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Correlation between CH2DS2-VASc Score and Serum Leptin Levels in Cardioembolic Stroke Patients: The Impact of Metabolic Syndrome.
Authors: Szczepańska-Szerej A, Kurzepa J, Grabarska A, Bielewicz J, Wlizło-Dyś E, Rejdak K Abstract Objective: To determine adipokines levels in patients with different etiologic subtypes of acute ischemic stroke (AIS) and metabolic syndrome (MetS) status. Methods: Serum adiponectin, leptin, and resistin levels were determined by ELISA in 99 AIS patients and 59 stroke-free control group subjects. Stroke patients were grouped based on MetS, modified TOAST classification, and CHA2DS2-VASc scale in case of cardioembolic stroke following atrial fibrillation. Results: No differences were found in all adipokin...
Source: International Journal of Endocrinology - December 13, 2017 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Comment on "Identification of Differentially Expressed Genes in Pituitary Adenomas by Integrating Analysis of Microarray Data".
Comment on "Identification of Differentially Expressed Genes in Pituitary Adenomas by Integrating Analysis of Microarray Data". Int J Endocrinol. 2017;2017:2023530 Authors: Bujko M PMID: 29209366 [PubMed] (Source: International Journal of Endocrinology)
Source: International Journal of Endocrinology - December 8, 2017 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Functional Characterization of Preadipocytes Derived from Human Periaortic Adipose Tissue.
In this study, biochemical and phenotypical characteristics of adipose tissue from periaortic fat were evaluated. Periaortic and subcutaneous adipose tissues were obtained from areas surrounding the ascending aorta and sternotomy incision, respectively. Adipose tissues were collected from patients undergoing myocardial revascularization or mitral valve replacement surgery. Morphological studies with hematoxylin/eosin and immunohistochemical assay were performed in situ to quantify adipokine expression. To analyze adipogenic capacity, adipokine expression, and the levels of thermogenic proteins, adipocyte precursor cells we...
Source: International Journal of Endocrinology - December 8, 2017 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Corrigendum to "Prevalence of Fracture Risk Factors in Postmenopausal Women Enrolled in the POSSIBLE US Treatment Cohort".
Corrigendum to "Prevalence of Fracture Risk Factors in Postmenopausal Women Enrolled in the POSSIBLE US Treatment Cohort". Int J Endocrinol. 2017;2017:4827469 Authors: Yurgin N, Wade S, Satram-Hoang S, Macarios D, Hochberg M Abstract [This corrects the article DOI: 10.1155/2013/715025.]. PMID: 29209368 [PubMed - in process] (Source: International Journal of Endocrinology)
Source: International Journal of Endocrinology - December 8, 2017 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Circulatory Immune Cells in Cushing Syndrome: Bystanders or Active Contributors to Atherometabolic Injury? A Study of Adhesion and Activation of Cell Surface Markers.
Authors: Aranda G, Lopez C, Fernandez-Ruiz R, Esteban Y, Garcia-Eguren G, Mora M, Halperin I, Casals G, Enseñat J, Hanzu FA Abstract Glucocorticoids (GC) induce cardiometabolic risk while atherosclerosis is a chronic inflammation involving immunity. GC are immune suppressors, and the adrenocorticotrophic hormone (ACTH) has immune modulator activities. Both may act in atherothrombotic inflammation involving immune cells (IMNC). Aim. To investigate adhesion and activation surface cell markers (CDs) of peripheral IMNC in endogenous Cushing syndrome (CS) and the immune modulator role of ACTH. Material and Method...
Source: International Journal of Endocrinology - December 8, 2017 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Low Levels of Sex Hormone-Binding Globulin Constitute an Independent Risk Factor for Arterial Stiffness in Korean Women.
Authors: Han K, Chun H, Kim MJ, Cho DY, Lee SH, Won BY, Kim KM, Joo NS, Kim YS Abstract The association between sex hormone-binding globulin (SHBG) and arterial stiffness in women is not conclusive. In addition, obesity might also be involved in the relationship between SHBG and atherosclerosis. The aim of this study was to determine the relationship between SHBG and arterial stiffness in association with central obesity in women. This cross-sectional study included 381 women who participated in the health checkup programs in one hospital. The brachial-ankle pulse wave velocity (baPWV) was measured as a marker for ...
