Losing Track of Lipids in Children and Adolescents with Type 1 Diabetes: Towards Individualized Patient Care
Conclusions A considerable number of children and adolescents with T1D loses track of lipids and does so within a 2-year screening interval. The predictive power of a risk score including age, BMI, gender, HbA1c, diabetes duration and ethnicity is only moderate. Future research should focus on another approach to the determinants used in this study or other determinants predictive of losing track of lipids on the short term. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Experimental an...
Source: Experimental and Clinical Endocrinology and Diabetes - July 4, 2019 Category: Endocrinology Authors: Heyden, Josine C. van der Birnie, Erwin Bovenberg, Sarah A. Dekker, Pim Veeze, Henk J. Mul, Dick Aanstoot, Henk-Jan Tags: Article Source Type: research

The Relationship Between β-cell Function Indices and Sudomotor Function in Chinese Patients with Type 2 Diabetes
Exp Clin Endocrinol Diabetes DOI: 10.1055/a-0950-9828 Purpose SUDOSCAN, a new non-invasive, quick, sensitive and quantitative technique, has been developed to detect diabetic peripheral neuropathy, and the latter is believed to be correlated with impaired β-cell function. The purpose of the present study was to investigate the associations between β-cell function indices and sudomotor function in Chinese type 2 diabetes. Methods A total of 266 Chinese patients with type 2 diabetes were enrolled. Sudomotor function was assessed using electrochemical skin conductance of hands and feet. Pancreatic β-cell functi...
Source: Experimental and Clinical Endocrinology and Diabetes - July 3, 2019 Category: Endocrinology Authors: Cao, Bai-lu Yao, Yue Xu, Yi-xin Fang, Jiang Song, Wen-jing Hu, Bin Guo, Qing-yu Lu, Bin Li, Jie Gu, Ping Shao, Jia-qing Tags: Article Source Type: research

Adherence, Attitudes and Beliefs of Growth Hormone Deficient Patients – A Questionnaire-based Cohort Study
Discussion Most often, misinformation causes patients to refuse GHRT. Possibly the understanding of their condition and consequences of non-treatment is limited. To improve adherence more focused educational and behavioural strategies may be needed. Willingness to begin a therapy with LAGH was lower than expected (36%). The reasons for reluctance against LAGH need to be elucidated. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes)
Source: Experimental and Clinical Endocrinology and Diabetes - July 2, 2019 Category: Endocrinology Authors: Amereller, Felix Schilbach, Katharina Schopohl, Jochen St örmann, Sylvère Tags: Article Source Type: research

Association Between Levels of Serum Insulin-like Growth Factor I and Functional Recovery, Mortality, and Recurrent Stroke at a 7-year Follow-up
Conclusion The association for s-IGF-I with long-term post-stroke recovery persists after 7 years, which is also reflected in the mRS score distributions at all time-points. The effects are however modest, and not driven by mortality or recurrent stroke. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  open access Full text (Source: Experimental and Clinical Endocrinology and Diabetes)
Source: Experimental and Clinical Endocrinology and Diabetes - July 1, 2019 Category: Endocrinology Authors: Åberg, N. David Åberg, Daniel Lagging, Cecilia Holmegaard, Lukas Redfors, Petra Jood, Katarina Nilsson, Michael Åberg, Maria Blomstrand, Christian Svensson, Johan Jern, Christina Isgaard, J örgen Tags: Article Source Type: research

Association Between Glycaemic Control and the Intake of Thiazide Diuretics, Beta Blockers and Levothyroxine in People Without Diabetes
Conclusion Thiazides and the combination of levothyroxine and thiazides were associated with slight changes in HbA1c. In this study there was no association between the intake of beta blockers and HbA1c. At least for people without diabetes these effects seem to be of minor importance. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes)
Source: Experimental and Clinical Endocrinology and Diabetes - July 1, 2019 Category: Endocrinology Authors: Roth, Johannes M üller, Nicole Kuniss, Nadine Wolf, Gunter M üller, Ulrich Alfons Tags: Article Source Type: research

Owning a Dog as a Determinant of Physical Activity and Metabolic Control in Patients With Type 1 and Type 2 Diabetes Mellitus
Conclusions Owning a dog motivates to a significant amount of physical activity, but this was fully compensated for by other forms of physical activity in (younger) patients with T1D. Even the higher physical activity in dog owners with T2D did not result in improved glycaemic or body weight control. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes)
Source: Experimental and Clinical Endocrinology and Diabetes - June 27, 2019 Category: Endocrinology Authors: Riske, Julia Janert, Martin Kahle-Stephan, Melanie Nauck, Michael A. Tags: Article Source Type: research

Vitamin D Replacement Mitigates Menopause-Associated Dyslipidaemia and Atherogenic Indices in Ovariectomized Rats; A Biochemical Study
Conclusions Our study sheds light on alarming levels of VD deficiency among ovariectomized rats. VD repletion improved the menopause-associated dyslipidaemia and atherogenic indices through hypolipidemic, antioxidant, and anti-inflammatory effects. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes)
Source: Experimental and Clinical Endocrinology and Diabetes - June 24, 2019 Category: Endocrinology Authors: Muhammad, Marwa Hassan Hussien, Noha Ibrahim Elwia, Sania K. Tags: Article Source Type: research

