Nephropathy, but not Angiographically Proven Retinopathy, is Associated with Neutrophil to Lymphocyte Ratio in Patients with Type 2 Diabetes
Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0035-1547257 Background: Type 2 Diabetes Mellitus is a leading cause of end stage renal disease in the worldwide. Inflammation is regarded as one of the main reasons for the progression of diabetes complications. We aimed to evaluate the association of neutrophil to lymphocyte ratio (NLR) as indicator of systemic inflammation with diabetic retinopathy and nephropathy. Patients and Methods: This is a cross-sectional study of 114 prevalent type 2 diabetic subjects. All of the patients underwent detailed examination for the presence of diabetic retinopathy and nephropathy. Diabetic r...
Source: Experimental and Clinical Endocrinology and Diabetes - April 8, 2015 Category: Endocrinology Authors: Ciray, H.Aksoy, A. H.Ulu, N.Cizmecioglu, A.Gaipov, A.Solak, Y. Tags: Article Source Type: research

Plasma Omentin-1 Levels are Related to Exercise Performance in Obese Women and Increase Upon Aerobic Endurance Training
Discussion: Data show a rather strong relationship between exercise performance and circulating omentin-1 levels as well as an increase of the adipokine in response to 6-week of endurance training in obese women. Our findings may hint to a skeletal muscle-adipose tissue crosstalk in regard of omentin-1 regulation.[...]© Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes)
Source: Experimental and Clinical Endocrinology and Diabetes - March 19, 2015 Category: Endocrinology Authors: Wilms, B.Ernst, B.Gerig, R.Schultes, B. Tags: Article Source Type: research

58th Symposium of the German Society of Endocrinology (DGE)
Experimental and Clinical Endocrinology & Diabetes 2015; 03Article in Thieme eJournals:Table of contents  |  Congress (Source: Experimental and Clinical Endocrinology and Diabetes)
Source: Experimental and Clinical Endocrinology and Diabetes - March 12, 2015 Category: Endocrinology Source Type: research

Spectrum of Diabetes Research does not Reflect Patients’ Scientific Preferences: A Longitudinal Evaluation of Diabetes Research Areas 2010–2013 vs. a Cross-sectional Survey in Patients with Diabetes
Conclusion: The distribution of research topics over the last 4 years as measured by the distribution of accepted EASD abstracts does not reflect what patients and their relatives want to have investigated. Better patient involvement and a reassessment of non-commercial funding strategies might help create more valuable research.[...]© Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes)
Source: Experimental and Clinical Endocrinology and Diabetes - February 6, 2015 Category: Endocrinology Authors: Arnolds, S.Heckermann, S.Heise, T.Sawicki, P. T. Tags: Short Communication Source Type: research

New Insights into the Role of Sex Steroid Hormones in Pregnancy: Possible Therapeutic Approach by Sex Steroid Hormones for the Treatment of Both Preeclampsia and Preterm Labor
Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0034-1398622Fetal peptide hormones are essential for the development of fetus, which increase in accordance with pregnancy term. Concentration of these hormones within the feto-placental unit is normally higher than that of maternal circulation. Since these hormones are biologically active, the leakage of these hormones into the maternal circulation is regulated by degradation activity by placental aminopeptidases, in order to maintain the balance between carriage of pregnancy and onset of labor.Because the concentration of these hormones, being regulated by the amount of endogeno...
Source: Experimental and Clinical Endocrinology and Diabetes - February 6, 2015 Category: Endocrinology Authors: Mizutani, S.Mizutani, E. Tags: Review Source Type: research

Pasireotide (SOM230) Prevents Sulfonylurea-induced Hypoglycemia in Rats
This study evaluated the effects of pasireotide and octreotide in rats with glyburide-induced hypoglycemia. In fasted rats, pasireotide (10 and 30 µg/kg) prevented glyburide-induced hypoglycemia in a dose-dependent manner for up to 6 h. Qualitatively similar results were observed in non-fasted rats. However, the antihypoglycemic effect of pasireotide was stronger in non-fasted rats, resulting in transient hyperglycemia. In contrast to pasireotide, octreotide 10 µg/kg did not prevent glyburide-induced hypoglycemia in fasted and non-fasted rats, while octreotide 30 µg/kg resulted...
Source: Experimental and Clinical Endocrinology and Diabetes - February 6, 2015 Category: Endocrinology Authors: Schmid, H. A. Tags: Article Source Type: research

Effects of Glycemic Control upon Serum Lipids and Lipid Transfers to HDL in Patients with Type 2 Diabetes Mellitus: Novel Findings in Unesterified Cholesterol Status
Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0034-1396863 Objective: Investigate the relations of glycemic levels with plasma lipids and in vitro lipid transfers to HDL in patients with type 2 diabetes mellitus. Materials and Methods: 143 patients with type 2 diabetes not taking anti-lipidemic drugs were separated into 2 groups: group A included 62 patients with glycated hemoglobin (HbA1c)≤6.5% (48 mmol/mol) and group B 81 patients with HbA1c>6.5%. In vitro transfer of lipids was determined by 1 h incubation of a donor nanoemulsion containing radioactively labeled unesterified and esterified cholesterol, ...
Source: Experimental and Clinical Endocrinology and Diabetes - February 6, 2015 Category: Endocrinology Authors: Laverdy, O. G.Hueb, W. A.Sprandel, M.C. O.Kalil-Filho, R.Maranhão, R. C. Tags: Article Source Type: research

