken to investigate the fibrinogen levels in type 2 diabetes mellitus (T2DM) and its relation to peripheral artery disease (PAD) based on a more accurate and applied noninvasive measurements of duplex ultrasonography. Methods: We performed a cross-sectional study including 1096 T2DM patients (474 males and 622 females). The odds ratios (ORs) and 95% confidence intervals (CIs) were presented to show the association between PAD and fibrinogen in the subjects divided by fibrinogen levels quarterly. Furthermore, the univa...
Source: International Journal of Endocrinology - December 13, 2018 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Safety and Efficacy of Low-Level Laser Therapy in Autoimmune Thyroiditis: Long-Term Follow-Up Study.
Conclusion: LLLT, by the methods described, has been shown to be safe for the treatment of hypothyroidism resulting from CAT. This trial is registered with ClinicalTrials.gov Identifier: NCT02240563. PMID: 30532779 [PubMed] (Source: International Journal of Endocrinology)
Source: International Journal of Endocrinology - December 13, 2018 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Intranasal Insulin Administration Does Not Affect LH Concentrations in Men with Diabetes.
Authors: Dhindsa S, Chemitiganti R, Ghanim H, Santiago E, Haider A, Chaar N, Mok M, McKee A, Dandona P Abstract A quarter of men with obesity or type 2 diabetes have hypogonadotropic hypogonadism. Animal studies and in vitro data have shown that insulin action and insulin responsiveness in the brain are necessary for the maintenance of the functional integrity of the hypothalamo-hypophyseal-gonadal axis. We conducted a randomized, placebo-controlled trial to evaluate the effect of one dose of intranasal insulin (40 IU of regular insulin) or saline on LH concentrations in 14 men (8 with type 2 diabetes and 6 ...
Source: International Journal of Endocrinology - December 7, 2018 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Effects of Estrogen and Estrogen Receptors on Transcriptomes of HepG2 Cells: A Preliminary Study Using RNA Sequencing.
Authors: Shen M, Cao J, Shi H Abstract Men have a much higher incidence of hepatocellular carcinoma (HCC), the predominant form of liver cancer, than women, suggesting that estrogens play a protective role in liver cancer development and progression. To begin to understand the potential mechanisms of estrogens' inhibitory effects on HCC development, RNA sequencing was used to generate comprehensive global transcriptome profiles of the human HCC-derived HepG2 cell line following treatment of vehicle (control), estradiol (E2), estrogen receptor alpha- (ERα-) specific agonist 1,3,5-tris(4-hydroxyphenyl)-4-propyl...
Source: International Journal of Endocrinology - December 6, 2018 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Fasting-Evoked En Route Hypoglycemia in Diabetes (FEEHD): An Overlooked Form of Hypoglycemia in Clinical Practice.
Conclusion: Our study shows a significant rate of occurrence of FEEHD in the real world (a clinical practice). FEEHD is especially dangerous, as patients often commute (drive) to and from the laboratory facility (potential risk of traffic accidents). Given study limitations, further studies are needed to assess prevalence of FEEHD in other settings and in the general populations. PMID: 30473710 [PubMed] (Source: International Journal of Endocrinology)
Source: International Journal of Endocrinology - November 27, 2018 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Corrigendum to "Chronic Glucocorticoid-Rich Milieu and Liver Dysfunction".
Corrigendum to "Chronic Glucocorticoid-Rich Milieu and Liver Dysfunction". Int J Endocrinol. 2018;2018:1239718 Authors: Villagarcía HG, Sabugo V, Castro MC, Schinella G, Castrogiovanni D, Spinedi E, Massa ML, Francini F Abstract [This corrects the article DOI: 10.1155/2016/7838290.]. PMID: 30425740 [PubMed - in process] (Source: International Journal of Endocrinology)
Source: International Journal of Endocrinology - November 16, 2018 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Characteristics and Outcomes of 79 Patients with an Insulinoma: A Nationwide Retrospective Study in Finland.
