Experimental and Clinical Endocrinology and Diabetes 
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This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.Considering Insulin Secretory Capacity as Measured by a Fasting
C-Peptide/Glucose Ratio in Selecting Glucose-Lowering
Medications
Exp Clin Endocrinol Diabetes DOI: 10.1055/a-1242-9809Type 2 diabetes mellitus is a heterogeneous disease. Recently introduced new
subclassifications promise more efficacious, tailored treatments which could
complement current guidelines. In the differentiation of the new diabetes
subphenotypes, assessment of insulin secretion is one of the essential
components. Based on a large number of insulin secretion measurements, we
propose fasting C-peptide/glucose ratio (CGR) as an adequate and
practicable estimate of insulin secretion. CGR discriminates insulin deficiency...
Source: Experimental and Clinical Endocrinology and Diabetes - September 17, 2020 Category: Endocrinology Authors: Fritsche, Andreas Heni, Martin Peter, Andreas Gallwitz, Baptist Kellerer, Monika Birkenfeld, Andreas L. H äring, Hans-Ulrich Wagner, Robert Tags: Commentary Source Type: research
ICAT acts as a Coactivator in Regulating PPAR γ
Transcriptional Activity in Mesangial Cells
Conclusions β-catenin and ICAT interact as coactivator to
modulate PPARγ transcriptional activation. In HMCs cultured in HG, the
low expression of ICAT leads to low PPARγ transcriptional
activation. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents | Abstract | Full text (Source: Experimental and Clinical Endocrinology and Diabetes)
Source: Experimental and Clinical Endocrinology and Diabetes - September 15, 2020 Category: Endocrinology Authors: Wei, Yi Yu, Jiawei Zhang, Xiaopeng Mu, Jiao Zhang, Jun Zeng, Wei Feng, Bing Tags: Article Source Type: research
Liver Expressed Antimicrobial Peptide 2 is Associated with Steatosis
in Mice and Humans
Conclusions The study suggests LEAP2 is associated with hepatic
steatosis, which may involve lipolytic/lipogenic pathway and insulin
signaling. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents | Abstract | Full text (Source: Experimental and Clinical Endocrinology and Diabetes)
Source: Experimental and Clinical Endocrinology and Diabetes - September 14, 2020 Category: Endocrinology Authors: Ma, Xiaoming Xue, Xing Zhang, Jingxin Liang, Shuang Xu, Chunfang Wang, Yue Zhu, Jinzhou Tags: Article Source Type: research
Clinical and Genetic Characteristics of 23 Korean Patients with
Haploinsufficiency of the Short-stature Homeobox-containing Gene
Conclusions A high index of suspicion and the genetic confirmation of
SHOX deficiency are helpful for the timely management of the
condition and are needed to provide genetic counselling to the family members of
the patients. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents | Abstract | Full text (Source: Experimental and Clinical Endocrinology and Diabetes)
Source: Experimental and Clinical Endocrinology and Diabetes - September 14, 2020 Category: Endocrinology Authors: Lee, Jeong-Seon Kim, Hwa Young Lee, Young-Ah Lee, Seong-Young Cho, Tae-Joon Ko, Jung Min Tags: Article Source Type: research
COVID-19 and Sodium-Glucose Cotransporter 2 Inhibitors: No Fear to
Attempt?
Exp Clin Endocrinol Diabetes DOI: 10.1055/a-1235-5617Novel coronavirus infectious disease (COVID-19) has been recognised as a pandemic by
the World Health Organization (WHO) 1.
Mortality and morbidity are higher in elderly individuals and those with
comorbidities, such as diabetes mellitus (DM), obesity, hypertension, respiratory
tract diseases, coronary heart disease or cancer 1. Indeed, two thirds of individuals who
died from COVID-19 had DM in Italy 2. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents | Abstract ...
