Experimental and Clinical Endocrinology and Diabetes This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Thyroid Hormone Deficiency Modifies Hepatic Lipid Droplet Morphology and Molecular Properties in Lithogenic-Diet Supplemented Mice
Conclusion This study demonstrates that thyroid hormone deficiency alters hepatic lipid droplet morphology and hepatic gene expression of lipid droplet-associated proteins in a lithogenic diet mouse model of steatohepatitis. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents | Abstract | Full text (Source: Experimental and Clinical Endocrinology and Diabetes)
Source: Experimental and Clinical Endocrinology and Diabetes - May 28, 2021 Category: Endocrinology Authors: Kube, Irina Jastrow, Holger F ührer, Dagmar Zwanziger, Denise Tags: Article Source Type: research

Evaluation of Meal Carbohydrate Counting Errors in Patients with Type 1 Diabetes
Conclusions Participants generally underestimated the carbohydrate content of the test meals, especially in meals with higher carbohydrate content. Repetition of estimation resulted in significant improvements in estimation accuracy and is important for the maintenance of correct carbohydrate estimations. The ability to estimate the carbohydrate content of a meal should be checked and trained regularly in patients with diabetes. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents | Abstract | Fu...
Source: Experimental and Clinical Endocrinology and Diabetes - May 25, 2021 Category: Endocrinology Authors: Buck, Sina Krauss, Collin Waldenmaier, Delia Liebing, Christina Jendrike, Nina H ögel, Josef Pfeiffer, Boris M. Haug, Cornelia Freckmann, Guido Tags: Article Source Type: research

Increased Serum WISP1 Levels are Associated with Lower Extremity Atherosclerotic Disease in Patients with type 2 Diabetes Mellitus
Conclusion The results suggest that increased serum WISP1 levels independently contribute to the incidence of LEAD in patients with newly diagnosed T2DM. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents | Abstract | Full text (Source: Experimental and Clinical Endocrinology and Diabetes)
Source: Experimental and Clinical Endocrinology and Diabetes - April 30, 2021 Category: Endocrinology Authors: Cheng, Yangyang Du, Xiaohui Zhang, Bilin Zhang, Junxia Tags: Review Source Type: research

The Effect of Prandial Insulin Applied for Fat Protein Units on Postprandial Glucose Excursions in Type 1 Diabetes Patients with Insulin Pump Therapy: Results of a Randomized, Controlled, Cross-Over Study
Conclusions In adult type 1 diabetes patients using CSII, it is not recommended to consider a high fat and protein content in the diet when calculating prandial insulin dosage with the selected algorithms, as this increases the risk of hypoglycemia disproportionately. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents | Abstract | Full text (Source: Experimental and Clinical Endocrinology and Diabetes)
Source: Experimental and Clinical Endocrinology and Diabetes - April 20, 2021 Category: Endocrinology Authors: Haak, Thomas Herrmann, Ekaterina Lippmann-Grob, Bernhard Tombek, Astrid Hermanns, Norbert Krichbaum, Michael Tags: Article Source Type: research

Diabetes and Migration
Exp Clin Endocrinol Diabetes DOI: 10.1055/a-1284-6778 Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents | Full text (Source: Experimental and Clinical Endocrinology and Diabetes)
Source: Experimental and Clinical Endocrinology and Diabetes - April 14, 2021 Category: Endocrinology Authors: Şat, Sebahat Ayd ınkoç-Tuzcu, Kadriye Berger, Faize Barakat, Alain Schindler, Karin Fasching, Peter Tags: German Diabetes Association: Clinical Practice Guidelines Source Type: research