Source: International Journal of Endocrinology - December 8, 2017 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Psychometric Properties of Diabetes Management Self-Efficacy in Thai Type 2 Diabetes Mellitus Patients: A Multicenter Study.
This study recruited patients from outpatient diabetes clinics of both community and university hospitals. The first phases of this study involved translation of the existing DMSES into Thai, and in the second phase, we evaluated its psychometric properties. The construct validity was evaluated using confirmatory factor analysis. Criterion validity of DMSES was subsequently evaluated by examining DMSES's association with HbA1c control. Results: The T-DMSES contains 20 items across four factors. Confirmatory factor analysis demonstrated the construct validity of T-DMSES (χ2 = 645.142, df = 164, p
Source: International Journal of Endocrinology - December 5, 2017 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Rapid Action of Aldosterone on Protein Levels of Sodium-Hydrogen Exchangers and Protein Kinase C Beta Isoforms in Rat Kidney.
Authors: Eiam-Ong S, Chaipipat M, Manotham K, Eiam-Ong S Abstract Previous in vitro studies demonstrated that aldosterone rapidly activates sodium-hydrogen exchangers 1 and 3 (NHE 1 and 3). In vitro investigations revealed that protein kinase C (PKC) regulates NHE properties. We previously demonstrated that aldosterone rapidly enhances PKCα protein abundance in the rat kidney. There are no reports of renal PKCβ (I and II) protein levels related to the regulation by aldosterone. There are also no in vivo data regarding the rapid effects of aldosterone on renal protein levels of NHE (1 and 3) and PKCβ...
Source: International Journal of Endocrinology - December 5, 2017 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Correlation between Insulin Resistance and Thyroid Nodule in Type 2 Diabetes Mellitus.
Conclusion: IR might be a risk factor for thyroid nodule. Whether alleviating the IR might slow the growth, or diminish the volume and size of the thyroid nodules, is yet to be elucidated. PMID: 29158735 [PubMed] (Source: International Journal of Endocrinology)
Source: International Journal of Endocrinology - November 23, 2017 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Clinical Presentation, Management, and Outcomes of Primary Hyperparathyroidism during Pregnancy.
Conclusions: MIP under cervical plexus block might be a safe and effective treatment for pregnant women with pHPT. Even though both conservative and surgical treatments are applicable for most mothers and fetuses with asymptomatic and mild hyperparathyroidism, serious complications may have catastrophic consequences for both. PMID: 29147113 [PubMed] (Source: International Journal of Endocrinology)
Source: International Journal of Endocrinology - November 18, 2017 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Influence of SPK with Enteric Drainage on the Pancreatic Exocrine Function in Diabetic Patients with Uremia.
Conclusions: The present study indicated that SPK with enteric drainage improves pancreatic endocrine and exocrine functions. Fecal elastase may be a clinically relevant means to determine the therapeutic effects. PMID: 29138633 [PubMed] (Source: International Journal of Endocrinology)
Source: International Journal of Endocrinology - November 17, 2017 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

The Synergistic Interplay between Vitamins D and K for Bone and Cardiovascular Health: A Narrative Review.
Authors: van Ballegooijen AJ, Pilz S, Tomaschitz A, Grübler MR, Verheyen N Abstract Vitamins D and K are both fat-soluble vitamins and play a central role in calcium metabolism. Vitamin D promotes the production of vitamin K-dependent proteins, which require vitamin K for carboxylation in order to function properly. The purpose of this review is to summarize available evidence of the synergistic interplay between vitamins D and K on bone and cardiovascular health. Animal and human studies suggest that optimal concentrations of both vitamin D and vitamin K are beneficial for bone and cardiovascular health as su...
Source: International Journal of Endocrinology - November 17, 2017 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Obese Children with Metabolic Syndrome Have 3 Times Higher Risk to Have Nonalcoholic Fatty Liver Disease Compared with Those without Metabolic Syndrome.