Source: Experimental and Clinical Endocrinology and Diabetes - September 9, 2020 Category: Endocrinology Authors: Papachristou, Stella Penlioglou, Theano Stoian, Anca Pantea Papanas, Nikolaos Tags: Commentary Source Type: research
The TUDID Study – Background and Design of a Prospective
Cohort
Exp Clin Endocrinol Diabetes DOI: 10.1055/a-1221-9618Prevalence of both type 1 and type 2 diabetes mellitus is growing worldwide and
one major cause for morbidity and mortality. However, not every patient develops
diabetes-related complications, but causes for the individual susceptibility are
still not fully understood. As a platform to address this, we initiated the
TUDID (TUebingen DIabetes Database) study, a prospective, monocentric,
observational study that includes adults with diabetes mellitus who are treated
in the inpatient clinic of a University Hospital...
Source: Experimental and Clinical Endocrinology and Diabetes - September 9, 2020 Category: Endocrinology Authors: Jaghutriz, Benjamin Assad Wagner, Robert Kullmann, Stephanie Fritsche, Louise Eckstein, Sabine S. Dannecker, Corinna Willmann, Caroline Randrianarisoa, Elko Lehn-Stefan, Angela Hieronimus, Anja Hudak, Sarah Vosseler, Dorothea Lamprinou, Apostolia Huber, P Tags: Article Source Type: research
Flash Glucose Monitoring Improves Glucose Control in People with Type
2 Diabetes Mellitus Receiving Anti-diabetic Drug Medication
Conclusion Using FGM to monitor glucose concentration at 11.7
times/day, people with T2DM can achieve a better glucose control in
addition to anti-diabetic drug medication through changing daily diet and
exercise, especially in patients with high concentration of HbA1c
(>66.1 mmol/mol). [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents | Abstract | Full text (Source: Experimental and Clinical Endocrinology and Diabetes)
Source: Experimental and Clinical Endocrinology and Diabetes - August 27, 2020 Category: Endocrinology Authors: Chen, Maoyuan Li, Huiqin Shen, Yun Liu, Bingli Yan, Renna Sun, Xiaojuan Ye, Lei Lee, Kok-Onn Ma, Jianhua Su, Xiaofei Tags: Article Source Type: research
Establishment of Clinical and Lab Algorithms for the Identification
of Carriers of Mutations in CYP21A2 – A Study of 365 Children and
Adolescents
Conclusion Alternatively to the above mentioned cut-offs the difference
of 60 min after stimulation to basal 17OHP (Δ17OHP60) can be
used for the benefit of a combined test to identify both heterozygotes and
bi-allelic patients. There are minimal decreases in sensitivity and specificity
compared to an approach that applies two tests. However, it denotes a simpler
approach in the clinical routine. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents | Abstract | Full text (Source: Experimental and Clinical Endocrinology and Diabetes)
Source: Experimental and Clinical Endocrinology and Diabetes - August 23, 2020 Category: Endocrinology Authors: Meinel, J. Haverkamp, T. W ünsche, F. Richter-Unruh, A. Tags: Article Source Type: research
SNPs of miR-23b, miR-107 and HMGA2 and their Relations with the
Response to Medical Treatment in Acromegaly Patients
Conclusion The genetic variations of the miRNAs genes related with HMGA2
and AIP genes were not seen in our study. Although there is no relationship
between HMGA2-rs1351394 polymorphism and acromegaly disease, T allele was
associated with some clinical features related to adenoma in patients with
acromegaly. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents | Abstract | Full text (Source: Experimental and Clinical Endocrinology and Diabetes)
Source: Experimental and Clinical Endocrinology and Diabetes - August 23, 2020 Category: Endocrinology Authors: Armagan, Derya Metin Akdemir, Ayse Seda Ozkaya, Hande Mefkure Korkmaz, Ozge Polat Gazioglu, Nurperi Kadioglu, Pinar Tanriover, Necmettin Dagistanli, Kaya-Fatma Dirican, Ahmet Ozturk, Melek Tags: Article Source Type: research
Persistent Cushing ’s Disease after Transsphenoidal Surgery:
Challenges and Solutions
Exp Clin Endocrinol Diabetes DOI: 10.1055/a-1220-6056Transsphenoidal surgery remains the primary treatment for Cushing’s
disease (CD). However, despite the vast improvements in pituitary surgery,
successful treatment of CD remains a great challenge. Although selective
transsphenoidal removal of the pituitary tumor is a safe and effective
procedure, the disease persists in around 22% of CD patients due to
incomplete tumor resection. The persistence of hypercortisolism after pituitary
surgery may also be the consequence of a misdiagnosis, as can occur in case of
...