The Effect of Metformin on the Hypothalamic-pituitary-thyroid Axis in Patients with Type 2 Diabetes and Subclinical Hyperthyroidism
Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0034-1398621In hypothyroid patients, metformin was found to reduce serum levels of TSH. No previous study investigated metformin action on hypothalamic-pituitary-thyroid axis in patients with hyperthyroidism. The aim of our study was to assess the effect of metformin treatment on thyroid function tests in patients with untreated subclinical hyperthyroidism. We studied 15 patients with low but detectable TSH levels (0.1–0.4 mIU/L) (group 1), 12 patients with suppressed TSH levels (less than 0.1 mIU/L) (group 2) and 15 euthyroid patients with a history of hyperth...
Source: Experimental and Clinical Endocrinology and Diabetes - February 6, 2015 Category: Endocrinology Authors: Krysiak, R.Szkrobka, W.Okopien, B. Tags: Article Source Type: research

Different Effects of Atorvastatin on Metabolic and Cardiovascular Risk Factors in Hypercholesterolemic Women with Normal Thyroid Function and Subclinical Hypothyroidism
Conclusions: Our results suggest that the effect of atorvastatin on plasma lipids and circulating levels of other cardiovascular risk factors partially depends on thyroid function.[...]© Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes)
Source: Experimental and Clinical Endocrinology and Diabetes - February 6, 2015 Category: Endocrinology Authors: Krysiak, R.Gilowski, W.Okopien, B. Tags: Article Source Type: research

Variation in C-reactive Protein Following Weight Loss in Obese Insulin Resistant Postmenopausal Women: is there an Independent Contribution of Lean Body Mass?
Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0034-1398551 Background: We showed that obese insulin resistant postmenopausal women are characterized by higher lean body mass and elevated C-reactive protein. Although counterintuitive, we hypothesized that losses in muscle mass following caloric restriction and increase in muscle quality will be associated with improvements in glucose homeostasis through decreases in C-reactive protein. Objectives: To determine 1) if improvements in C-reactive protein concentrations occurs through losses in lean body mass; and 2) if decreases in C-reactive protein levels contribute to improveme...
Source: Experimental and Clinical Endocrinology and Diabetes - February 6, 2015 Category: Endocrinology Authors: Barsalani, R.Riesco, É.Perreault, K.Imbeault, P.Brochu, M.Dionne, I. J. Tags: Article Source Type: research

Short-term and Divergent Regulation of FGF-19 and FGF-21 during Oral Lipid Tolerance Test but not Oral Glucose Tolerance Test
Exp Clin Endocrinol Diabetes 2015; 123: 88-94DOI: 10.1055/s-0034-1395635 Context: Regulation of FGF-19 and FGF-21 by oral uptake of lipids and carbohydrates in healthy individuals is poorly characterized. Objective: We investigated the regulation of FGF-19 and FGF-21 in 2 large cohorts of healthy volunteers during oral lipid tolerance test (OLTT; n=100) and oral glucose tolerance test (OGTT; n=100). Design and setting: 100 volunteers underwent OLTT and OGTT in an outpatient setting. Venous blood was drawn at 0 h (fasting) and at 2, 4, and 6 h in OLTT or 1 and 2 h in OGTT. In order to dissect carbohydra...
Source: Experimental and Clinical Endocrinology and Diabetes - February 5, 2015 Category: Endocrinology Authors: Schmid, A.Leszczak, S.Ober, I.Karrasch, T.Schäffler, A. Tags: Article Source Type: research

Impact of Toll-like-receptor-9 (TLR9) Deficiency on Visceral Adipose Tissue Adipokine Expression during Chronic DSS-induced Colitis in Mice
Conclusions: DSS-CC leads to differential adipokine expression profiles in the visceral fat pad in TLR9wt/wt vs. TLR9-/- mice. In vitro, inhibition of TLR9 signaling induces visfatin secretion while inhibiting leptin secretion in adipocytes. Thus, visceral adipokines are regulated by intact TLR9 signaling pathway and a specific interplay between the leptin- and the TLR9-pathways might be of pathophysiological importance in chronic intestinal inflammation.[...]© Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents  |  Abstract  |  Full t...
Source: Experimental and Clinical Endocrinology and Diabetes - February 5, 2015 Category: Endocrinology Authors: Karrasch, T.Schmid, A.Kopp, A.Obermeier, F.Hofmann, C.Schäffler, A. Tags: Article Source Type: research