Authors: Peltola E, Hannula P, Huhtala H, Metso S, Kiviniemi U, Vornanen M, Sand J, Laukkarinen J, Tiikkainen M, Schalin-Jäntti C, Arola J, Sirén J, Piiroinen A, Soinio M, Nuutila P, Söderström M, Hämäläinen H, Moilanen L, Laaksonen D, Pirinen E, Sundelin F, Ebeling T, Salmela P, Mäkinen MJ, Jaatinen P Abstract Objective: Insulinomas are rare pancreatic tumours. Population-based data on their incidence, clinical picture, diagnosis, and treatment are almost nonexistent. The aim of this study was to clarify these aspects in a nationwide cohort of insulinoma patients diagnosed...
Source: International Journal of Endocrinology - November 16, 2018 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Is Atorvastatin Associated with New Onset Diabetes or Deterioration of Glycemic Control? Systematic Review Using Data from 1.9 Million Patients.
Conclusion: This systematic review suggests that there is an association between atorvastatin treatment and NOD. Moreover, it showed that atorvastatin in high dose causes worsening of the glycemic control in patients with DM. PMID: 30425742 [PubMed] (Source: International Journal of Endocrinology)
Source: International Journal of Endocrinology - November 16, 2018 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Corrigendum to "Expression of Intratumoral IGF-II Is Regulated by the Gene Imprinting Status in Triple Negative Breast Cancer from Vietnamese Patients".
Corrigendum to "Expression of Intratumoral IGF-II Is Regulated by the Gene Imprinting Status in Triple Negative Breast Cancer from Vietnamese Patients". Int J Endocrinol. 2018;2018:8434297 Authors: Radhakrishnan VK, Hernandez LC, Anderson K, Tan Q, De León M, De León DD Abstract [This corrects the article DOI: 10.1155/2015/401851.]. PMID: 30425743 [PubMed - in process] (Source: International Journal of Endocrinology)
Source: International Journal of Endocrinology - November 16, 2018 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Palmitic Acid Downregulates Thyroglobulin (Tg), Sodium Iodide Symporter (NIS), and Thyroperoxidase (TPO) in Human Primary Thyrocytes: A Potential Mechanism by Which Lipotoxicity Affects Thyroid?
This study aimed to assess the effect of palmitic acid stimulation on thyrocyte function. Upon palmitic acid stimulation, intracellular contents of lipids, as well as the expression and activity of three key molecules in thyroid hormone synthesis (i.e., thyroglobulin, sodium iodide symporter, and thyroperoxidase), were determined in human primary thyrocytes. The contents of BODIPY® FL C16 (the fluorescently labeled palmitic acid analogue) entering into the thyrocytes were gradually increased with time extending. Accordingly, the intracellular accumulation of both triglyceride and free fatty acids increased in dose- and...
Source: International Journal of Endocrinology - November 14, 2018 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Influence of Methylprednisolone Pulse Therapy on Liver Function in Patients with Graves' Orbitopathy.
Conclusion: Therapy of GO with higher doses (1.0 g) of IVMP in consecutive days is associated with higher risk of liver damage than treatment with moderate doses (≤0.5 g) in every week schedule. This trial is registered with NCT03667157. PMID: 30420883 [PubMed] (Source: International Journal of Endocrinology)
Source: International Journal of Endocrinology - November 14, 2018 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Gender in Endocrine Diseases: Role of Sex Gonadal Hormones.
Authors: Lauretta R, Sansone M, Sansone A, Romanelli F, Appetecchia M Abstract Gender- and sex- related differences represent a new frontier towards patient-tailored medicine, taking into account that theoretically every medical specialty can be influenced by both of them. Sex hormones define the differences between males and females, and the different endocrine environment promoted by estrogens, progesterone, testosterone, and their precursors might influence both human physiology and pathophysiology. With the term Gender we refer, instead, to behaviors, roles, expectations, and activities carried out by the indiv...
Source: International Journal of Endocrinology - November 14, 2018 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Clinical, Genetics, and Bioinformatic Characterization of Mutations Affecting an Essential Region of PLS3 in Patients with BMND18.