Authors: Papandreou D, Karavetian M, Karabouta Z, Andreou E Abstract Background: The aim of this study was to investigate the relationship between metabolic syndrome (MS) and nonalcoholic fatty liver disease (NAFLD) in obese children. One hundred and twenty-five subjects aged 11-12 years old participated in the study. Methods: Anthropometric and biochemical indices were measured, including lipid and liver profile, blood glucose, serum insulin, and liver ultrasound. Results: Forty-four children (58.6%) were found to have MS. Insulin resistance was present in 78 (62.4%) children. Patients with MS were more li...
Source: International Journal of Endocrinology - November 11, 2017 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

PDE5 Overexpression in Well-Differentiated Thyroid Carcinomas Is Associated with Lymph Node Metastasis.
Authors: Zhang N, Fang Z, Li Q, Wang K, Li S, Li W, Wang S Abstract Overexpression of PDE5 is observed in certain human cancers, but PDE5 expression in well-differentiated thyroid carcinoma (WDTC) is unknown. We therefore examined PDE5 expression and its relationship with the clinicopathological features of WDTC. Real-time qPCR and Western blotting were performed to analyze the expression of PDE5 mRNA and protein in paired WDTC tumor and adjacent nontumor tissues. Immunohistochemistry was used to analyze the expression of PDE5 in paraffin-embedded tissues obtained from 103 cases of WDTC. Statistical analyses were p...
Source: International Journal of Endocrinology - November 11, 2017 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Melatonin as an Anti-Inflammatory Agent Modulating Inflammasome Activation.
Authors: Favero G, Franceschetti L, Bonomini F, Rodella LF, Rezzani R Abstract Inflammation may be defined as the innate response to harmful stimuli such as pathogens, injury, and metabolic stress; its ultimate function is to restore the physiological homeostatic state. The exact aetiology leading to the development of inflammation is not known, but a combination of genetic, epigenetic, and environmental factors seems to play an important role in the pathogenesis of many inflammation-related clinical conditions. Recent studies suggest that the pathogenesis of different inflammatory diseases also involves the inflam...
Source: International Journal of Endocrinology - November 8, 2017 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Comparative Agreement Analysis of Differences in 1,5-Anhydroglucitol, Glycated Albumin, and Glycated Hemoglobin A1c Levels between Fasting and Postprandial States in Steamed Bread Meal Test.
Conclusion: Agreement analyses indicated good stability of 1,5-AG, GA, and HbA1c levels after the SBMT. HbA1c had an optimal stability, which was superior to that of GA or 1,5-AG. PMID: 29104592 [PubMed] (Source: International Journal of Endocrinology)
Source: International Journal of Endocrinology - November 8, 2017 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Associations of Salivary BPIFA1 Protein in Chronic Periodontitis Patients with Type 2 Diabetes Mellitus.
Conclusions: BPIFA1 protein is rich in saliva and might be used as a potential predictive biomarker of T2DM, especially in patients with severe periodontitis and nonperiodontitis. This trial is registered with ChiCTR-ROC-17010310. PMID: 29109737 [PubMed] (Source: International Journal of Endocrinology)
Source: International Journal of Endocrinology - November 8, 2017 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Association between Sex Hormone and Blood Uric Acid in Male Patients with Type 2 Diabetes.
In this study, we enrolled 205 male patients with T2DM and investigated the relationship between sex hormone levels and SUA. Patients were divided into four groups based on SUA quartiles. On the other hand, based on the total testosterone (TT) level, patients were divided into three groups; SUA and other laboratory indices were determined. Increase in SUA level was significantly associated with decreased levels of TT, luteinizing hormone, follicle-stimulating hormone, sex hormone-binding globulin, and increased levels of dehydroepiandrosterone, age, body mass index (BMI), waist circumference, glycated hemoglobin, serum cre...
Source: International Journal of Endocrinology - November 8, 2017 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Novel and Simple Ultrasonographic Methods for Estimating the Abdominal Visceral Fat Area.
Authors: Asano T, Kubota N, Koizumi N, Itani K, Mitake T, Yuhashi K, Liao H, Mitsuishi M, Takeishi S, Takahashi T, Ohnishi S, Sasaki S, Sakuma I, Kadowaki T Abstract Objectives: To evaluate the abdominal visceral fat area (VFA), we developed novel ultrasonographic (US) methods for estimating. Methods: 100 male volunteers were recruited, and their VFA was calculated by two novel US methods, the triangle method and the ellipse method. The VFA calculated by these methods was compared with the VFA calculated by CT. Results: Both the VFA calculated by the triangle method (r = 0.766, p
Source: International Journal of Endocrinology - November 4, 2017 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

The Clinical Values of Insulin-Like Growth Factor-1 and Insulin-Like Growth Factor Binding Protein-3 Levels in Blood and Thyroid Nodules.
