Rosiglitazone Attenuates Memory Impairment in Aged Rat with Diabetes by Inhibiting NF-kappa B Signal Pathway Activation
Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0035-1559607Although the cognitive impairment in geriatric diabetes is common, its mechanisms remain unclear and therapies are limited. The present study investigated the effects of rosiglitazone on memory impairment in aged rats with diabetes. Diabetes was induced by streptozotocin in aged Wistar rats of 20–22 months. Then, the diabetic rats were divided randomly into the diabetic model group and rosiglitazone treatment group for assessment of cognitive function and cerebral injury at 8 weeks using Morris water maze (MWM) paradigm, real-time PCR and western blot analysis. W...
Source: Experimental and Clinical Endocrinology and Diabetes - August 18, 2015 Category: Endocrinology Authors: Fei, L.Yong-Jun, H.Zhang-Min, M.Bing, X.Shuang, W.Qian-qian, S.Jun, L. Tags: Article Source Type: research

Quality of Life and Psychological Screening in Children with Type 1 Diabetes and their Mothers
This study aimed to assess the levels of depression in children with type 1 diabetes mellitus (T1DM) and evaluate the quality of life as well as levels of depression and anxiety of their mothers.30 children with T1DM (mean age: 12.9±2.9 years) and their mothers (mean age: 40.0±7.5 years) were included in the study. Control group consisted of 30 healthy children (mean age: 12.7±2.7 years) and their mothers (mean age: 39.8±7.2 years). The presence and severity of depressive symptoms in the children were evaluated using the Children’s Depression Inventory (CDI). The short form 36-health surve...
Source: Experimental and Clinical Endocrinology and Diabetes - August 18, 2015 Category: Endocrinology Authors: Duru, N. S.Civilibal, M.Elevli, M. Tags: Article Source Type: research

Nerve Excitability and Structural Changes in Myelinated Axons from Diabetic Mice
Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0035-1559606 Objective: The mechanisms associated with nerve dysfunction and axonal loss in diabetes has not been fully clarified. Excitability and pathological aspects in nerves from diabetic mice were studied in order to explore the pathophysiology of diabetic neuropathy. Methods: Myelinated nerve fibres from the sciatic nerve of BKS.Cg-m +/+ Lepr db /J mice were studied by registering the CMAP controlled by an automated threshold tracking method. The sciatic nerve was also studied pathologically. Results: Diabetic mice displayed longer latencies, higher thresholds and lower am...
Source: Experimental and Clinical Endocrinology and Diabetes - August 18, 2015 Category: Endocrinology Authors: Campero, M.Ezquer, M.Ezquer, F. Tags: Article Source Type: research

Prevalence of Retinopathy in Adult Patients with GCK-MODY and HNF1A-MODY
In conclusion, DR of any degree was not present in our GCK-MODY group, while in spite of young age almost every fourth subject with HNF1A-MODY showed signs of this complication.[...]© Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes)
Source: Experimental and Clinical Endocrinology and Diabetes - August 4, 2015 Category: Endocrinology Authors: Szopa, M.Wolkow, J.Matejko, B.Skupien, J.Klupa, T.Wybrańska, I.Trznadel-Morawska, I.Kiec-Wilk, B.Borowiec, M.Malecki, M. T. Tags: Article Source Type: research

Group Singing as a Therapy during Diabetes Training – A Randomized Controlled Pilot Study
Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0035-1555941Comprehensive diabetes treatment has been shown to reduce quality of life in diabetic patients. However, there is evidence to suggest that group singing can have positive effects on quality of life in various clinical settings. In this randomized controlled pilot study, the effect of singing as a therapy to reduce stress and improve quality of life was investigated in insulin-dependent diabetic patients, undergoing a lifestyle intervention program. Patients from the singing group felt less discontented following treatment. This effect, however, was lost after 3 months....
Source: Experimental and Clinical Endocrinology and Diabetes - August 4, 2015 Category: Endocrinology Authors: Groener, J. B.Neus, I.Kopf, S.Hartmann, M.Schanz, J.Kliemank, E.Wetekam, B.Kihm, L.Fleming, T.Herzog, W.Nawroth, P.P. Tags: Article Source Type: research

Low-grade Albuminuria Associated with Subclinical Left Ventricular Diastolic Dysfunction and Left Ventricular Remodeling
Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0035-1550052 Aims: Low-grade albuminuria (LGA) has been shown to be associated with increased risk for cardiovascular disease. Our study investigated the relationship between normal urinary albumin-to-creatinine ratios (UACRs) and subclinical left ventricular (LV) diastolic dysfunction and remodeling in diabetics and non-diabetics. Methods: A total of 888 diabetic and 208 non-diabetic patients with normal UACRs (
Source: Experimental and Clinical Endocrinology and Diabetes - July 27, 2015 Category: Endocrinology Authors: Yan, S.Yao, F.Huang, L.Ruan, Q.Shen, X.Zhang, S.Huang, C. Tags: Article Source Type: research