The Impact of Ethinyl Estradiol on Metformin Action on Prolactin Levels in Women with Hyperprolactinemia
Conclusions The obtained results suggest that the effect of metformin on overactive lactotropes depends on estrogen levels. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes)
Source: Experimental and Clinical Endocrinology and Diabetes - June 24, 2019 Category: Endocrinology Authors: Krysiak, Robert Szkr óbka, Witold Okopie ń, Bogusław Tags: Article Source Type: research

Primary hypophysitis: Experience of a Single Tertiary Center
Conclusion Correctly diagnosing PH and giving appropriate treatment is challenging. It is unclear whether active treatment with steroids improves clinical outcomes. The serious adverse effects of steroids are also taken into account. Observation, surgery and/or radiotherapy can be appropriate treatment modalities for selected patients. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes)
Source: Experimental and Clinical Endocrinology and Diabetes - June 24, 2019 Category: Endocrinology Authors: Korkmaz, Ozge Polat Sahin, Serdar Ozkaya, Hande Mefkure Apaydin, Tugce Durmaz, Emine Sebnem Haliloglu, Ozlem Durcan, Emre Kadioglu, Pinar Tags: Article Source Type: research

Healing and Mortality Rates Following Toe Amputation in Type 2 Diabetes Mellitus
Conclusion In conclusion, this study highlighted high re-intervention, re-amputation and new ulceration rates. Strategies to improves these outcomes in such high-risk patients are warranted. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes)
Source: Experimental and Clinical Endocrinology and Diabetes - June 17, 2019 Category: Endocrinology Authors: Vassallo, Ian Mario Gatt, Alfred Cassar, Kevin Papanas, Nikolaos Formosa, Cynthia Tags: Article Source Type: research

Moderate Consumption of Red Meat, Compared to Soy or Non-Soy Legume, Has No Adverse Effect on Cardio-Metabolic Factors in Patients with Type 2 Diabetes
This study aimed to compare the effect of red meat, soy bean, and non-soy legume consumption on cardio-metabolic factors in patients with type 2 diabetes. Methods This was a randomized controlled clinical trial which included 75 patients with diabetes, aged 40–65 years. Participants were randomly allocated to receive two servings of red meat (control group), soy bean, or non-soy legume, 3 days a week for 8 weeks. All groups also received a balanced-macronutrients weight maintenance diet. Body composition and cardio-metabolic factors including fasting blood glucose (FBG), fasting insulin, glycated hemoglobin (HbA1c), ...
Source: Experimental and Clinical Endocrinology and Diabetes - June 17, 2019 Category: Endocrinology Authors: Hassanzadeh-Rostami, Zahra Hemmatdar, Zeinab Pishdad, Gholam Reza Faghih, Shiva Tags: Article Source Type: research

Cardiometabolic Risk Factors in Men with Elevated Macroprolactin Content: A Pilot Study
Conclusions The obtained results suggest that macroprolactinemia may increase cardiometabolic risk but to a lesser extent than monomeric hyperprolactinemia. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes)
Source: Experimental and Clinical Endocrinology and Diabetes - June 11, 2019 Category: Endocrinology Authors: Krysiak, Robert Szkr óbka, Witold Okopie ń, Bogusław Tags: Original Article Source Type: research

Adeno-Associated Virus-Mediated Knockdown of SLC16A11 Improves Glucose Tolerance and Hepatic Insulin Signaling in High Fat Diet-Fed Mice
Conclusions Inactivation of SLC16A11, which is robustly induced by HFD, improved glucose tolerance and hepatic insulin signaling, independent of body weight, but related to TAG. Additionally, SLC16A11 might mediate the health benefits of endurance exercise. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes)
Source: Experimental and Clinical Endocrinology and Diabetes - June 11, 2019 Category: Endocrinology Authors: Zhang, Tan Qi, Zhengtang Wang, Haiyan Ding, Shuzhe Tags: Article Source Type: research

Dimethyloxalylglycine (DMOG) and the Caspase Inhibitor “Ac-LETD-CHO” Protect Neuronal ND7/23 Cells of Gluocotoxicity
Exp Clin Endocrinol Diabetes DOI: 10.1055/a-0919-4489It well known that long-lasting hyperglycaemia disrupts neuronal function and leads to neuropathy and other neurodegenerative diseases. The α-ketoglutarate analogue (DMOG) and the caspase-inhibitor “Ac-LETD-CHO are potential neuroprotective molecules. Whether their protections may also extend glucotoxicity-induced neuropathy is not known. Herein, we evaluated the possible cell-protective effects of DMOG and Ac-LETD-CHO against hyperglycaemia-induced reactive oxygen species and apoptosis in ND7/23 neuronal cells. The impact of glucotoxicity on the expression o...
Source: Experimental and Clinical Endocrinology and Diabetes - June 11, 2019 Category: Endocrinology Authors: Mukhopadhyay, Debasmita Hammami, Mohammad Khalouf, Amani Shaikh, Yazan Al Mohammed, Abdul Khader Hamad, Mawieh Salehi, Albert Taneera, Jalal Tags: Article Source Type: research