Conclusions: This report identified a novel mutation that truncates the PLS3 gene. Moreover, bioinformatic analyses of the previous reported mutations in PLS3 gene lead us to find a critical LOOP-1 region of plastin-3 mutations at which may be detrimental to the integral conformation of plastin-3 and thus affect its binding to actin filament. PMID: 30405713 [PubMed] (Source: International Journal of Endocrinology)
Source: International Journal of Endocrinology - November 10, 2018 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Combination of Maximum Shear Wave Elasticity Modulus and TIRADS Improves the Diagnostic Specificity in Characterizing Thyroid Nodules: A Retrospective Study.
Conclusions: Combining SWE and TIRADS improves the specificity of TIRADS-alone in differentiating between benign and malignant thyroid nodules. PMID: 30402095 [PubMed] (Source: International Journal of Endocrinology)
Source: International Journal of Endocrinology - November 9, 2018 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Breg Cells in Celiac Disease Isolated or Associated to Hashimoto's Thyroiditis.
In conclusion, celiac disease, isolated and even more when associated with HT, determines a peculiar behavior of Breg cells which are increased in number but possibly functionally defective. Furthermore, the association CD + HT was characterized by a reduction of Breg memory subsets as compared with the isolated disorders. The behavior of Th17 subset in patients with celiac disease associated with HT might have been sensitive to the effect of long-lasting GFD, and it is essentially determined by the presence of thyroid autoimmunity. PMID: 30402096 [PubMed] (Source: International Journal of Endocrinology)
Source: International Journal of Endocrinology - November 9, 2018 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Irisin a Novel Metabolic Biomarker: Present Knowledge and Future Directions.
Authors: Martinez Munoz IY, Camarillo Romero EDS, Garduno Garcia JJ Abstract The rising prevalence of chronic diseases such as type 2 diabetes and cardiovascular diseases owing to fat mass excess has been described. In recent years, muscle function/dysfunction has become relevant in metabolic homeostasis. Irisin was described as an exercise-induced myokine. It is the product of type I membrane protein cleavage encoded by the fibronectin type III domain containing 5 (FNDC5) gene. The main beneficial function attributable to irisin is the change of subcutaneous and visceral adipose tissue into brown adipose tissue, w...
Source: International Journal of Endocrinology - November 9, 2018 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Support Needs of Patients with Cushing's Disease and Cushing's Syndrome: Results of a Survey Conducted in Germany and the USA.
Conclusion: Patients in both countries need skilled physicians and long-term medical care in dealing with the effects of CD/CS, whereas other support needs differ between patients of both countries. The latter implies that not only disease-specific but also culture-specific training programs would need to be considered to satisfy the needs of patients in different countries. PMID: 30402098 [PubMed] (Source: International Journal of Endocrinology)
Source: International Journal of Endocrinology - November 9, 2018 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Translational Significance of Selective Estrogen Receptor Modulators in Psychiatric Disorders.
Authors: Khan MM Abstract Accumulating data from various clinical trial studies suggests that adjuvant therapy with ovarian hormones (estrogens) could be effective in reducing cognitive deficit and psychopathological symptoms in women with psychiatric disorders. However, estrogen therapy poses serious limitations and health issues including feminization in men and increased risks of thromboembolism, hot flashes, breast hyperplasia, and endometrium hyperplasia when used for longer duration in older women (aged ≥ 60 years) or in women who have genetic predispositions. On the other hand, selective est...
Source: International Journal of Endocrinology - November 9, 2018 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Melatonin: An Anti-Tumor Agent in Hormone-Dependent Cancers.
Authors: Menéndez-Menéndez J, Martínez-Campa C Abstract Melatonin (N-acetyl-5-methoxytryptamine) is a hormone synthesized and secreted by the pineal gland mainly during the night, since light exposure suppresses its production. Initially, an implication of this indoleamine in malignant disease was described in endocrine-responsive breast cancer. Data from several clinical trials and multiple experimental studies performed both in vivo and in vitro have documented that the pineal hormone inhibits endocrine-dependent mammary tumors by interfering with the estrogen signaling-mediated transcription...
