Effectiveness of Cabergoline Treatment in Patients with Acromegaly Uncontrolled with SSAs: Experience of a Single Tertiary Center
Exp Clin Endocrinol Diabetes DOI: 10.1055/a-1274-1276 Purpose To evaluate the effectiveness of cabergoline and the parameters affecting cabergoline response as add-on treatment to somatostatin analaogues (SSA) in patients with acromegaly uncontrolled with SSAs. Material and Method One hundred and twenty-nine acromegalic patients uncontrolled with SSA who had cabergoline added to their treatment were included in this retrospective study. Patients were divided into the SSAs + cabergoline-responsive (group 1) and non-responsive groups (group 2), and biochemical, pathologic, and radiologic parameters were assessed. Results IGF...
Source: Experimental and Clinical Endocrinology and Diabetes - October 23, 2020 Category: Endocrinology Authors: Sahin, Serdar Fidan, Mehmet Cem Korkmaz, Ozge Polat Durcan, Emre Ozkaya, Hande Mefkure Kadioglu, Pinar Tags: Article Source Type: research

Antecubital Vein Cannula Position Impacts Assessment of Forearm Glucose Uptake During an Oral Glucose Challenge in Healthy Volunteers
This study aimed to determine the impact of venous cannula position on calculated forearm glucose uptake following an oral glucose challenge in resting and post-exercise states. Materials and Methods In 9 young, lean, males, the impact of sampling blood from two antecubital vein positions; the perforating vein (‘perforating’ visit) and, at the bifurcation of superficial and perforating veins (‘bifurcation’ visit), was assessed. Brachial artery blood flow and arterialised-venous and venous blood glucose concentrations were measured in 3 physiological states; resting-fasted, resting-fed, and fed follo...
Source: Experimental and Clinical Endocrinology and Diabetes - October 23, 2020 Category: Endocrinology Authors: B étry, Cécile Nixon, Aline V. Greenhaff, Paul L. Simpson, Elizabeth J. Tags: Article Source Type: research

G-protein Coupled Estrogen Receptor Expression in Growth Hormone Secreting and Non-Functioning Adenomas
Exp Clin Endocrinol Diabetes DOI: 10.1055/a-1274-1330 Purpose To evaluate the expression of G-protein coupled estrogen receptor (GPER1), aromatase, estrogen receptor α (ERα), estrogen receptor β (ERβ), pituitary tumor transforming gene (PTTG), and fibroblast growth factor 2 (FGF2) in GH-secreting and non-functioning adenomas (NFA). Methods Thirty patients with acromegaly and 27 patients with NFA were included. Gene expression was determined via quantitative reverse transcription polymerase chain reaction (QRT-PCR). Protein expression was determined via immunohistochemistry. Results There was no differ...
Source: Experimental and Clinical Endocrinology and Diabetes - October 22, 2020 Category: Endocrinology Authors: Ozkaya, Hande Mefkure Sayitoglu, Muge Comunoglu, Nil Sun, Eda Keskin, Fatma Ela Ozata, Duygu Hocaoglu, Rabia Hacer Khodzaev, Khusan Firtina, Sinem Tanriover, Necmettin Gazioglu, Nurperi Oz, Buge Kadioglu, Pinar Tags: Article Source Type: research

How Reliable are Commercially Available Glypican4 ELISA Kits?
Conclusions Extensive evaluation of the performance of two commercially available ELISA kits led to the conclusion that none of them is applicable for the measurement of glypican4 in human blood samples. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes)
Source: Experimental and Clinical Endocrinology and Diabetes - October 16, 2020 Category: Endocrinology Authors: Buhl, Joseph P. Garten, Antje Kratzsch, J ürgen Kiess, Wieland Penke, Melanie Tags: Article Source Type: research

Let7b-5p is Upregulated in the Serum of Emirati Patients with Type 2 Diabetes and Regulates Insulin Secretion in INS-1 Cells
Exp Clin Endocrinol Diabetes DOI: 10.1055/a-1261-5282 Let7b-5p is a member of the Let-7 miRNA family and one of the top expressed miRNAs in human islets that implicated in glucose homeostasis. The levels of Let7b-5p in type 2 diabetes (T2DM) patients or its role in β-cell function is still unclear. In the current study, we measured the serum levels of let7b-5p in Emirati patients with T2DM (with/without complications) and control subjects. Overexpression or silencing of let7b-5p in INS-1 (832/13) cells was performed to investigate the impact on insulin secretion, content, cell viability, apoptosis, and key functional ...
Source: Experimental and Clinical Endocrinology and Diabetes - October 9, 2020 Category: Endocrinology Authors: Aljaibeji, Hayat Elemam, Noha Mousaad Mohammed, Abdul Khader Hasswan, Hind Thahyabat, Mahammad Al Alkhayyal, Noura Sulaiman, Nabil Taneera, Jalal Tags: Article Source Type: research

Football – Novel Approaches to Tackle Diabetes
Exp Clin Endocrinol Diabetes DOI: 10.1055/a-1262-6352Balanced diet and regular physical activity are of key importance to the prevention of the development and progression of non-communicable diseases. In 2050, 50% of the European population is expected to be obese. Cardiovascular diseases, diabetes mellitus, cancer, as well as joint impairments, will further increase. Therefore, programmes are critical to the improvement of the population’s health status in the long run. New ways have to be found that allow addressing more people than with the current approaches. Football has a great potential to attract people at r...
Source: Experimental and Clinical Endocrinology and Diabetes - October 7, 2020 Category: Endocrinology Authors: M üssig, Karsten Adamek, Henning E. Tags: Mini-Review Source Type: research