The Impact of Thyroid Autoimmunity on the Clinical and Diabetes Parameters of Patients with Latent Autoimmune Diabetes in Adults
Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0035-1555764 Aim: We evaluated the clinical and diabetes parameters of latent autoimmune diabetes in adults (LADA) patients according to the presence of thyroid autoimmunity (TA). Materials and methods: Patients with LADA (diabetes onset after 30 years of age, no need for insulin treatment for at least 6 months after diabetes onset, positive for glutamic acid decarboxylase antibodies (GADA)) were evaluated for the presence of thyroid peroxidase antibodies (TPOAb) and were subjected to clinical and laboratory evaluations of the glycated hemoglobin and basal C peptide levels. The pa...
Source: Experimental and Clinical Endocrinology and Diabetes - July 27, 2015 Category: Endocrinology Authors: Reghina, A. D.Florea, S.Constantin, M.Fica, S. Tags: Article Source Type: research

Effects of Commonly Used Antidiabetic Drugs on Antioxidant Enzymes and Liver Function Test Markers in Type 2 Diabetes Mellitus Subjects – Pilot Study
Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0035-1554654 Objective: The present study analyzed the effects of antidiabetic drugs on antioxidant enzymes and liver function test (LFT) markers and their association with homeostatic model assessment of insulin resistance (HOMA-IR) in type 2 diabetic subjects. Methods: We assessed healthy and diabetic subjects (100 each). Diabetic subjects were divided based on treatment with only metformin, metformin in combination with other antidiabetic drugs and insulin in combination with other antidiabetic drugs. LFT markers, antioxidant status and HOMA-IR were assessed in the subjects. Re...
Source: Experimental and Clinical Endocrinology and Diabetes - July 27, 2015 Category: Endocrinology Authors: Ghadge, A.Harke, S.Khadke, S.Diwan, A.Pankaj, M.Kulkarni, O.Ranjekar, P.Harsulkar, A.Kuvalekar, A. A. Tags: Article Source Type: research

Serum Cystatin C Levels are Positively Associated with Cardiovascular Autonomic Neuropathy in Patients with Type 2 Diabetes
Conclusions: Serum cystatin C levels are positively associated with CAN in patients with type 2 diabetes.[...]© Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes)
Source: Experimental and Clinical Endocrinology and Diabetes - July 27, 2015 Category: Endocrinology Authors: Chung, J. O.Cho, D. H.Chung, D. J.Chung, M. Y. Tags: Article Source Type: research

The Association between Macroprolactin Levels and Vitamin D Status in Premenopausal Women with Macroprolactinemia: A Pilot Study
Conclusions: The results of our study suggest the association between vitamin D status and elevated macroprolactin levels in premenopausal women.[...]© Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes)
Source: Experimental and Clinical Endocrinology and Diabetes - July 15, 2015 Category: Endocrinology Authors: Krysiak, R.Kowalska, B.Szkróbka, W.Okopień, B. Tags: Article Source Type: research

Introducing Dendrosomal Nanocurcumin as a Compound Capable of in vitro Eliminating Undifferentiated Stem Cells in Cell Therapy Practices
In this study the ability of dendrosomal nanocurcumin (solublized curcumin using a biodegradable non-toxic nano-carrier) to affect undifferentiated/hazardous cell, and hence increasing the safety of cell therapy (particularly in diabetes type I) by mesenchymal stem cells (MSCs) was examined. The results showed that after completion of differentiation of human mesenchymal stem cells (hMSCs) into insulin producing cells (IPCs), the expression level of insulin increases, although there remains a minority of undifferentiated cells which still express nestin (gene which is expressed in progenitor stem cells of IPCs). It indicat...
Source: Experimental and Clinical Endocrinology and Diabetes - July 15, 2015 Category: Endocrinology Authors: Javidi, M. A.Zolghadr, F.Babashah, S.Sadeghizadeh, M. Tags: Article Source Type: research

Metabolic Profiles during an Oral Glucose Tolerance Test in Pregnant Women with and without Gestational Diabetes
Conclusion: Our data suggest an additional value of metabolite pattern in the diagnosis of GDM and describe altered pathways that might be subjected to a more precise diagnosis and individualized therapy.[...]© Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes)
Source: Experimental and Clinical Endocrinology and Diabetes - July 14, 2015 Category: Endocrinology Authors: Lehmann, R.Friedrich, T.Krebiehl, G.Sonntag, D.Häring, H.-U.Fritsche, A.Hennige, A. M. Tags: Article Source Type: research