Source: International Journal of Endocrinology - November 4, 2018 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Newer Perspectives of Mechanisms for Euglycemic Diabetic Ketoacidosis.
Authors: Yu X, Zhang S, Zhang L Abstract Euglycemic diabetic ketoacidosis (EDKA) was considered a rare condition with its specific definition and precipitating factors. However, with the wide use of sodium glucose cotransporter 2 (SGLT-2) inhibitors, the newest class of antidiabetic agents, EDKA has come back into the spotlight. Relevant cases are increasingly being reported along with insights into the mechanism of EDKA. It seems increasingly clear that EDKA is more common than we used to believe. The SGLT-2 inhibitor-associated EDKA also indicates a necessary review of our previous understanding of "diabetic...
Source: International Journal of Endocrinology - October 31, 2018 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Follicular Development and Secretion of Ovarian Hormones during the Juvenile and Adult Reproductive Lives of the Myelin Mutant taiep Rat: An Animal Model of Demyelinating Diseases.
Authors: Muñoz-de-la-Torre LP, Eguibar JR, Cortés C, Ugarte A, Trujillo A Abstract Infertility and reproductive problems have been reported in women with several neurological disorders, for example, demyelination. However, the physiology of such problems has remained unknown so far. The taiep rats are an animal neurological model that initially shows a hypomyelination followed by a progressive demyelination of the central nervous system. This animal has reproductive problems, and the aim of this work is to characterize the follicular development, secretion of ovarian hormones, and presence of noradren...
Source: International Journal of Endocrinology - October 28, 2018 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Energy Sensors in Female and Male Reproduction and Fertility.
Authors: Dupont J, Bertoldo MJ, Rak A PMID: 30363723 [PubMed] (Source: International Journal of Endocrinology)
Source: International Journal of Endocrinology - October 28, 2018 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Comparison of Initial Clinical Presentations between Primary Hyperparathyroidism Patients from New Brunswick and Changsha.
Authors: Meng L, Liu S, Al-Dayyeni A, Sheng Z, Zhou Z, Wang X Abstract Purpose: To compare the initial clinical features, laboratory values, and bone mineral density among patients with primary hyperparathyroidism (PHPT) in Changsha (China) and New Brunswick (USA). Methods: In this retrospective study, we reviewed 169 PHPT patients who presented at Robert Wood Johnson University Hospital and 133 PHPT patients who presented at the Second Xiangya Hospital of Central South University in the same time period. The following characteristics were compared between the groups: age, gender, BMI, serum calcium, alkaline p...
Source: International Journal of Endocrinology - October 28, 2018 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Corrigendum to "4-Phenylbutyric Acid Attenuates Pancreatic Beta-Cell Injury in Rats with Experimental Severe Acute Pancreatitis".
Corrigendum to "4-Phenylbutyric Acid Attenuates Pancreatic Beta-Cell Injury in Rats with Experimental Severe Acute Pancreatitis". Int J Endocrinol. 2018;2018:6307830 Authors: Hong YP, Guo WY, Wang WX, Zhao L, Xiang MW, Mei FC, Abliz A, Hu P, Deng WH, Yu J Abstract [This corrects the article DOI: 10.1155/2016/4592346.]. PMID: 30344605 [PubMed - in process] (Source: International Journal of Endocrinology)
Source: International Journal of Endocrinology - October 24, 2018 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Spontaneously Diabetic Torii (SDT) Fatty Rat, a Novel Animal Model of Type 2 Diabetes Mellitus, Shows Blunted Circadian Rhythms and Melatonin Secretion.
Authors: Sakimura K, Maekawa T, Kume SI, Ohta T Abstract In patients with diabetes mellitus (DM), impairments of circadian rhythms, including the sleep-wake cycle, blood pressure, and plasma melatonin concentrations, are frequently observed. Animal models of DM are also reported to show aberrant circadian rhythms. However, the changes in the circadian rhythms of plasma soluble substances, including melatonin, in diabetic animals are controversial. In the present study, we investigated the circadian rhythms of spontaneous locomotor activity, metabolic parameters (plasma glucose, triglyceride, and total cholesterol),...
