Mortality of Patients with Cushing ’s Disease
Exp Clin Endocrinol Diabetes DOI: 10.1055/a-1197-6380Cushing’s disease is a rare condition of cortisol excess attributed to a pituitary adenoma with an annual incidence of 1.2–2.4 cases per million population. It is associated with several co-morbidities leading to increased mortality predominantly due to cardiovascular disease. Despite the advances in its diagnosis and management, survival can be compromised even after apparent successful treatment. Minimizing the duration and extent of exposure to hypercortisolaemia by early diagnosis and rapid, effective therapeutic interve...
Source: Experimental and Clinical Endocrinology and Diabetes - July 9, 2020 Category: Endocrinology Authors: Ntali, Georgia Hakami, Osamah Wattegama, Milanka Ahmed, Shahzada Karavitaki, Niki Tags: Review Source Type: research

A Prospective, Randomized Trial Testing Different Regimens of Carbohydrate Administration to Prevent Major Reduction in Plasma Glucose Follwing a Standardized Bout of Moderate Physical Activity in Patients with Type 1 Diabetes
Exp Clin Endocrinol Diabetes DOI: 10.1055/a-1190-3614 Aim/Hypothesis It was the aim to prospectively study regimes of “preventive” carbohydrate administration to avoid major reduction in plasma glucose during physical activity. Methods 24 patients with type 1 diabetes (age 41±12 years; 11 women, 13 men; BMI 26.5±4.7 kg/m2; HbA1c 9.1±1.5%; insulin dose 0.64±0.22 IU/kg body weight and day) participated in one experiment without physical activity and in three experiments with a 4 km, 60 min hike starting at 2 p.m.. No “prevent...
Source: Experimental and Clinical Endocrinology and Diabetes - July 2, 2020 Category: Endocrinology Authors: Frenzke, Hanna Varnhorn, Annette Schulze, Heike Kahle-Stephan, Melanie Nauck, Michael A. Tags: Article Source Type: research

Cardiac Autonomic Neuropathy is Associated with Improved Diabetic Foot Ulcer Healing: A Single Centre Prospective Cohort Study
Conclusions We demonstrate a high prevalence of CAN in a DFU cohort and that CAN is associated with improved DFU healing. The results of this study establish the scientific rationale for further studies to better understand the mechanisms between CAN and DFU outcomes. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes)
Source: Experimental and Clinical Endocrinology and Diabetes - July 2, 2020 Category: Endocrinology Authors: Farrow, Frederick Fountoulakis, Nikolaos Cummins, Kelly Sharma, Angelica Mahmood, Rabiah Vas, Prashanth Thomas, Stephen Karalliedde, Janaka Tags: Article Source Type: research

Medical Therapy of Acromegaly in Germany 2019 – Data from the German Acromegaly Registry
Conclusion The majority of German acromegalic patients receiving medical therapy are controlled according to normal IGF-1 levels. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes)
Source: Experimental and Clinical Endocrinology and Diabetes - June 30, 2020 Category: Endocrinology Authors: Quinkler, Marcus Petroff, David Knappe, Ulrich J. Schopohl, Jochen T önjes, Anke Schmid, Sebastian M. Tags: Article Source Type: research

Predictive Effect of Inflammatory Response and Foot Ulcer Localization on Outcome in Younger and Older Individuals with Infected Diabetic Foot Syndrome
Exp Clin Endocrinol Diabetes DOI: 10.1055/a-1149-8989The diabetic foot syndrome (DFS) is the most important cause for non-traumatic major amputation in adult individuals and actually one of the most frightening events in diabetics’ life. Despite the often protracted treatment of infected DFS at the end patients are often confronted with amputation. We investigated 352 individuals with infected DFS in two age separated-groups. Older individuals presented with significant worse renal function and lower HbA1c on day of admittance. Most detected ulcers involved the plantar sides of the ...
Source: Experimental and Clinical Endocrinology and Diabetes - June 24, 2020 Category: Endocrinology Authors: D örr, Stefan Schlecht, Michael Chatzitomaris, Apostolos Weisser, Gregor Lucke-Paulig, Lara Friedl, Alexander Joachim, Regina Lobmann, Ralf Tags: Article Source Type: research

Liraglutide Effect on Ventricular Transient Outward K  +  Channel and Connexin-43 Protein Expression
Conclusions We have shown that pathological alterations in myocardial Cx43 expression and distribution, in addition to reduced Ito channel expression, may underlie the QTc interval prolongation in high-fat diet/STZ rat model of type 2 diabetes mellitus. The beneficial effects of Liraglutide, as those of Ramipril, on cardiac electrophysiology could be at least attributed to its direct ability to normalize expression and distribution of Cx43 and Ito channels in the diabetic rat heart. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of...
Source: Experimental and Clinical Endocrinology and Diabetes - June 19, 2020 Category: Endocrinology Authors: Ramadan, Nehal M. Malek, Hala Abdel Rahman, Karawan Abd-el El-Kholy, Elhamy Shaalan, Dalia Elkashef, Wagdi Tags: Article Source Type: research