Elevated Circulating LINC-P21 Serves as a Diagnostic Biomarker of Type 2 Diabetes Mellitus and Regulates Pancreatic β-cell Function by Sponging miR-766-3p to Upregulate NR3C2
Conclusion All the data demonstrated that serum elevated LINC-P21 and decreased miR-766-3p serve as candidate diagnostic biomarkers in T2DM patients. LINC-P21 acts as a potential regulator in insulin secretion and proliferation of pancreatic β-cells through targeting miR-766-3p to upregulate NR3C2. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes)
Source: Experimental and Clinical Endocrinology and Diabetes - October 1, 2020 Category: Endocrinology Authors: Cao, Zhibin Yao, Fuwang Lang, Yuqin Feng, Xueqiang Tags: Article Source Type: research

Neuropsychological Functioning in Patients with Cushing ’s Disease and Cushing’s Syndrome
Conclusions Memory is the most extensively investigated domain in CS/CD patients and impairment is most prominent in active disease. Patients should be counseled that neuropsychological function will improve with normalization of hypercortisolism and over time. More studies with more stringent methodological criteria, larger patient samples and controlling for confounders are required to enhance our understanding of neuropsychological function in patients with CS/CD. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |&nb...
Source: Experimental and Clinical Endocrinology and Diabetes - September 28, 2020 Category: Endocrinology Authors: Siegel, Sonja Kirstein, Cedric Fabian Grzywotz, Agnieszka H ütter, Bernd Otto Wrede, Karsten Henning Kuhna, Victoria Kreitschmann-Andermahr, Ilonka Tags: Review Source Type: research

Glucagon Like Peptide-1 Receptor Agonists Alters Pancreatic and Hepatic Histology and Regulation of Endoplasmic Reticulum Stress in High-fat Diet Mouse Model
Exp Clin Endocrinol Diabetes DOI: 10.1055/a-1240-4936 Background Obesity is a major health problem worldwide, and non-alcoholic fatty pancreas disease (NAFPD) and non-alcoholic fatty liver disease (NAFLD) are obesity-associated complications. Liraglutide, a glucagon-like peptide-1 (GLP-1) agonist, has been approved for treatment of obesity. We aimed to evaluate the therapeutic effects of liraglutide on the complications through its regulation of endoplasmic reticulum (ER) stress. Methods A high-fat diet mouse model was established in C57BL/6J mice. Two groups of mice were fed a high-fat diet with 60% fat for 16 weeks and c...
Source: Experimental and Clinical Endocrinology and Diabetes - September 21, 2020 Category: Endocrinology Authors: Fang, Taiyong Huang, Siying Chen, Yongpeng Chen, Zongchi Chen, Jiangmu Hu, Weitao Tags: Article Source Type: research

Considering Insulin Secretory Capacity as Measured by a Fasting C-Peptide/Glucose Ratio in Selecting Glucose-Lowering Medications
Exp Clin Endocrinol Diabetes DOI: 10.1055/a-1242-9809Type 2 diabetes mellitus is a heterogeneous disease. Recently introduced new subclassifications promise more efficacious, tailored treatments which could complement current guidelines. In the differentiation of the new diabetes subphenotypes, assessment of insulin secretion is one of the essential components. Based on a large number of insulin secretion measurements, we propose fasting C-peptide/glucose ratio (CGR) as an adequate and practicable estimate of insulin secretion. CGR discriminates insulin deficiency from insulin hypersecret...
Source: Experimental and Clinical Endocrinology and Diabetes - September 17, 2020 Category: Endocrinology Authors: Fritsche, Andreas Heni, Martin Peter, Andreas Gallwitz, Baptist Kellerer, Monika Birkenfeld, Andreas L. H äring, Hans-Ulrich Wagner, Robert Tags: Commentary Source Type: research

ICAT acts as a Coactivator in Regulating PPAR γ Transcriptional Activity in Mesangial Cells
Conclusions β-catenin and ICAT interact as coactivator to modulate PPARγ transcriptional activation. In HMCs cultured in HG, the low expression of ICAT leads to low PPARγ transcriptional activation. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes)
Source: Experimental and Clinical Endocrinology and Diabetes - September 15, 2020 Category: Endocrinology Authors: Wei, Yi Yu, Jiawei Zhang, Xiaopeng Mu, Jiao Zhang, Jun Zeng, Wei Feng, Bing Tags: Article Source Type: research

Liver Expressed Antimicrobial Peptide 2 is Associated with Steatosis in Mice and Humans
Conclusions The study suggests LEAP2 is associated with hepatic steatosis, which may involve lipolytic/lipogenic pathway and insulin signaling. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes)
Source: Experimental and Clinical Endocrinology and Diabetes - September 14, 2020 Category: Endocrinology Authors: Ma, Xiaoming Xue, Xing Zhang, Jingxin Liang, Shuang Xu, Chunfang Wang, Yue Zhu, Jinzhou Tags: Article Source Type: research

