Hypoxia-inducible Factor 2 α: A Key Player in Tumorigenesis and Metastasis of Pheochromocytoma and Paraganglioma?
Exp Clin Endocrinol Diabetes DOI: 10.1055/a-1526-5263Germline or somatic driver mutations linked to specific phenotypic features are identified in approximately 70% of all catecholamine-producing pheochromocytomas and paragangliomas (PPGLs). Mutations leading to stabilization of hypoxia-inducible factor 2α (HIF2α) and downstream pseudohypoxic signaling are associated with a higher risk of metastatic disease. Patients with metastatic PPGLs have a variable prognosis and treatment options are limited. In most patients with PPGLs, germline mutations lead to the stabilization of HIF2α. Mutations in HIF2α...
Source: Experimental and Clinical Endocrinology and Diabetes - July 28, 2021 Category: Endocrinology Authors: Bechmann, Nicole Eisenhofer, Graeme Tags: Review Source Type: research

Is Telemedicine the Preferred Visit Modality in Patients with Type 1 Diabetes?
Conclusions Patients from a wide range of treatment modalities are willing to use telemedicine. However, virtual meetings cannot fully replace conventional visits in T1D especially in the older age group. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes)
Source: Experimental and Clinical Endocrinology and Diabetes - July 22, 2021 Category: Endocrinology Authors: Kirzhner, Alena Zornitzki, Taiba Ostrovsky, Viviana Knobler, Hilla Schiller, Tal Tags: Article Source Type: research

Multicenter, Observational Study of Lanreotide Autogel for the Treatment of Patients with Neuroendocrine Tumors in Routine Clinical Practice in Germany and Austria
Exp Clin Endocrinol Diabetes 2021; 129: 500-509 DOI: 10.1055/a-1342-2755 Background The long-acting somatostatin analog lanreotide autogel is effective in the treatment of patients with neuroendocrine tumors. Objective To evaluate the long-term treatment response in patients with neuroendocrine tumors receiving lanreotide autogel in routine clinical practice. Methods Non-interventional, 24-month study in patients with neuroendocrine tumors treated with lanreotide autogel (NCT01840449). Results Patients (n=80) from 26 centers in Germany and Austria were enrolled. Neuroendocrine tumors were mainly grade 1/2, metastasized, in...
Source: Experimental and Clinical Endocrinology and Diabetes - July 22, 2021 Category: Endocrinology Authors: Rinke, Anja Maintz, Christoph M üller, Lothar Weber, Matthias M. Lahner, Harald Pavel, Marianne Saeger, Wolfgang Houchard, Aude Ungewiss, Hanna Petersenn, Stephan Tags: Article Source Type: research

Out-of-Hospital Management of Diabetic Emergencies in Germany: Structural and Process Quality
Conclusion Structural and process quality of the management of diabetic emergencies in Germany has improved considerably since 2001. Persisting deficiencies could be improved by providing better medical equipment in ambulances and ongoing education to the entire emergency teams. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes)
Source: Experimental and Clinical Endocrinology and Diabetes - July 20, 2021 Category: Endocrinology Authors: Holstein, David J.F. Holstein, Judith D. Fischer, Daniel Mende, Meinhard Frier, Brian M. Holstein, Andreas Tags: Article Source Type: research

Influence of Spinal Cord Stimulation on Insulin Sensitivity in Chronic Pain Patients
Conclusion The results of this study show that tonic stimulation used for the treatment of pain could also improve glucose metabolism and insulin sensitivity. Further investigations are required to investigate the clinical relevance of the role of glucose metabolism in diabetic chronic pain participants and its underlying mechanisms. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes)
Source: Experimental and Clinical Endocrinology and Diabetes - July 12, 2021 Category: Endocrinology Authors: Morgalla, Matthias H. Fritschle, Hannah Vosseler, Andreas Benkendorff, Charlotte Lamprinou, Apostolia Heni, Martin Fritsche, Andreas Tags: Article Source Type: research

Fibroblast Growth Factor Receptor-4 Expression in Pituitary Adenomas is Associated with Aggressive Tumor Features
Exp Clin Endocrinol Diabetes DOI: 10.1055/a-1523-7216 Purpose To investigate the relationship of Fibroblast Growth Factor Receptor-4 (FGFR-4) expression with radiologic, pathologic, and clinical parameters in pituitary adenomas. Methods Among 307 patients who underwent pituitary surgery for a pituitary adenoma between 2000 and 2015, we included 161 patients (53 gonadotroph, 26 corticotroph, 25 null cell, 22 lactotroph, 13 somatotroph, 8 adenomas with unusual combination, 7 Pit-1 positive adenomas, and 7 lactosomatotroph) based on availability of pathology specimens. Patients’ radiologic, pathologic, and clinical para...
Source: Experimental and Clinical Endocrinology and Diabetes - July 12, 2021 Category: Endocrinology Authors: Durcan, Emre Keskin, Fatma Ela Ozkaya, Hande Mefkure Sirolu, Sabri Sahin, Serdar Korkmaz, Ozge Polat Gazioglu, Nurperi Tanriover, Necmettin Comunoglu, Nil Oz, Buge Kizilkilic, Osman Kadioglu, Pinar Tags: Article Source Type: research