In this study, 80 subjects who performed fine-needle aspiration biopsy (FNAB) were required in order to investigate the effects of serum and intranodular IGF-1 and IGFBP-3 in the pathogenesis of nodules. After performing FNAB, IGF-1 and IGFBP-3 levels were determined in blood and aspiration samples. RESULTS: The serum levels of IGF-1 (232.8 ± 12.9 ng/ml) and IGFBP-3 (4.8 μg/ml) were found significantly higher than that of the intranodular IGF-1 (39.1 ng/ml) and intranodular IGFBP-3 levels (0.173 μg/ml) (p
Source: International Journal of Endocrinology - November 1, 2017 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Chronic Hyperglycemia Modulates Rat Osteoporotic Cortical Bone Microarchitecture into Less Fragile Structures.
In this study, the effect of chronic hyperglycemia in bone turnover, morphology, and biomechanics was evaluated in female Wistar rats in the presence/absence of estrogens (ovariectomy). Animals (n = 28) were divided into sham, ovariectomized (OVX), hyperglycemic (streptozotocin 40 mg/kg, single-dose i.p.-STZ), and hyperglycemic-ovariectomized (STZ + OVX) animals. Blood biomarkers were estimated 60 days postovariectomy. Body weight, vertebral microarchitecture (L4-histomorphometry), femur biomechanical properties (bending tests), tibia ultrastructure (scanning electron microscopy), and femur and urinary...
Source: International Journal of Endocrinology - November 1, 2017 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Swim Training Attenuates Inflammation and Improves Insulin Sensitivity in Mice Fed with a High-Fat Diet.
Authors: Zhang G, Yu P, Liu X Abstract Exercise could afford multiple beneficial effects on obesity-related metabolic disorders. To address this issue, C57BL/6J mice were used to investigate the effects of 13 weeks of swim training on HFD-induced obesity and related insulin resistance and inflammation. Our results show that swim training can significantly prevent HFD-induced weight gain and increase resting energy expenditure without affecting food intake. The insulin sensitivity was enhanced in the HFD + swim group than in the HFD + sedentary group. Moreover, swim training considerably ...
Source: International Journal of Endocrinology - November 1, 2017 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Relationship between Subclinical Thyroid Dysfunction and the Risk of Cardiovascular Outcomes: A Systematic Review and Meta-Analysis of Prospective Cohort Studies.
Authors: Sun J, Yao L, Fang Y, Yang R, Chen Y, Yang K, Tian L Abstract BACKGROUND: Evidence on the association between subclinical thyroid dysfunction and the risk of cardiovascular outcomes are conflicting. METHODS AND RESULTS: PubMed, EMbase, Web of Science, Cochrane Library, and China Biology Medicine (CBM) databases were searched from inception to July 10, 2016. A total of 16 studies were included for meta-analysis. We found that subclinical hypothyroidism was not correlated with coronary heart disease (CHD) (RR = 1.17; 95% CI, 0.91-1.52), total mortality (RR = 1.02; 95% CI, 0.93...
Source: International Journal of Endocrinology - November 1, 2017 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Pretreatment BMI Is Associated with Aggressive Clinicopathological Features of Papillary Thyroid Carcinoma: A Multicenter Study.
CONCLUSION: A higher pretreatment BMI has been strongly associated with aggressive features of PTC according to the BMI classification for Asians. Obesity was not found to be associated with a greater risk of recurrence. PMID: 29085428 [PubMed] (Source: International Journal of Endocrinology)
Source: International Journal of Endocrinology - November 1, 2017 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Does HbA1c Level Have Clinical Implications in Diabetic Patients Undergoing Coronary Artery Bypass Grafting? A Systematic Review and Meta-Analysis.