The High-Resolution Three-Dimensional Magnetic Detector System 3D-Magma Accurately Measures Gastric and Small Bowel Motility in People with Type 2 Diabetes with Neuropathy
Discussion and conclusion: 3D-MAGMA is able to detect changes in intestinal motility. Its clinical value might be useful in patients with fluctuating blood glucose levels and unexplained hypoglycemic episodes. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes)
Source: Experimental and Clinical Endocrinology and Diabetes - June 18, 2020 Category: Endocrinology Authors: Jacob, Veit Yves Pascal Felber, J örg M üller, Nicolle Kloos, Christof M üller, Ulrich Alfons Stallmach, Andreas Tags: Article Source Type: research

Screening for New Markers to Assess Thyroid Hormone Action by OMICs Analysis of Human Samples
Exp Clin Endocrinol Diabetes 2020; 128: 479-487 DOI: 10.1055/a-1144-2636Determination of the levels of thyroid-stimulating hormone (TSH) and free thyroid hormones (fTHs) is crucial for assessing thyroid function. However, as a result of inter-individual genetic variability and different environmental factors individual set points exist for TSH and fTHs and display considerable variation. Furthermore, under specific pathophysiological conditions like central hypothyroidism, TSH secreting pituitary tumors, or thyroid hormone resistance the established markers TSH and fTH fail to reli...
Source: Experimental and Clinical Endocrinology and Diabetes - June 16, 2020 Category: Endocrinology Authors: Friedrich, Nele Pietzner, Maik Engelmann, Beatrice Homuth, Georg F ührer, Dagmar Brabant, Georg Wallaschofski, Henri V ölker, Uwe Tags: Mini-Review Source Type: research

Mass Spectrometry-Based Determination of Thyroid Hormones and Their Metabolites in Endocrine Diagnostics and Biomedical Research – Implications for Human Serum Diagnostics
Exp Clin Endocrinol Diabetes 2020; 128: 358-374 DOI: 10.1055/a-1175-4610The wide spectrum of novel applications for the LC-MS/MS-based analysis of thyroid hormone metabolites (THM) in blood samples and other biological specimen highlights the perspectives of this novel technology. However, thorough development of pre-analytical sample workup and careful validation of both pre-analytics and LC-MS/MS analytics, is needed, to allow for quantitative detection of the thyronome, which spans a broad concentration range in these biological samples.This minireview summarizes recent developments i...
Source: Experimental and Clinical Endocrinology and Diabetes - June 16, 2020 Category: Endocrinology Authors: K öhrle, Josef Richards, Keith H. Tags: Mini-Review Source Type: research

Seven Years of Active Thyroid Hormone Research in Germany: Thyroid Hormone Action beyond Classical Concepts
Exp Clin Endocrinol Diabetes 2020; 128: 355-357 DOI: 10.1055/a-1163-7355 © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes)
Source: Experimental and Clinical Endocrinology and Diabetes - June 16, 2020 Category: Endocrinology Authors: Biebermann, Heike Brix, Klaudia F ührer, Dagmar Tags: Editorial Source Type: research

Combined Effects of Single Nucleotide Polymorphisms (SNPs) within C-reactive Protein (CRP) and Environmental Parameters on Risk and Prognosis for Diabetic Foot Osteomyelitis Patients
Conclusion Genetic mutations within CRP functioned interactively with external factors to affect DFO risk. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes)
Source: Experimental and Clinical Endocrinology and Diabetes - June 15, 2020 Category: Endocrinology Authors: Wang, Shanjin Xu, Haowei Zhou, Ningfeng Zhao, Weidong Wu, Desheng Shen, Bin Tags: Article Source Type: research

Sulforaphane and Vitamin E Protect From Glucotoxic Neurodegeneration and Lifespan Reduction In C. Elegans
Exp Clin Endocrinol Diabetes DOI: 10.1055/a-1158-9248 Caenorhabditis elegans is an established model organism in neurodegeneration and aging research. Oxidative stress and formation of advanced glycation endproducts (AGEs), as they occur under hyperglycemic conditions in diabetes mellitus, contribute to neuronal damage and lifespan reduction. Sulforaphane (SFN) is an indirect antioxidant, alpha-tocopherol (vitamin E) is a direct antioxidant that acts as a free radical scavenger. Aim of this study is to investigate the protective effects of SFN and vitamin E against glucotoxic damages...
Source: Experimental and Clinical Endocrinology and Diabetes - June 5, 2020 Category: Endocrinology Authors: Schlotterer, Andrea Masri, Benan Humpert, M. Kr ämer, Bernhard Karl Hammes, Hans-Peter Morcos, Michael Tags: Article Source Type: research

Functional Characteristics of Novel FGFR1 Mutations in Patients with Isolated Gonadotropin-Releasing Hormone Deficiency
Conclusions This study identified seven rare sequence variants in FGFR1 in patients with KS and nIHH. Probands with an FGFR1 mutations displayed a wide phenotypic spectrum ranging from KS to anosmia. A prepubertal male with anosmia should be followed up to assess pubertal development because they can manifest hypogonadotropic hypogonadism after puberty. These results expand the phenotypic spectrum of FGFR1 mutations and suggest a broader biologic role of FGFR1 in reproduction. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents &n...
Source: Experimental and Clinical Endocrinology and Diabetes - June 2, 2020 Category: Endocrinology Authors: Choi, Jin-Ho Oh, Arum Lee, Yena Kim, Gu-Hwan Yoo, Han-Wook Tags: Article Source Type: research