Source: International Journal of Endocrinology - October 24, 2018 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Sex- and Age-Specific Optimal Anthropometric Indices as Screening Tools for Metabolic Syndrome in Chinese Adults.
Conclusions: In Chinese adults, WHtR and BRI showed a superior predictive power for MetS in both sexes, which can be used as simple and effective screening tools for cardiometabolic risks and MetS in clinical practice. PMID: 30310390 [PubMed] (Source: International Journal of Endocrinology)
Source: International Journal of Endocrinology - October 14, 2018 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Serum Matrix Metalloproteinase 9 and Macrophage Migration Inhibitory Factor (MIF) Are Increased in Young Healthy Nonobese Subjects with Positive Family History of Type 2 Diabetes.
Authors: Nikołajuk A, Matulewicz N, Stefanowicz M, Karczewska-Kupczewska M Abstract Insulin resistance increases the risk for cardiovascular disease (CVD) even in the absence of classic risk factors, such as hyperglycemia, hypertension, dyslipidemia, and obesity. Low-grade chronic inflammatory state is associated both with insulin resistance and atherosclerosis. An increased circulating level of proinflammatory proatherogenic factors and biomarkers of endothelial activation was observed in diabetes and CVD. The aim of our study was to assess serum proatherogenic and proinflammatory factors in young healthy nonobes...
Source: International Journal of Endocrinology - October 12, 2018 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Effectiveness of Coenzyme Q10 Supplementation for Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis.
Conclusion: Based on current evidence, coenzyme Q10 may assist glycemic control, decrease TG, and improve HDL-C in patients with T2DM. PMID: 30305810 [PubMed] (Source: International Journal of Endocrinology)
Source: International Journal of Endocrinology - October 12, 2018 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Corrigendum to "Beta-Arrestin 1 Mediates Liver Thyrotropin Regulation of Cholesterol Conversion Metabolism via the Akt-Dependent Pathway".
Corrigendum to "Beta-Arrestin 1 Mediates Liver Thyrotropin Regulation of Cholesterol Conversion Metabolism via the Akt-Dependent Pathway". Int J Endocrinol. 2018;2018:3029602 Authors: Niu S, Li H, Chen W, Zhao J, Gao L, Bo T Abstract [This corrects the article DOI: 10.1155/2018/4371396.]. PMID: 30275826 [PubMed - in process] (Source: International Journal of Endocrinology)
Source: International Journal of Endocrinology - October 4, 2018 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Corrigendum to "Myoinositol: The Bridge (PONTI) to Reach a Healthy Pregnancy".
Corrigendum to "Myoinositol: The Bridge (PONTI) to Reach a Healthy Pregnancy". Int J Endocrinol. 2018;2018:6050369 Authors: Cavalli P, Ronda E Abstract [This corrects the article DOI: 10.1155/2017/5846286.]. PMID: 30275827 [PubMed - in process] (Source: International Journal of Endocrinology)
Source: International Journal of Endocrinology - October 4, 2018 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Waist Circumference Coupled with Either HDL-C or TG Can Be Used as a Diagnostic Marker for Metabolic Syndrome in Chinese Women with Polycystic Ovary Syndrome.
Authors: Sun Y, Wang W, Shen Q, Du S, Guo Y, He F, Zhang W Abstract Although quite a few polycystic ovary syndrome (PCOS) patients suffering from metabolic syndrome (MS) have been reported in previous studies, no reliable and early diagnostic biomarkers for MS in PCOS patients have yet been identified. To identify early and reliable diagnostic biomarkers for MS in Chinese women with PCOS, a total of 401 patients (200 PCOS patients and 201 controls) were enrolled in our present study. All of the subjects were examined for anthropometric (weight, waist circumference, blood pressure, etc.) and biochemical (fasting glu...
Source: International Journal of Endocrinology - October 4, 2018 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Corrigendum to "Different Effects of Myoinositol plus Folic Acid versus Combined Oral Treatment on Androgen Levels in PCOS Women".