Association between Flash Glucose Monitoring and Metabolic Control as well as Treatment Satisfaction in Outpatients With Diabetes Type 1
Conclusions FGM was associated with an enormous increase in treatment satisfaction and slightly improved metabolic control in people with baseline HbA1c>7.5%. The number of capillary glucose measurements decreased significantly. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes)
Source: Experimental and Clinical Endocrinology and Diabetes - June 11, 2019 Category: Endocrinology Authors: Kramer, Guido Michalak, Laura M üller, Ulrich Alfons Kloos, Christof Werner, Christoph Kuniss, Nadine Tags: Article Source Type: research

Disease Activity May Not Affect the Prognosis of Coexisting Thyroid Cancer in Acromegalic Patients
In this study, we evaluated the course of DTC in 14 acromegalic patients retrospectively. Fourteen papillary thyroid cancer patients without acromegaly, who were matched with the acromegalic patient group for age, gender and properties of thyroid cancer, were investigated as the control group. We identified no change in the course and treatment responses of DTC in association with the acromegaly activity, gender, age and disease duration, and all patients were found to be in remission for DTC at the time of investigation. Retrospective analysis of this cohort suggests that the activity of acromegaly may not affect the trea...
Source: Experimental and Clinical Endocrinology and Diabetes - June 11, 2019 Category: Endocrinology Authors: Gul, Nurdan Soyluk, Ozlem Dogansen, Sema Ciftci Kurtulmus, Neslihan Yarman, Sema Tags: Article Source Type: research

Computer Vision Technology in the Differential Diagnosis of Cushing ’s Syndrome
Conclusion Regarding the advanced problem of detecting Cushing’s syndrome within a study sample matched by body mass index, we found moderate classification accuracy by facial image analysis. Classification accuracy is most likely higher in a larger sample with healthy control subjects. Further studies might pursue a more advanced analysis and classification algorithm. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes)
Source: Experimental and Clinical Endocrinology and Diabetes - June 3, 2019 Category: Endocrinology Authors: Popp, Kathrin Hannah Kosilek, Robert Philipp Frohner, Richard Stalla, G ünther Karl Athanasoulia-Kaspar, AnastasiaP. Berr, ChristinaM. Zopp, Stephanie Reincke, Martin Witt, Matthias W ürtz, Rolf P Deutschbein, Timo Quinkler, Marcus Schneider, Harald J Tags: Original Article Source Type: research

Nonthyroidal Illness Syndrome in Ischaemic Stroke Patients is Associated with Increased Mortality
Conclusions. Higher FT3 levels on admission versus lower are significantly associated with lower mortality within 365 days after AIS. FT3 serum levels changes over time didn’t show any association with mortality within first year. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes)
Source: Experimental and Clinical Endocrinology and Diabetes - June 3, 2019 Category: Endocrinology Authors: Taroza, Saulius Rastenyt ė, Daiva Podlipskyt ė, Aurelija Kazlauskas, Henrikas Mickuvien ė, Narseta Tags: Article Source Type: research

Self-Compassion, Metabolic Control and Health Status in Individuals with Type 2 Diabetes: A UK Observational Study
Exp Clin Endocrinol Diabetes DOI: 10.1055/a-0897-3772 Aims Self-compassion is a modifiable characteristic, linked with psychological well being and intrinsic motivation to engage in positive health behaviours. We aimed to explore levels of self-compassion in individuals with type 2 diabetes (T2DM) and their association with levels of depression, diabetes-related distress and glycaemic control. Methods A cross-sectional study in 176 patients with T2DM in Leicester, UK, using three self-report questionnaires: the Self Compassion Scale (SCS); Patient Health Questionnaire (PHQ-9), and Diabetes Distress Scale (DDS-17). Demograp...
Source: Experimental and Clinical Endocrinology and Diabetes - June 3, 2019 Category: Endocrinology Authors: Morrison, Amy E Zaccardi, Francesco Chatterjee, Sudesna Brady, Emer Doherty, Yvonne Robertson, Noelle Hadjiconstantinou, Michelle Daniels, Lois Hall, Andrew Khunti, Kamlesh Davies, Melanie J Tags: Article Source Type: research

Altered Brain Regional Homogeneity in First-Degree Relatives of Type 2 Diabetics: A functional MRI Study
Conclusion These findings suggest that altered regional homogeneity in the left anterior cingulate cortex, left insula, left superior frontal gyrus, bilateral posterior cingulate cortex, and bilateral temporal lobes might be a neuroimaging biomarker of type 2 diabetes -related brain dysfunction. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes)
Source: Experimental and Clinical Endocrinology and Diabetes - May 28, 2019 Category: Endocrinology Authors: Liu, Yiyong Shi, Lin Song, Xiubao Shi, Changzheng Lou, Wutao Zhang, Dong Wang, Alan D. Luo, Liangping Tags: Article Source Type: research