Vitamin D in Thyroid Disorders
Exp Clin Endocrinol Diabetes 2015; 123: 386-393DOI: 10.1055/s-0035-1554714Vitamin D’s canonical role are its effects exerted on the musculoskeletal system. In the last decades the importance of this hormone has been studied in the context of extraskeletal health. Hypovitaminosis D and several polymorphic variants of genes coding proteins crucial in the transport, metabolism and effects of vitamin D have been associated with negative health outcomes.In this review the current state of knowledge on the role of vitamin D in thyroid disorders is presented. The review is based on a literature search of the PubMed database...
Source: Experimental and Clinical Endocrinology and Diabetes - July 14, 2015 Category: Endocrinology Authors: Kmieć, P.Sworczak, K. Tags: Review Source Type: research

This Year’s Best Paper Award now Decided!
Exp Clin Endocrinol Diabetes 2015; 123: 385-385DOI: 10.1055/s-0035-1555903© Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes)
Source: Experimental and Clinical Endocrinology and Diabetes - July 14, 2015 Category: Endocrinology Authors: Wenzel, R. Tags: Editorial Source Type: research

The Dark Side of Blocking RAS in Diabetic Patients with Incipient or Manifested Nephropathy
Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0035-1550017Renin-angiotensin system (RAS) inhibitors are currently advocated as the first line approach for diabetic patients with high blood pressure, particularly if early signs of renal damage are manifest. This mostly relies on the supposed benefits of these drugs, either achieved indirectly by blood pressure lowering or directly by pleiotropic effects, on cardiovascular and renal outcomes. Yet, data from large randomized controlled trials and independent meta-analyses seem to raise some concerns on the compelling use of RAS-inhibitors in the whole diabetic population as impr...
Source: Experimental and Clinical Endocrinology and Diabetes - June 11, 2015 Category: Endocrinology Authors: Bolignano, D.Pisano, A.Coppolino, G. Tags: Review Source Type: research

Does Elevated Morning Prolactin Concentration in Children Always Mean the Diagnosis of Hyperprolactinemia?
Conclusions: In children with elevated Prl concentrations in the morning, a circadian Prl secretion profile should be performed in order to avoid overdiagnosing of continuous HPrl. In children with the presence of pituitary adenoma and increased morning Prl concentrations, the diagnosis of Prl-secreting adenoma is not completely obvious.[...]© Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes)
Source: Experimental and Clinical Endocrinology and Diabetes - June 11, 2015 Category: Endocrinology Authors: Stawerska, R.Smyczyńska, J.Hilczer, M.Lewiński, A. Tags: Article Source Type: research

Relevance and Clinical Significance of Serum Resistin Level in Obese T2DM Rhesus Monkey Models
Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0035-1554653Resistin is a type of hormone-like adipocytokines, which is secreted specifically by adipocytes. It may be a key factor in the development of type 2 diabetes mellitus (T2DM) from obesity- associated insulin resistance due to results that show that it has a close relationship with insulin resistance in rodents. We utilized the rhesus monkeys as study objects to preliminarily test the association with glucose metabolism and to conduct a correlation analysis for clinical parameters and serum resistin levels in obese rhesus monkey models of T2DM. The results suggested that...
Source: Experimental and Clinical Endocrinology and Diabetes - June 11, 2015 Category: Endocrinology Authors: Qi, S.-d.He, Z.-l.Chen, Y.Ma, J.Yu, W.-h.Li, Y.-y.Yang, F.-m.Wang, J.-b.Chen, L.-x.Zhao, Y.Lu, S.-y. Tags: Article Source Type: research

Interleukin-1β Increases Angptl4 (FIAF) Expression via the JNK Signaling Pathway in Osteoblastic MC3T3-E1 Cells
Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0035-1554624Angiopoietin-like protein 4 (Angptl4), also known as fasting-induced adiopogenic factor (FIAF), has recently been reported to influence bone metabolism. However, there have been few studies on regulatory factors other than hypoxia for Angptl4 in bone, and particularly in osteoblasts. Expression of interleukin-1β (IL-1β), a proinflammatory cytokine, is increased in serum or bone microenvironments in inflammatory bone diseases or estrogen deficient-conditions. The present study was conducted to determine whether Angptl4 expression in osteoblasts is affected by ...
Source: Experimental and Clinical Endocrinology and Diabetes - June 11, 2015 Category: Endocrinology Authors: Noh, J. M.Shen, C.Kim, S. J.Kim, M. R.Kim, S. H.Kim, J. H.Park, B. H.Park, J. H. Tags: Article Source Type: research

Circulating Insulin-like Growth Factor Binding Protein-3 Predicts One-year Outcome after Ischemic Stroke
Conclusion: IGFBP-3 levels after ischemic stroke may independently predict functional outcome after one year.[...]© Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes)
Source: Experimental and Clinical Endocrinology and Diabetes - June 11, 2015 Category: Endocrinology Authors: Ebinger, M.Ipsen, N.Leonards, C. O.Empl, L.Hanne, L.Liman, T.Mai, K.Strasburger, C. J.Spranger, J.Endres, M. Tags: Article Source Type: research