Corrigendum to "Different Effects of Myoinositol plus Folic Acid versus Combined Oral Treatment on Androgen Levels in PCOS Women". Int J Endocrinol. 2018;2018:7502102 Authors: Ozay AC, Ozay OE, Okyay RE, Cagliyan E, Kume T, Gulekli B Abstract [This corrects the article DOI: 10.1155/2016/3206872.]. PMID: 30275829 [PubMed - in process] (Source: International Journal of Endocrinology)
Source: International Journal of Endocrinology - October 4, 2018 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Free Testosterone Reflects Metabolic as well as Ovarian Disturbances in Subfertile Oligomenorrheic Women.
Conclusions: Assessing SHBG and free testosterone is important in evaluating androgen excess in subfertile women with ovulatory dysfunction and suspected PCOS, as it reflects both ovarian and metabolic disturbances. PMID: 30275830 [PubMed] (Source: International Journal of Endocrinology)
Source: International Journal of Endocrinology - October 4, 2018 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Differential Relationship between Intermuscular Adipose Depots with Indices of Cardiometabolic Health.
Conclusions: The strength of the relationship between IMAT and glucose control-related indices of cardiometabolic health is dependent on IMAT location. Specifically, greater IMAT in the thigh is a better predictor of cardiometabolic risk than greater IMAT in the calf in adults who are overweight and obese. PMID: 30254672 [PubMed] (Source: International Journal of Endocrinology)
Source: International Journal of Endocrinology - September 28, 2018 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

The Influence of Obesity on Puberty and Insulin Resistance in Mexican Children.
Authors: Cardenas-Vargas E, Nava JA, Garza-Veloz I, Torres-Castañeda MC, Galván-Tejada CE, Cid-Baez MA, Castañeda-Arteaga RE, Ortiz-Castro Y, Trejo-Ortiz PM, Araujo-Espino R, Mollinedo-Montaño FE, Muñoz-Torres JR, Martinez-Fierro ML Abstract Obesity is considered the main risk factor associated with the development of insulin resistance (IR). The aim of this study was to evaluate the influence of obesity on puberty onset and IR in Mexican children. A total of 378 children (189 boys and 189 girls) aged 8-14 years participated in the study. IR was estimated using the homeostasis mod...
Source: International Journal of Endocrinology - September 28, 2018 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Efficacy of Shear-Wave Elastography for Detecting Postoperative Cervical Lymph Node Metastasis in Papillary Thyroid Carcinoma.
Authors: Kim HJ, Choi IH, Jin SY, Park HK, Byun DW, Suh K, Yoo MH Abstract Aims: To evaluate shear-wave elastography (SWE) as a tool to detect postoperative cervical lymph node (LN) metastasis in patients with papillary thyroid carcinoma (PTC). Methods: Forty-three LNs of 43 patients with PTC undergoing ultrasound (US) and SWE before ultrasound-guided fine-needle aspiration (FNA) for the evaluation of postoperative cervical LN recurrences were analyzed. The mean (EMean), minimum (EMin), maximum (EMax), and standard deviation (ESD) of SWE elasticity indices were measured. Results: Among 43 indeterminate or s...
Source: International Journal of Endocrinology - September 28, 2018 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Erratum to "Hypophyseal Involvement in Immunoglobulin G4-Related Disease: A Retrospective Study from a Single Tertiary Center".
Erratum to "Hypophyseal Involvement in Immunoglobulin G4-Related Disease: A Retrospective Study from a Single Tertiary Center". Int J Endocrinol. 2018;2018:3457046 Authors: Liu Y, Wang L, Zhang W, Pan H, Yang H, Deng K, Lu L, Yao Y, Chen S, Chai X, Feng F, You H, Jin Z, Zhu H Abstract [This corrects the article DOI: 10.1155/2018/7637435.]. PMID: 30258459 [PubMed - in process] (Source: International Journal of Endocrinology)
Source: International Journal of Endocrinology - September 28, 2018 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Corrigendum to "Identification of Differentially Expressed Genes in Pituitary Adenomas by Integrating Analysis of Microarray Data".