CONCLUSIONS: Our meta-analysis demonstrated that the HbA1c level is potentially associated with increased risks of all-cause mortality, myocardial infarction, and stroke in diabetic subjects undergoing CABG surgery. However, further clinical studies with larger sample sizes and longer follow-up period are urgently warranted. PMID: 29075292 [PubMed] (Source: International Journal of Endocrinology)
Source: International Journal of Endocrinology - October 28, 2017 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Bacterial Profile and Antibiotic Resistance in Patients with Diabetic Foot Ulcer in Guangzhou, Southern China: Focus on the Differences among Different Wagner's Grades, IDSA/IWGDF Grades, and Ulcer Types.
CONCLUSIONS: Different bacterial profiles and antibiotic sensitivity were found in different DFU grades and types. Clinician should try to stay updated in antibiotic resistance pattern of common pathogens in their area. This paper provided them the detailed information in this region. PMID: 29075293 [PubMed] (Source: International Journal of Endocrinology)
Source: International Journal of Endocrinology - October 28, 2017 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Salt, Aldosterone, and Parathyroid Hormone: What Is the Relevance for Organ Damage?
Authors: Catena C, Colussi GL, Brosolo G, Bertin N, Novello M, Palomba A, Sechi LA Abstract Structured interventions on lifestyle have been suggested as a cost-effective strategy for prevention of cardiovascular disease. Epidemiologic studies demonstrate that dietary salt restriction effectively decreases blood pressure, but its influence on cardiovascular morbidity and mortality is still under debate. Evidence gathered from studies conducted in patients with primary aldosteronism, essential hypertension, or heart failure demonstrates that long-term exposure to elevated aldosterone results in cardiac structural and...
Source: International Journal of Endocrinology - October 25, 2017 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

The Association of Thyrotropin and Autoimmune Thyroid Disease in Developing Papillary Thyroid Cancer.
CONCLUSIONS: A high proportion of the patients with PTC had HT. There was a trend that a higher serum TSH level was associated with a greater risk of thyroid cancer. PMID: 28951739 [PubMed] (Source: International Journal of Endocrinology)
Source: International Journal of Endocrinology - September 28, 2017 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Perspectives on Peripheral Neuropathy as a Consequence of Metformin-Induced Vitamin B12 Deficiency in T2DM.
Authors: Ahmed MA, Muntingh GL, Rheeder P Abstract Peripheral neuropathy (PN) is a primary complication of type 2 diabetes mellitus (T2DM) and a direct manifestation of vitamin B12 deficiency. Examining the effects of metformin use on PN status became imperative following clinical studies that showed the vitamin B12-lowering effect of the medication. The complexity of the topic and the inconsistency of the results warrant consideration of topic-specific perspectives for better understanding of the available evidence and more appropriate design of future studies. PMID: 28932240 [PubMed] (Source: International Jo...
Source: International Journal of Endocrinology - September 22, 2017 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Association of Polymorphisms in Toll-Like Receptors 4 and 9 with Autoimmune Thyroid Disease in Korean Pediatric Patients.
CONCLUSIONS: Our results suggest that TLR4 and 9 polymorphisms might contribute to the pathogenesis of GD and TAO. PMID: 28912808 [PubMed] (Source: International Journal of Endocrinology)
Source: International Journal of Endocrinology - September 17, 2017 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

The Biphasic Effect of Vitamin D on the Musculoskeletal and Cardiovascular System.
In conclusion, dose-response relationships indicate deleterious effects on the musculoskeletal system and probably on the cardiovascular system at circulating 25OHD levels 100 nmol/L. Future studies should focus on populations with 25OHD levels  100 nmol/L. PMID: 28912809 [PubMed] (Source: International Journal of Endocrinology)
Source: International Journal of Endocrinology - September 17, 2017 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Latent Inflammation and Insulin Resistance in Adipose Tissue.
Authors: Stafeev IS, Vorotnikov AV, Ratner EI, Menshikov MY, Parfyonova YV Abstract Obesity is a growing problem in modern society and medicine. It closely associates with metabolic disorders such as type 2 diabetes mellitus (T2DM) and hepatic and cardiovascular diseases such as nonalcoholic fatty liver disease, atherosclerosis, myocarditis, and hypertension. Obesity is often associated with latent inflammation; however, the link between inflammation, obesity, T2DM, and cardiovascular diseases is still poorly understood. Insulin resistance is the earliest feature of metabolic disorders. It mostly develops as a resu...