Clinical and Genetic Characteristics of 23 Korean Patients with Haploinsufficiency of the Short-stature Homeobox-containing Gene
Conclusions A high index of suspicion and the genetic confirmation of SHOX deficiency are helpful for the timely management of the condition and are needed to provide genetic counselling to the family members of the patients. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes)
Source: Experimental and Clinical Endocrinology and Diabetes - September 14, 2020 Category: Endocrinology Authors: Lee, Jeong-Seon Kim, Hwa Young Lee, Young-Ah Lee, Seong-Young Cho, Tae-Joon Ko, Jung Min Tags: Article Source Type: research

COVID-19 and Sodium-Glucose Cotransporter 2 Inhibitors: No Fear to Attempt?
Exp Clin Endocrinol Diabetes DOI: 10.1055/a-1235-5617Novel coronavirus infectious disease (COVID-19) has been recognised as a pandemic by the World Health Organization (WHO) 1. Mortality and morbidity are higher in elderly individuals and those with comorbidities, such as diabetes mellitus (DM), obesity, hypertension, respiratory tract diseases, coronary heart disease or cancer 1. Indeed, two thirds of individuals who died from COVID-19 had DM in Italy 2. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract&nb...
Source: Experimental and Clinical Endocrinology and Diabetes - September 9, 2020 Category: Endocrinology Authors: Papachristou, Stella Penlioglou, Theano Stoian, Anca Pantea Papanas, Nikolaos Tags: Commentary Source Type: research

The TUDID Study – Background and Design of a Prospective Cohort
Exp Clin Endocrinol Diabetes DOI: 10.1055/a-1221-9618Prevalence of both type 1 and type 2 diabetes mellitus is growing worldwide and one major cause for morbidity and mortality. However, not every patient develops diabetes-related complications, but causes for the individual susceptibility are still not fully understood. As a platform to address this, we initiated the TUDID (TUebingen DIabetes Database) study, a prospective, monocentric, observational study that includes adults with diabetes mellitus who are treated in the inpatient clinic of a University Hospital in southern Germany. Besides ...
Source: Experimental and Clinical Endocrinology and Diabetes - September 9, 2020 Category: Endocrinology Authors: Jaghutriz, Benjamin Assad Wagner, Robert Kullmann, Stephanie Fritsche, Louise Eckstein, Sabine S. Dannecker, Corinna Willmann, Caroline Randrianarisoa, Elko Lehn-Stefan, Angela Hieronimus, Anja Hudak, Sarah Vosseler, Dorothea Lamprinou, Apostolia Huber, P Tags: Article Source Type: research

Flash Glucose Monitoring Improves Glucose Control in People with Type 2 Diabetes Mellitus Receiving Anti-diabetic Drug Medication
This study analyzed the data of a total of 111 people with T2DM (male 60 and female 51). The general clinical data of these patients were as follows: age: 65.0±6.7 years old; duration of diabetes: 11.6±6.8 years; HbA1c: 61.2±13.3 mmol/mol; body mass index (BMI): 25.2±3.2 kg/m². Using FGM, people with T2DM were able to change daily diet and exercise through which significant reductions in MPG on days 12 or 13 were achieved as compared with that of day 2 (P=0.04 or P=0.003, respectively). The glucose variations, such as standard deviation ...
Source: Experimental and Clinical Endocrinology and Diabetes - August 27, 2020 Category: Endocrinology Authors: Chen, Maoyuan Li, Huiqin Shen, Yun Liu, Bingli Yan, Renna Sun, Xiaojuan Ye, Lei Lee, Kok-Onn Ma, Jianhua Su, Xiaofei Tags: Article Source Type: research

Establishment of Clinical and Lab Algorithms for the Identification of Carriers of Mutations in CYP21A2 – A Study of 365 Children and Adolescents
Conclusion Alternatively to the above mentioned cut-offs the difference of 60 min after stimulation to basal 17OHP (Δ17OHP60) can be used for the benefit of a combined test to identify both heterozygotes and bi-allelic patients. There are minimal decreases in sensitivity and specificity compared to an approach that applies two tests. However, it denotes a simpler approach in the clinical routine. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Experi...
Source: Experimental and Clinical Endocrinology and Diabetes - August 23, 2020 Category: Endocrinology Authors: Meinel, J. Haverkamp, T. W ünsche, F. Richter-Unruh, A. Tags: Article Source Type: research

SNPs of miR-23b, miR-107 and HMGA2 and their Relations with the Response to Medical Treatment in Acromegaly Patients
Conclusion The genetic variations of the miRNAs genes related with HMGA2 and AIP genes were not seen in our study. Although there is no relationship between HMGA2-rs1351394 polymorphism and acromegaly disease, T allele was associated with some clinical features related to adenoma in patients with acromegaly. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes)
Source: Experimental and Clinical Endocrinology and Diabetes - August 23, 2020 Category: Endocrinology Authors: Armagan, Derya Metin Akdemir, Ayse Seda Ozkaya, Hande Mefkure Korkmaz, Ozge Polat Gazioglu, Nurperi Kadioglu, Pinar Tanriover, Necmettin Dagistanli, Kaya-Fatma Dirican, Ahmet Ozturk, Melek Tags: Article Source Type: research