Endocrine, Metabolic and Pharmacological Effects of Thyronamines (TAM), Thyroacetic Acids (TA) and Thyroid Hormone Metabolites (THM) – Evidence from in vitro, Cellular, Experimental Animal and Human Studies
Exp Clin Endocrinol Diabetes DOI: 10.1055/a-1139-9200Thyroid hormone metabolites (THM) with few or no iodine substituents such as 3,5-T2, the thyronamines 3-T1AM and T0AM, and their oxidation products, the thyroacetic acids (TA) formed by monoamine oxidases, have recently attracted major interest due to their metabolic actions which are in part distinct from those of the classical thyromimetic hormone T3, the major ligand of T3 receptors. This review compiles and discusses in vitro effects of 3,5-T2, TAM and TA reported for thyrocytes, pancreatic islets and hepatocytes as well as findings from in vivo studies in mouse mode...
Source: Experimental and Clinical Endocrinology and Diabetes - May 25, 2020 Category: Endocrinology Authors: Homuth, Georg Lietzow, Julika Schanze, Nancy Golchert, Janine K öhrle, Josef Tags: Article Source Type: research

Epigenetic Downregulation of FASN in Visceral Adipose Tissue of Insulin Resistant Subjects
Exp Clin Endocrinol Diabetes DOI: 10.1055/a-1150-7446 Objective The risk to develop type 2 diabetes increases with the amount of visceral adiposity presumably due to increased lipolysis and subsequent lipid accumulation in visceral organs. However, data describing the molecular regulation of these pathways in humans are rare. We tested if genes of the lipogenic and lipolytic pathways are associated with glucose intolerance independently of obesity in visceral adipose tissue (VAT) of obese subjects. Moreover, we studied DNA methylation of FASN (fatty acid synthase), that catalyses th...
Source: Experimental and Clinical Endocrinology and Diabetes - May 20, 2020 Category: Endocrinology Authors: Sievert, Helen Krause, Christin Gei ßler, Cathleen Grohs, Martina El-Gammal, Alexander T. Wolter, Stefan Mann, Oliver Lehnert, Hendrik Kirchner, Henriette Tags: Article Source Type: research

Additional Insulin for Coping with Fat- and Protein-Rich Meals in Adolescents with Type 1 Diabetes: The Protein Unit
Exp Clin Endocrinol Diabetes DOI: 10.1055/a-1149-8766 Objective Dietary proteins raise blood glucose levels; dietary fats delay this rise. We sought to assess the insulin amount required to normalize glucose levels after a fat- and protein-rich meal (FPRM). Methods Sixteen adolescents (5 female) with type 1 diabetes (median age: 18.2 years; range: 15.2–24.0; duration: 7.1 years; 2.3–14.3; HbA1c: 7.2%; 6.2–8.3%) were included. FPRM (carbohydrates 57 g; protein 92 g; fat 39 g; fibers 7 g; calories 975 Kcal) was served in the evening, with 20 or 40% extra insulin compared t...
Source: Experimental and Clinical Endocrinology and Diabetes - May 20, 2020 Category: Endocrinology Authors: Schweizer, Roland Herrlich, Susann L ösch-Binder, Martina Gl ökler, Michaela Heimg ärtner, Magdalena Liebrich, Franziska Me ßner, Katja Muckenhaupt, Tina Schneider, Angelika Ziegler, Julian Neu, Andreas Tags: Article Source Type: research

Metformin Associated Lactic Acidosis in Clinical Practice – A Case Series
Conclusions Every patient matching the screening criteria of acute renal failure, lactic acidosis and continued intake of metformin can be considered a potential MALA case. A risk score assessment which includes severe comorbidities may help to identify high-risk individuals and should be evaluated in larger studies.To prevent MALA, patients should be trained to immediately interrupt their own metformin use when showing signs of volume depletion. Physicians should be aware of the additional risk factors such as co-medication with diuretics, ACE (angiotensin converting enzyme) ACE inhibitors and NSAIDs (non steroidal anti i...
Source: Experimental and Clinical Endocrinology and Diabetes - May 13, 2020 Category: Endocrinology Authors: Sch ädle, Philipp Tschritter, Otto Kellerer, Monika Tags: Article Source Type: research

Correction: Steroidogenesis in the NCI-H295 Cell Line Model is Strongly Affected By Culture Conditions and Substrain
Exp Clin Endocrinol Diabetes DOI: 10.1055/a-1169-5951 [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes)
Source: Experimental and Clinical Endocrinology and Diabetes - May 12, 2020 Category: Endocrinology Authors: Kurlbaum, Max Sbiera, Silviu Kendl, Sabine Fassnacht, Martin Kroiss, Matthias Tags: Article Source Type: research