Treatment Outcome Results from the Bulgarian Acromegaly Database: Adjuvant Dopamine Agonist Therapy is Efficient in Less than One Fifth of Non-irradiated Patients
Conclusion: DAs are efficient in less than 20% of non-irradiated patients. They are a good cost-effective alternative for carefully selected patients.[...]© Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes)
Source: Experimental and Clinical Endocrinology and Diabetes - January 22, 2015 Category: Endocrinology Authors: Vandeva, S.Elenkova, A.Natchev, E.Kirilov, G.Tcharaktchiev, D.Yaneva, M.Kalinov, K.Marinov, M.Hristozov, K.Kamenov, Z.Orbetzova, M.Gerenova, J.Tsinlikov, I.Zacharieva, S. Tags: Article Source Type: research

Clinical Characteristics and Predictive Factors of Subclinical Diabetic Nephropathy
Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0034-1396810 Background: To investigate the clinical characteristics and predictive factors of subclinical diabetic nephropathy in type 2 diabetes patients. Methods: A total of 298 type 2 diabetes patients were divided into 3 groups based on 24-h urinary microalbumin and estimated glomerular filtration rate: patients with normal albuminuria and glomerular filtration rate (NC), patients with normoalbuminuria and glomerular hyperfiltration (SDN) and patients with microalbuminuria (EDN). The renal size, tubular injury markers and ambulatory blood pressure were analyzed. Results: Rena...
Source: Experimental and Clinical Endocrinology and Diabetes - January 21, 2015 Category: Endocrinology Authors: Zhang, Y.Yang, J.Zheng, M.Wang, Y.Ren, H.Xu, Y.Yang, Y.Cheng, J.Han, F.Yang, X.Chen, L.Shan, C.Chang, B. Tags: Article Source Type: research

Secondary IGF-I Deficiency as a Prognostic Factor of Growth Hormone (GH) Therapy Effectiveness in Children with Isolated, Non-acquired GH Deficiency
Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0034-1395665 Objective: Growth hormone (GH) deficiency (GHD) has recently been classified as secondary IGF-I deficiency but the significance of IGF-I measurement in diagnosing GHD is still discussed. The aim of the study was to assess the relationships between IGF-I secretion and GH therapy effectiveness in children with GHD. Patients and methods: The analysis comprised 300 children with isolated, non-acquired GHD (GH peak below 10 μg/l) who completed GH therapy and attained final height (FH). In all patients IGF-I concentration was measured before the treatment and IGF-...
Source: Experimental and Clinical Endocrinology and Diabetes - January 21, 2015 Category: Endocrinology Authors: Smyczyńska, J.Stawerska, R.Hilczer, M.Lewiński, A. Tags: Article Source Type: research

The Comparative Effect of Pioglitazone and Metformin on Serum Osteoprotegerin, Adiponectin and Intercellular Adhesion Molecule Concentrations in Patients with Newly Diagnosed Type 2 Diabetes: a Randomized Clinical Trial
In this study, the authors aimed to compare the anti-inflammatory properties of pioglitazone and metformin, with respect to their effect on serum concentrations of highly sensitive C-reactive protein (hsCRP), osteoprotegerin (OPG), intercellular adhesion molecule-1 (ICAM-1) and adiponectin. Methods: In an open-label randomized clinical trial, 117 patients with newly diagnosed type 2 diabetes mellitus were visited; 84 fulfilled the inclusion criteria, and were randomly allocated to 2 arms receiving either 1 000 mg/d metformin or 30 mg/d pioglitazone, respectively. Biochemical assessments were made at ba...
Source: Experimental and Clinical Endocrinology and Diabetes - January 21, 2015 Category: Endocrinology Authors: Esteghamati, A.Azizi, R.Ebadi, M.Noshad, S.Mousavizadeh, M.Afarideh, M.Nakhjavani, M. Tags: Article Source Type: research

Frequency of Dermatological Side Effects of Continuous Subcutaneous Insulin Infusion in Children and Adolescents with Type 1 Diabetes
Conclusion: Skin-related complications during CSII are frequent and regular examination of the insertion sites is crucial. To verify the occurrence of lipoatrophy associated with insulin pump therapy – an otherwise rare complication – larger studies would be needed.[...]© Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes)
Source: Experimental and Clinical Endocrinology and Diabetes - January 21, 2015 Category: Endocrinology Authors: Binder, E.Lange, O.Edlinger, M.Meraner, D.Abt, D.Moser, C.Steichen, E.Hofer, S. E. Tags: Article Source Type: research

The Plasma Osteoprotegerin Level and Osteoprotegerin Expression in Renal Biopsy Tissue are Increased in Type 2 Diabetes with Nephropathy
Conclusions: The plasma osteoprotegerin level and the osteoprotegerin expression in renal tubule cells of biopsy tissue were increased in nephropathy of type 2 diabetes. This finding supports the growing concept that osteoprotegerin may act as an important regulatory molecule in the angiopathy, and particularly, that it may be involved in the occurrence and development of nephropathy in type 2 diabetes.[...]© Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes)
Source: Experimental and Clinical Endocrinology and Diabetes - December 12, 2014 Category: Endocrinology Authors: Wang, S.-TZhang, C.-Y.Zhang, C.-M.Rong, W. Tags: Article Source Type: research

