Serum 25(OH)D Levels Modify the Association between Triglyceride and IR: A Cross-Sectional Study
CONCLUSION: This study demonstrates that triglyceride levels are significantly associated with insulin in the US adult population and can be used as a predictor of IR. This correlation was compromised at different 25 (OH)D levels, so future studies need to be explored in more ethnically diverse contexts.PMID:35592754 | PMC:PMC9113899 | DOI:10.1155/2022/5457087 (Source: International Journal of Endocrinology)
Source: International Journal of Endocrinology - May 20, 2022 Category: Endocrinology Authors: Rongpeng Gong Xin Tang Ziying Jiang Gang Luo Chaofan Dong Xiuxia Han Source Type: research

Forskolin Stimulates Estrogen Receptor (ER) < em > α < /em > Transcriptional Activity and Protects ER from Degradation by Distinct Mechanisms
Int J Endocrinol. 2022 May 9;2022:7690166. doi: 10.1155/2022/7690166. eCollection 2022.ABSTRACTEstradiol action is mediated by estrogen receptors (ERs), a and ß. Estradiol binding initiates ER-mediated transcription and ER degradation, the latter of which occurs via the ubiquitin-proteasome pathway. Inhibition of proteasome activity prevents estradiol-induced ERα degradation and transactivation. In ER-positive GH3 cells (a rat pituitary prolactinoma cell line), forskolin, acting via protein kinase A (PKA), stimulates ERα transcriptional activity without causing degradation, and proteasome inhibition does not block forsk...
Source: International Journal of Endocrinology - May 19, 2022 Category: Endocrinology Authors: Houng-Wei Tsai Vicky Y Lin Margaret A Shupnik Source Type: research

Serum PTH Associated with Malnutrition Determined by Bioelectrical Impedance Technology in Chronic Kidney Disease Patients
CONCLUSIONS: Bioelectrical impedance analysis might be useful in estimating the nutritional status of CKD patients in terms of fat and muscle parameters. High levels of PTH are an independent risk factor for developing low SMI in CKD patients.PMID:35573870 | PMC:PMC9095397 | DOI:10.1155/2022/1222480 (Source: International Journal of Endocrinology)
Source: International Journal of Endocrinology - May 16, 2022 Category: Endocrinology Authors: Lilin Liu Lulu Wang Xiao Wang Mingxia Xiong Hongdi Cao Lei Jiang Junwei Yang Source Type: research

Harmful Consequences of Proton Pump Inhibitors on Male Fertility: An Evidence from Subchronic Toxicity Study of Esomeprazole and Lansoprazole in Wistar Rats
Int J Endocrinol. 2022 Apr 28;2022:4479261. doi: 10.1155/2022/4479261. eCollection 2022.ABSTRACTProton pump inhibitors (PPIs) are frequently prescribed as gastric acid-suppressing agents. Nevertheless, there is limited evidence supporting the risk of detrimental effects of PPIs on male fertility. The purpose of the current study was to evaluate the effect of subchronic use of proton pump inhibitors on male fertility. Seventy adult male Wistar rats were assigned into seven groups. The normal control group orally received solvent only. Groups 2, 3, and 4 were orally given esomeprazole while groups 5, 6, and 7 received lansop...
Source: International Journal of Endocrinology - May 9, 2022 Category: Endocrinology Authors: Namra Mumtaz Muhammad Furqan Akhtar Ammara Saleem Amjad Riaz Source Type: research

Contrast-Enhanced Ultrasound: An Effective Method for Noninvasive Diagnosis of Mummified Thyroid Nodules
This study investigated the usefulness of contrast-enhanced ultrasound (CEUS) in the diagnosis of mummified nodules. 66 patients with mummified nodules were divided into two groups: a no-enhancement group and a low-enhancement group. 32 patients with papillary thyroid carcinoma (PTC) were recruited in control group. In the no-enhancement group, CEUS showed that there was no contrast agent entering the nodules, with or without a little dot enhancement or regular ring enhancement around the nodules. The low-enhancement group showed low enhancement inside nodules, which was similar to that in the PTC group. In semiquantitativ...
Source: International Journal of Endocrinology - May 9, 2022 Category: Endocrinology Authors: Hong Zhang Xiaoqu Tan Linxue Qian Source Type: research

Discriminatory Value of Adiponectin to Leptin Ratio for COVID-19 Pneumonia
CONCLUSION: Our data indicate that high Adpn/Lep (>2.23) in lean patients is consistent with a state of good health, which decreases in case of inflammatory states, ranging from adipose tissue dysfunction with low-grade inflammation to COVID-19 pneumonia.PMID:35529082 | PMC:PMC9072020 | DOI:10.1155/2022/9908450 (Source: International Journal of Endocrinology)
Source: International Journal of Endocrinology - May 9, 2022 Category: Endocrinology Authors: Federica Tonon Stefano Di Bella Fabiola Giudici Verena Zerbato Ludovica Segat Raffaella Koncan Andrea Misin Barbara Toffoli Pierlanfranco D'Agaro Roberto Luzzati Bruno Fabris Stella Bernardi Source Type: research