A ‘Speed-Dating’ Model of Wound Care? Rapid, High-Volume Assessment of Patients With Diabetes in a Multidisciplinary Foot Wound Clinic
Conclusion Our study shows that the use of a rapid-access interdisciplinary team to assess and manage patients’ diabetes in a foot wound clinic is feasible. Patients with higher-risk diabetes foot wounds exposed to RAIT had comparable wound healing outcomes to lower risk patients. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes)
Source: Experimental and Clinical Endocrinology and Diabetes - May 7, 2020 Category: Endocrinology Authors: Sung, Jasper A. Gurung, Seema Lam, Teresa Yusaf, Shehzi Vicaretti, Mauro Begg, Lindy Cheung, N. Wah Padmanabhan, Suja Girgis, Christian M. Tags: Article Source Type: research

Rhinological Consequences of Microsurgical Endonasal-Transsphenoidal Surgery for Pituitary Tumors
Conclusion Microsurgical resection of pituitary tumors via the endonasal transsphenoidal approach poses an acceptable risk with regards to sinonasal complications. The incidence of secondary rhinosurgical interventions is low. Standardized comparative studies between endoscopic and microsurgical transsphenoidal operations should be undertaken. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes)
Source: Experimental and Clinical Endocrinology and Diabetes - May 7, 2020 Category: Endocrinology Authors: Hondronikos, Nikolaos Alomari, Ali Schrader, Martin Knappe, Ulrich J. Tags: Article Source Type: research

Assessing the benefits and challenges of video consultations for the treatment of children with type 1 diabetes – A qualitative study among diabetes professionals
Conclusions Prerequisites for successful video consultations include a comprehensive initial technical training and an agreement on treatment responsibilities of all health care professionals involved in the patient’s care. Under these conditions, the experts reported significant advantages of video consultation in the treatment of children with type 1 diabetes. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes)
Source: Experimental and Clinical Endocrinology and Diabetes - May 7, 2020 Category: Endocrinology Authors: Frielitz, Fabian-Simon D ördelmann, Jana Lemke, Stella Lange, Karin Hiort, Olaf Katalinic, Alexander von Sengbusch, Simone Tags: Article Source Type: research

Steroidogenesis in the NCI-H295 Cell Line Model is Strongly Affected By Culture Conditions and Substrain
Exp Clin Endocrinol Diabetes DOI: 10.1055/a-1105-6332 Context NCI-H295 cells are the most widely used model for adrenal steroidogenesis and adrenocortical carcinoma and have been used for decades in laboratories worldwide. However, reported steroidogenic properties differ considerably. Objective To evaluate heterogeneity of steroidogenesis among NCI-H295 cell strains, clarify the influence of culture media and test response to inhibitors of steroidogenesis by using liquid chromatography tandem mass spectrometry (LC-MS/MS). Methods NCI-H295 cells were obtained from two cell banks...
Source: Experimental and Clinical Endocrinology and Diabetes - April 29, 2020 Category: Endocrinology Authors: Kurlbaum, Max Sbiera, Silviu Kendl, Sabine Martin Fassnacht, M. Kroiss, Matthias Tags: Article Source Type: research

Noncanonical Action of Thyroid Hormone Receptors α and β
Exp Clin Endocrinol Diabetes DOI: 10.1055/a-1088-1187Thyroid hormone (TH) is essential for the regulation of many physiological processes, especially growth, organ development, energy metabolism and cardiovascular effects. TH acts via the TH receptors (TR) α and β. By binding to thyroid hormone responsive elements (TREs) on the DNA, TRs regulate expression of TH target genes. Thus, TRs are mainly characterized as ligand dependent transcription factors and regulation of gene expression and protein synthesis is considered the canonical mode of TH/TR action. The demonstration that...
Source: Experimental and Clinical Endocrinology and Diabetes - April 24, 2020 Category: Endocrinology Authors: H önes, G. Sebastian Geist, Daniela Moeller, Lars C. Tags: Article Source Type: research

Letter to the Editor – Defining Diabetes Mellitus
Exp Clin Endocrinol Diabetes DOI: 10.1055/a-1135-8636 © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes)
Source: Experimental and Clinical Endocrinology and Diabetes - April 20, 2020 Category: Endocrinology Authors: Cimolai, Nevio Tags: Letter to the Editor Source Type: research

Pituitary Adenomas with Changing Phenotype: A Systematic Review
Conclusion PA can change from functioning to (NF) non-functioning (vice versa) and even exchange their hormonal expression. Clinicians should be aware and a careful lifelong follow-up is mandatory to detect it. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes)
Source: Experimental and Clinical Endocrinology and Diabetes - April 14, 2020 Category: Endocrinology Authors: Guerrero-P érez, Fernando Marengo, Agustina Pia Vidal, Noemi Villabona, Carles Tags: Review Source Type: research