Persistent Cushing ’s Disease after Transsphenoidal Surgery: Challenges and Solutions
Exp Clin Endocrinol Diabetes DOI: 10.1055/a-1220-6056Transsphenoidal surgery remains the primary treatment for Cushing’s disease (CD). However, despite the vast improvements in pituitary surgery, successful treatment of CD remains a great challenge. Although selective transsphenoidal removal of the pituitary tumor is a safe and effective procedure, the disease persists in around 22% of CD patients due to incomplete tumor resection. The persistence of hypercortisolism after pituitary surgery may also be the consequence of a misdiagnosis, as can occur in case of ectopic ACTH secretion...
Source: Experimental and Clinical Endocrinology and Diabetes - August 23, 2020 Category: Endocrinology Authors: Albani, Adriana Theodoropoulou, Marily Tags: Article Source Type: research

Progression of Diabetic Complications in Subgroups of People with Long Term Diabetes Type 1 According to Clinical Course
Conclusion In our analysis, we were able to confirm known risk factors for microvascular disease in people with type 1 diabetes. Overall, prediction of individual risk was difficult, the effect of individual markers minor and we could not find differences regarding slow or fast progression. We therefore emphasis the need for additional markers to predict individual risk for microvascular disease. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Experimental and Cl...
Source: Experimental and Clinical Endocrinology and Diabetes - August 9, 2020 Category: Endocrinology Authors: Gerdes, Christian Werner, Christoph Kloos, Christof Lehmann, Thomas Wolf, Gunter M üller, Ulrich Alfons M üller, Nicolle Tags: Article Source Type: research

Clinical Characteristics of Primary Hypophysitis – A Single-Centre Series of 60 Cases
Conclusions The cohort of clinically diagnosed patients did not differ from our histopathologically diagnosed patients or from published cohorts with predominantly surgical patients. Thus, diagnosis of primary hypophysitis using clinical criteria seems feasible. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes)
Source: Experimental and Clinical Endocrinology and Diabetes - August 6, 2020 Category: Endocrinology Authors: Amereller, Felix K üppers, Anna-Maria Schilbach, Katharina Schopohl, Jochen St örmann, Sylvère Tags: Article Source Type: research

Therapeutic Patient Education for Adrenal Insufficiency under COVID-19 Pandemic Conditions
Exp Clin Endocrinol Diabetes DOI: 10.1055/a-1217-7208Adrenal insufficiency (AI) requires life-long treatment with glucocorticoid replacement therapy. Over- or under-substitution carries the risk of increased morbidity in the form of side effects or adrenal crises. Glucocorticoid replacement therapy needs to be flexible with dose adaptation in special situations. This could not be managed by medical personnel on a daily basis, but requires an educated patient who has a good knowledge of the disease, understands his medical therapy and is able to perform situational dose adaptation. ...
Source: Experimental and Clinical Endocrinology and Diabetes - August 5, 2020 Category: Endocrinology Authors: Kienitz, Tina Hahner, Stefanie Burger-Stritt, Stephanie Quinkler, Marcus Tags: Review Source Type: research

Glucagon and Liver Fat are Downregulated in Response to Very Low-calorie Diet in Patients with Obesity and Type-2 Diabetes
This study investigated the effects of a very low-calorie diet on plasma levels of glucagon and liver fat in obese patients with type-2 diabetes. Patients and Methods Ten obese patients with type-2 diabetes, 6 men and 4 women, were included. At baseline, fasting plasma glucagon, insulin and glucose were determined, and liver fat and stiffness evaluated by transient elastography. The subjects were then prescribed a very low-calorie diet of maximum 800 kcal/day for 7 weeks and reexamined after 7 weeks and 12 months. Results At baseline, BMI was 42±4 ...
Source: Experimental and Clinical Endocrinology and Diabetes - August 5, 2020 Category: Endocrinology Authors: Haas, Stephan L. L öfgren, Patrik St ål, Per Hoffstedt, Johan Tags: Article Source Type: research

Efficacy and Safety of Stereotactic Radiotherapy in Cushing ’s Disease: A Single Center Experience
Conclusion In this current single center experience, postoperative cortisol and 1mg DST levels were found as the determinants of time to remission. Although medical therapy before RT did not affect the rate of- and time to remission, medical therapy after RT prolonged the time to biochemical control . This latter finding might suggest a radioprotective effect of cortisol lowering medication use on peri-RT period. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Sourc...
Source: Experimental and Clinical Endocrinology and Diabetes - August 5, 2020 Category: Endocrinology Authors: Apaydin, Tugce Ozkaya, Hande Mefkure Durmaz, Sebnem Memis Meral, Rasim Kadioglu, Pinar Tags: Article Source Type: research

Revived Attention for Adult Craniopharyngioma
Exp Clin Endocrinol Diabetes DOI: 10.1055/a-1217-7282Craniopharyngioma as a rare tumor originating from cells of rathke’s pouch and representing 2–5% of all intracranial tumors is a rare and generally benign neoplasm of the central nervous system with two incidence peaks one in childhood and one after 40 years of age. Data on adult patients is scarce compared to childhood onset tumors, however the burden of disease caused by the tumors and related treatment options is significant. Clinical symptoms range from headaches, visual disability, cranial nerve affection or hypothalamic ...
Source: Experimental and Clinical Endocrinology and Diabetes - August 3, 2020 Category: Endocrinology Authors: Mende, Klaus Christian Pantel, Tobias Fabian Flitsch, J örg Tags: Review Source Type: research