Neuropeptides, Inflammation, Biofilms, and diabetic Foot Ulcers
Exp Clin Endocrinol Diabetes DOI: 10.1055/a-1493-0458A diabetic foot ulcer (DFU) is a serious complication in patients with diabetes mellitus (DM). A DFU is the most common cause of non-traumatic limb amputation, and patients with DFUs have increased mortality rates within 5 years after amputation. DFUs also increase the risk of cardiovascular and cerebrovascular diseases; therefore, with the increasing incidence and prevalence of diabetic foot wounds, DFUs are gradually becoming a major public health problem. The pathophysiology of DFUs is complicated and remains unclear. In recent years, many studies have demonstrated th...
Source: Experimental and Clinical Endocrinology and Diabetes - July 5, 2021 Category: Endocrinology Authors: Yang, Shaoling Hu, Liye Han, Rui Yang, Yiwen Tags: Review Source Type: research

Diabetes Mellitus as the Major Factor of Prolonged Hospitalisation in Mild or Moderate COVID-19 Pneumonia
Exp Clin Endocrinol Diabetes DOI: 10.1055/a-1468-4296 Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes)
Source: Experimental and Clinical Endocrinology and Diabetes - June 23, 2021 Category: Endocrinology Authors: Petrakis, Vasileios Trypsianis, Grigorios Panagopoulos, Periklis Papazoglou, Dimitrios Papanas, Nikolaos Tags: Letter to the Editor Source Type: research

One-hour Post-load Plasma Glucose Cut-off Value for Diagnosing Diabetes: Do the New Data Bring us Closer to the Answer?
Exp Clin Endocrinol Diabetes DOI: 10.1055/a-1516-3850 Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes)
Source: Experimental and Clinical Endocrinology and Diabetes - June 21, 2021 Category: Endocrinology Authors: Popovic, Djordje S. Papanas, Nikolaos Tags: Letter to the Editor Source Type: research

Prevalence of Atherosclerotic Cardiovascular Disease, Heart Failure, and Chronic Kidney Disease in Patients with Type 2 Diabetes Mellitus: A Primary Care Research Network-based Study
This study aims to assess the prevalence of atherosclerotic cardiovascular disease (ASCVD), heart failure (HF), chronic kidney disease (CKD), and their combined presence in type 2 diabetes (T2D) patients in primary care for whom the 2019 ADA/EASD consensus update “Management of Hyperglycemia in Type 2 Diabetes” recommends GLP-1 receptor agonists (GLP-1RA) or sodium-glucose cotransporter-2 inhibitors (SGLT-I) as first-line medications after metformin. Methods Data were obtained in 2015 from Intego, a morbidity registration network of 111 general practitioners (GPs) working in 48 practices and including 123&thins...
Source: Experimental and Clinical Endocrinology and Diabetes - June 21, 2021 Category: Endocrinology Authors: Goderis, Geert Vaes, Bert Mamouris, Pavlos van Craeyveld, Eline Mathieu, Chantal Tags: Article Source Type: research

Is there an HbA1c Threshold for Symptoms of Chronic Hyperglycemia?
Exp Clin Endocrinol Diabetes DOI: 10.1055/a-1493-0683 Aims of the study The minimum therapeutic goal regarding metabolic control for people with diabetes mellitus is the “absence of symptoms of hyperglycemia.” However, it is uncertain whether a level of HbA1c can be defined that guarantees the absence of these symptoms. The aim was to define an HbA1c threshold above which most patients show hyperglycemic symptoms. Methods In a multicenter cross-sectional study, 137 patients with type 1 and 285 with type 2 diabetes were asked about their symptoms during periods of hyperglycemi...
Source: Experimental and Clinical Endocrinology and Diabetes - June 7, 2021 Category: Endocrinology Authors: M üller, Nicolle Lehmann, Thomas M üller, Ulrich Alfons Kloos, Christof Tags: Article Source Type: research