CTRP3 is Significantly Decreased in Patients with Primary Hyperparathyroidism and Closely Related with Osteoporosis
This study included 53 patients with diagnosed primary hyperparathyroidism and 30 healthy controls. Laboratory tests for the diagnosis of primary hyperparathyroidism and serum levels of CTRP3 measured for all patients. Bone mineral density was obtained on lumbar spine 1 and 4 by dual energy X-ray absorptiometry. Results Serum CTRP3 levels were lower in patients with primary hyperparathyroidism than in the control group (p
Source: Experimental and Clinical Endocrinology and Diabetes - May 22, 2019 Category: Endocrinology Authors: Demirtas, Derya Ac ıbucu, Fettah Baylan, Filiz Alkan Gulumsek, Erdinc Saler, Tayyibe Tags: Article Source Type: research

Circulating FGF21 Levels in Human Health and Metabolic Disease
Exp Clin Endocrinol Diabetes DOI: 10.1055/a-0879-2968Human fibroblast growth factor 21 (FGF21) is primarily produced and secreted by the liver as a hepatokine. This hormone circulates to its target tissues (e. g., brain, adipose tissue), which requires two components, one of the preferred FGF receptor isoforms (FGFR1c and FGFR3c) and the co-factor beta-Klotho (KLB) to trigger downstream signaling pathways. Although targeting FGF21 signaling in humans by analogues and receptor agonists results in beneficial effects, e. g., improvements in plasma lipids and decreased body weight, it failed to recapitulate the i...
Source: Experimental and Clinical Endocrinology and Diabetes - May 20, 2019 Category: Endocrinology Authors: Keuper, Michaela H äring, Hans-Ulrich Staiger, Harald Tags: Review Source Type: research

Metabolomic Characteristics of Fatty Pancreas
Conclusion The amount of pancreatic fat is not associated with the metabolomic pattern in individuals with prediabetes. This might be due to the relatively low pancreatic fat content compared to the total amount of fat stored in other depots. The impact of pancreatic steatosis on insulin secretion might be mediated by paracrine effects which cannot be detected in the circulation. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes)
Source: Experimental and Clinical Endocrinology and Diabetes - May 16, 2019 Category: Endocrinology Authors: Jaghutriz, Benjamin Assad Wagner, R óbert Heni, Martin Lehmann, Rainer Machann, J ürgen Stefan, Norbert H äring, Hans-Ulrich Fritsche, Andreas Tags: Article Source Type: research

Early Basal Cortisol Level as a Predictor of Hypothalamic-Pituitary-Adrenal (HPA) Axis Function After Pituitary Tumor Surgery
Conclusion The basal cortisol level on the second postoperative day is a valuable tool to predict integrity of the HPA axis after pituitary tumor surgery. Our data suggest that the cortisol level of ≥300 nmol/L accurately predicts adrenal sufficiency and that in these patients glucocorticoid therapy can be withdrawn. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes)
Source: Experimental and Clinical Endocrinology and Diabetes - May 15, 2019 Category: Endocrinology Authors: Polovina, Tanja Skoric Kraljevic, Ivana Solak, Mirsala Balasko, Annemarie Haxhiu, Arta Haxhiu, Arita Dusek, Tina Poljicanin, Tamara Kastelan, Darko Tags: Article Source Type: research

Role of RF-amid Related Peptide-3 (RFRP-3) in Inhibitory Effect of Orexin A on Reproductive Function in the Animal Model of Male Wistar Rats
Conclusions The results of this study are related to the impact of orexin on the HPG axis. It is recommended that RFRP-3/GPR-147 system as the interneural pathway relay the data of orexin to the neurons of GnRH. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes)
Source: Experimental and Clinical Endocrinology and Diabetes - May 15, 2019 Category: Endocrinology Authors: Hefshejanni, Jafar Alipoor Khazali, Homayoun Tags: Article Source Type: research

Adequate Structured Inpatient Diabetes Intervention in People With Type 1 Diabetes Improves Metabolic Control and Frequency of Hypoglycaemia
Conclusions In people with DM1, metabolic control improved after the inpatient intervention without increasing insulin dosage or BMI. The inpatient intervention remains effective to substantially improve metabolic control under the present circumstances of care. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes)
Source: Experimental and Clinical Endocrinology and Diabetes - May 15, 2019 Category: Endocrinology Authors: Burghardt, Katharina M üller, Ulrich Alfons M üller, Nicolle Kloos, Christof Kramer, Guido J örgens, Viktor Kuniss, Nadine Tags: Article Source Type: research