Corrigendum to "Identification of Differentially Expressed Genes in Pituitary Adenomas by Integrating Analysis of Microarray Data". Int J Endocrinol. 2018;2018:6069189 Authors: Zhao P, Hu W, Wang H, Yu S, Li C, Bai J, Gui S, Zhang Y Abstract [This corrects the article DOI: 10.1155/2015/164087.]. PMID: 30258460 [PubMed - in process] (Source: International Journal of Endocrinology)
Source: International Journal of Endocrinology - September 28, 2018 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Positive Antithyroid Antibodies and Nonsuppressed TSH Are Associated with Thyroid Cancer: A Retrospective Cross-Sectional Study.
Authors: Krátký J, Ježková J, Kosák M, Vítková H, Bartáková J, Mráz M, Lukáš J, Límanová Z, Jiskra J Abstract The relationship between Hashimoto's thyroiditis (HT) and thyroid cancer (TC) is a controversial topic; it remains unclear if HT acts as a risk factor of TC. The aim of our study was to compare the presence of HT and thyroid function in patients with TC and benign nodules. We analyzed 2571 patients after fine needle aspiration biopsy of thyroid nodule. Totally, 91 patients with primary TC and 182 sex- and age-matched...
Source: International Journal of Endocrinology - September 28, 2018 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Thyroid Function in Korean Adolescents with Obesity: Results from the Korea National Health and Nutrition Examination Survey VI (2013-2015).
In this study, we investigated the status of thyroid function and its association with metabolic risk factors in Korean adolescents. Methods: Among 2679 subjects aged 10-19 years who participated in the Korea National Health and Nutrition Examination Survey VI (2013-2015), 1067 adolescents (M = 559, F = 508) with available data on free T4 (FT4) and thyroid-stimulating hormone (TSH) were included. Study participants were classified into normal weight [body mass index (BMI) below 85th percentile, 80.7%], overweight (85th ≤ BMI
Source: International Journal of Endocrinology - September 27, 2018 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Cardiometabolic Changes in Different Gonadal Female States Caused by Mild Hyperuricemia and Exposure to a High-Fructose Diet.
The objective of this study is to observe if mild hyperuricemia and a high-fructose diet influence the cardiovascular and metabolic systems in hypogonadic female Wistar rats compared to normogonadic female rats. Methods: Fifty-six (56) adult female Wistar rats were used in the present work. Animals were divided into two groups: normogonadic (NGN) and hypogonadic (HGN). These groups were also divided into four subgroups in accordance with the treatment: control with only water (C), fructose (F), oxonic acid (OA), and fructose + oxonic acid (FOA). Lipid profile, glycemia, uric acid, and creatinine determina...
Source: International Journal of Endocrinology - September 25, 2018 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Selected Metabolic Markers in Girls with Turner Syndrome: A Pilot Study.
Authors: Błaszczyk E, Lorek M, Francuz T, Gieburowska J, Gawlik A Abstract Background: Turner syndrome (TS) predisposes an individual to obesity and related metabolic disorders. As the TS population is at a higher risk of cardiovascular diseases and malformations, research into laboratory markers of metabolic complications has been ongoing. Special significance has recently been attributed to matrix metalloproteinases (MMPs), their inhibitors (TIMPs), and neurotrophic factors, such as BDNF and GDNF. Objective: To establish whether cardiometabolic risk in patients with TS is reflected in the concentrations of m...
Source: International Journal of Endocrinology - September 25, 2018 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Management and Follow-up of Patients with a Bronchial Neuroendocrine Tumor in the Last Twenty Years in Ireland: Expected Inconsistencies and Unexpected Discoveries.
Authors: Agasarova A, Harnett C, Mulligan N, Majeed MS, Caimo A, Tamagno G Abstract Bronchial neuroendocrine tumors (NET) are classified into well-differentiated typical carcinoids (TC), atypical carcinoids (AC), large cell neuroendocrine carcinomas (LCNEC), and small cell lung carcinomas (SCLC). We retrospectively reviewed and analyzed the diagnostic and therapeutic aspects, follow-up data, and outcomes of all patients diagnosed with a bronchial NET from 1995 to 2015 at our institution. Patients with LCNEC or SCLC were excluded due to the biological and clinical differences from the other bronchial NET. The clinic...