Thyroid Hormone Deficiency Modifies Hepatic Lipid Droplet Morphology and Molecular Properties in Lithogenic-Diet Supplemented Mice
Conclusion This study demonstrates that thyroid hormone deficiency alters hepatic lipid droplet morphology and hepatic gene expression of lipid droplet-associated proteins in a lithogenic diet mouse model of steatohepatitis. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes)
Source: Experimental and Clinical Endocrinology and Diabetes - May 28, 2021 Category: Endocrinology Authors: Kube, Irina Jastrow, Holger F ührer, Dagmar Zwanziger, Denise Tags: Article Source Type: research

Evaluation of Meal Carbohydrate Counting Errors in Patients with Type 1 Diabetes
Exp Clin Endocrinol Diabetes DOI: 10.1055/a-1493-2324 Aim Correct estimation of meal carbohydrate content is a prerequisite for successful intensified insulin therapy in patients with diabetes. In this survey, the counting error in adult patients with type 1 diabetes was investigated. Methods Seventy-four patients with type 1 diabetes estimated the carbohydrate content of 24 standardized test meals. The test meals were categorized into 1 of 3 groups with different carbohydrate content: low, medium, and high. Estimation results were compared with the meals’ actual carbohydrate ...
Source: Experimental and Clinical Endocrinology and Diabetes - May 25, 2021 Category: Endocrinology Authors: Buck, Sina Krauss, Collin Waldenmaier, Delia Liebing, Christina Jendrike, Nina H ögel, Josef Pfeiffer, Boris M. Haug, Cornelia Freckmann, Guido Tags: Article Source Type: research

Increased Serum WISP1 Levels are Associated with Lower Extremity Atherosclerotic Disease in Patients with type 2 Diabetes Mellitus
Exp Clin Endocrinol Diabetes DOI: 10.1055/a-1474-8220 Background Serum wnt1-induced signaling pathway protein 1 (WISP1) levels are increased with obesity, which is a common complication associated with lower extremity atherosclerotic disease (LEAD). However, to date, the relationship between elevated WISP1 levels and the incidence of lower extremity atherosclerotic disease (LEAD) in type 2 diabetes mellitus (T2DM) remains unclear. Methods 174 newly diagnosed type 2 diabetic patients were enrolled in our study. Patients were divided into two groups, LEAD group (n=100) and control group (n=74). Anthropometric parameters, blo...
Source: Experimental and Clinical Endocrinology and Diabetes - April 30, 2021 Category: Endocrinology Authors: Cheng, Yangyang Du, Xiaohui Zhang, Bilin Zhang, Junxia Tags: Review Source Type: research

The Effect of Prandial Insulin Applied for Fat Protein Units on Postprandial Glucose Excursions in Type 1 Diabetes Patients with Insulin Pump Therapy: Results of a Randomized, Controlled, Cross-Over Study
Conclusions In adult type 1 diabetes patients using CSII, it is not recommended to consider a high fat and protein content in the diet when calculating prandial insulin dosage with the selected algorithms, as this increases the risk of hypoglycemia disproportionately. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes)
Source: Experimental and Clinical Endocrinology and Diabetes - April 20, 2021 Category: Endocrinology Authors: Haak, Thomas Herrmann, Ekaterina Lippmann-Grob, Bernhard Tombek, Astrid Hermanns, Norbert Krichbaum, Michael Tags: Article Source Type: research

The Effect of Prandial Insulin Applied for Fat Protein Units on Postprandial Glucose Excursions in Type 1 Diabetes Patients with Insulin Pump Therapy: Results of a Randomized, Controlled, Cross-Over Study
Conclusions In adult type 1 diabetes patients using CSII, it is not recommended to consider a high fat and protein content in the diet when calculating prandial insulin dosage with the selected algorithms, as this increases the risk of hypoglycemia disproportionately. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes)
Source: Experimental and Clinical Endocrinology and Diabetes - April 20, 2021 Category: Endocrinology Authors: Haak, Thomas Herrmann, Ekaterina Lippmann-Grob, Bernhard Tombek, Astrid Hermanns, Norbert Krichbaum, Michael Tags: Review Source Type: research

Diabetes and Migration
Exp Clin Endocrinol Diabetes DOI: 10.1055/a-1284-6778 Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes)
Source: Experimental and Clinical Endocrinology and Diabetes - April 14, 2021 Category: Endocrinology Authors: Şat, Sebahat Ayd ınkoç-Tuzcu, Kadriye Berger, Faize Barakat, Alain Schindler, Karin Fasching, Peter Tags: German Diabetes Association: Clinical Practice Guidelines Source Type: research