A Comprehensive Review of Erectile Dysfunction in Men with Diabetes
Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0034-1394383Erectile dysfunction (ED) is more common in men with diabetes (DM). Dependent on the selected population, age, DM type and duration, the prevalence of diabetic ED (DED) varies from 32 to 90%. In 12–30% of men ED is the first sign of diabetes, diagnosed later. Today men with diabetes live longer than ever, and develop more late diabetic complications. Having in mind also the global ageing of the world population all this data suggests an increasing number of men with DED in the future. The main factors playing in the complex pathogenesis of DED are diabetic neurop...
Source: Experimental and Clinical Endocrinology and Diabetes - December 11, 2014 Category: Endocrinology Authors: Kamenov, Z. A. Tags: Review Source Type: research

The Polymorphism of Type 1 Collagen (COL1A1) Gene does not Correlate with an Increased Risk of Foot Ulcers in Patients with Diabetes Mellitus
Conclusion: A multifaceted set of factors is involved in the development of DFS and only a combination of them may lead to such occurrence. In our DM patient population, COL1A1 polymorphism does not correlate with the occurrence of DFS, which appears to depend mostly on the presence of vascular risk factors. However, the impact of genetic factors affecting other components of the subcutaneous tissue cannot be excluded.[...]© Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinica...
Source: Experimental and Clinical Endocrinology and Diabetes - December 11, 2014 Category: Endocrinology Authors: Tamagno, G.Fedtke, K.Eidenmüller, M.Geks, J.Hamann, A.Langer, K.Kann, P. H. Tags: Article Source Type: research

Losartan Reduces Insulin Resistance by Inhibiting Oxidative Stress and Enhancing Insulin Signaling Transduction
Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0034-1395658 Background: Inhibition of the rennin-angiotensin system (RAS) could reduce insulin resistance in patients with hypertension and diabetic kidney disease (DKD), but whether the effect of losartan on insulin resistance is associated with reduction of oxidative stress and enhancement of insulin signaling transduction has not been fully elucidated. Methods: 130 patients with type 2 DKD were randomly assigned into 2 groups, the losartan group (n=65, 100 mg orally daily for 12 months) and the amlodipine group (n=65, 10 mg orally daily for 12 months). Oxidative ...
Source: Experimental and Clinical Endocrinology and Diabetes - December 11, 2014 Category: Endocrinology Authors: Pan, Y.Qiao, Q. Y.Pan, L. H.Zhou, D. C.Hu, C.Gu, H. F.Fu, S. K.Liu, X. L.Jin, H. M. Tags: Article Source Type: research

Effects of Different Gastrointestinal Surgical Approaches on Pancreatic β-cell Function in Type 2 Diabetic Patients with BMIs
This study determined the effects of different surgical operations on pancreatic β-cell function in patients with T2DM with BMIs
Source: Experimental and Clinical Endocrinology and Diabetes - December 11, 2014 Category: Endocrinology Authors: Lubai, X.Kejia, W.Jingli, C.Zhenzhai, C.Baoqing, LJisheng, W.Bing, Z.Hai, H Tags: Article Source Type: research

Amelioration of High Fat Diet-induced Glucose Intolerance by Blockade of Smad4 in Pancreatic Beta-Cells
Conclusion: Inhibition of Smad4 in beta-cells conferred mild but significant improvements in glucose levels and glucose tolerance in HFD-induced obese mice. Therefore, regulation of Smad4 expression may be one of the mechanisms regulating physiological expansion of beta-cells during development of type 2 diabetes.[...]© Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes)
Source: Experimental and Clinical Endocrinology and Diabetes - December 11, 2014 Category: Endocrinology Authors: Li, H. Y.Oh, Y. S.Lee, Y.-J.Lee, E.-K.Jung, H. S.Jun, H.-S. Tags: Article Source Type: research

Ozone Partially Prevents Diabetic Neuropathy in Rats
Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0034-1389954Neuropathy is one of the most common complications of diabetes mellitus. Although the beneficial effects of good blood glucose control on diabetic neuropathy are known, this control cannot completely prevent the occurrence and progression of diabetic neuropathy. The aim of this study was to investigate whether ozone prevents diabetic neuropathy. 36 adult female Sprague-Dawley rats were randomly divided into 6 groups (n=6): control (C), ozone (O), diabetic (D), ozone-treated diabetic (DO), insulin-treated diabetic (DI), and ozone- and insulin-treated diabetic (DOI). Dia...
Source: Experimental and Clinical Endocrinology and Diabetes - December 11, 2014 Category: Endocrinology Authors: Erken, H. A.Genç, O.Erken, G.Ayada, C.Gündoğdu, G.Doğan, H. Tags: Article Source Type: research

