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Analysis of Subclinical Thyroid Dysfunction and Metabolic Abnormality in 28568 Healthy People
Int J Endocrinol. 2023 Oct 16;2023:5216945. doi: 10.1155/2023/5216945. eCollection 2023.ABSTRACTWe analyzed the detection rates of metabolic syndrome (MetS) and subclinical thyroid dysfunction, including subclinical hyperthyroidism (SCHyper) and subclinical hypothyroidism (SCH), in healthy people, as well as their relationship. Clinical data were collected from 28,568 healthy individuals who underwent physical examinations. The detection rates of SCHyper, SCH, and MetS, as well as in different genders and ages, were analyzed. The detection rate of SCHyper and SCH in females was significantly higher than that in males (P &l...
Source: International Journal of Endocrinology - October 25, 2023 Category: Endocrinology Authors: Yan Xie Zhixue Wang Zongtao Chen Source Type: research

Sildenafil Enhances the Therapeutic Effect of Islet Transplantation for Diabetic Peripheral Neuropathy via mTOR/S6K1 Pathway
CONCLUSIONS: Islet transplantation can reverse sciatic nerve injury in diabetic mice, and islet cells exhibit a protective effect on RSC96 cells under high glucose conditions via the activation of the mTOR/S6K1 pathway. Sildenafil enhances the therapeutic effect of islet transplantation, which may represent a potential treatment strategy for diabetic peripheral neuropathy.PMID:37841556 | PMC:PMC10576648 | DOI:10.1155/2023/8199029 (Source: International Journal of Endocrinology)
Source: International Journal of Endocrinology - October 16, 2023 Category: Endocrinology Authors: Xiandong Zhu Shangjing Xie Jiawei Chen Qiaohong Lu Xiaowu Wang Feixiang Duan Sinian Xu Yan Zhang Hongjian Huang Yongqiang Wang Hongwei Wang Bicheng Chen Huanjie Huang Source Type: research