Antidiabetic Therapy and Rate of Severe Hypoglycaemia in Patients with Type 2 Diabetes and Chronic Kidney Disease of Different Stages – A Follow-up Analysis of Health Insurance Data from Germany
Conclusion The prevalence of CKD increased from 2006 to 2016. Patients with CKD exhibited a 9-fold increased probability of sHypo, especially in patients treated with insulin plus oral anti-diabetic drugs. However, the rate and risk for sHypo decreased over time, probably as a consequence of new antidiabetic treatment options, better awareness of sHypo, and changed therapy goals. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes)
Source: Experimental and Clinical Endocrinology and Diabetes - April 14, 2020 Category: Endocrinology Authors: Busch, Martin Lehmann, Thomas Wolf, Gunter G ünster, Christian M üller, Ulrich Alfons M üller, Nicolle Tags: Article Source Type: research

Allan-Herndon-Dudley-Syndrome: Considerations about the Brain Phenotype with Implications for Treatment Strategies
Exp Clin Endocrinol Diabetes DOI: 10.1055/a-1108-1456Despite its first description more than 75 years ago, effective treatment for “Allan-Herndon-Dudley-Syndrome (AHDS)”, an X-linked thyroid hormone transporter defect, is unavailable. Mutations in the SLC16A2 gene have been discovered to be causative for AHDS in 2004, but a comprehensive understanding of the function of the encoded protein, monocarboxylate transporter 8 (MCT8), is incomplete. Patients with AHDS suffer from neurodevelopmental delay, as well as extrapyramidal (dystonia, chorea, athetosis), pyramidal (spasticity), and cerebellar symptoms (ataxia)....
Source: Experimental and Clinical Endocrinology and Diabetes - April 2, 2020 Category: Endocrinology Authors: Krude, Heiko Biebermann, Heike Schuelke, Markus M üller, Timo D. Tsch öp, Matthias Tags: Article Source Type: research

HOMA-Adiponectin Closely Associates with Cardiometabolic Risk Markers in Middle-Aged Indians with Metabolic Syndrome
Exp Clin Endocrinol Diabetes DOI: 10.1055/a-1120-8163 Background Unhealthy dietary habits and sedentary lifestyles have raised alarming concerns for the rising prevalence of metabolic syndrome (MetS) and associated cardiometabolic risk among Indians at an early age. Insulin resistance and adiposity are the important risk factors associated with MetS. The present study aimed to investigate the relationship between a modified marker of insulin resistance (homeostatic model assessment-adiponectin (HOMA-AD)) and cardiometabolic risk among middle-aged Indians. Methods The study comprised of 144 subjects of age-group 31–50...
Source: Experimental and Clinical Endocrinology and Diabetes - March 18, 2020 Category: Endocrinology Authors: Banerjee, Joyita Dhas, Yogita Mishra, Neetu Tags: Article Source Type: research

Enhanced Inflammatory Reaction and Thrombosis in High-Fat Diet-Fed ApoE-/- Mice are Attenuated by Celastrol
Conclusions Celastrol administration significantly attenuated HFD-induced inflammatory reaction, platelet aggregation and thrombosis in apoE-/- mice, and celastrol may be used as a drug for the prevention of HFD-induced inflammatory reaction and thrombus. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes)
Source: Experimental and Clinical Endocrinology and Diabetes - March 16, 2020 Category: Endocrinology Authors: Ouyang, Mao Qin, Tao Liu, Hengdao Lu, Junya Peng, Caixia Guo, Qin Tags: Article Source Type: research

Associations Between Migration Background and Media and Information Behavior in Primary School Children
Conclusions Children attending 3rd grade class, especially with migration background, can be addressed through digital media rather than the radio. This may help to sustainably support children outside school with targeted health information. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes)
Source: Experimental and Clinical Endocrinology and Diabetes - March 12, 2020 Category: Endocrinology Authors: Dauben, Laura Weber, Katharina S. Nie ßen, Lisa Verket, Marlo Sp örkel, Olaf Strassburger, Klaus Roden, Michael Kronsbein, Peter M üssig, Karsten Tags: Article Source Type: research

Congenital Adrenal Hyperplasia Due to 21-Hydroxylase Deficiency: An Update on Genetic Analysis of CYP21A2 Gene
Exp Clin Endocrinol Diabetes DOI: 10.1055/a-1108-1419Congenital Adrenal Hyperplasia is a group of genetic autosomal recessive disorders that affects adrenal steroidogenesis in the adrenal cortex. One of the most common defects associated with Congenital Adrenal Hyperplasia is the deficiency of 21-hydroxylase enzyme, responsible for the conversion of 17-hydroxyprogesterone to 11-deoxycortisol and progesterone to deoxycorticosterone. The impairment of cortisol and aldosterone production is directly related to the clinical form of the disease that ranges from classic or severe to non-classic or mild late onset. The deficiency...
Source: Experimental and Clinical Endocrinology and Diabetes - March 4, 2020 Category: Endocrinology Authors: Carvalho, Berta Marques, C.Joana Santos-Silva, Rita Fontoura, Manuel Carvalho, Davide Carvalho, Filipa Tags: Review Source Type: research