The Relationship Between Visceral Adiposity Index and Epicardial Adipose Tissue in Patients with Type 2 Diabetes Mellitus
Exp Clin Endocrinol Diabetes DOI: 10.1055/a-0892-4290 Introduction and aim Cardiovascular diseases remain the most common cause of morbidity and mortality in patients with diabetes. Epicardial adipose tissue (EAT), visceral fat depot of the heart, was found to be associated with coronary artery disease in cardiac and non-cardiac patients. Increased visceral adiposity is associated with proinflammatory activity, impaired insulin sensitivity, increased risk of atherosclerosis and high mortality. In the present study we aimed to investigate the relationship between EAT and visceral adiposity index (VAI) in patients with diabe...
Source: Experimental and Clinical Endocrinology and Diabetes - May 6, 2019 Category: Endocrinology Authors: Baloglu, Ismail Turkmen, Kultigin Selcuk, Nedim Y ılmaz Tonbul, Halil Zeki Ozcicek, Adalet Hamur, Hikmet Iy ısoy, Sinan Akbas, Emin Murat Tags: Article Source Type: research

Chronic Periodontitis is a Risk Factor of Renal Dysfunction in Patients with Type 2 Diabetes
Conclusion In patients with T2DM, those with periodontitis may be more susceptible to decreased kidney function. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes)
Source: Experimental and Clinical Endocrinology and Diabetes - May 2, 2019 Category: Endocrinology Authors: Zhang, Dongxue Liu, Wenyan Miao, Ran Wang, Lei Zhou, Xuan Wang, Haiyan Li, Yufeng Wang, Zuomin Tags: Article Source Type: research

Serum Myeloperoxidase, C-reactive Protein and α1-acid Glycoprotein: Insights about Cardiovascular Risk in End-stage Renal Disease
The objective of this study was to evaluate serum MPO levels, as well as other laboratory parameters, in individuals with ESRD, with and without CVD, undergoing hemodialysis. Methods 80 volunteers were admitted, divided into the following groups: control group (CON): 20 individuals without chronic kidney disease (CKD); ESRD group: 45 individuals with CKD stage V and ESRD/CVD group: 15 individuals with CKD stage V and with CVD. The following biomarkers were evaluated: MPO, High sensitivity C-reactive protein (hs-CRP) and α1-acid glycoprotein, following the manufacturer's guidelines in the package inserts. The data wer...
Source: Experimental and Clinical Endocrinology and Diabetes - May 2, 2019 Category: Endocrinology Authors: Rickli, Cristiane Borato, Danielle Cristyane Kalva Silva, Anderson Jos é de Melo E Schuinski, Adriana Fatima Menegat Vilela, Gustavo Henrique Frigieri Vellosa, Jos é Carlos Rebuglio Tags: Article Source Type: research

Insulin Resistance in Adults with Type 1 Diabetes is Associated with Lower Vitamin D Serum Concentration
Exp Clin Endocrinol Diabetes DOI: 10.1055/a-0895-5166 Aim Type 1 diabetes mellitus (T1DM) is a disease characterized by an absolute deficiency of endogenous insulin secretion. Insulin resistance (IR) may develop among patients with T1DM. Vitamin D deficiency was reported to be a risk factor in the development of IR. The aim of the study was to assess the relationship between serum concentrations of 25-hydroxyvitamin D (25(OH)D) and IR among patients with T1DM. Methods The test group consisted of 110 adult patients [males=65 (59%)] with T1DM. Participants were recruited in Poland between 1st October and 30th April in 2015/2...
Source: Experimental and Clinical Endocrinology and Diabetes - May 2, 2019 Category: Endocrinology Authors: Kami ński, Mikołaj Uruska, Aleksandra Rogowicz-Frontczak, Anita Lipski, Dawid Nied źwiecki, Paweł R óżańska, Olga Skonieczna, Paulina Michalska, Anna Floty ńska, Justyna Araszkiewicz, Aleksandra Uruski, Pawe ł Pawlak, Regina Zozuli ńska-Ziółki Tags: Article Source Type: research

Reconsidering the HbA1c Cutoff for Diabetes Diagnosis Based on a Large Chinese Cohort
Conclusions We recommend that the effects of age, gender and BMI should be taken into consideration when using HbA1c for the diagnosis and management of diabetes, especially in the young and middle-aged population. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes)
Source: Experimental and Clinical Endocrinology and Diabetes - April 30, 2019 Category: Endocrinology Authors: Qi, Jiying Su, Yang Song, Qianqian Ding, Zhaojun Cao, Min Cui, Bin Qi, Yan Tags: Article Source Type: research

Accuracy Evaluation of Five Blood Glucose Monitoring Systems in Patients from Different Departments
Conclusion Compared with other SMBG systems, Gold AQ Glucose Monitoring System manufactured by Sinocare Inc. had the highest accuracy in measuring blood glucose level in patients from multi-departments at this hospital. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes)
Source: Experimental and Clinical Endocrinology and Diabetes - April 30, 2019 Category: Endocrinology Authors: Li, Xiaona Zheng, Suhua Pan, Suiyue Yan, Ting Di, Jie Yang, Yinian Cheng, Jinluo Tags: Article Source Type: research