ZFAND3 Overexpression in the Mouse Liver Improves Glucose Tolerance and Hepatic Insulin Resistance
This study aimed to investigate the association between ZFAND3 and type 2 diabetes mellitus. ZFAND3 was significantly upregulated in the liver of diabetic mice compared to wild-type mice. To overexpress ZFAND3, we generated a ZFAND3-expressing adenovirus (Ad) vector using an improved Ad vector exhibiting significantly lower hepatotoxicity (Ad-ZFAND3). Glucose tolerance was significantly improved in Ad-ZFAND3-treated mice compared to the control Ad-treated mice. ZFAND3 overexpression in the mouse liver also improved insulin resistance. Furthermore, gluconeogenic gene expression was significantly lower in primary mouse hepat...
Source: Experimental and Clinical Endocrinology and Diabetes - March 29, 2021 Category: Endocrinology Authors: Shimizu, Kahori Ogiya, Yuya Yoshinaga, Kaede Kimura, Hajime Michinaga, Shotaro Ono, Moe Taketomi, Ayako Terada, Tomoyuki Sakurai, Fuminori Mizuguchi, Hiroyuki Tomita, Koji Nishinaka, Toru Tags: Article Source Type: research

Gestational Diabetes Mellitus (GDM), Diagnostics, Therapy and Follow-up Care
Exp Clin Endocrinol Diabetes DOI: 10.1055/a-1284-6011 Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes)
Source: Experimental and Clinical Endocrinology and Diabetes - March 26, 2021 Category: Endocrinology Authors: Sch äfer-Graf, Ute Laubner, Katharina Hummel, Sandra Gembruch, Ulrich Groten, Tanja Kainer, Franz Grieshop, Melita Bancher-Todesca, Dagmar Cervar-Zivakovic, Mila H ösli, Irene Kaltheuner, Matthias Gellner, Reinhold Kautzky-Willer, Alexandra B ührer, Ch Tags: German Diabetes Association: Clinical Practice Guidelines Source Type: research

Effects of Treatment Adherence on Quality of Life in Hypoparathyroid Patients
This study aimed to evaluate the current situation of hypoparathyroid patients and to investigate the relationship between treatment adherence and quality of life. Study design Prospective, multicentre study. Methods Adult patients presenting with the diagnosis of hypoparathyroidism to 20 different endocrinology clinics were included. They were receiving conventional therapies for hypoparathyroidism, using calcium, active vitamin D, and magnesium. We collected data on demographic features, disease- and treatment-related information, and results of routine laboratory tes...
Source: Experimental and Clinical Endocrinology and Diabetes - March 10, 2021 Category: Endocrinology Authors: Anaforoglu, Inan Sancak, Seda Akbas, Emin Murat Oruk, Guzide Gonca Canat, Masum Tezcan, Kadriye Ayd ın Uc, Ziynet Alphan Gorar, Suheyla Duman, Gulhan Cavlak Yaylali, Guzin Fidan Y ılmaz, Merve Bilir, Betul Ekiz Bozoglan, Humeyra Akbaba, Gulhan Tuna, Maz Tags: Article Source Type: research

First German Guideline on Diagnostics and Therapy of Clinically Non-Functioning Pituitary Tumors
Exp Clin Endocrinol Diabetes 2021; 129: 250-264 DOI: 10.1055/a-1373-4087Although non-functioning pituitary tumors are frequent, diagnostic and therapeutic concepts are not well standardized. We here present the first German multidisciplinary guideline on this topic. The single most important message is to manage the patients by a multidisciplinary team (consisting at least of an endocrinologist, a neurosurgeon, and a (neuro-) radiologist). The initial diagnostic work-up comprises a detailed characterization of both biochemical (focusing on hormonal excess or deficiency states) and morphological aspects (with magnetic reson...
Source: Experimental and Clinical Endocrinology and Diabetes - March 9, 2021 Category: Endocrinology Authors: Deutschbein, Timo Jaursch-Hancke, Cornelia Knappe, Ulrich J. Saeger, Wolfgang Flitsch, J örg Bojunga, J örg Buchfelder, Michael Ditzen, Beate Gerlach, R üdiger Gertzen, Elfriede Honegger, J ürgen Horstmann, Gerhard A. Koch, Arend Kreitschmann-Andermah Tags: Guideline Source Type: research

Medical Therapy of Aggressive Pituitary Tumors
Exp Clin Endocrinol Diabetes 2021; 129: 186-193 DOI: 10.1055/a-1331-6939The rare aggressive pituitary adenoma presents a special challenge, due to the heterogenous presentation of the disease. The prognosis of aggressive pituitary adenomas has been improved due to recent studies demonstrating clinically-relevant efficacy of temozolomide, which is now considered first-line chemotherapy. However, there is limited data on second-line therapies in patients with treatment failure. This review presents a summary on the potential of medical therapies in aggressive pituitary tumors. [...] Georg Thieme Verlag KG Rüdigerstra&sz...
Source: Experimental and Clinical Endocrinology and Diabetes - March 9, 2021 Category: Endocrinology Authors: Petersenn, Stephan Tags: Review Source Type: research