Carotid Intima-Media Thickness is a Predictor of Subclinical Myocardial Damage in Men with Type 2 Diabetes Mellitus
Conclusion In a real-world clinical setting in patients with T2DM, cIMT is a predictor of subclinical myocardial damage in men, but not in women. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes)
Source: Experimental and Clinical Endocrinology and Diabetes - March 4, 2020 Category: Endocrinology Authors: H örber, Sebastian Lehn-Stefan, Angela Hieronimus, Anja Hudak, Sarah Fritsche, Louise Fritsche, Andreas Heni, Martin H äring, Hans-Ulrich Peter, Andreas Randrianarisoa, Elko Tags: Article Source Type: research

Auto-Regulation of the Thyroid Gland Beyond Classical Pathways
Exp Clin Endocrinol Diabetes DOI: 10.1055/a-1080-2969This mini-review asks how self-regulation of the thyroid gland is realized at the cellular and molecular levels by canonical and non-canonical means. Canonical pathways of thyroid regulation comprise thyroid stimulating hormone-triggered receptor signaling. As part of non-canonical regulation, we hypothesized an interplay between protease-mediated thyroglobulin processing and thyroid hormone release into the circulation by means of thyroid hormone transporters like Mct8. We proposed a sensing mechanism by different thyroid hormone transporters, present in specific subcel...
Source: Experimental and Clinical Endocrinology and Diabetes - February 19, 2020 Category: Endocrinology Authors: Brix, Klaudia Szumska, Joanna Weber, Jonas Qatato, Maria Venugopalan, Vaishnavi Al-Hashimi, Alaa Rehders, Maren Tags: Mini-Review Source Type: research

Class I and II Histone Deacetylase Inhibitor LBH589 Promotes Endocrine Differentiation in Bone Marrow Derived Human Mesenchymal Stem Cells and Suppresses Uncontrolled Proliferation
In conclusion, we deliver evidence that a combined class I and II histone deacetylase inhibition is able to modulate the transcripts of differentiation markers of mesenchymal stem cells. The treatment holds the capability to facilitate endocrine differentiation in future approaches to replace endocrine cells by stem cell therapy. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes)
Source: Experimental and Clinical Endocrinology and Diabetes - February 12, 2020 Category: Endocrinology Authors: Schr öder, Christoph Khatri, Rahul Petry, Sebastian Friedrich Linn, Thomas Tags: Article Source Type: research

The Influence of Thyroid Hormones on Brain Structure and Function in Humans
Exp Clin Endocrinol Diabetes DOI: 10.1055/a-1101-9090The pleiotropic function of thyroid hormones (TH) is mediated by an organ specific expression of thyroid hormone transporters, deiodinases and TH receptors. In a series of studies we used the model of an experimentally induced hyper- or hypothyroidism in human volunteers to delineate TH action on the brain. A battery of neuropsychological testing paradigms was employed and complemented by structural and functional multimodal neuroimaging. Experimentally induced mild thyrotoxicosis for 6 weeks was associated with changes in brain structure (determined with voxel-based mor...
Source: Experimental and Clinical Endocrinology and Diabetes - February 10, 2020 Category: Endocrinology Authors: G öbel, Anna G öttlich, Martin Reinwald, Jonathan Rogge, Berenike Uter, Jan-Christoph Heldmann, Marcus Sartorius, Alexander Brabant, Georg M ünte, Thomas F. Tags: Article Source Type: research

Correction: Single Nucleotide Polymorphisms in Thyroid Hormone Transporter Genes MCT8, MCT10 and Deiodinase DIO2 Contribute to Inter-Individual Variance of Executive Functions and Personality Traits
Exp Clin Endocrinol Diabetes DOI: 10.1055/a-1102-8862 [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes)
Source: Experimental and Clinical Endocrinology and Diabetes - January 24, 2020 Category: Endocrinology Authors: Uter, Jan Christoph Kr ämer, Ulrike M. Sch öls, Ludger Rodriguez-Fornells, Antoni G öbel, Anna Heldmann, Marcus Lichtner, Peter Brabant, Georg M ünte, Thomas F. Tags: Erratum Source Type: research

Placental Accumulation of Triacylglycerols in Gestational Diabetes Mellitus and Its Association with Altered Fetal Growth are Related to the Differential Expressions of Proteins of Lipid Metabolism
Conclusion Differential expressions of placental proteins related to lipid metabolism in GDM might have led to placental TG accumulation. This might have contributed to the fetal overgrowth in GDM. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes)
Source: Experimental and Clinical Endocrinology and Diabetes - January 22, 2020 Category: Endocrinology Authors: Balachandiran, Manoharan Bobby, Zachariah Dorairajan, Gowri Jacob, Sajini Elizabeth Gladwin, Victorraj Vinayagam, Vickneshwaran Packirisamy, Rajaa Muthu Tags: Article Source Type: research

Thyroid Hormone Actions and Bone Remodeling – The Role of the Wnt Signaling Pathway
Exp Clin Endocrinol Diabetes DOI: 10.1055/a-1088-1215Thyroid hormones are indispensable for bone development and growth. Also in adults, bone mass maintenance is under the control of thyroid hormones. Preclinical and clinical studies established untreated hyperthyroidism as a cause for secondary osteoporosis with increased fracture risk. Thus, normal thyroid function is essential for bone health. Mechanistically, thyroid hormone excess accelerates bone turnover with predominant bone resorption. How thyroid hormones affect osteoblast and osteoclast functions, however, still remains ill-defined. The Wnt signaling pathway is ...
Source: Experimental and Clinical Endocrinology and Diabetes - January 20, 2020 Category: Endocrinology Authors: Lademann, Franziska Tsourdi, Elena Hofbauer, Lorenz C. Rauner, Martina Tags: Mini-Review Source Type: research