Source: International Journal of Endocrinology - September 17, 2017 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Corrigendum to "In Vitro Antioxidant Treatment of Semen Samples in Assisted Reproductive Technology: Effects of Myo-Inositol on Nemaspermic Parameters".
Corrigendum to "In Vitro Antioxidant Treatment of Semen Samples in Assisted Reproductive Technology: Effects of Myo-Inositol on Nemaspermic Parameters". Int J Endocrinol. 2017;2017:5942741 Authors: Palmieri M, Papale P, Della Ragione A, Quaranta G, Russo G, Russo S Abstract [This corrects the article DOI: 10.1155/2016/2839041.]. PMID: 28912811 [PubMed] (Source: International Journal of Endocrinology)
Source: International Journal of Endocrinology - September 17, 2017 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

BMI Modulates the Effect of Thyroid Hormone on Lipid Profile in Euthyroid Adults.
Authors: Wang Y, Yin Q, Xu M, Ni Q, Wang W, Wang Q Abstract The impacts of thyroid hormones (TH) on lipid profile in euthyroid adults have gained much attention. It is currently unknown whether BMI influences such interaction. In the present study, we investigate the role of BMI in modulating the association between TH and lipid parameters in 1372 euthyroid healthy adults. Our results show that thyroid parameters are differentially associated with lipid profile. FT3 is positively correlated with total cholesterol (β = 0.176 ± 0.046, P
Source: International Journal of Endocrinology - September 9, 2017 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Regulation of Corticosteroidogenic Genes by MicroRNAs.
This study demonstrates that corticosteroidogenesis is regulated at multiple points by several microRNAs and that certain of these microRNAs are differentially expressed in tumorous adrenal tissue, which may contribute to dysregulation of corticosteroid secretion. These findings provide new insights into the regulation of corticosteroid production and have implications for understanding the pathology of disease states where abnormal hormone secretion is a feature. PMID: 28852406 [PubMed] (Source: International Journal of Endocrinology)
Source: International Journal of Endocrinology - September 1, 2017 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

The Association between Bone Quality and Atherosclerosis: Results from Two Large Population-Based Studies.
CONCLUSIONS: Our data argue against an independent role of bone metabolism in atherosclerotic changes in women. Yet, in men, associations with advanced atherosclerosis, exist. Thus, men presenting with clinical signs of osteoporosis may be at increased risk for atherosclerotic disease. PMID: 28852407 [PubMed] (Source: International Journal of Endocrinology)
Source: International Journal of Endocrinology - September 1, 2017 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Baseline Demographic and Clinical Characteristics of Patients with Adrenal Incidentaloma from a Single Center in China: A Survey.
Authors: Li L, Yang G, Zhao L, Dou J, Gu W, Lv Z, Lu J, Mu Y Abstract AIM: To investigate the clinical and endocrinological characteristics of patients with adrenal incidentaloma (AI). MATERIALS AND METHODS: This retrospective study enrolled 1941 AI patients hospitalized at the Department of Endocrinology, Chinese PLA General Hospital, Beijing, China, between January 1997 and December 2016. The patient gender, age at visits, imaging features, functional status, and histological results were analyzed. RESULTS: Of the 1941 patients, 984 (50.70%) were men. The median age was 52 years (interquartile range: 44-6...
Source: International Journal of Endocrinology - August 30, 2017 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Thickness of Extraocular Muscle and Orbital Fat in MRI Predicts Response to Glucocorticoid Therapy in Graves' Ophthalmopathy.
Authors: Xu L, Li L, Xie C, Guan M, Xue Y Abstract 33 patients with active, moderate-severe Graves' ophthalmopathy (GO) received 4.5 g methylprednisolone for 12 weeks and were divided by efficacy into two groups (responsive and unresponsive). All patients and 10 controls underwent orbital MRI examination at baseline. No significant difference was seen in baseline clinical characteristics between the two GO groups. The values of exophthalmos were higher in both GO groups than in the control and were higher in the responsive group versus the unresponsive group. Compared to the unresponsive group, the responsiv...