Source: International Journal of Endocrinology - September 21, 2018 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Interplay between Body Size Measures and Thyroid Cancer Aggressiveness: A Retrospective Analysis.
Authors: de Melo TG, da Assumpção LVM, Zantut-Wittmann DE Abstract Considering controversial data about the relationship between body size and prognosis of differentiated thyroid cancer (DTC), the current study aimed to assess the influence of body weight, body mass index (BMI), and body surface area (BSA) on DTC. We conducted a retrospective analysis of patients' records from the Thyroid Cancer Unit, assessing body size measures, clinical and laboratory prognostic factors, and disease evolution. 337 patients, aged 45.95 ± 13.04 years old, with BMI of 27.87 ± ...
Source: International Journal of Endocrinology - September 20, 2018 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Cardiovascular Risk and Metabolic Syndrome Characteristics in Patients with Nonfunctional Pituitary Macroadenoma.
Conclusion: A high prevalence of cardiovascular and metabolic disease and a high cardiovascular risk were evidenced in patients with NFPMA, especially in men. Risk factors such as the personal history of hypertension and dyslipidemia could explain the foregoing, so the control and treatment of metabolic parameters and cardiovascular risk should be an integral part of the follow-up of these patients. PMID: 30224919 [PubMed] (Source: International Journal of Endocrinology)
Source: International Journal of Endocrinology - September 20, 2018 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Comment on "The Gut Microbiome Profile in Obesity: A Systematic Review".
Comment on "The Gut Microbiome Profile in Obesity: A Systematic Review". Int J Endocrinol. 2018;2018:6015278 Authors: Alwardat N, Di Renzo L, De Lorenzo A PMID: 30210540 [PubMed] (Source: International Journal of Endocrinology)
Source: International Journal of Endocrinology - September 15, 2018 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Uterine Artery Doppler in Pregnancy: Women with PCOS Compared to Healthy Controls.
Conclusions. In the first and second trimesters of pregnancy, there was no difference in UtAPI between women with PCOS and healthy controls. Metformin had no immediate effect on the UtAPI. Interestingly, blood flow decreased after a meal, suggesting that time since last meal should be taken into consideration when interpreting the results of UtAPI measurements in pregnancy. This trial is registered with ClinicalTrials.gov (NCT00466622) Metformin in Pregnant PCOS women (PregMet) (NCT00159536). PMID: 30186323 [PubMed] (Source: International Journal of Endocrinology)
Source: International Journal of Endocrinology - September 8, 2018 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Long-Term Dietary Nitrate Supplementation Does Not Prevent Development of the Metabolic Syndrome in Mice Fed a High-Fat Diet.
Conclusions: Dietary nitrate does not prevent development of the metabolic syndrome in mice fed a high-fat diet. This may be due, in part due, to reductions in the concentration of important short-chain fatty acids. PMID: 30174691 [PubMed] (Source: International Journal of Endocrinology)
Source: International Journal of Endocrinology - September 5, 2018 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Pericardial Fat Relates to Disturbances of Glucose Metabolism in Women with the Polycystic Ovary Syndrome, but Not in Healthy Control Subjects.
The objective of the present study is to investigate the relationship of cardiac fat depots with disturbances of the carbohydrate metabolism in women with PCOS. Methods: An oral glucose tolerance test (OGTT) was realized, and metabolic parameters were collected in 48 women with PCOS and in 20 controls. Intramyocardial fat (MYCL) and pericardial fat (PERI) were measured using 1H-magnetic resonance spectroscopy and imaging. Results: Only in PCOS women, PERI was positively and independently related to parameters of glucose metabolism (HbA1c: p = 0.001, fasting plasma glucose: p
Source: International Journal of Endocrinology - September 1, 2018 Category: Endocrinology Tags: Int J Endocrinol Source Type: research