Individual Risk Factors of the Metabolic Syndrome in Adult Patients with Growth Hormone Deficiency – A Cross-sectional Case-control Study
Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0034-1390460 Objective: Growth hormone deficiency in adults (GHDA) is considered to be associated with increased cardiovascular risk, most commonly reflected by the prevalence of the metabolic syndrome (MS). However, there are still a limited number of studies comparing directly the MS prevalence in GHD patients to that in general population. The aim of this study was to investigate the individual risk factors of the MS in a cohort of GHD patients and to compare its prevalence with an age- and sex-matched control group. Design: A cross-sectional case-control study. Methods: In tot...
Source: Experimental and Clinical Endocrinology and Diabetes - November 20, 2014 Category: Endocrinology Authors: Uzunova, I.Kirilov, G.Zacharieva, S.Shinkov, A.Borissova, A.-M.Kalinov, K. Tags: Article Source Type: research

Type 2 Diabetes Mellitus Non-genetic Rhesus Monkey Model Induced by High Fat and High Sucrose Diet
Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0034-1395595[...]© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes)
Source: Experimental and Clinical Endocrinology and Diabetes - November 13, 2014 Category: Endocrinology Authors: Lu, Shuai-yao.Qi, Su-dong.Zhao, Yuan.Li, Yan-yan.Yang, Feng-mei.Yu, Wen-hai.Ma, JinChen, Li-xiong.Wang, Jun-bin.He, Zhan-long.Li, Hong-jun. Tags: Erratum Source Type: research

Differential Signaling by Regulatory Subunits of Phosphoinositide-3-kinase Influences Cell Survival in INS-1E Insulinoma Cells
In conclusion, signalling of p50α, p55α and p85α is similar at the level of Akt, but differentially influence downstream GSK-3 activation and cell cycle entry. PI3K isoform p50α induction by cytokines provides a link between regeneration and cell survival under cytotoxic stress in insulin-producing pancreatic beta-cells.[...]© Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes)
Source: Experimental and Clinical Endocrinology and Diabetes - November 13, 2014 Category: Endocrinology Authors: Schrader, J.Niebel, P.Rossi, A.Archontidou-Aprin, E.Hörsch, D. Tags: Article Source Type: research

Relationship between the Level of Hippocampal Leptin Receptor Gene Expression and Learning Performance in Diabetic Rats
In this study was conducted on a total of 40 Winstar albino female rats, including a control group consisting of 20 rats and experimental group comprising of 20 rats in which diabetes was induced by means of STZ administration. Leptin receptor gene expression was detected in hippocampal samples by using real time-PCR. According to the evaluation, the learning performance of rats with induced diabetes was found to be same throughout the first 3 days after STZ in comparison to the control group rats. End of the 45 days the learning performance of the control group was found to be better than the diabetic group (p
Source: Experimental and Clinical Endocrinology and Diabetes - November 7, 2014 Category: Endocrinology Authors: Demirel, C.Balcı, S. O.Korkmaz, H.Akarsu, E. Tags: Article Source Type: research

Could Red Cell Distribution Width be a Marker in Hashimoto’s Thyroiditis?
Conclusion: We suggest that elevated RDW values in patients without iron deficiency anemia may require further evaluation for HT, especially in female population.[...]© Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes)
Source: Experimental and Clinical Endocrinology and Diabetes - November 7, 2014 Category: Endocrinology Authors: Aktas, G.Sit, M.Dikbas, O.Tekce, B. K.Savli, H.Tekce, H.Alcelik, A. Tags: Article Source Type: research

Osteoblast Proliferation is Enhanced upon the Insulin Receptor Substrate 1 Overexpression via PI3K Signaling Leading to Down-regulation of NFκB and BAX Pathway
Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0034-1390422The insulin receptor substrate 1 (IRS1) promotes bone formation via osteoblast proliferation mediated by PI3K/Akt signaling. A reduction in NFκB activity in osteoblasts results in an increase in bone formation. The NFκB signaling pathway leads to increased expression of BAX, which contributes to osteoblast apoptosis. The purpose of this study was to investigate the expression of recombinant plasmid enhanced green fluorescent protein-N1 (pEGFP-N1) that transferred IRS1 gene into osteoblasts in vitro and evaluate the effects of IRS1 overexpression on NF&kappa...
Source: Experimental and Clinical Endocrinology and Diabetes - November 5, 2014 Category: Endocrinology Authors: Ma, H.Ma, JX.Xue, P.Gao, Y.Li, YK. Tags: Article Source Type: research

The Effect of Atorvastatin and Atorvastatin-Ezetimibe Combination Therapy on Androgen Production in Hyperandrogenic Women with Elevated Cholesterol Levels
Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0034-1394400Statins decreased serum androgen levels in hyperandrogenemic women with polycystic ovary syndrome. No previous study has investigated whether this effect is dose-dependent and observed in patients simultaneously treated with other hypolipidemic agents. The study included 23 premenopausal women with elevated total testosterone levels coexisting with hypercholesterolemia, unsuccessfully treated for at least 6 months with atorvastatin (20 mg daily). These patients were then treated with either an increased dose of atorvastatin (40 mg daily, n=11) or atorvast...
Source: Experimental and Clinical Endocrinology and Diabetes - October 28, 2014 Category: Endocrinology Authors: Krysiak, R.Okopien, B. Tags: Article Source Type: research