Source: International Journal of Endocrinology - August 29, 2017 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

2D-Shear Wave Elastography in the Evaluation of Parathyroid Lesions in Patients with Hyperparathyroidism.
Authors: Golu I, Sporea I, Moleriu L, Tudor A, Cornianu M, Vlad A, Timar R, Balas M, Amzar D, Vlad M Abstract BACKGROUND AND AIMS: 2D-shear wave elastography (2D-SWE) is a relatively new elastographic technique. The aim of the present study is to determine the values of the elasticity indexes (EI) measured by 2D-SWE in parathyroid benign lesions (adenomas or hyperplasia) and to establish if this investigation is helpful for the preoperative identification of the parathyroid adenoma. MATERIAL AND METHODS: The study groups were represented by 22 patients with primary or tertiary hyperparathyroidism, diagnosed by ...
Source: International Journal of Endocrinology - August 29, 2017 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Variants of Interleukin-22 Gene Confer Predisposition to Autoimmune Thyroid Disease.
In conclusion, genetic variants of IL-22 are associated with the occurrence of AITD. PMID: 28839453 [PubMed] (Source: International Journal of Endocrinology)
Source: International Journal of Endocrinology - August 26, 2017 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Screening for Cushing Syndrome at the Primary Care Level: What Every General Practitioner Must Know.
Authors: Yorke E, Atiase Y, Akpalu J, Sarfo-Kantanka O Abstract Cushing's syndrome is a rare entity, and a high index of suspicion is needed for screening in a primary care setting. The clinical awareness of the primary care physician (PCP) to the highly indicative signs and symptoms such as facial plethora, proximal myopathy, reddish purple striae, and easy bruisability should alert him to look for biochemical evidence of Cushing's syndrome through any of the first-line screening tests, namely, 24-hour urinary free cortisol, overnight dexamethasone suppression test, or late-night salivary cortisol. Commonly used r...
Source: International Journal of Endocrinology - August 19, 2017 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Angiotensin-Converting Enzyme Inhibition and Parathyroid Hormone Secretion.
Authors: Zaheer S, Brown JM, Connors M, Williams JS, Adler GK, Vaidya A Abstract BACKGROUND: Prior studies suggest that renin-angiotensin-aldosterone system (RAAS) inhibitors decrease parathyroid hormone (PTH) secretion. OBJECTIVE: To evaluate the effect of angiotensin-converting enzyme inhibitors (ACEi) on serum PTH in participants with and without primary hyperparathyroidism (P-HPT). METHODS: An open-label, single-arm, pilot study whereby participants with and without P-HPT had PTH were evaluated before and after 1 week of maximally tolerated lisinopril therapy. RESULTS: A total of 12 participants wit...
Source: International Journal of Endocrinology - August 18, 2017 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Association of SUDOSCAN Values with Vibration Perception Threshold in Chinese Patients with Type 2 Diabetes Mellitus.
In this study, we determine to detect the possible relationship between vibration perception threshold (VPT) and cardiac autonomic neuropathy (CAN) values produced by SUDOSCAN. MATERIALS AND METHODS: A total of 920 Chinese patients with T2DM were enrolled in the study. Spearman correlation analysis and multivariate regression analysis were performed to determine the relation between CAN and VPT values. Mean VPT values across the CAN value tertiles were analyzed stratified by HbA1c status. RESULTS: In the study, we discovered a relatively high correlation between CAN value and both VPT values from dorsal feet and to...
Source: International Journal of Endocrinology - August 18, 2017 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Corrigendum to "Fracture Risk in Type 2 Diabetes: Current Perspectives and Gender Differences".
Corrigendum to "Fracture Risk in Type 2 Diabetes: Current Perspectives and Gender Differences". Int J Endocrinol. 2017;2017:4576102 Authors: Russo GT, Giandalia A, Romeo EL, Morabito N, Muscianisi M, Ruffo MC, Catalano A, Cucinotta D Abstract [This corrects the article DOI: 10.1155/2016/1615735.]. PMID: 28791046 [PubMed] (Source: International Journal of Endocrinology)
Source: International Journal of Endocrinology - August 11, 2017 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Central Precocious Puberty and Response to GnRHa Therapy in Children with Cerebral Palsy and Moderate to Severe Motor Impairment: Data from a Longitudinal, Case-Control, Multicentre, Italian Study.