ZFAND3 Overexpression in the Mouse Liver Improves Glucose Tolerance and Hepatic Insulin Resistance
This study aimed to investigate the association between ZFAND3 and type 2 diabetes mellitus. ZFAND3 was significantly upregulated in the liver of diabetic mice compared to wild-type mice. To overexpress ZFAND3, we generated a ZFAND3-expressing adenovirus (Ad) vector using an improved Ad vector exhibiting significantly lower hepatotoxicity (Ad-ZFAND3). Glucose tolerance was significantly improved in Ad-ZFAND3-treated mice compared to the control Ad-treated mice. ZFAND3 overexpression in the mouse liver also improved insulin resistance. Furthermore, gluconeogenic gene expression was significantly lower in primary mouse hepat...
Source: Experimental and Clinical Endocrinology and Diabetes - March 29, 2021 Category: Endocrinology Authors: Shimizu, Kahori Ogiya, Yuya Yoshinaga, Kaede Kimura, Hajime Michinaga, Shotaro Ono, Moe Taketomi, Ayako Terada, Tomoyuki Sakurai, Fuminori Mizuguchi, Hiroyuki Tomita, Koji Nishinaka, Toru Tags: Article Source Type: research

Gestational Diabetes Mellitus (GDM), Diagnostics, Therapy and Follow-up Care
Exp Clin Endocrinol Diabetes DOI: 10.1055/a-1284-6011 Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents | Full text (Source: Experimental and Clinical Endocrinology and Diabetes)
Source: Experimental and Clinical Endocrinology and Diabetes - March 26, 2021 Category: Endocrinology Authors: Sch äfer-Graf, Ute Laubner, Katharina Hummel, Sandra Gembruch, Ulrich Groten, Tanja Kainer, Franz Grieshop, Melita Bancher-Todesca, Dagmar Cervar-Zivakovic, Mila H ösli, Irene Kaltheuner, Matthias Gellner, Reinhold Kautzky-Willer, Alexandra B ührer, Ch Tags: German Diabetes Association: Clinical Practice Guidelines Source Type: research

Effects of Treatment Adherence on Quality of Life in Hypoparathyroid Patients
Conclusions Nearly 40% of the patients were non-adherent to conventional treatment for hypoparathyroidism, and such patients had higher anxiety and depression scores and poorer quality of life scores. Conventional treatment might not be sufficient to meet the needs of patients with hypoparathyroidism. In addition to seeking new therapeutic options, factors influencing quality of life should also be investigated and strategies to improve treatment adherence should be developed. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArt...
Source: Experimental and Clinical Endocrinology and Diabetes - March 10, 2021 Category: Endocrinology Authors: Anaforoglu, Inan Sancak, Seda Akbas, Emin Murat Oruk, Guzide Gonca Canat, Masum Tezcan, Kadriye Ayd ın Uc, Ziynet Alphan Gorar, Suheyla Duman, Gulhan Cavlak Yaylali, Guzin Fidan Y ılmaz, Merve Bilir, Betul Ekiz Bozoglan, Humeyra Akbaba, Gulhan Tuna, Maz Tags: Article Source Type: research

First German Guideline on Diagnostics and Therapy of Clinically Non-Functioning Pituitary Tumors
Exp Clin Endocrinol Diabetes 2021; 129: 250-264 DOI: 10.1055/a-1373-4087Although non-functioning pituitary tumors are frequent, diagnostic and therapeutic concepts are not well standardized. We here present the first German multidisciplinary guideline on this topic. The single most important message is to manage the patients by a multidisciplinary team (consisting at least of an endocrinologist, a neurosurgeon, and a (neuro-) radiologist). The initial diagnostic work-up comprises a detailed characterization of both biochemical (focusing on hormonal excess or deficiency states) and morphological aspects (with magnetic reson...
Source: Experimental and Clinical Endocrinology and Diabetes - March 9, 2021 Category: Endocrinology Authors: Deutschbein, Timo Jaursch-Hancke, Cornelia Knappe, Ulrich J. Saeger, Wolfgang Flitsch, J örg Bojunga, J örg Buchfelder, Michael Ditzen, Beate Gerlach, R üdiger Gertzen, Elfriede Honegger, J ürgen Horstmann, Gerhard A. Koch, Arend Kreitschmann-Andermah Tags: Guideline Source Type: research