Angiopoietin-Like 8 in Gestational Diabetes Mellitus: Reduced Levels in Third Trimester Maternal Serum and Placenta, Increased Levels in Cord Blood Serum
Int J Endocrinol. 2022 Apr 26;2022:1113811. doi: 10.1155/2022/1113811. eCollection 2022.ABSTRACTGestational diabetes mellitus (GDM) poses a significant health risk to pregnant women, and thus exploring the potential underlying mechanism is highly desirable. The aim of the study was to compare maternal serum, cord blood serum, and placental angiopoietin-like 8 (ANGPTL8) levels in the third trimester of pregnancy in women with and without gestational diabetes and explore the potential underlying mechanism. A total of 42 pregnant women (23 with GDM and 19 with normal glucose tolerance (NGT)) along with 29 age-matched non-preg...
Source: International Journal of Endocrinology - May 9, 2022 Category: Endocrinology Authors: Junhua Yuan Di Zhang Yunyang Wang Zhen Zhu Qian Lin Manwen Li Weizhen Zhong Jing Han Fengsen Xu Jing Dong Source Type: research

Harmful Consequences of Proton Pump Inhibitors on Male Fertility: An Evidence from Subchronic Toxicity Study of Esomeprazole and Lansoprazole in Wistar Rats
Int J Endocrinol. 2022 Apr 28;2022:4479261. doi: 10.1155/2022/4479261. eCollection 2022.ABSTRACTProton pump inhibitors (PPIs) are frequently prescribed as gastric acid-suppressing agents. Nevertheless, there is limited evidence supporting the risk of detrimental effects of PPIs on male fertility. The purpose of the current study was to evaluate the effect of subchronic use of proton pump inhibitors on male fertility. Seventy adult male Wistar rats were assigned into seven groups. The normal control group orally received solvent only. Groups 2, 3, and 4 were orally given esomeprazole while groups 5, 6, and 7 received lansop...
Source: International Journal of Endocrinology - May 9, 2022 Category: Endocrinology Authors: Namra Mumtaz Muhammad Furqan Akhtar Ammara Saleem Amjad Riaz Source Type: research

Contrast-Enhanced Ultrasound: An Effective Method for Noninvasive Diagnosis of Mummified Thyroid Nodules
This study investigated the usefulness of contrast-enhanced ultrasound (CEUS) in the diagnosis of mummified nodules. 66 patients with mummified nodules were divided into two groups: a no-enhancement group and a low-enhancement group. 32 patients with papillary thyroid carcinoma (PTC) were recruited in control group. In the no-enhancement group, CEUS showed that there was no contrast agent entering the nodules, with or without a little dot enhancement or regular ring enhancement around the nodules. The low-enhancement group showed low enhancement inside nodules, which was similar to that in the PTC group. In semiquantitativ...
Source: International Journal of Endocrinology - May 9, 2022 Category: Endocrinology Authors: Hong Zhang Xiaoqu Tan Linxue Qian Source Type: research

Discriminatory Value of Adiponectin to Leptin Ratio for COVID-19 Pneumonia
CONCLUSION: Our data indicate that high Adpn/Lep (>2.23) in lean patients is consistent with a state of good health, which decreases in case of inflammatory states, ranging from adipose tissue dysfunction with low-grade inflammation to COVID-19 pneumonia.PMID:35529082 | PMC:PMC9072020 | DOI:10.1155/2022/9908450 (Source: International Journal of Endocrinology)
Source: International Journal of Endocrinology - May 9, 2022 Category: Endocrinology Authors: Federica Tonon Stefano Di Bella Fabiola Giudici Verena Zerbato Ludovica Segat Raffaella Koncan Andrea Misin Barbara Toffoli Pierlanfranco D'Agaro Roberto Luzzati Bruno Fabris Stella Bernardi Source Type: research

Angiopoietin-Like 8 in Gestational Diabetes Mellitus: Reduced Levels in Third Trimester Maternal Serum and Placenta, Increased Levels in Cord Blood Serum
Int J Endocrinol. 2022 Apr 26;2022:1113811. doi: 10.1155/2022/1113811. eCollection 2022.ABSTRACTGestational diabetes mellitus (GDM) poses a significant health risk to pregnant women, and thus exploring the potential underlying mechanism is highly desirable. The aim of the study was to compare maternal serum, cord blood serum, and placental angiopoietin-like 8 (ANGPTL8) levels in the third trimester of pregnancy in women with and without gestational diabetes and explore the potential underlying mechanism. A total of 42 pregnant women (23 with GDM and 19 with normal glucose tolerance (NGT)) along with 29 age-matched non-preg...
Source: International Journal of Endocrinology - May 9, 2022 Category: Endocrinology Authors: Junhua Yuan Di Zhang Yunyang Wang Zhen Zhu Qian Lin Manwen Li Weizhen Zhong Jing Han Fengsen Xu Jing Dong Source Type: research

Harmful Consequences of Proton Pump Inhibitors on Male Fertility: An Evidence from Subchronic Toxicity Study of Esomeprazole and Lansoprazole in Wistar Rats
Int J Endocrinol. 2022 Apr 28;2022:4479261. doi: 10.1155/2022/4479261. eCollection 2022.ABSTRACTProton pump inhibitors (PPIs) are frequently prescribed as gastric acid-suppressing agents. Nevertheless, there is limited evidence supporting the risk of detrimental effects of PPIs on male fertility. The purpose of the current study was to evaluate the effect of subchronic use of proton pump inhibitors on male fertility. Seventy adult male Wistar rats were assigned into seven groups. The normal control group orally received solvent only. Groups 2, 3, and 4 were orally given esomeprazole while groups 5, 6, and 7 received lansop...
Source: International Journal of Endocrinology - May 9, 2022 Category: Endocrinology Authors: Namra Mumtaz Muhammad Furqan Akhtar Ammara Saleem Amjad Riaz Source Type: research