Early Postoperative Fasting Serum Glucose Levels are Useful in Depicting Future Diabetes Mellitus in Patients with Curative Insulinoma Surgery
Conclusions Early postoperative (first 48 h) fasting serum glucose levels in insulinoma patients showed significant hyperglycemia above 200 mg/dl in only few patients (20.8%) and chronic postoperative Diabetes mellitus developed in only one of 77 patients (
Source: Experimental and Clinical Endocrinology and Diabetes - April 30, 2019 Category: Endocrinology Authors: Akca, Aycan Starke, Achim A. R. Dobek, Anna Ulrich, Alexis Goretzki, Peter E. Tags: Article Source Type: research

Diagnosis, Therapy and Follow-up of Diabetes Mellitus in Children and Adolescents
Exp Clin Endocrinol Diabetes DOI: 10.1055/a-0869-0210 © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes)
Source: Experimental and Clinical Endocrinology and Diabetes - April 29, 2019 Category: Endocrinology Authors: Neu, Andreas B ürger-Büsing, Jutta Danne, Thomas Dost, Axel Holder, Martin Holl, Reinhard W. Holterhus, Paul-Martin Kapellen, Thomas Karges, Beate Kordonouri, Olga Lange, Karin M üller, Susanne Raile, Klemens Schweizer, Roland Sengbusch, Simone von Sta Tags: German Diabetes Associaton: Clinical Practice Guidelines Source Type: research

Short-term Resistance Training Increases APPL1 Content in the Liver and the Insulin Sensitivity of Mice Fed a Long-term High-fat Diet
Conclusion In summary, our data suggested that short-term RT improves glycemic homeostasis and increases APPL1 in the hepatic tissue of mice treated with long-term high-fat diet. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes)
Source: Experimental and Clinical Endocrinology and Diabetes - April 16, 2019 Category: Endocrinology Authors: Minuzzi, Luciele Guerra Kuga, Gabriel Keine Breda, Leonardo Gaspar, Rafael Calais Mu ñoz, Vitor Rosetto Pereira, Rodrigo Martins Botezelli, Jos é Diego da Silva, Adelino S. R. Cintra, Dennys Esper de Moura, Leandro Pereira Ropelle, Eduardo Rochete Pauli Tags: Article Source Type: research

The Predictive Low Glucose Management System in Prevention of Clinically Significant Hypoglycemia in Type 1 Diabetes. A Preliminary Study Identifying the Most Common Events Leading Up to Hypoglycemia During Insulin Pump Therapy
Conclusions The results indicated that the use of the Minimed 640G pump system can help reduce the frequency of clinically significant hypoglycemia. Management of hyperglycemia must be addressed in diabetes education programs in order to encourage proper adjustment of high blood glucose levels. Future studies would be useful in exploring the details of the events preceding hypoglycemia episodes in insulin pump users. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinic...
Source: Experimental and Clinical Endocrinology and Diabetes - April 15, 2019 Category: Endocrinology Authors: Thomakos, Petros Mitrakou, Asimina Kepaptsoglou, Olga Taraoune, Ibrahim Barreto, Carol Zoupas, Christos Sp. Tags: Article Source Type: research

Glucose Responsiveness of β-Cells Depends on Fatty Acids
This study examined the influence of bovine serum albumin (BSA)-coupled fatty acids on GSIS. Isolated islet preparations of human donors and of 12-months old mice displayed impaired GSIS in the presence of 0.5% FFA-free BSA compared to 0.5% BSA (fraction V, not deprived from fatty acids). In aged INS-1E cells, i. e. at a high passage number, GSIS became highly sensitive to FFA-free BSA. Readdition of 30 µM palmitate or 30 µM oleate to FFA-free BSA did not rescue GSIS, while the addition of 100 µM palmitate and the raise of extracellular Ca2+from 1.3 to 2.6 mM improved gl...
Source: Experimental and Clinical Endocrinology and Diabetes - April 15, 2019 Category: Endocrinology Authors: Gerst, Felicia Singer, Christine Noack, Katja Graf, Dunia Kaiser, Gabriele Panse, Madhura Kovarova, Marketa Schleicher, Erwin H äring, Hans-Ulrich Drews, Gisela Ullrich, Susanne Tags: Article Source Type: research

The Mitochondrial DNA Control Region Might Have Useful Diagnostic and Prognostic Biomarkers for Thyroid Tumors
In conclusion, mtDNA D310 instability does not play a role in the tumorigenesis of PTC but the results indicate that it might be used as a diagnostic clonal expansion biomarker for premalignant thyroid tumor cells. In addition, D514 CA instability might be considered as a prognostic biomarker for benign to malign transformation in thyroid tumors. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes)
Source: Experimental and Clinical Endocrinology and Diabetes - April 15, 2019 Category: Endocrinology Authors: Bircan, R ıfat G özü, Hülya Ilıksu Ulu, Esra Sar ıkaya, Şükran G ül, Aylin Ege Şirin, Duygu Yaşar Özçelik, Serhat Aral, Cenk Tags: Article Source Type: research