Clinical Characteristics and Follow-Up Results of Adrenal Incidentaloma
Exp Clin Endocrinol Diabetes DOI: 10.1055/a-1079-4915It is recommended that adrenal incidentaloma patients should be monitored for radiological changes, increase in size and new functionality that may occur in the future, even if they are benign and nonfunctional at the initial evaluation. Our aim is to evaluate the key clinical characteristics of adrenal incidentaloma patients focusing on changes during follow-up and associated clinical outcomes. A total of 755 patients (median age: 56 years), with an adrenal incidentaloma> 1 cm and underwent functionality tests, were included in the study. Clinical chara...
Source: Experimental and Clinical Endocrinology and Diabetes - January 20, 2020 Category: Endocrinology Authors: Yilmaz, Nusret Avsar, Esin Tazegul, Gokhan Sari, Ramazan Altunbas, Hasan Balci, Mustafa Kemal Tags: Article Source Type: research

Angiopoietin 2 and Neuropeptide Y are Associated with Diabetic Kidney Disease in Type 1 Diabetes Mellitus
Exp Clin Endocrinol Diabetes DOI: 10.1055/a-1079-4711 Background Serum angiopoietin 2 levels have been associated with endothelial dysfunction and diabetic kidney disease. Derangements in autonomous nervous system lead to increased production of vasoconstrictory and angiogenic mediators such as norepinephrine and neuropeptide Y and are associated with increased risk of microvascular complications. Aim To investigate associations between angiopoietin 2, neuropeptide Y and diabetic kidney disease in patients with type 1 diabetes mellitus. Methods 289 patients with type 1 diabetes mellitus duration> 1 year were included. P...
Source: Experimental and Clinical Endocrinology and Diabetes - January 20, 2020 Category: Endocrinology Authors: Sokolovska, Jelizaveta Stefanovics, Juris Gersone, Gita Pahirko, Leonora Valeinis, Janis Kalva-Vaivode, Sanita Rovite, Vita Blumfelds, Leons Pirags, Valdis Tretjakovs, Peteris Tags: Article Source Type: research

Gene Regulatory Effect of Pyruvate Kinase M2 is Involved in Renal Inflammation in Type 2 Diabetic Nephropathy
Conclusion The gene regulatory effect of PKM2 is involved in renal inflammation in type 2 diabetic nephropathy by promoting the phosphorylation of STAT3 and NF-kB and the expression of intercellular adhesion molecule 1. Thus, the down-regulation of phosphorylated PKM2 may have protective effects against diabetic nephropathy by inhibiting renal inflammation. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes)
Source: Experimental and Clinical Endocrinology and Diabetes - January 20, 2020 Category: Endocrinology Authors: Li, Le Tang, Lei Yang, Xiaoping Chen, Ruifang Zhang, Zhen Leng, Yiping Chen, Alex F. Tags: Article Source Type: research

Decreased Expression of the Human Urea Transporter SLC14A1 in Bone is Induced by Cytokines and Stimulates Adipogenesis of Mesenchymal Progenitor Cells
Exp Clin Endocrinol Diabetes DOI: 10.1055/a-1084-3888The human urea transporter SLC14A1 (HUT11/UT-B) has been suggested as a marker for the adipogenic differentiation of bone cells with a relevance for bone diseases. We investigated the function of SLC14A1 in different cells models from bone environment. SLC14A1 expression and cytokine production was investigated in bone cells obtained from patients with osteoporosis. Gene and protein expression of SLC14A1 was studied during adipogenic or osteogenic differentiation of human mesenchymal progenitor cells (hMSCs) and of the single-cell–derived hMSC line (SCP-1), as well...
Source: Experimental and Clinical Endocrinology and Diabetes - January 20, 2020 Category: Endocrinology Authors: Komrakova, Marina Blaschke, Martina Ponce, Maria Laura Kl üver, Anne K öpp, Regine H üfner, Michael Schieker, Matthias Miosge, Nicolai Siggelkow, Heide Tags: Article Source Type: research

Giant Non-Functioning Pituitary Adenoma: Clinical Characteristics and Therapeutic Outcomes
Exp Clin Endocrinol Diabetes DOI: 10.1055/a-1089-4659 [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes)
Source: Experimental and Clinical Endocrinology and Diabetes - January 13, 2020 Category: Endocrinology Authors: Iglesias, Pedro Arcano, Karina Trivi ño, Vanessa Guerrero-P érez, Fernando Rodr íguez Berrocal, Víctor Vior, Carlos Cordido, Fernando Villabona, Carles D íez, Juan J Tags: Erratum Source Type: research