Knock-Down of Long Non-Coding RNA ANRIL Suppresses Mouse Mesangial Cell Proliferation, Fibrosis, Inflammation via Regulating Wnt/ β-Catenin and MEK/ERK Pathways in Diabetic Nephropathy
Conclusions Lnc-ANRIL knock-down suppresses mouse mesangial cell proliferation, fibrosis, inflammation, Wnt/β-catenin and MEK/ERK pathways in DN. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes)
Source: Experimental and Clinical Endocrinology and Diabetes - July 28, 2020 Category: Endocrinology Authors: Fang, Xun Hu, Jun Zhou, Hongyan Tags: Article Source Type: research

Prevalence of Signs and Symptoms of Pseudotumor Cerebri Syndrome Before and After Transsphenoidal Surgery for Cushing ’s Disease – A Prospective Consecutive Case Series
Conclusion Our results suggest a very low frequency of signs and symptoms of PTCS after surgical treatment for CD in adults. This estimate is in line with previous outcomes from retrospective pediatric CD series. Further large-scale studies are needed to determine the actual prevalence of this condition following biochemical remission of CD. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes)
Source: Experimental and Clinical Endocrinology and Diabetes - July 27, 2020 Category: Endocrinology Authors: Huckhagel, Torge Flitsch, J örg Rotermund, Roman Knospe, Volker Tags: Article Source Type: research

Quality of Life and Treatment Satisfaction in Participants with Maturity-Onset Diabetes of the Young: A Comparison to Other Major Forms of Diabetes
Exp Clin Endocrinol Diabetes DOI: 10.1055/a-1200-1482 Aims We investigated the quality of life (QoL), treatment satisfaction and perception of genetic results in participants with Maturity-Onset Diabetes of the Young (MODY) and compared the results with those of subjects with type 1 (T1D) or type 2 (T2D) diabetes. Methods A total of 162 adults with GCK-MODY, 62 with HNF1A-MODY and 29 with HNF4A-MODY answered the questionnaire Audit of Diabetes Dependent Quality of Life, the Diabetes Treatment Satisfaction Questionnaire and non-validated instrument examining the respondent’s per...
Source: Experimental and Clinical Endocrinology and Diabetes - July 27, 2020 Category: Endocrinology Authors: Dusatkova, Petra Pavlikova, Marketa Spirkova, Alena Elblova, Lenka Zdarska, Denisa Janickova Rozenkova, Klara Hron, Jakub Sumnik, Zdenek Cinek, Ondrej Lebl, Jan Pruhova, Stepanka Tags: Article Source Type: research

Mortality of Patients with Cushing ’s Disease
Exp Clin Endocrinol Diabetes DOI: 10.1055/a-1197-6380Cushing’s disease is a rare condition of cortisol excess attributed to a pituitary adenoma with an annual incidence of 1.2–2.4 cases per million population. It is associated with several co-morbidities leading to increased mortality predominantly due to cardiovascular disease. Despite the advances in its diagnosis and management, survival can be compromised even after apparent successful treatment. Minimizing the duration and extent of exposure to hypercortisolaemia by early diagnosis and rapid, effective therapeutic interve...
Source: Experimental and Clinical Endocrinology and Diabetes - July 8, 2020 Category: Endocrinology Authors: Ntali, Georgia Hakami, Osamah Wattegama, Milanka Ahmed, Shahzada Karavitaki, Niki Tags: Review Source Type: research

A Prospective, Randomized Trial Testing Different Regimens of Carbohydrate Administration to Prevent Major Reduction in Plasma Glucose Follwing a Standardized Bout of Moderate Physical Activity in Patients with Type 1 Diabetes
Exp Clin Endocrinol Diabetes DOI: 10.1055/a-1190-3614 Aim/Hypothesis It was the aim to prospectively study regimes of “preventive” carbohydrate administration to avoid major reduction in plasma glucose during physical activity. Methods 24 patients with type 1 diabetes (age 41±12 years; 11 women, 13 men; BMI 26.5±4.7 kg/m2; HbA1c 9.1±1.5%; insulin dose 0.64±0.22 IU/kg body weight and day) participated in one experiment without physical activity and in three experiments with a 4 km, 60 min hike starting at 2 p.m.. No “prevent...
Source: Experimental and Clinical Endocrinology and Diabetes - July 1, 2020 Category: Endocrinology Authors: Frenzke, Hanna Varnhorn, Annette Schulze, Heike Kahle-Stephan, Melanie Nauck, Michael A. Tags: Article Source Type: research

Cardiac Autonomic Neuropathy is Associated with Improved Diabetic Foot Ulcer Healing: A Single Centre Prospective Cohort Study
Conclusions We demonstrate a high prevalence of CAN in a DFU cohort and that CAN is associated with improved DFU healing. The results of this study establish the scientific rationale for further studies to better understand the mechanisms between CAN and DFU outcomes. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes)
Source: Experimental and Clinical Endocrinology and Diabetes - July 1, 2020 Category: Endocrinology Authors: Farrow, Frederick Fountoulakis, Nikolaos Cummins, Kelly Sharma, Angelica Mahmood, Rabiah Vas, Prashanth Thomas, Stephen Karalliedde, Janaka Tags: Article Source Type: research