Impairment of Endothelial Cell Function Induced by Hemoglobin A1c and the Potential Mechanisms
Conclusion: These findings provide direct evidence that HbA1c is involved in the development and progression of the cardiovascular complications of diabetes.[...]© Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes)
Source: Experimental and Clinical Endocrinology and Diabetes - June 11, 2015 Category: Endocrinology Authors: Bo, J.Guan, Y.Guo, Y.Xie, S.Zhang, C.Zhang, H.Chen, Z.Lu, J.Meng, Q. H. Tags: Article Source Type: research

Socioeconomic Deprivation Independently Predicts Painful Diabetic Neuropathy in Type 2 Diabetes
Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0035-1549966 Objective: Painful peripheral neuropathy in people with type 2 diabetes is a disabling complication. We explored associations of this condition with socioeconomic deprivation. Research Design and Methods: The Townsend index of socioeconomic deprivation was examined in the pseudonymised GP records of 15388 (44.1% female) individuals with type 2 diabetes in the Cheshire county of England, and related to prevalence of drug treated painful diabetic neuropathy. We also analysed prescription trends with respect to pharmacotherapy for neuropathy pain relief. Results: Treatme...
Source: Experimental and Clinical Endocrinology and Diabetes - June 11, 2015 Category: Endocrinology Authors: Anderson, S. G.Narayanan, R. P.Malipatil, N. S.Roberts, H.Dunn, G.Heald, A. H. Tags: Article Source Type: research

People with Type 2 Diabetes on Premixed Insulin Therapy: How is the Daily Insulin Dose Partitioned and are there Effects on the Metabolic Control?
Conclusion: The quite common recommendation in German and Austrian medical textbooks, that premixed insulin therapy should consists of a dose distribution with two thirds before breakfast and one third before dinner, is not observed in daily practice. Diurnal insulin dose distribution and HbA1c are not associated in this cohort. Novelty statement: The circadian insulin dose distribution of 2/3 before breakfast and 1/3 before dinner could not be confirmed for patients with diabetes type 2 and conventional insulin therapy. No correlation between metabolic control and insulin circadian insulin dose distribution was detected.[...
Source: Experimental and Clinical Endocrinology and Diabetes - June 9, 2015 Category: Endocrinology Authors: Roth, J.Milke, B.Müller, N.Zitterbart, U.Rechtacek, S.Rechtacek, T.Kloos, C.Wolf, G.Müller, U. A. Tags: Article Source Type: research

The Effect of Parathyroidectomy on Insulin Sensitivity in Patients with Primary Hyperparathyroidism – an never Ending Story?
In conclusion, we observed significant improvement in insulin sensitivity after parathyroidectomy in patients with PHPT. There was no difference in parameters of insulin secretion before and after parathyroidectomy in patients with PHPT.[...]© Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes)
Source: Experimental and Clinical Endocrinology and Diabetes - June 9, 2015 Category: Endocrinology Authors: Cvijovic, G.Micic, D.Kendereski, A.Milic, N.Zoric, S.Sumarac-Dumanovic, M.Stamenkovic-Pejkovic, D.Polovina, S.Jeremic, D.Gligic, A. Tags: Article Source Type: research

Serum Leptin in Neonatal Lambs is Associated with Temperature, Plasma Lipids and Metabolites
In this study we investigated changes of serum leptin in 74 newborn lambs and associations with environmental temperature (from − 8°C to + 25°C), body temperature, and concentrations of plasma lipids, 3-beta-hydroxybutyric acid and blood glucose. A leptin radioimmunoassay was established, using an antiserum (rabbit) produced against a partial sequence of ovine leptin (31–44). Before measurement, serum samples were denatured. The sensitivity of the assay was 0.4 µg l−1 and intra- and interassay coefficients of variation were 5.1% and 2.5%, respectively. Blood sampl...
Source: Experimental and Clinical Endocrinology and Diabetes - May 26, 2015 Category: Endocrinology Authors: Schilling, J.Hospes, R.Kaya, G.Failing, K.Gortner, L.Wudy, S. A.Blum, W. F. Tags: Article Source Type: research

The Value of Total antioxidant Status and Serum Tumor Necrosis Factor-α Levels at 24–28 Weeks of Gestation in the Prediction of Optimal Treatment Protocol in Gestational Diabetes Mellitus
Conclusions: Increased TNF-α levels and low TAS are significantly associated with the increased risk of insulin requirement for achieving good glycemic control in GDM.[...]© Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes)
Source: Experimental and Clinical Endocrinology and Diabetes - May 26, 2015 Category: Endocrinology Authors: Ozler, S.Oztas, E.Uygur, D.Ersoy, A. O.Ergin, M.Koca, C.Danisman, N.Erkaya, S. Tags: Article Source Type: research