CONCLUSIONS: Diagnosis of CPP could be partially mislead in CP due to growth failure that got worse during follow-up despite therapy. CPP in CP seems to progress rapidly along time supporting the hypothesis of a more intense activation of hypothalamic-pituitary-gonadal-axis in these patients. PMID: 28791047 [PubMed] (Source: International Journal of Endocrinology)
Source: International Journal of Endocrinology - August 11, 2017 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Plasma lncRNA GAS8-AS1 as a Potential Biomarker of Papillary Thyroid Carcinoma in Chinese Patients.
Authors: Zhang D, Liu X, Wei B, Qiao G, Jiang T, Chen Z Abstract BACKGROUND: Long noncoding RNAs (lncRNAs) were recently shown to have potential in the diagnosis and prognosis for numerous cancers. lncRNA GAS8-AS1 is decreased in papillary thyroid cancer (PTC) tissue, but its plasma expression and clinical value in patients with PTC remain unknown. MATERIALS AND METHODS: We investigated the expression profile of plasma GAS8-AS1 in 97 patients with PTC and 39 patients with nodular goiter by quantitative real-time polymerase chain reaction. RESULTS: GAS8-AS1 expression in plasma was downregulated in patients ...
Source: International Journal of Endocrinology - August 8, 2017 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

STK11 rs2075604 Polymorphism Is Associated with Metformin Efficacy in Chinese Type 2 Diabetes Mellitus.
In conclusion, this study suggested that the STK11 rs2075604 genetic polymorphism was significantly associated with metformin efficacy in Chinese T2DM patients and the carriers of the T allele may gain a better therapeutic metformin efficacy compared with the G allele. This trial is registered with clinical study registration number NCT03155087. PMID: 28775741 [PubMed] (Source: International Journal of Endocrinology)
Source: International Journal of Endocrinology - August 6, 2017 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Implementing a Reminder System in the Northern Part of Belgium to Stimulate Postpartum Screening for Glucose Intolerance in Women with Gestational Diabetes: The "Sweet Pregnancy" Project.
Implementing a Reminder System in the Northern Part of Belgium to Stimulate Postpartum Screening for Glucose Intolerance in Women with Gestational Diabetes: The "Sweet Pregnancy" Project. Int J Endocrinol. 2017;2017:3971914 Authors: Benhalima K, Verstraete S, Muylle F, Decochez K, Devlieger R, Crombrugge PV, Verhaegen A, Wens J, Mathieu C Abstract AIMS: To evaluate the feasibility and efficacy of a gestational diabetes (GDM) recall register on the long-term screening uptake postpartum and to evaluate the prevalence of prediabetes postpartum. METHODS: Evaluation of a GDM recall register im...
Source: International Journal of Endocrinology - August 6, 2017 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Effects of Exercise Training on Fat Loss and Lean Mass Gain in Mexican-American and Korean Premenopausal Women.
Authors: Wu S, Park KS, McCormick JB Abstract We investigated the effect of exercise training on body composition change in women. Nineteen Mexican-American and 18 Korean premenopausal overweight/obese women were randomized into one of the following groups: control, low-intensity training group (LI), and high-intensity training group (HI). Subjects completed 12 weeks of training at 50-56% maximal oxygen consumption (LI) or 65-70% maximal oxygen consumption (HI). Body composition components were measured at baseline and after training using dual-energy X-ray absorptiometry for Mexican-Americans, while whole-body com...
Source: International Journal of Endocrinology - August 2, 2017 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Corrigendum to "The Alliance of Mesenchymal Stem Cells, Bone, and Diabetes".
Corrigendum to "The Alliance of Mesenchymal Stem Cells, Bone, and Diabetes". Int J Endocrinol. 2017;2017:5924671 Authors: Napoli N, Strollo R, Paladini A, Briganti SI, Pozzilli P, Epstein S Abstract [This corrects the article DOI: 10.1155/2014/690783.]. PMID: 28751910 [PubMed] (Source: International Journal of Endocrinology)
Source: International Journal of Endocrinology - July 30, 2017 Category: Endocrinology Tags: Int J Endocrinol Source Type: research