Medical Therapy of Acromegaly in Germany 2019 – Data from the German Acromegaly Registry
Conclusion The majority of German acromegalic patients receiving medical therapy are controlled according to normal IGF-1 levels. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes)
Source: Experimental and Clinical Endocrinology and Diabetes - June 29, 2020 Category: Endocrinology Authors: Quinkler, Marcus Petroff, David Knappe, Ulrich J. Schopohl, Jochen T önjes, Anke Schmid, Sebastian M. Tags: Article Source Type: research

Predictive Effect of Inflammatory Response and Foot Ulcer Localization on Outcome in Younger and Older Individuals with Infected Diabetic Foot Syndrome
Exp Clin Endocrinol Diabetes DOI: 10.1055/a-1149-8989The diabetic foot syndrome (DFS) is the most important cause for non-traumatic major amputation in adult individuals and actually one of the most frightening events in diabetics’ life. Despite the often protracted treatment of infected DFS at the end patients are often confronted with amputation. We investigated 352 individuals with infected DFS in two age separated-groups. Older individuals presented with significant worse renal function and lower HbA1c on day of admittance. Most detected ulcers involved the plantar sides of the ...
Source: Experimental and Clinical Endocrinology and Diabetes - June 23, 2020 Category: Endocrinology Authors: D örr, Stefan Schlecht, Michael Chatzitomaris, Apostolos Weisser, Gregor Lucke-Paulig, Lara Friedl, Alexander Joachim, Regina Lobmann, Ralf Tags: Article Source Type: research

Liraglutide Effect on Ventricular Transient Outward K  +  Channel and Connexin-43 Protein Expression
Conclusions We have shown that pathological alterations in myocardial Cx43 expression and distribution, in addition to reduced Ito channel expression, may underlie the QTc interval prolongation in high-fat diet/STZ rat model of type 2 diabetes mellitus. The beneficial effects of Liraglutide, as those of Ramipril, on cardiac electrophysiology could be at least attributed to its direct ability to normalize expression and distribution of Cx43 and Ito channels in the diabetic rat heart. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of...
Source: Experimental and Clinical Endocrinology and Diabetes - June 18, 2020 Category: Endocrinology Authors: Ramadan, Nehal M. Malek, Hala Abdel Rahman, Karawan Abd-el El-Kholy, Elhamy Shaalan, Dalia Elkashef, Wagdi Tags: Article Source Type: research

The High-Resolution Three-Dimensional Magnetic Detector System 3D-Magma Accurately Measures Gastric and Small Bowel Motility in People with Type 2 Diabetes with Neuropathy
Discussion and conclusion: 3D-MAGMA is able to detect changes in intestinal motility. Its clinical value might be useful in patients with fluctuating blood glucose levels and unexplained hypoglycemic episodes. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes)
Source: Experimental and Clinical Endocrinology and Diabetes - June 17, 2020 Category: Endocrinology Authors: Jacob, Veit Yves Pascal Felber, J örg M üller, Nicolle Kloos, Christof M üller, Ulrich Alfons Stallmach, Andreas Tags: Article Source Type: research

Screening for New Markers to Assess Thyroid Hormone Action by OMICs Analysis of Human Samples
Exp Clin Endocrinol Diabetes 2020; 128: 479-487 DOI: 10.1055/a-1144-2636Determination of the levels of thyroid-stimulating hormone (TSH) and free thyroid hormones (fTHs) is crucial for assessing thyroid function. However, as a result of inter-individual genetic variability and different environmental factors individual set points exist for TSH and fTHs and display considerable variation. Furthermore, under specific pathophysiological conditions like central hypothyroidism, TSH secreting pituitary tumors, or thyroid hormone resistance the established markers TSH and fTH fail to reli...
Source: Experimental and Clinical Endocrinology and Diabetes - June 15, 2020 Category: Endocrinology Authors: Friedrich, Nele Pietzner, Maik Engelmann, Beatrice Homuth, Georg F ührer, Dagmar Brabant, Georg Wallaschofski, Henri V ölker, Uwe Tags: Mini-Review Source Type: research

Mass Spectrometry-Based Determination of Thyroid Hormones and Their Metabolites in Endocrine Diagnostics and Biomedical Research – Implications for Human Serum Diagnostics
Exp Clin Endocrinol Diabetes 2020; 128: 358-374 DOI: 10.1055/a-1175-4610The wide spectrum of novel applications for the LC-MS/MS-based analysis of thyroid hormone metabolites (THM) in blood samples and other biological specimen highlights the perspectives of this novel technology. However, thorough development of pre-analytical sample workup and careful validation of both pre-analytics and LC-MS/MS analytics, is needed, to allow for quantitative detection of the thyronome, which spans a broad concentration range in these biological samples.This minireview summarizes recent developments i...
Source: Experimental and Clinical Endocrinology and Diabetes - June 15, 2020 Category: Endocrinology Authors: K öhrle, Josef Richards, Keith H. Tags: Mini-Review Source Type: research