Risks and Benefits of Carnitine Supplementation in Diabetes
Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0034-1390481L-carnitine is a very popular food supplement due to its safety profile, antioxidant-type activity and suggested effects on energy metabolism pathways. L-carnitine participates in both fatty acid transport pathways and the export of acetyl groups out of the mitochondria. However, contradictory data exist concerning the pharmacological outcomes of L-carnitine treatment in diabetes mellitus, which is a highly prevalent metabolic disease characterised by hyperglycemia and associated with severe complications, including cardiovascular disease and dyslipidemia. Recently, th...
Source: Experimental and Clinical Endocrinology and Diabetes - October 24, 2014 Category: Endocrinology Authors: Dambrova, M.Liepinsh, E. Tags: Mini-Review Source Type: research

The Relationship between Serum Calcium Level and Early-phase Insulin Secretion in Normoglycemic and Pre-diabetic Individuals
Conclusions: In non-diabetic Japanese men, serum calcium levels significantly correlate with early-phase insulin secretion. Serum calcium levels may be an independent predictor of β-cell function in men.[...]© Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes)
Source: Experimental and Clinical Endocrinology and Diabetes - October 24, 2014 Category: Endocrinology Authors: Shimodaira, M.Niwa, T.Nakajima, K.Kobayashi, M.Hanyu, N.Nakayama, T. Tags: Article Source Type: research

Association of the Renal Resistive Index with Microvascular Complications in type 2 Diabetic Subjects
Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0034-1390448Chronic complications are the leading causes of morbidity and mortality in the diabetic population. The intrarenal resistive index (RI) has been reported to be increased in hypertensive subjects with microalbuminuria and limited data is present for diabetic subjects. 101 subjects with Type 2 Diabetes Mellitus were included in the study. We grouped the study population according to the urinary albumin excretion (UAE). Group 1: UAE300 mg/day (n: 28). We also grouped the study population according to the intrarenal RI value. Group I consisted of subjects with RI≥0.70 and group II
Source: Experimental and Clinical Endocrinology and Diabetes - October 24, 2014 Category: Endocrinology Authors: Ozmen, N. D.Mousa, U.Aydin, Y.Deren, T.Unlu, E. B. Tags: Article Source Type: research

The Importance of Education in Diabetic Foot Care of Patients with Diabetic Neuropathy
Conclusion: Our study reveal that educating diabetic patients about foot care is an effective method to develop their knowledge. However we observed that this education is not provided to all diabetic patients. We believe that every diabetic patient should receive education from the moment of diagnosis and repeated education during check-ups by doctors will increase effectiveness.[...]© Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes)
Source: Experimental and Clinical Endocrinology and Diabetes - October 14, 2014 Category: Endocrinology Authors: Şen, H. M.Şen, H.Aşık, M.Özkan, A.Binnetoglu, E.Erbağ, G.Karaman, H. I. Ö. Tags: Article Source Type: research

Expression Analysis of Stemness Genes in a Rat Thyroid Cell Line FRTL5
In this study, we analyzed the expression of stemness genes in a rat thyroid cell lines FRTL5 using FACS-mQ. 3 stemness genes, NANOG, ABCG2 and GATA4, were expressed in FRTL5. In FRTL5 cells, varied expression of thyroglobulin (TG) among cells was observed by flow cytometry. Cell populations with high or low TG expression were analyzed by FACS-mQ. The cell population with low TG expression showed increased expression of the stemness genes. Furthermore, Ki67-positive cells showed increased expression of TG, which suggested that cells with high TG proliferated rapidly. These results indicated that FRTL5 contains a cell popul...
Source: Experimental and Clinical Endocrinology and Diabetes - October 14, 2014 Category: Endocrinology Authors: Shimasue, A.Yamakawa, N.Watanabe, M.Hidaka, Y.Iwatani, Y.Takano, T. Tags: Article Source Type: research

Low “quotient” Lp(a) Concentration Mediates Autoimmune Activation and Independently Predicts Cardiometabolic Risk
Conclusion: Elevated cardiometabolic risk is conferred by apparently reduced circulating Lp(a) assays supporting the notion that “low” serum Lp(a), mediating autoimmune activation, is a major determinant of cardiometabolic risk.[...]© Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes)
Source: Experimental and Clinical Endocrinology and Diabetes - October 14, 2014 Category: Endocrinology Authors: Onat, A.Çoban, N.Can, G.Yüksel, M.Karagöz, A.Yüksel, H.Ademoğlu, E.Erginel-Ünaltuna, N. Tags: Article Source Type: research