Medical Therapy of Aggressive Pituitary Tumors
Exp Clin Endocrinol Diabetes 2021; 129: 186-193 DOI: 10.1055/a-1331-6939The rare aggressive pituitary adenoma presents a special challenge, due to the heterogenous presentation of the disease. The prognosis of aggressive pituitary adenomas has been improved due to recent studies demonstrating clinically-relevant efficacy of temozolomide, which is now considered first-line chemotherapy. However, there is limited data on second-line therapies in patients with treatment failure. This review presents a summary on the potential of medical therapies in aggressive pituitary tumors. [...] Georg Thieme Verlag KG Rüdigerstraße 14,...
Source: Experimental and Clinical Endocrinology and Diabetes - March 9, 2021 Category: Endocrinology Authors: Petersenn, Stephan Tags: Review Source Type: research

Clinical Implications of the New WHO Classification 2017 for Pituitary Tumors
Exp Clin Endocrinol Diabetes 2021; 129: 146-156 DOI: 10.1055/a-1310-7900According to the WHO classification 2017 of Pituitary Tumors adenomas are classified not only by structure and immunostaining for pituitary hormones but also by expression of the pituitary transcription factors Pit-1, T-pit and SF-1. By these factors, three cell lineages can be identified: Pit-1 for the GH-, Prolactin- and TSH-cell lineage, T-pit for the ACTH-cell lineage, and SF-1 for the gonadotrophic cell lineage. By this principle, all GH and/or Prolactin producing and all TSH producing adenomas must be positive for Pit-1, all corticotrophic adenom...
Source: Experimental and Clinical Endocrinology and Diabetes - March 9, 2021 Category: Endocrinology Authors: Saeger, Wolfgang Koch, Arend Tags: Review Source Type: research

Pituitary in the Spotlight
Exp Clin Endocrinol Diabetes 2021; 129: 143-145 DOI: 10.1055/a-1369-8898The German Society of Endocrinology (DGE) has a long-standing scientific and clinical focus on the pituitary. The pituitary working group ‘Arbeitsgemeinschaft Hypophyse’ is an interdisciplinary special interest group with a focus on advancing diagnosis and treatment of pituitary conditions. On the occasion of the English publication of the S2K clinical guideline Diagnosis and therapy of clinically hormonally inactive pituitary tumors, we present here a series of 12 articles from internationally renowned authors from inside and outside of Germany. [...
Source: Experimental and Clinical Endocrinology and Diabetes - March 9, 2021 Category: Endocrinology Authors: Reincke, Martin Honegger, J ürgen Tags: Editorial Source Type: research

Double Diabetes: A Growing Problem Requiring Solutions
Exp Clin Endocrinol Diabetes DOI: 10.1055/a-1392-0590The growing proportion of type 1 diabetes mellitus (T1DM) patients with clinical features of insulin resistance (IR) has led to the description of a distinctive T1DM subgroup, still unrecognised by current guidelines, called double diabetes, assumingly associated with poorer metabolic phenotype and increased risk of micro- and macrovascular complications. The main goal of identifying double diabetes, estimated to be present in up to half of T1DM patients, is timely implementation of appropriate therapeutic interventions to reduce the increased risk of chronic complicatio...
Source: Experimental and Clinical Endocrinology and Diabetes - February 26, 2021 Category: Endocrinology Authors: Popovic, Djordje S. Papanas, Nikolaos Tags: Article Source Type: research

Impact of Smoking, Obesity and Maternal Diabetes on SHBG Levels in Newborns
Conclusions: SHBG levels are lower in newborns born to mothers with diabetes than without diabetes, and may be a marker for babies’ life-long risk for abnormal metabolic health. On the other hand, the adverse effects of tobacco smoke on the fetus do not appear to directly influence SHBG levels. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents | Abstract | Full text (Source: Experimental and Clinical Endocrinology and Diabetes)
Source: Experimental and Clinical Endocrinology and Diabetes - February 22, 2021 Category: Endocrinology Authors: Aydin, Banu Kucukemre Yasa, Beril Moore, Joseph P. Yasa, Cenk Poyrazoglu, Sukran Bas, Firdevs Coban, Asuman Darendeliler, Feyza Winters, Stephen J. Tags: Article Source Type: research