The Case for an Estrogen-iron Axis in Health and Disease
Exp Clin Endocrinol Diabetes DOI: 10.1055/a-0885-1677Clinical and experimental evidence suggest that estrogen manipulates intracellular iron metabolism and that elevated levels of estrogen associate with increased systemic iron availability. This has been attributed to the ability of estrogen to suppress hepcidin synthesis, maintain ferroportin integrity and enhance iron release from iron-absorbing duodenal enterocytes and iron-storing macrophages and hepatocytes. These observations speak of a potential “estrogen-iron” axis that manipulates iron metabolism in response to hematologic (erythropoiesis) and non-hem...
Source: Experimental and Clinical Endocrinology and Diabetes - April 12, 2019 Category: Endocrinology Authors: Hamad, Mawieh Bajbouj, Khuloud Taneera, Jalal Tags: Review Source Type: research

Mirabegron, A Selective β3-Adrenoceptor Agonist Causes an Improvement in Erectile Dysfunction in Diabetic Rats
Exp Clin Endocrinol Diabetes DOI: 10.1055/a-0869-7493 Aim To investigate the possible beneficial effect of mirabegron [a selective β3-adrenoceptor (AR) agonist] treatment on erectile dysfunction (ED) in streptozotocin-induced diabetic rats. Methods Sprague-Dawley rats (n=20) were divided into two groups: control group and streptozotocin-induced diabetic group. In vivo erectile responses were evaluated after intracavernosal injection of mirabegron (0.4 mg/kg) in rats. The relaxation responses to electrical field stimulation (EFS, 10 Hz), sodium nitroprusside (SNP, 10 nM) and sildenafil (1 &m...
Source: Experimental and Clinical Endocrinology and Diabetes - April 12, 2019 Category: Endocrinology Authors: Yilmaz-Oral, Didem Kaya-Sezginer, Ecem Askin, Dilan Hamurtekin, Yesim Gur, Serap Tags: Article Source Type: research

Periodontal Disease May be Associated With the Occurrence of Diabetic Retinopathy: A Subgroup Analysis of The Survey of the Diabetes Coordination Notebook in Gifu
Exp Clin Endocrinol Diabetes DOI: 10.1055/a-0879-1890 Aims A questionnaire survey of the prevalence of diabetic retinopathy was recently conducted in Japan. A subgroup analysis to examine the association of periodontal disease with diabetic retinopathy in subjects with diabetes and prediabetes was conducted. Methods The association of the presence of periodontal disease with the occurrence of diabetic retinopathy was examined using multivariate logistic regression analysis. Results Of 27 016 subjects who completed a survey at 217 community pharmacies, 5 572 had diabetes or prediabetes, among whom 522 and 1&th...
Source: Experimental and Clinical Endocrinology and Diabetes - April 11, 2019 Category: Endocrinology Authors: Horikawa, Yukio Suzuki, Akio Enya, Mayumi Hashimoto, Ken-ichi Nishida, Shohei Kobayashi, Ryo Ohashi, Tetsuya Yamazaki, Futoshi Totani, Rieko Kobayashi, Hiroshi Yamamoto, Mayumi Itoh, Yoshinori Takeda, Jun Tags: Article Source Type: research

Related Risk Factors between Subclinical Carotid Atherosclerosis and Diabetic Retinopathy in Newly Diagnosed Type 2 Diabetes Mellitus in China
Conclusions It should be paid attention to the screening of both DR and subclinical atherosclerosis in each age group of newly diagnosed T2DM. Except for the control of blood glucose, the control of the dyslipidemia is important in the prevention and treatment of the micro- and macro-vascular diseases. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes)
Source: Experimental and Clinical Endocrinology and Diabetes - April 9, 2019 Category: Endocrinology Authors: Guo, Fengqi Zhou, Ting Tang, Juan Dong, Mingxia Wei, Qianping Tags: Original Article Source Type: research

Effects of Insulin Therapy and Oral Hypoglycemic Agents on Glycemic Control for Type 2 Diabetes Mellitus Patients in China –A Case Control Study
Exp Clin Endocrinol Diabetes DOI: 10.1055/a-0881-9611 Objective The purpose of the study was to compare glycemic control in patients with type 2 diabetes (T2DM) receiving insulin therapy (IT) or oral hypoglycemic agents (OHA), and explore associations between treatment modality and pancreatic beta-cell function. Methods A matched, case-control study was conducted from April, 2016 to November, 2016. 2 272 patients with T2DM were identified from electronic medical records at four academic hospitals in China. Based on 1 136 eligible patients using IT, eligible 1 136 OHA patients were matched by age and du...
Source: Experimental and Clinical Endocrinology and Diabetes - April 8, 2019 Category: Endocrinology Authors: Zuo, PanPan Shi, JianFeng Yan, Juan Yang, LiHong Liu, Chao Yuan, Li Lou, QingQing Tags: Article Source Type: research

Elevated C-reactive Protein Levels Independently Predict the Development of Prediabetes Markers in Subjects with Normal Glucose Regulation
Conclusions Elevated serum C-reactive protein levels independently predicted elevated HbA1c levels, but not IFG. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes)
Source: Experimental and Clinical Endocrinology and Diabetes - April 8, 2019 Category: Endocrinology Authors: Kato, Katsuhito Otsuka, Toshiaki Saiki, Yoshiyuki Kobayashi, Nobuyuki Nakamura, Takayuki Kon, Yoichi Kawada, Tomoyuki Tags: Article Source Type: research