Seven Years of Active Thyroid Hormone Research in Germany: Thyroid Hormone Action beyond Classical Concepts
Exp Clin Endocrinol Diabetes 2020; 128: 355-357 DOI: 10.1055/a-1163-7355 © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes)
Source: Experimental and Clinical Endocrinology and Diabetes - June 15, 2020 Category: Endocrinology Authors: Biebermann, Heike Brix, Klaudia F ührer, Dagmar Tags: Editorial Source Type: research

Combined Effects of Single Nucleotide Polymorphisms (SNPs) within C-reactive Protein (CRP) and Environmental Parameters on Risk and Prognosis for Diabetic Foot Osteomyelitis Patients
Conclusion Genetic mutations within CRP functioned interactively with external factors to affect DFO risk. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes)
Source: Experimental and Clinical Endocrinology and Diabetes - June 14, 2020 Category: Endocrinology Authors: Wang, Shanjin Xu, Haowei Zhou, Ningfeng Zhao, Weidong Wu, Desheng Shen, Bin Tags: Article Source Type: research

Sulforaphane and Vitamin E Protect From Glucotoxic Neurodegeneration and Lifespan Reduction In C. Elegans
Exp Clin Endocrinol Diabetes DOI: 10.1055/a-1158-9248 Caenorhabditis elegans is an established model organism in neurodegeneration and aging research. Oxidative stress and formation of advanced glycation endproducts (AGEs), as they occur under hyperglycemic conditions in diabetes mellitus, contribute to neuronal damage and lifespan reduction. Sulforaphane (SFN) is an indirect antioxidant, alpha-tocopherol (vitamin E) is a direct antioxidant that acts as a free radical scavenger. Aim of this study is to investigate the protective effects of SFN and vitamin E against glucotoxic damages...
Source: Experimental and Clinical Endocrinology and Diabetes - June 4, 2020 Category: Endocrinology Authors: Schlotterer, Andrea Masri, Benan Humpert, M. Kr ämer, Bernhard Karl Hammes, Hans-Peter Morcos, Michael Tags: Article Source Type: research

Functional Characteristics of Novel FGFR1 Mutations in Patients with Isolated Gonadotropin-Releasing Hormone Deficiency
Conclusions This study identified seven rare sequence variants in FGFR1 in patients with KS and nIHH. Probands with an FGFR1 mutations displayed a wide phenotypic spectrum ranging from KS to anosmia. A prepubertal male with anosmia should be followed up to assess pubertal development because they can manifest hypogonadotropic hypogonadism after puberty. These results expand the phenotypic spectrum of FGFR1 mutations and suggest a broader biologic role of FGFR1 in reproduction. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents &n...
Source: Experimental and Clinical Endocrinology and Diabetes - June 1, 2020 Category: Endocrinology Authors: Choi, Jin-Ho Oh, Arum Lee, Yena Kim, Gu-Hwan Yoo, Han-Wook Tags: Article Source Type: research

Endocrine, Metabolic and Pharmacological Effects of Thyronamines (TAM), Thyroacetic Acids (TA) and Thyroid Hormone Metabolites (THM) – Evidence from in vitro, Cellular, Experimental Animal and Human Studies
Exp Clin Endocrinol Diabetes DOI: 10.1055/a-1139-9200Thyroid hormone metabolites (THM) with few or no iodine substituents such as 3,5-T2, the thyronamines 3-T1AM and T0AM, and their oxidation products, the thyroacetic acids (TA) formed by monoamine oxidases, have recently attracted major interest due to their metabolic actions which are in part distinct from those of the classical thyromimetic hormone T3, the major ligand of T3 receptors. This review compiles and discusses in vitro effects of 3,5-T2, TAM and TA reported for thyrocytes, pancreatic islets and hepatocytes as well as findings from in vivo studies in mouse mode...
Source: Experimental and Clinical Endocrinology and Diabetes - May 24, 2020 Category: Endocrinology Authors: Homuth, Georg Lietzow, Julika Schanze, Nancy Golchert, Janine K öhrle, Josef Tags: Article Source Type: research

Epigenetic Downregulation of FASN in Visceral Adipose Tissue of Insulin Resistant Subjects
Exp Clin Endocrinol Diabetes DOI: 10.1055/a-1150-7446 Objective The risk to develop type 2 diabetes increases with the amount of visceral adiposity presumably due to increased lipolysis and subsequent lipid accumulation in visceral organs. However, data describing the molecular regulation of these pathways in humans are rare. We tested if genes of the lipogenic and lipolytic pathways are associated with glucose intolerance independently of obesity in visceral adipose tissue (VAT) of obese subjects. Moreover, we studied DNA methylation of FASN (fatty acid synthase), that catalyses th...
Source: Experimental and Clinical Endocrinology and Diabetes - May 19, 2020 Category: Endocrinology Authors: Sievert, Helen Krause, Christin Gei ßler, Cathleen Grohs, Martina El-Gammal, Alexander T. Wolter, Stefan Mann, Oliver Lehnert, Hendrik Kirchner, Henriette Tags: Article Source Type: research