Radiotherapy-induced Hypopituitarism in Nasopharyngeal Carcinoma: the Tip of an Iceberg
Conclusions: Radiation-induced hypopituitarism is more common than expected in patients with nasopharyngeal carcinoma.[...]© Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes)
Source: Experimental and Clinical Endocrinology and Diabetes - May 26, 2015 Category: Endocrinology Authors: Ipekci, S. H.Cakir, M.Kiyici, A.Koc, O.Artac, M. Tags: Article Source Type: research

Effects of DSP-8658, a Novel Selective Peroxisome Proliferator-activated Receptors a/γ Modulator, on Adipogenesis and Glucose Metabolism in Diabetic Obese Mice
Conclusion: Unlike PPARγ full agonists, DSP-8658 ameliorates blood glucose without increasing adipogenesis in diabetic obesity mice.[...]© Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes)
Source: Experimental and Clinical Endocrinology and Diabetes - May 26, 2015 Category: Endocrinology Authors: Goto, T.Nakayama, R.Yamanaka, M.Takata, M.Takazawa, T.Watanabe, K.Maruta, K.Nagata, R.Nagamine, J.Tsuchida, A.Kato, H. Tags: Article Source Type: research

The Protective Effect of Losartan on Diabetic Neuropathy in a Diabetic Rat Model
Conclusions: As a result, it has been shown in this study that perineural thickness of the Losartan treatment was significantly reduced when compared to saline receiving group, significantly increased the immunoexpression of NGF, and also provided a significantly recovery in EMG when compared to Saline receiving group.[...]© Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes)
Source: Experimental and Clinical Endocrinology and Diabetes - May 26, 2015 Category: Endocrinology Authors: Cavusoglu, T.Karadeniz, T.Cagiltay, E.Karadeniz, M.Yigitturk, G.Acikgoz, E.Uyanikgil, Y.Ates, U.Tuglu, M. İ.Erbas, O. Tags: Article Source Type: research

Fluoxetine Impairs Insulin Secretion without Modifying Extracellular Serotonin Levels in MIN6 β-cells
Conclusion: The inhibitory effect of fluoxetine on β-cell glucose stimulated insulin secretion is not mediated by blockage of 5HT transporter through SERT.[...]© Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes)
Source: Experimental and Clinical Endocrinology and Diabetes - May 26, 2015 Category: Endocrinology Authors: Cataldo, L. R.Cortés, V. A.Mizgier, M. L.Aranda, E.Mezzano, D.Olmos, P.Galgani, J. E.Suazo, J.Santos, J. L. Tags: Article Source Type: research

The Value of Total antioxidant Status and Serum Tumor Necrosis Factor- α Levels at 24–28 Weeks of Gestation in the Prediction of Optimal Treatment Protocol in Gestational Diabetes Mellitus
Conclusions: Increased TNF-α levels and low TAS are significantly associated with the increased risk of insulin requirement for achieving good glycemic control in GDM.[...]© Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes)
Source: Experimental and Clinical Endocrinology and Diabetes - May 26, 2015 Category: Endocrinology Authors: Ozler, S. Oztas, E. Uygur, D. Ersoy, A. O. Ergin, M. Koca, C. Danisman, N. Erkaya, S. Tags: Article Source Type: research

Comparative Efficacy of Four Treatments in Patients with Graves’ Disease: a Network Meta-analysis
Conclusions: Radioiodine+prednisone therapy might have the least probability of leading to an exacerbation or new appearance of ophthalmopathy, and radioiodine therapy might have the least probability of causing a recurrence.[...]© Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes)
Source: Experimental and Clinical Endocrinology and Diabetes - May 19, 2015 Category: Endocrinology Authors: Ren, Z.Qin, L.Wang, J. Q.Li, Y.Li, J.Zhang, R.-G. Tags: Article Source Type: research

Glucose- and Triglyceride-lowering Dietary Penta-O-galloyl-α-D-Glucose Reduces Expression of PPARγ and C/EBPα, Induces p21-Mediated G1 Phase Cell Cycle Arrest, and Inhibits Adipogenesis in 3T3-L1 Preadipocytes
In this study, high fat diet (HFD)-induced diabetic and obese mice were treated with α-PGG to determine its effects on blood glucose and triglycerides. 3T3-L1 preadipocytes were used as a cell model for identifying the anti-adipogenic activity of α-PGG at molecular and cellular levels as a first step in elucidating the mechanism of action of the compound. In vivo, oral administration of α-PGG significantly reduced levels of blood glucose, triglyceride, and insulin in HFD-induced diabetic/obese mice (P
Source: Experimental and Clinical Endocrinology and Diabetes - May 19, 2015 Category: Endocrinology Authors: Liu, X.Malki, A.Cao, Y.Li, Y.Qian, Y.Wang, X.Chen, X. Tags: Article Source Type: research