Clinical Implications of the New WHO Classification 2017 for Pituitary Tumors
Exp Clin Endocrinol Diabetes 2021; 129: 146-156 DOI: 10.1055/a-1310-7900According to the WHO classification 2017 of Pituitary Tumors adenomas are classified not only by structure and immunostaining for pituitary hormones but also by expression of the pituitary transcription factors Pit-1, T-pit and SF-1. By these factors, three cell lineages can be identified: Pit-1 for the GH-, Prolactin- and TSH-cell lineage, T-pit for the ACTH-cell lineage, and SF-1 for the gonadotrophic cell lineage. By this principle, all GH and/or Prolactin producing and all TSH producing adenomas must be positive for Pit-1, all corticotrophic adenom...
Source: Experimental and Clinical Endocrinology and Diabetes - March 9, 2021 Category: Endocrinology Authors: Saeger, Wolfgang Koch, Arend Tags: Review Source Type: research

Pituitary in the Spotlight
Exp Clin Endocrinol Diabetes 2021; 129: 143-145 DOI: 10.1055/a-1369-8898The German Society of Endocrinology (DGE) has a long-standing scientific and clinical focus on the pituitary. The pituitary working group ‘Arbeitsgemeinschaft Hypophyse’ is an interdisciplinary special interest group with a focus on advancing diagnosis and treatment of pituitary conditions. On the occasion of the English publication of the S2K clinical guideline Diagnosis and therapy of clinically hormonally inactive pituitary tumors, we present here a series of 12 articles from internationally renowned authors from inside and outside of Ge...
Source: Experimental and Clinical Endocrinology and Diabetes - March 9, 2021 Category: Endocrinology Authors: Reincke, Martin Honegger, J ürgen Tags: Editorial Source Type: research

Double Diabetes: A Growing Problem Requiring Solutions
Exp Clin Endocrinol Diabetes DOI: 10.1055/a-1392-0590The growing proportion of type 1 diabetes mellitus (T1DM) patients with clinical features of insulin resistance (IR) has led to the description of a distinctive T1DM subgroup, still unrecognised by current guidelines, called double diabetes, assumingly associated with poorer metabolic phenotype and increased risk of micro- and macrovascular complications. The main goal of identifying double diabetes, estimated to be present in up to half of T1DM patients, is timely implementation of appropriate therapeutic interventions to reduce the increased risk of chronic complicatio...
Source: Experimental and Clinical Endocrinology and Diabetes - February 26, 2021 Category: Endocrinology Authors: Popovic, Djordje S. Papanas, Nikolaos Tags: Article Source Type: research

Impact of Smoking, Obesity and Maternal Diabetes on SHBG Levels in Newborns
Conclusions: SHBG levels are lower in newborns born to mothers with diabetes than without diabetes, and may be a marker for babies’ life-long risk for abnormal metabolic health. On the other hand, the adverse effects of tobacco smoke on the fetus do not appear to directly influence SHBG levels. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes)
Source: Experimental and Clinical Endocrinology and Diabetes - February 22, 2021 Category: Endocrinology Authors: Aydin, Banu Kucukemre Yasa, Beril Moore, Joseph P. Yasa, Cenk Poyrazoglu, Sukran Bas, Firdevs Coban, Asuman Darendeliler, Feyza Winters, Stephen J. Tags: Article Source Type: research

Impact of Non-Alcoholic Fatty Liver Disease on Metabolic Comorbidities in Type 2 Diabetes Mellitus
Conclusion The coded prevalence of NAFLD in T2D patients is low, which is in contrast to published series. Enhancing disease awareness of NAFLD and screening recommendations in high risk populations will be beneficial for the active management of these patients. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes)
Source: Experimental and Clinical Endocrinology and Diabetes - February 18, 2021 Category: Endocrinology Authors: Labenz, Christian Kostev, Karel Alqahtani, Saleh A. Galle, Peter R. Schattenberg, J örn M. Tags: Article Source Type: research

Reduced Thalamic Volume and Metabolites in Type 1 Diabetes with Polyneuropathy
Conclusions In this cohort with type 1 diabetes and severe DSPN, thalamic atrophy was present and associated with reduced NAA/cre, indicating thalamic structural loss and dysfunction. Thalamic atrophy was associated to reduced sensory function involving large fiber neuropathy and sensation to tetanic stimulation that may reflect synaptic transmission. This may ultimately contribute to the current understanding of the pathophysiology behind the perception changes evident in DSPN. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents  | ...
Source: Experimental and Clinical Endocrinology and Diabetes - February 1, 2021 Category: Endocrinology Authors: Hansen, Tine M. Fr økjær, Jens B. Selvarajah, Dinesh Muthulingam, Janusiya A. Tesfaye, Solomon Juhl, Anne Drewes, Asbj ørn M. Jakobsen, Poul E. Karmisholt, Jesper Brock, Birgitte Brock, Christina Tags: Article Source Type: research