Additional Insulin for Coping with Fat- and Protein-Rich Meals in Adolescents with Type 1 Diabetes: The Protein Unit
Exp Clin Endocrinol Diabetes DOI: 10.1055/a-1149-8766 Objective Dietary proteins raise blood glucose levels; dietary fats delay this rise. We sought to assess the insulin amount required to normalize glucose levels after a fat- and protein-rich meal (FPRM). Methods Sixteen adolescents (5 female) with type 1 diabetes (median age: 18.2 years; range: 15.2–24.0; duration: 7.1 years; 2.3–14.3; HbA1c: 7.2%; 6.2–8.3%) were included. FPRM (carbohydrates 57 g; protein 92 g; fat 39 g; fibers 7 g; calories 975 Kcal) was served in the evening, with 20 or 40% extra insulin compared t...
Source: Experimental and Clinical Endocrinology and Diabetes - May 19, 2020 Category: Endocrinology Authors: Schweizer, Roland Herrlich, Susann L ösch-Binder, Martina Gl ökler, Michaela Heimg ärtner, Magdalena Liebrich, Franziska Me ßner, Katja Muckenhaupt, Tina Schneider, Angelika Ziegler, Julian Neu, Andreas Tags: Article Source Type: research

Metformin Associated Lactic Acidosis in Clinical Practice – A Case Series
Conclusions Every patient matching the screening criteria of acute renal failure, lactic acidosis and continued intake of metformin can be considered a potential MALA case. A risk score assessment which includes severe comorbidities may help to identify high-risk individuals and should be evaluated in larger studies.To prevent MALA, patients should be trained to immediately interrupt their own metformin use when showing signs of volume depletion. Physicians should be aware of the additional risk factors such as co-medication with diuretics, ACE (angiotensin converting enzyme) ACE inhibitors and NSAIDs (non steroidal anti i...
Source: Experimental and Clinical Endocrinology and Diabetes - May 12, 2020 Category: Endocrinology Authors: Sch ädle, Philipp Tschritter, Otto Kellerer, Monika Tags: Article Source Type: research

Correction: Steroidogenesis in the NCI-H295 Cell Line Model is Strongly Affected By Culture Conditions and Substrain
Exp Clin Endocrinol Diabetes DOI: 10.1055/a-1169-5951 [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes)
Source: Experimental and Clinical Endocrinology and Diabetes - May 11, 2020 Category: Endocrinology Authors: Kurlbaum, Max Sbiera, Silviu Kendl, Sabine Fassnacht, Martin Kroiss, Matthias Tags: Article Source Type: research

A ‘Speed-Dating’ Model of Wound Care? Rapid, High-Volume Assessment of Patients With Diabetes in a Multidisciplinary Foot Wound Clinic
Conclusion Our study shows that the use of a rapid-access interdisciplinary team to assess and manage patients’ diabetes in a foot wound clinic is feasible. Patients with higher-risk diabetes foot wounds exposed to RAIT had comparable wound healing outcomes to lower risk patients. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes)
Source: Experimental and Clinical Endocrinology and Diabetes - May 6, 2020 Category: Endocrinology Authors: Sung, Jasper A. Gurung, Seema Lam, Teresa Yusaf, Shehzi Vicaretti, Mauro Begg, Lindy Cheung, N. Wah Padmanabhan, Suja Girgis, Christian M. Tags: Article Source Type: research

Rhinological Consequences of Microsurgical Endonasal-Transsphenoidal Surgery for Pituitary Tumors
Conclusion Microsurgical resection of pituitary tumors via the endonasal transsphenoidal approach poses an acceptable risk with regards to sinonasal complications. The incidence of secondary rhinosurgical interventions is low. Standardized comparative studies between endoscopic and microsurgical transsphenoidal operations should be undertaken. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes)
Source: Experimental and Clinical Endocrinology and Diabetes - May 6, 2020 Category: Endocrinology Authors: Hondronikos, Nikolaos Alomari, Ali Schrader, Martin Knappe, Ulrich J. Tags: Article Source Type: research

Assessing the benefits and challenges of video consultations for the treatment of children with type 1 diabetes – A qualitative study among diabetes professionals
Conclusions Prerequisites for successful video consultations include a comprehensive initial technical training and an agreement on treatment responsibilities of all health care professionals involved in the patient’s care. Under these conditions, the experts reported significant advantages of video consultation in the treatment of children with type 1 diabetes. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes)
Source: Experimental and Clinical Endocrinology and Diabetes - May 6, 2020 Category: Endocrinology Authors: Frielitz, Fabian-Simon D ördelmann, Jana Lemke, Stella Lange, Karin Hiort, Olaf Katalinic, Alexander von Sengbusch, Simone Tags: Article Source Type: research

Steroidogenesis in the NCI-H295 Cell Line Model is Strongly Affected By Culture Conditions and Substrain
Exp Clin Endocrinol Diabetes DOI: 10.1055/a-1105-6332 Context NCI-H295 cells are the most widely used model for adrenal steroidogenesis and adrenocortical carcinoma and have been used for decades in laboratories worldwide. However, reported steroidogenic properties differ considerably. Objective To evaluate heterogeneity of steroidogenesis among NCI-H295 cell strains, clarify the influence of culture media and test response to inhibitors of steroidogenesis by using liquid chromatography tandem mass spectrometry (LC-MS/MS). Methods NCI-H295 cells were obtained from two cell banks...
Source: Experimental and Clinical Endocrinology and Diabetes - April 28, 2020 Category: Endocrinology Authors: Kurlbaum, Max Sbiera, Silviu Kendl, Sabine Martin Fassnacht, M. Kroiss, Matthias Tags: Article Source Type: research