Cardiac Nitric Oxide Synthases and Na+/K+-ATPase in the Rat Model of Polycystic Ovary Syndrome Induced by Dihydrotestosterone
In conclusion, DHT treatment impaired effectiveness of NOSs and Na+/K+-ATPase in the female rat heart. Regarding the importance of NO production and sodium/potassium transport in the cardiac contraction and blood flow regulation, it implicates strong consequences of PCOS for heart functioning.[...]© Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes)
Source: Experimental and Clinical Endocrinology and Diabetes - May 19, 2015 Category: Endocrinology Authors: Tepavčević, S.Milutinović, D. V.Macut, D.Stanišić, J.Nikolić, M.Božić-Antić, I.Rodaljević, S.Bjekić-Macut, J.Matić, G.Korićanac, G. Tags: Article Source Type: research

Elevated Plasma Levels of Betatrophin in Women with Gestational Diabetes Mellitus
Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0035-1549888 Aim: The role of betatrophin in pancreatic β-cell proliferation and development of diabetes has been demonstrated experimentally and within clinical studies. The aim of this study was to measure betatrophin concentration in blood of women with gestational diabetes mellitus (GDM) and to investigate the association of betatrophin with clinical-biochemical parameters and an atherogenic index in pregnant with GDM. Methods: The study included 50 women diagnosed with GDM and 60 healthy pregnant women. Plasma betatrophin was measured by ELISA. Results: The GDM group sho...
Source: Experimental and Clinical Endocrinology and Diabetes - May 6, 2015 Category: Endocrinology Authors: Yilmaz, H.Cakmak, M.Darcin, T.Demir, C.Inan, O.Ceydilek, B.Onaran, Y.Bavbek, N.Bilgic, M. A.Akcay, A. Tags: Article Source Type: research

Complete Evaluation of Adrenal Tumours in a Tertiary Care Institution in Thuringia, Germany
Conclusions: The prevalence of detected adrenal tumours is rising due to widely available and applied abdominal imaging procedures. The vast majority of them are benign, of small size (
Source: Experimental and Clinical Endocrinology and Diabetes - May 6, 2015 Category: Endocrinology Authors: Askitis, D.Kloos, C.Battefeld, W.Müller, N.Wolf, G.Dirsch, O.Müller, U. A. Tags: Article Source Type: research

Oxidative Stress in Hypertension: Mechanisms and Therapeutic Opportunities
Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0035-1548765Hypertension is a highly prevalent disease worldwide. It is known for being one of the most important risk factors for developing cardiovascular disease, including acute myocardial infarction and stroke. Therefore, during the last decades there have been multiple efforts to fully understand the mechanisms underlying hypertension, and then develop effective therapeutic interventions to attenuate the morbidity and mortality associated with this condition. In this regard, oxidative stress has been proposed as a key mechanistic mediator of hypertension, which is an imbalan...
Source: Experimental and Clinical Endocrinology and Diabetes - April 28, 2015 Category: Endocrinology Authors: Brito, R.Castillo, G.González, J.Valls, N.Rodrigo, R. Tags: Review Source Type: research

Revealing the Underlying Mechanism of Diabetic Nephropathy Viewed by Microarray Analysis
Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0035-1548849To explore the molecular mechanisms of diabetic nephropathy (DN) progression and provide the theoretical basis for treating DN, GSE1009 microarray data were downloaded from Gene Expression Omnibus database. Microarray data were obtained from glomeruli isolated from normal kidneys (n=3) and kidneys from patients with DN (n=3). We first screened the differentially expressed genes (DEGs) in kidneys by the Linear Models for Microarray Data package in R. Then the function of DEGs in DN was explored through Gene Ontology (GO) and KEGG pathway enrichment analyses. Critical DE...
Source: Experimental and Clinical Endocrinology and Diabetes - April 28, 2015 Category: Endocrinology Authors: Qu, W.Han, C.Li, M.Zhang, J.Li, L. Tags: Article Source Type: research

Biomechanical Properties of Achilles Tendon in Diabetic vs. Non-diabetic Patients
This study aimed to examine the biomechanical and histopathological alterations in Achilles tendon specimens from diabetic vs. non-diabetic individuals. Materials and methods: 42 Achilles tendon samples obtained from patients treated with below-knee or above-knee amputation for chronic diabetic foot ulcers (n=21) or for non-diabetic conditions (n=21) were included. A tensile test was performed for each tendon and a stress vs. strain graft was obtained to calculate following biomechanical parameters: elasticity (Young modulus), load, stiffness, toughness, energy, strain, elongation and tenacity. Groups were also compared wi...
Source: Experimental and Clinical Endocrinology and Diabetes - April 28, 2015 Category: Endocrinology Authors: Guney, A.Vatansever, F.Karaman, I.Kafadar, I. H.Oner, M.Turk, C. Y. Tags: Article Source Type: research