Comparison of Safety Profiles of the New and Old Formulations of Levothyroxine in a First Global Introduction in France
Conclusions The new formulation safety profile aligns with the established profile of the old formulation of levothyroxine. The benefit–risk profile is unchanged, such that the benefits of using the new formulation in the approved indications outweigh the risks associated with the treatment. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes)
Source: Experimental and Clinical Endocrinology and Diabetes - January 28, 2021 Category: Endocrinology Authors: Lehnert, Hendrik Castello-Bridoux, Claire Channaiah, Bushan Martiniere, Karine Hildemann, Steven W émeau, Jean-Louis Tags: Article Source Type: research

Choice of Continuous Glucose Monitoring Systems May Affect Metrics: Clinically Relevant Differences in Times in Ranges
Discussion The differences in metrics found between the two continuous glucose monitoring systems may result in different therapy recommendations. In order to make adequate clinical decisions, measurement performance of CGM systems should be standardized and all available information, including the HbA1c, should be utilized. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes)
Source: Experimental and Clinical Endocrinology and Diabetes - January 28, 2021 Category: Endocrinology Authors: Freckmann, Guido Pleus, Stefan Schauer, Sebastian Link, Manuela Jendrike, Nina Waldenmaier, Delia Haug, Cornelia Stuhr, Andreas Tags: Article Source Type: research

Diabetes Mellitus at an Elderly Age
Exp Clin Endocrinol Diabetes DOI: 10.1055/a-1284-6023 Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes)
Source: Experimental and Clinical Endocrinology and Diabetes - January 21, 2021 Category: Endocrinology Authors: Zeyfang, Andrej Wernecke, J ürgen Bahrmann, Anke Tags: German Diabetes Association: Clinical Practice Guidelines Source Type: research

Functional Hypogonadism and Testosterone Deficiency in Aging Males With and Without HIV-infection
This study aimed at comparing the prevalence of testosterone deficiency and functional hypogonadism in men ≥ 50 years in these three groups. Patients and Methods Multi-center, cross-sectional substudy of the German-wide 50/2010 study, including men aged 50 years or older with HIV-infection, type 2 diabetes, and controls. Results Altogether, 322 men were included (mean age: 62 years (SD±7.9)). The prevalence of testosterone deficiency in men living with HIV, type 2 diabetes, and controls was 34.5, 44.9, and 35.0%, respectively; the prevalence of functional hypogonadism was 7.7, 14.3 and 3.5%, respectively. Single-...
Source: Experimental and Clinical Endocrinology and Diabetes - January 21, 2021 Category: Endocrinology Authors: Postel, Nils Wolf, Eva Balogh, Annamaria Obermeier, Martin Degen, Olaf Mayr, Christoph Baumgarten, Axel Pauli, Ramona Mueck, Birgit Jaeger, Hans Noe, Sebastian Tags: Article Source Type: research

Role of the Specialized Pro-resolving Mediator Resolvin D1 in Hashimoto ʼs Thyroiditis
Conclusions Thyroid autoimmunity may be associated with low levels of RVD1. Decreased RVD1 levels indicate impaired resolution of inflammation in HT patients. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes)
Source: Experimental and Clinical Endocrinology and Diabetes - January 19, 2021 Category: Endocrinology Authors: Song, Jing Sun, Rongxin Zhang, Yuanyuan Fu, Ying Zhao, Dong Tags: Article Source Type: research

Outcomes of Transsphenoidal Microsurgery for Prolactinomas – A Contemporary Series of 162 Cases
Conclusion Transsphenoidal microsurgery is safe and efficient for treatment of prolactinomas. It is particularly suitable for enclosed prolactinomas. The patient should be well informed of the pros and cons of the treatment options, which include DA medication and TSS, and the patient’s preference should be taken into account during decision-making. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes)
Source: Experimental and Clinical Endocrinology and Diabetes - January 18, 2021 Category: Endocrinology Authors: Giese, Sabrina Nasi-Kordhishti, Isabella Honegger, J ürgen Tags: Article Source Type: research