Elevated Circulating Levels of Motilin are Associated with Diabetes in Individuals after Acute Pancreatitis
Conclusions Diabetes in individuals after acute pancreatitis appears to be characterised by elevated plasma motilin but not gastroparesis cardinal symptom index. The role of motilin in this setting warrants further investigations. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes)
Source: Experimental and Clinical Endocrinology and Diabetes - March 14, 2019 Category: Endocrinology Authors: Gold-Smith, Fuchsia D. Singh, Ruma G. Petrov, Maxim S. Tags: Article Source Type: research

Thermographic Characteristics of the Diabetic Foot With Peripheral Arterial Disease Using the Angiosome Concept
Conclusions These results confirm that patients with PAD exhibit significantly higher forefoot temperatures, according to the angiosome concept. The challenge by foot elevation did not affect the thermal pattern significantly. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes)
Source: Experimental and Clinical Endocrinology and Diabetes - March 14, 2019 Category: Endocrinology Authors: Carabott, Matthew Formosa, Cynthia Mizzi, Anabelle Papanas, Nikolaos Gatt, Alfred Tags: Article Source Type: research

Baseline Leptin/Adiponectin Ratio is a Significant Predictor of BMI Changes in Children/Adolescents after Intensive Lifestyle Intervention
Exp Clin Endocrinol Diabetes DOI: 10.1055/a-0859-7041 Introduction Abdominal obesity is a strong cardiometabolic risk factor that often occurs as early as in childhood. The negative effect of abdominal obesity on the metabolism is partially mediated by changes to the production of the major adipocyte hormones leptin and adiponectin. Leptin/adiponectin imbalance is associated with increased risk of developing obesity and type 2 diabetes mellitus. Aim To determine whether leptin, adiponectin and the leptin/adiponectin ratio are significant predictors of body weight loss in intensively treated children/adolescents. Methods 18...
Source: Experimental and Clinical Endocrinology and Diabetes - March 6, 2019 Category: Endocrinology Authors: Pejsova, Hana Hubacek, Jaroslav A. Zemankova, Petra Zlatohlavek, Lukas Tags: Article Source Type: research

Review of Health Problems in Adult Patients with Classic Congenital Adrenal Hyperplasia due to 21-Hydroxylase Deficiency
Exp Clin Endocrinol Diabetes 2019; 127: 171-177 DOI: 10.1055/a-0820-2085The introduction of newborn screening programmes in most Western countries for classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency (CAH) enables timely introduction of life-saving glucocorticoid replacement in affected babies. Early diagnosis and optimised pediatric care not only successfully led to survival but also allow that almost all patients reach adulthood. Cohort studies in adults, however, provided evidence for significant health problems and co-morbidities of adult patients such as life-threatening adrenal crises, cardiova...
Source: Experimental and Clinical Endocrinology and Diabetes - February 27, 2019 Category: Endocrinology Authors: Reisch, Nicole Tags: Review Source Type: research

The Adrenal Gland: Central Relay in Health and Disease
Exp Clin Endocrinol Diabetes 2019; 127: 81-83 DOI: 10.1055/a-0752-4176Diseases of the adrenal gland are as important for the general practitioner as for the endocrine specialist. The high prevalence of some adrenal endocrinopathies, such as adrenal incidentalomas (1–2% of the population) and primary aldosteronism (6% of hypertensives), which affect millions of patients, makes adrenal diseases a relevant health issue. The high morbidity and mortality of some of the rarer adrenal diseases, i. e., Addison’s disease and Cushing’s syndrome (Table 1), make early detection and appropriate treatment such a...
Source: Experimental and Clinical Endocrinology and Diabetes - February 27, 2019 Category: Endocrinology Authors: Reincke, Martin Beuschlein, Felix Bornstein, Stefan Eisenhofer, Graeme Fassnacht, Martin Reisch, Nicole Williams, Tracy Ann Tags: Editorial Source Type: research

Progression of Albuminuria Among Patients with Type 1 Diabetes Mellitus: A Long Term Observational Follow-up Study
Conclusions Improvement of glycemic control with close monitoring of DM1 patients together with the appropriate use ACE or AT2 inhibitors and statins, seems to exert nephron-protective potential and to delay or even reverse the presence of micro/macroalbuminuria. This long term follow-up study has demonstrated a statistically significant increase in serum HDLcholesterol levels. The study also revealed that intensively treated diabetes patients may show reductions in serum ALP levels. Whether this finding is related to diabetic nephropathy, NAFLD, or diabetic hepatosclerosis remains to be assessed in future trials. [...] &c...
Source: Experimental and Clinical Endocrinology and Diabetes - February 25, 2019 Category: Endocrinology Authors: Stratigou, Theodora Vallianou, Natalia Koutroumpi, Stavroula Vlassopoulou, Barbara Apostolou, Theofanis Tsagarakis, Stylianos Ioannidis, George Tags: Article Source Type: research