Type 2 Diabetes Mellitus Non-genetic Rhesus Monkey Model Induced by High Fat and High Sucrose Diet
Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0034-1385923To build an ideal animal model for studying the mechanism of occurrence, developing and treating of diabetes become a more important issue, facing with the fact that the big threat of diabetes to human health has been worsen. First, we used the normal control diets or the high-fat/high-sucrose diets to feed the adult rhesus monkeys and the macaques induced by the high-fat/high-sucrose diets in the high-fat/high-sucrose group and the type 2 diabetes mellitus (T2DM) group developed the hyperglycemia, hyperinsulinemia at 6 months in accordance with the precious researches...
Source: Experimental and Clinical Endocrinology and Diabetes - October 14, 2014 Category: Endocrinology Authors: Lu, Shuai-yao.Qi, Su-dong.Zhao, Yuan.Li, Yan-yan.Yang, Feng-mei.Yu, Wen-hai.Jin, M. AChen, Li-xiong.Wang, Jun-bin.He, Zhan-long.Li, Hong-jun. Tags: Article Source Type: research

Analyses of Gonadoblastoma Y (GBY)-locus and of Y Centromere in Turner Syndrome Patients
Conclusions: Presence of the GBY locus in Turner patients with no indication of the Y chromosome in standard cytogenetic chromosome analysis can be revealed by sensitive molecular PCR assays screening for presence of the Y centromere and the GBY-candidate-genes in proximal Yp11 and Yq11, respectively.[...]© Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes)
Source: Experimental and Clinical Endocrinology and Diabetes - October 14, 2014 Category: Endocrinology Authors: Knauer-Fischer, S.Besikoglu, B.Inta, I.Kneppo, C.Vogt, P. H.Bettendorf, M. Tags: Article Source Type: research

Investigation of Several Biomarkers Associated with Diabetic Nephropathy
Conclusion: Our study displayed underlying biomarkers including biological pathways and several hub genes of DN.[...]© Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes)
Source: Experimental and Clinical Endocrinology and Diabetes - October 14, 2014 Category: Endocrinology Authors: Jiang, Z. S.Jia, H. X.Xing, W. J.Han, C. D.Wang, J.Zhang, Z. J.Qu, W. Tags: Article Source Type: research

Implications of a Clinically Ignored Site of Acanthosis Nigricans: The Knuckles
Conclusion: AN occurs with a high prevalence in Latin American youths, and its prevalence is much higher in a “non-classical” and ignored location where it is very easy to detect during physical examination: the knuckles. It may also occur earlier in this location in the evolution to obesity. The presence of AN in the knuckles in any patient, even if they have a normal body mass index, might indicate the likelihood of an early clinical manifestation of insulin resistance and metabolic consequences.[...]© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Tab...
Source: Experimental and Clinical Endocrinology and Diabetes - October 14, 2014 Category: Endocrinology Authors: Gómez-Flores, M.González-Saldivar, G.Santos-Santos, OR.Álvarez-Villalobos, NA.Rodríguez-Gutiérrez, R.Tellez-Hinojosa, CA.González-González, JG. Tags: Article Source Type: research

Influence of Thyrotropin and Thyroid Volume on Basal Serum Calcitonin
This study aims to evaluate if this finding is confirmed in patients undergoing ultrasonography-guided fine-needle aspiration cytology of suspicious thyroid nodules. A dataset of 561 patients including basal serum FT4, FT3, TSH, calcitonin, thyroid volume, anti-thyroperoxidase antibodies (TPOAb), and cytology report, was retrospectively analysed. The median thyroid volume was 20.5 ml (14.5–26.8) in males and 12.0 ml (9.3–17.0) in females (p
Source: Experimental and Clinical Endocrinology and Diabetes - October 14, 2014 Category: Endocrinology Authors: Grani, G.D’Alessandri, M.Del Sordo, M.Carbotta, G.Vitale, M.Fumarola, A Tags: Article Source Type: research

Interleukin 1 Beta (IL1beta) Gene Polymorphisms (SNP-511 and SNP+3953) in Hashimoto’s Thyroiditis among the Polish Population
Conclusions: An association between the SNPs of the IL1 beta and susceptibility to Hashimoto’s thyroiditis among the group of Caucasian-Polish population studied was found.[...]© Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes)
Source: Experimental and Clinical Endocrinology and Diabetes - October 13, 2014 Category: Endocrinology Authors: Lacka, K.Paradowska-Gorycka, A.Maciejewski, A.Kramer, L.Herman, W. A.Lacki, J. K. Tags: Article Source Type: research

Markers of the Progression of Complications in Patients with Type 2 Diabetes: A One-year Longitudinal Study
Exp Clin Endocrinol Diabetes 2014; 122: 484-490DOI: 10.1055/s-0034-1372594Hyperglycemia induces tissue damage and complications by mechanisms that produce advanced glycation end-products (AGEs) and inflammation.To investigate the factors associated with the progression of complications in Type 2 diabetes patients.We recruited 157 patients (110 women and 47 men) with diabetes for more than 5 years who were non-smokers and did not have current infections or chronic diseases. Patients were grouped according to neuropathy, nephropathy, and retinopathy status: without (I), slight or moderate (II), and severe complications (III)...
Source: Experimental and Clinical Endocrinology and Diabetes - September 17, 2014 Category: Endocrinology Authors: Preciado-Puga, M. C. Malacara, J. M.Fajardo-Araujo, M. E.Wröbel, K.Wröbel, K.Kornhauser-Araujo, C.Garay-Sevilla, M. E. Tags: Article Source Type: research