The Effect of High-Intensity Interval Training on Physical Parameters, Metabolomic Indexes and Serum Ficolin-3 Levels in Patients with Prediabetes and Type 2 Diabetes
Conclusions Both HIIT and MICT were beneficial exercise strategies for health in patients with prediabetes or T2D. However, HIIT is a more time-efficient strategy and could lower the serum level of ficolin-3 in patients after 3 weeks of training. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes)
Source: Experimental and Clinical Endocrinology and Diabetes - January 13, 2020 Category: Endocrinology Authors: Liu, Xiaochen Wang, Gaifeng Tags: Article Source Type: research

Age and Sex Influence Thyroid Hormone Effects in Target Tissues with Organ-Specific Responses
Exp Clin Endocrinol Diabetes DOI: 10.1055/a-1083-6272Age and sex impact prevalence and clinical features of thyroid disease. Thyroid dysfunction occurs with a higher frequency in elderly patients and females. Moreover, age alters clinical presentation of hyper- and hypothyroidism and onset of thyroid hormone (TH) related co-morbidities leading to increased risk for underdiagnosis and maltreatment in the elderly. Rodent models allow further insights into mechanisms of age- and sex-dependent TH action in target tissues. In this review, we summarize findings from mouse studies showing distinct effects of age and sex on system...
Source: Experimental and Clinical Endocrinology and Diabetes - January 13, 2020 Category: Endocrinology Authors: Kerp, Helena Gassen, Janina F ührer, Dagmar Tags: Article Source Type: research

Non-Surgical and Non-Radioiodine Techniques for Ablation of Benign Thyroid Nodules: Consensus Statement and Recommendation
Exp Clin Endocrinol Diabetes DOI: 10.1055/a-1075-2025Thyroid nodules and cysts are frequently diagnosed in Germany with a prevalence of about 20% in young adults reaching up to 70% in older adults. Surgery is the standard treatment of symptomatic nodules, nodules with suspicion of malignancy and thyroid cancer. Radioiodine treatment is applied for autonomously functioning nodules. During the last years new non-surgical and non-radioiodine techniques have been introduced to treat thyroid nodules. These techniques include ethanol/polidocanol treatment, radiofrequency, microwave, and laser ablation, and high frequency ultraso...
Source: Experimental and Clinical Endocrinology and Diabetes - January 7, 2020 Category: Endocrinology Authors: Feldkamp, Joachim Gr ünwald, F. Luster, Markus Lorenz, Kerstin Vorl änder, Christian F ührer, Dagmar Tags: Article Source Type: research

A Big Thank You to Our Reviewers in The Past Year!
Exp Clin Endocrinol Diabetes 2020; 128: 5-7 DOI: 10.1055/a-1060-0438 © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes)
Source: Experimental and Clinical Endocrinology and Diabetes - January 7, 2020 Category: Endocrinology Tags: Acknowledgment to the Reviewers Source Type: research

Luteolin Attenuates Diabetic Nephropathy through Suppressing Inflammatory Response and Oxidative Stress by Inhibiting STAT3 Pathway
Conclusions Lut attenuates DN mainly via suppression of inflammatory response and oxidative response. STAT3 pathway is the potential target, which ultimately reduces renal fibrosis and delays the progress of DN. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes)
Source: Experimental and Clinical Endocrinology and Diabetes - January 2, 2020 Category: Endocrinology Authors: Zhang, Miaoyuan He, Liyu Liu, Jingsong Zhou, Lin Tags: Article Source Type: research

Giant Non-Functioning Pituitary Adenoma: Clinical Characteristics and Therapeutic Outcomes
Exp Clin Endocrinol Diabetes DOI: 10.1055/a-1017-3288 Background Giant pituitary adenoma (≥4 cm) is a rare tumor whose clinical features and prognosis are not well known. Aim To evaluate the clinical characteristics and therapeutic outcomes of giant non-functioning PA (gNFPA). Patients and Methods A retrospective multicenter study of gNFPA patients diagnosed in a 12-year period was performed. In each patient, clinical data and therapeutic outcomes were registered. Results Forty patients (24 men, age 54.2 ± 16.2 years) were studied. The maximum tumor diameter [median (interquartile range)] was 4.6 cm (4.1&n...
Source: Experimental and Clinical Endocrinology and Diabetes - January 2, 2020 Category: Endocrinology Authors: Iglesias, Pedro Arcano, Karina Trivi ño, Vanessa Guerrero-P érez, Fernando Berrocal, V íctor Rodríguez Vior, Carlos Cordido, Fernando Villabona, Carles D íez, Juan J Tags: Article Source Type: research

Bile Acids in Patients with Uncontrolled Type 2 Diabetes Mellitus – The Effect of Two Days of Oatmeal Treatment
Conclusion Two days of oatmeal diet led to significant reductions in total BA as compared to a diabetes-adapted control diet. The magnitude of BA reduction was directly correlated with a decrease in proinsulin. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes)
Source: Experimental and Clinical Endocrinology and Diabetes - January 2, 2020 Category: Endocrinology Authors: Delgado, Graciela E. Kr ämer, Bernhard K. Scharnagl, Hubert Fauler, G ünther Stojakovic, Tatjana M ärz, Winfried Kleber, Marcus Edi Lammert, Alexander Tags: Article Source Type: research