β1-adrenergic and Muscarinic Acetylcholine Type 2 Receptor Antibodies are Increased in Graves’ Hyperthyroidism and Decrease During Antithyroid Therapy
Exp Clin Endocrinol Diabetes DOI: 10.1055/a-1342-2853 Objective To determine the association between autoantibodies to G-protein-coupled receptors with effect on the cardiovascular system and the cardiac biomarker N-terminal pro-brain natriuretic peptide reflecting heart function in Gravesʼ disease. Design and Methods Sixty premenopausal women with Graves’ disease were analyzed for IgG autoantibodies against β1-adrenergic, muscarinic acetylcholine type 2 and angiotensin II type 1 receptors using enzyme-linked immunosorbent assays based on cell membranes overexpres...
Source: Experimental and Clinical Endocrinology and Diabetes - January 12, 2021 Category: Endocrinology Authors: Tammelin, Karin Lundgren, Anna Holmberg, Mats Andersson, Bengt Nystr öm, Helena Filipsson Tags: Article Source Type: research

Diabetes and Pregnancy
Exp Clin Endocrinol Diabetes DOI: 10.1055/a-1284-5758 Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes)
Source: Experimental and Clinical Endocrinology and Diabetes - January 8, 2021 Category: Endocrinology Authors: Kleinwechter, Helmut Sch äfer-Graf, Ute B ührer, Christoph Hoesli, Irene Kainer, Franz Kautzky-Willer, Alexandra Pawlowski, Brigitte Schunck, Karl-Ulrich Somville, Thierry Sorger, Marianne Tags: German Diabetes Association: Clinical Practice Guidelines Source Type: research

Nephropathy in Diabetes
Exp Clin Endocrinol Diabetes DOI: 10.1055/a-1284-6211 Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes)
Source: Experimental and Clinical Endocrinology and Diabetes - January 4, 2021 Category: Endocrinology Authors: Merker, Ludwig Bautsch, Bernd-Walter Ebert, Thomas Guthoff, Martina Isermann, Berend Tags: German Diabetes Association: Clinical Practice Guidelines Source Type: research

A Big Thank You to Our Reviewers in the Past Year!
Exp Clin Endocrinol Diabetes 2021; 129: 5-6 DOI: 10.1055/a-1309-3655 Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes)
Source: Experimental and Clinical Endocrinology and Diabetes - January 4, 2021 Category: Endocrinology Tags: Acknowledgment to the Reviewers Source Type: research

Nutritional Recommendations for People with Type 1 Diabetes Mellitus
Exp Clin Endocrinol Diabetes DOI: 10.1055/a-1284-6036 Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes)
Source: Experimental and Clinical Endocrinology and Diabetes - December 29, 2020 Category: Endocrinology Authors: Rubin, Diana Bosy-Westphal, Anja Kabisch, Stefan Kronsbein, Peter Simon, Marie-Christine Tombek, Astrid Weber, Katharina S. Skurk, Thomas Tags: German Diabetes Association: Clinical Practice Guidelines Source Type: research

Correction: Continuous Glucose Monitoring for Glycemic Control in Children and Adolescents Diagnosed with Diabetes Type 1: A Systematic Review and Meta-Analysis
Exp Clin Endocrinol Diabetes DOI: 10.1055/a-1340-1391 [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes)
Source: Experimental and Clinical Endocrinology and Diabetes - December 23, 2020 Category: Endocrinology Authors: Dorando, Elena Haak, Thomas Pieper, Dawid Tags: Erratum Source Type: research

Conversations and Reactions Around Severe Hypoglycaemia (CRASH): Results from the German Cohort of a Global Survey of People with Type 1 Diabetes or Insulin-Treated Type 2 Diabetes and Caregivers
Conclusions The survey identified areas for improvement in the prevention and management of severe hypoglycaemic events. For healthcare professionals, these include enquiring more frequently about severe hypoglycaemia and adjusting blood glucose-lowering medication after a severe hypoglycaemic event. For individuals with diabetes and their caregivers, potential improvements include ensuring availability of glucagon at all times. Changes in these areas could lead not only to improved patient wellbeing but also to reduced use of emergency services/hospitalisation and, consequently, lower healthcare costs. [...] Georg Thieme ...
Source: Experimental and Clinical Endocrinology and Diabetes - December 23, 2020 Category: Endocrinology Authors: M önnig, Elisabeth Spaepen, Erik Osumili, Beatrice Mitchell, Beth D. Snoek, Frank Peyrot, Mark Kern, Werner Holstein, Andreas Tags: Article Source Type: research

Diabetic Foot Syndrome
Exp Clin Endocrinol Diabetes DOI: 10.1055/a-1284-6412 Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes)
Source: Experimental and Clinical Endocrinology and Diabetes - December 22, 2020 Category: Endocrinology Authors: Morbach, Stephan Lobmann, Ralf Eckhard, Michael M üller, Eckhard Reike, Heinrich Risse, Alexander R ümenapf, Gerhard Spraul, Maximilian Tags: German Diabetes Association: Clinical Practice Guidelines Source Type: research