Atypical Polycystic Ovary Syndrome – A Genetic Analysis
Conclusion: The detected mutations do not alter the AR protein sequence but they change the codon usage towards less frequent codons that potentially may alter AR protein levels and androgen signaling. In addition to this, we postulate also other causes for manifestation of atypical PCOS, which may include AR-coregulators or epigenetic alterations. To our knowledge this is the first report of combining chromosomal analysis of PCOS patients with full sequencing of the human AR gene and linking codon usage to PCOS.[...]© Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents ...
Source: Experimental and Clinical Endocrinology and Diabetes - August 22, 2014 Category: Endocrinology Authors: Scholten, M.Vilser, C.Weise, A.Baniahmad, A. Tags: Article Source Type: research

Protective Effects of the Sodium/Calcium Exchanger Inhibitor on Endothelial Dysfunction Induced by High Glucose
This study was designed to investigate the protective effects of KB-R7943, an inhibitor of sodium/calcium exchanger (NCX) on endothelial dysfunction induced by high glucose in endothelial cells. NCX expression, NCX activity and oxidative stress index were determined after endothelial cells were exposed to high glucose in the absence and presence of KB-R7943. Coincubation of endothelial cells with high glucose for 6, 12, 24 and 48 h resulted in a significant decrease in NCX expression, superoxide dismutase (SOD) activity and the release of nitric oxide (NO), and increased NCX activity and malondialdehyde (MDA) produc...
Source: Experimental and Clinical Endocrinology and Diabetes - August 22, 2014 Category: Endocrinology Authors: Liu, D.Cui, K.-Z.Sun, Y.-M.Liu, J.-W.Li, Y.-B.Su, Y. Tags: Article Source Type: research

The GLP-1 Analogue Liraglutide Protects Cardiomyocytes from High Glucose-induced Apoptosis by Activating the Epac-1/Akt Pathway
Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0034-1384584 Background: Cardiomyocyte apoptosis is closely related to cardiac dysfunction in diabetic patients. Although GLP-1 analogs are used as anti-diabetic drugs, their effects on cardiomyocytes remain unclear. The aim of this study was to assess the effects of the GLP-1 analog liraglutide on high glucose-induced cardiomyocyte apoptosis. Methods: Wistar rats were divided into normal (N), diabetes mellitus (DM), and liraglutide (LIR) groups. H9c2 cardiomyocytes were divided into normal (NG) and high glucose (HG) groups, 4 liraglutide groups (Lir1–4), 3 Epac-1 agonist in...
Source: Experimental and Clinical Endocrinology and Diabetes - August 20, 2014 Category: Endocrinology Authors: Wu, X.-M.Ou, Q.-Y.Zhao, W.Liu, J.Zhang, H. Tags: Article Source Type: research

Serum Concentration of VEGF and PDGF-AA in Patients with Active Thyroid Orbitopathy before and after Immunosuppressive Therapy
Conclusions: Results of the present study confirm the fact that angiogenesis could play a role in pathogenesis of thyroid orbitopathy.[...]© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes)
Source: Experimental and Clinical Endocrinology and Diabetes - August 20, 2014 Category: Endocrinology Authors: Nowak, M.Marek, B.Karpe, J.Kos-Kudla, B.Sieminska, L.Kajdaniuk, D.Treszer, M. Tags: Article Source Type: research

A 6-year Follow-up of a Randomized Prospective Trial Comparing Methimazole Treatment with or without Exogenous L-thyroxine in Chinese Patients with Graves’ Disease
Conclusions:  The addition of L-thyroxine to methimazole treatment in patients with Graves’ disease neither improves nor prevents the remission or recurrence of Graves’ disease in China.[...]© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes)
Source: Experimental and Clinical Endocrinology and Diabetes - August 20, 2014 Category: Endocrinology Authors: Liu, X.Qiang, W.Liu, X.Liu, L.Liu, S.Gao, A.Gao, S.Shi, B. Tags: Article Source Type: research

The Effects of Hypokalaemia on the Hormone Exocytosis in Adenohypophysis and Prolactinoma Cell Culture Model Systems
Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0034-1383580The extracellular ion milieu determines the exocytosis mechanism that is coupled to spontaneous electrical activity. The K+ ion plays crucial role in this mechanism: as the potassium current is associated with membrane hyperpolarization and hormone release through protein cascade activation. The primary aim of this study was to investigate the response mechanisms of normal adenohypophysis and adenohypophyseal prolactinoma cell populations at different extracellular K+ levels with an otherwise isoionic milieu of all other essential ions. We focused on prolactin (PRL) an...
Source: Experimental and Clinical Endocrinology and Diabetes - July 23, 2014 Category: Endocrinology Authors: Molnár, Z.Pálföldi, R.László, A.Radács, M.László, M.Hausinger, P.Tiszlavicz, L.Rázga, Z.Valkusz, Z.Gálfi, M. Tags: Article Source Type: research