Source: Experimental and Clinical Endocrinology and Diabetes - August 23, 2020 Category: Endocrinology Authors: Albani, Adriana Theodoropoulou, Marily Tags: Article Source Type: research
Progression of Diabetic Complications in Subgroups of People with
Long Term Diabetes Type 1 According to Clinical Course
Conclusion In our analysis, we were able to confirm known risk factors
for microvascular disease in people with type 1 diabetes. Overall, prediction of
individual risk was difficult, the effect of individual markers minor and we
could not find differences regarding slow or fast progression. We therefore
emphasis the need for additional markers to predict individual risk for
microvascular disease. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents | Abstract | Full text (Source: Experimental and Clinical Endocrinology and Diabetes)
Source: Experimental and Clinical Endocrinology and Diabetes - August 9, 2020 Category: Endocrinology Authors: Gerdes, Christian Werner, Christoph Kloos, Christof Lehmann, Thomas Wolf, Gunter M üller, Ulrich Alfons M üller, Nicolle Tags: Article Source Type: research
Clinical Characteristics of Primary Hypophysitis – A
Single-Centre Series of 60 Cases
Conclusions The cohort of clinically diagnosed patients did not differ
from our histopathologically diagnosed patients or from published cohorts
with predominantly surgical patients. Thus, diagnosis of primary
hypophysitis using clinical criteria seems feasible. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents | Abstract | Full text (Source: Experimental and Clinical Endocrinology and Diabetes)
Source: Experimental and Clinical Endocrinology and Diabetes - August 6, 2020 Category: Endocrinology Authors: Amereller, Felix K üppers, Anna-Maria Schilbach, Katharina Schopohl, Jochen St örmann, Sylvère Tags: Article Source Type: research
Therapeutic Patient Education for Adrenal Insufficiency under
COVID-19 Pandemic Conditions
Exp Clin Endocrinol Diabetes DOI: 10.1055/a-1217-7208Adrenal insufficiency (AI) requires life-long treatment with glucocorticoid
replacement therapy. Over- or under-substitution carries the risk of
increased morbidity in the form of side effects or adrenal crises.
Glucocorticoid replacement therapy needs to be flexible with dose adaptation
in special situations. This could not be managed by medical personnel on a
daily basis, but requires an educated patient who has a good knowledge of
the disease, understands his medical therapy and is able to perform...
Source: Experimental and Clinical Endocrinology and Diabetes - August 5, 2020 Category: Endocrinology Authors: Kienitz, Tina Hahner, Stefanie Burger-Stritt, Stephanie Quinkler, Marcus Tags: Review Source Type: research
Glucagon and Liver Fat are Downregulated in Response to Very
Low-calorie Diet in Patients with Obesity and Type-2 Diabetes
Conclusion In obese type-2 diabetic subjects, plasma glucagon and
liver fat are correlated and similarly affected by a very low-calorie diet,
supporting a role of hepatic steatosis in glucagon metabolism. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents | Abstract | Full text (Source: Experimental and Clinical Endocrinology and Diabetes)
Source: Experimental and Clinical Endocrinology and Diabetes - August 5, 2020 Category: Endocrinology Authors: Haas, Stephan L. L öfgren, Patrik St ål, Per Hoffstedt, Johan Tags: Article Source Type: research
Efficacy and Safety of Stereotactic Radiotherapy in Cushing ’s
Disease: A Single Center Experience
Conclusion In this current single center experience,
postoperative cortisol and 1mg DST levels were found as the determinants of
time to remission. Although medical therapy before RT did not affect the
rate of- and time to remission, medical therapy after RT prolonged the time
to biochemical control . This latter finding might suggest a radioprotective
effect of cortisol lowering medication use on peri-RT period. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents | Abstract | Full text (Source: Experimen...
Source: Experimental and Clinical Endocrinology and Diabetes - August 5, 2020 Category: Endocrinology Authors: Apaydin, Tugce Ozkaya, Hande Mefkure Durmaz, Sebnem Memis Meral, Rasim Kadioglu, Pinar Tags: Article Source Type: research