Obesity and Diabetes
Exp Clin Endocrinol Diabetes DOI: 10.1055/a-1284-6050 Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes)
Source: Experimental and Clinical Endocrinology and Diabetes - December 22, 2020 Category: Endocrinology Authors: Aberle, Jens Lautenbach, Anne Meyh öfer, Svenja Schmid, Sebastian M. Selig, Lars Bl üher, Matthias Tags: German Diabetes Association: Clinical Practice Guidelines Source Type: research

Outcomes after Emergency Admission with a Diabetic Foot Attack Indicate a High Rate of Healing and Limb Salvage But Increased Mortality: 18-Month Follow-up Study
Conclusions In a unique population of hospitalised individuals with DFA, we report excellent healing and limb salvage rates using a dedicated protocol in a multidisciplinary setting. An additional novel finding was the concerning observation that such an admission was associated with high 18-month mortality, almost all of which was after discharge from hospital. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes)
Source: Experimental and Clinical Endocrinology and Diabetes - December 22, 2020 Category: Endocrinology Authors: Vainieri, Erika Ahluwalia, Raju Slim, Hani Walton, Daina Manu, Chris Taori, Surabhi Wilkins, Jason Huang, Dean Y. Edmonds, Mike Rashid, Hisham Kavarthapu, Venu Vas, Prashanth R J Tags: Article Source Type: research

Role of Dkk2 in the Muscle/bone Interaction of Androgen-Deficient Mice
In conclusion, we showed that androgen deficiency enhances Dkk2 expression and secretion in the muscles of mice. Dkk2 might be involved in androgen deficiency-induced muscle wasting and osteopenia as a myokine linking muscle to bone. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes)
Source: Experimental and Clinical Endocrinology and Diabetes - December 22, 2020 Category: Endocrinology Authors: Iemura, Shunki Kawao, Naoyuki Akagi, Masao Kaji, Hiroshi Tags: Article Source Type: research

Diabetes, Sports and Exercise
Exp Clin Endocrinol Diabetes DOI: 10.1055/a-1284-6097 Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes)
Source: Experimental and Clinical Endocrinology and Diabetes - December 21, 2020 Category: Endocrinology Authors: Esefeld, Katrin Kress, Stephan Behrens, Meinolf Zimmer, Peter Stumvoll, Michael Thurm, Ulrike Gehr, Bernhard Brinkmann, Christian Halle, Martin Tags: German Diabetes Association: Clinical Practice Guidelines Source Type: research

Diabetic Retinopathy and Maculopathy
Exp Clin Endocrinol Diabetes DOI: 10.1055/a-1284-6223 Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes)
Source: Experimental and Clinical Endocrinology and Diabetes - December 17, 2020 Category: Endocrinology Authors: Hammes, Hans-Peter Lemmen, Klaus Dieter Bertram, Bernd Tags: German Diabetes Association: Clinical Practice Guidelines Source Type: research

Correction: Long-term Outcome of Subacute Thyroiditis
Exp Clin Endocrinol Diabetes 2020; 128: e1-e1 DOI: 10.1055/a-1325-3281 [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes)
Source: Experimental and Clinical Endocrinology and Diabetes - December 17, 2020 Category: Endocrinology Authors: G örges, Julia Ulrich, Jan Keck, Christoph M üller-Wieland, Dirk Diederich, Sven Janssen, Onno E. Tags: Erratum Source Type: research

Continuous Glucose Monitoring for Glycemic Control in Children and Adolescents Diagnosed with Diabetes Type 1: A Systematic Review and Meta-Analysis
Conclusion CGM systems may improve glycemic control in children and adolescents diagnosed with diabetes type 1, but the imprecision of effects is still a problem. Only a few studies examined and reported data for pediatric populations in sufficient detail. Further research is needed to clarify advantages and disadvantages of CGM systems in children and adolescents. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes)
Source: Experimental and Clinical Endocrinology and Diabetes - December 10, 2020 Category: Endocrinology Authors: Dorando, Elena Haak, Thomas Pieper, Dawid Tags: Meta-Analyses Source Type: research

Continuous Glucose Monitoring for Glycemic Control in Children and Adolescents Diagnosed with Diabetes Type 1: A Systematic Review and Meta-Analysis
Conclusion CGM systems may improve glycemic control in children and adolescents diagnosed with diabetes type 1, but the imprecision of effects is still a problem. Only a few studies examined and reported data for pediatric populations in sufficient detail. Further research is needed to clarify advantages and disadvantages of CGM systems in children and adolescents. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes)
Source: Experimental and Clinical Endocrinology and Diabetes - December 10, 2020 Category: Endocrinology Authors: Dorando, Elena Haak, Thomas Pieper, Dawid Tags: Meta-Analyses Source Type: research