Problems in Interpretation of the Short Acth Test: an Update and Historical Notes
Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0035-1548817ACTH stimulation test has been used for many years. Some important questions remain unsettled. These are reviewed and discussed in detail. Interpretation of a short ACTH test rests on the fact that a close correlation exists between the responses in plasma cortisol concentrations after administration of ACTH and during insulin induced hypoglycaemia which previously was the standard test. It is generally assumed that the plasma cortisol concentration after ACTH (and insulin) mirrors the response in major stress situations (surgery and critical disease). This notion rest...
Source: Experimental and Clinical Endocrinology and Diabetes - April 21, 2015 Category: Endocrinology Authors: Lindholm, J. Tags: Review Source Type: research

DNA Methylation Profiles in Placenta and Its Association with Gestational Diabetes Mellitus
This study is to uncover the genome-wide DNA methylation patterns in this disorder. DNA methylation was measured at>385 000 CpG sites using methylated DNA immunoprecipitation (MeDIP) and a huamn CpG island plus promoter microarray. We totally identified 6 641 differentially methylated regions (DMRs) targeting 3 320 genes, of which 2 729 DMRs targeting 1 399 genes, showed significant hypermethylation in GDM relative to the controls, whereas 3 912 DMRs targeting 1 970 genes showed significant hypomethylation. Functional analysis divided these genes into different functional...
Source: Experimental and Clinical Endocrinology and Diabetes - April 21, 2015 Category: Endocrinology Authors: Rong, C.Cui, X.Chen, J.Qian, Y.Jia, R.Hu, Y. Tags: Article Source Type: research

An Immunohistochemical Investigation of the Expression of Somatostatin Receptor Subtypes – Should Therapeutic Trials be Performed to Determine the Efficacy of Somatostatin Analogs in Treating Advanced Thyroid Malignances?
Conclusions: The somatostatin multiligand analogs or selective agonists could be considered alternatives to conventional therapeutic agents in aggressive thyroid tumors.[...]© Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes)
Source: Experimental and Clinical Endocrinology and Diabetes - April 21, 2015 Category: Endocrinology Authors: Pisarek, H.Pawlikowski, M.Marchlewska, M.Minias, R.Winczyk, K. Tags: Article Source Type: research

Na+/Ca2+ Exchanger Inhibitor Restores Endothelium-dependent Relaxation in Diabetic Rat Aorta
Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0035-1548928The aims of this study were to examine the effects of KB-R7943, an inhibitor of Na+/Ca2+ exchanger, on the endothelium-dependent relaxation (EDR) in diabetic rat aorta. Both acetylcholine (ACh)-induced EDR and sodium nitroprusside (SNP)-induced endothelium-independent relaxation (EIR) were measured in aortic rings of nondiabetic and streptozotocin-diabetic rats. Diabetes mellitus was induced by single injection of streptozotocin (60 mg/kg). The treated rats received 0.01 or 0.1 mg/kg/day of KB-R7943 for 8 weeks. ACh-induced relaxation was impaired in diab...
Source: Experimental and Clinical Endocrinology and Diabetes - April 21, 2015 Category: Endocrinology Authors: Li, X.-F.Wan, T.-T.Sun, Y.-M.Su, Y. Tags: Article Source Type: research

Analysis of Heart Rate Variability and Cardiac Autonomic Nerve Remodeling in Streptozotocin-induced Diabetic Rats
Conclusion: STZ-induced diabetes was associated with cardiac autonomic nerve dysfunction at both the organ and molecular levels. Parasympathetic nerves exhibited severe damage and/or weak recovery; remodeling of sympathetic nerves predominated during 10-weeks of STZ-induced diabetes.[...]© Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes)
Source: Experimental and Clinical Endocrinology and Diabetes - April 21, 2015 Category: Endocrinology Authors: Li, X.Jiang, Y.-H.Jiang, P.Lin, H.-Q.Yang, J.-L.Ma, D.-f.Wang, X.Yang, C.-H. Tags: Article Source Type: research

GLP-1-Exendin-4/IgG4 (Fc) Fusion Protein as a Novel Drug for Diabetes Treatment
Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0035-1548797In this paper, we aimed to look for a potent long acting GLP-1 receptor agonist for diabetes treatment. In this work, we constructed the eukaryotic expression vector of GLP-1-Exendin-4/IgG4 (Fc)-pOptiVEC™-TOPO® and then transfected it into Chinese hamster ovary DG44 (CHO/DG44) cells using liposome method. Then the beta-cell line INS-1 cells were treated with purified GLP-1-Exendin-4/IgG4 (Fc) fusion protein (0.01, 0.1, 1.0 mM respectively) and randomly assigned to 2 groups, each group were then grown in KRB buffer in the presence of 2.8 mM or 16...
Source: Experimental and Clinical Endocrinology and Diabetes - April 21, 2015 Category: Endocrinology Authors: Gan, Y.Dang, N.Qu, Z.Shi, R.Ding, L.Wang, L.Pang, S. Tags: Article Source Type: research

Curcumin Attenuates Urinary Excretion of Albumin in Type II Diabetic Patients with Enhancing Nuclear Factor Erythroid-Derived 2-Like 2 (Nrf2) System and Repressing Inflammatory Signaling Efficacies
In conclusion, short-term curcumin intervention ablates DKD progress with activating Nrf2 anti-oxidative system and anti-inflammatory efficacies in patients with T2DM.[...]© Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes)
Source: Experimental and Clinical Endocrinology and Diabetes - April 14, 2015 Category: Endocrinology Authors: Yang, H.Xu, W.Zhou, Z.Liu, J.Li, X.Chen, L.Weng, J.Yu, Z. Tags: Article Source Type: research

Expression of the Central Obesity and Type 2 Diabetes Mellitus Genes is Associated with Insulin Resistance in Young Obese Children
Exp Clin Endocrinol Diabetes 2015; 123: 252-259DOI: 10.1055/s-0034-1398503 Objectives: The assessment of the health consequences associated with obesity in young children is challenging. The aims of this study were: (1) to compare insulin resistance indices derived from OGTT in obese patients and healthy control (2) to analyze central obesity and Type 2 Diabetes genes expression in obese children, with special attention to the youngest group (
Source: Experimental and Clinical Endocrinology and Diabetes - April 13, 2015 Category: Endocrinology Authors: Skoczen, S.Wojcik, M.Fijorek, K.Siedlar, M.Starzyk, J. B. Tags: Article Source Type: research

Evaluation of Cognitive Functions in Gestational Diabetes Mellitus
Conclusions: Our findings may be a clue for early onset of impairment in cognitive functions in cases with new onset diabetes during pregnancy.[...]© Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes)
Source: Experimental and Clinical Endocrinology and Diabetes - April 13, 2015 Category: Endocrinology Authors: Keskin, F. E.Ozyazar, M.Pala, A. S.Elmali, A. D.Yilmaz, B.Uygunoglu, U.Bozluolcay, M.Tuten, A.Bingöl, A.Hatipoglu, E. Tags: Article Source Type: research

Effects of Zinc Supplementation on Markers of Insulin Resistance and Lipid Profiles in Women with Polycystic Ovary Syndrome: a Randomized, Double-blind, Placebo-controlled Trial
Conclusion: Taken together, 220 mg zinc sulfate supplementation per day for 8 weeks among PCOS women had beneficial effects on metabolic profiles.[...]© Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes)
Source: Experimental and Clinical Endocrinology and Diabetes - April 13, 2015 Category: Endocrinology Authors: Foroozanfard, F.Jamilian, M.Jafari, Z.Khassaf, A.Hosseini, A.Khorammian, H.Asemi, Z. Tags: Article Source Type: research

Human Islets Exhibit Electrical Activity on Microelectrode Arrays (MEA)
This study demonstrates for the first time that the microelectrode array (MEA) technique allows analysis of electrical activity of islets isolated from human biopsies. We have shown before that this method, i. e., measuring beta cell electrical activity with extracellular electrodes, is a powerful tool to assess glucose responsiveness of isolated murine islets. In the present study, human islets were shown to exhibit glucose-dependent oscillatory electrical activity. The glucose responsiveness could be furthermore demonstrated by an increase of insulin secretion in response to glucose. Electrical activity was increa...
Source: Experimental and Clinical Endocrinology and Diabetes - April 8, 2015 Category: Endocrinology Authors: Schönecker, S.Kraushaar, U.Guenther, E.Gerst, F.Ullrich, S.Häring, H.-U.Königsrainer, A.Barthlen, W.Drews, G.Krippeit-Drews, P. Tags: Letter to the Editor Source Type: research

Type 1 Diabetes Mellitus and Exercise in Competitive Athletes
Conclusion: These results point to a very individual adaption of the athlete’s therapy during training and competition. However, there are distinct differences in diabetes management between endurance and non-endurance athletes.[...]© Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes)
Source: Experimental and Clinical Endocrinology and Diabetes - April 8, 2015 Category: Endocrinology Authors: Ratjen, I.Weber, K. S.Roden, M.Herrmann, M.-E.Müssig, K. Tags: Article Source Type: research