Comparability of C-Peptide Measurements – Current Status and Clinical Relevance
Exp Clin Endocrinol Diabetes DOI: 10.1055/a-1998-6889C-peptide is an increasingly used and established marker for beta cell function by assessing endogenous insulin secretion. Accurate and comparable C-peptide measurements are needed in clinical practice and research studies. For example, to calculate HOMA-indices, the C-peptide/glucose ratio, and the classification of recently published novel subgroups of diabetes and prediabetes have used C-peptide measurements. Although the process for standardization of C-peptide measurements is advanced, its full implementati...
Source: Experimental and Clinical Endocrinology and Diabetes - January 11, 2023 Category: Endocrinology Authors: H örber, Sebastian Orth, Matthias Fritsche, Andreas Peter, Andreas Tags: Article Source Type: research

Gestational Diabetes Mellitus (GDM), Diagnostics, Therapy and Follow-up Care
Exp Clin Endocrinol Diabetes DOI: 10.1055/a-1946-3713 Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes)
Source: Experimental and Clinical Endocrinology and Diabetes - January 10, 2023 Category: Endocrinology Authors: Sch äfer-Graf, Ute Laubner, Katharina Hummel, Sandra Gembruch, Ulrich Groten, Tanja Kainer, Franz Grieshop, Melita Bancher-Todesca, Dagmar Cervar-Zivakovic, Mila H ösli, Irene Kaltheuner, Matthias Gellner, Reinhold Kautzky-Willer, Alexandra B ührer, Ch Tags: German Diabetes Association: Clinical Practice Guidelines Source Type: research

Diabetes and Pregnancy
Exp Clin Endocrinol Diabetes DOI: 10.1055/a-1946-3648 Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes)
Source: Experimental and Clinical Endocrinology and Diabetes - January 10, 2023 Category: Endocrinology Authors: Hummel, Michael F üchtenbusch, Martin Battefeld, Wilgard B ührer, Christoph Groten, Tanja Haak, Thomas Kainer, Franz Kautzky-Willer, Alexandra Lechner, Andreas Meissner, Thomas Nagel-Reuper, Christine Sch äfer-Graf, Ute Siegmund, Thorsten Tags: German Diabetes Association: Clinical Practice Guidelines Source Type: research

Discrepancies Between Osteoporotic Fracture Evaluations in Men Based on German (DVO) Osteoporosis Guidelines or the FRAX Score
This study compared the risk probabilities of major osteoporotic and hip fractures calculated by the FRAX tool with those of the DVO score, established in German-speaking countries. Material and Methods This seven-year retrospective study analyzed data of 125 male patients (mean age: 59.2±10.7 years) evaluated for osteoporosis. For the DVO score, the therapy threshold of>30% for vertebral and hip fractures suggested by DVO guidelines was implemented. We calculated fracture risks based on FRAX scores with aBMD and applied a common thera...
Source: Experimental and Clinical Endocrinology and Diabetes - January 9, 2023 Category: Endocrinology Authors: Witzel, J C Giessel, A Heppner, C Lamersdorf, A Leha, A Gl üer, C C Siggelkow, H Tags: Article Source Type: research

Do Glucagonlike Peptide-1 Receptor Agonist and Sodium-glucose Co-transporter 2 Inhibitor Prescriptions in Germany Reflect Recommendations for Type 2 Diabetes with Cardiovascular Disease of the ADA/EASD Consensus Report?
Conclusion National prescription use of GLP-1RA and SGLT2i did not come close to the recommendation in subjects with CVD issued by the 2018 ADA/EASD consensus. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes)
Source: Experimental and Clinical Endocrinology and Diabetes - December 15, 2022 Category: Endocrinology Authors: Barth, Sebastian Dietmar Kostev, Karel Krensel, Magdalene Mathey, Elke Rathmann, Wolfgang Tags: Article Source Type: research

Ghrelin-Reactive Autoantibodies as Potential Modulators of Dysfunctional Eating Patterns in Women: An Exploratory Study
This study aimed to evaluate the relationship between IgG ghrelin-reactive autoAbs with dysfunctional eating patterns, subjective perception of stress, and body composition parameters in young women. This cross-sectional study included 82 women (age 21±2 years) classified according to body fat percentage. Dysfunctional eating patterns were measured with the Spanish version of the Three-factor Eating Questionnaire-R18, and perceived stress was measured with the Spanish version of the Perceived Stress Scale – 10. A validated in-house enzyme-linked ...
Source: Experimental and Clinical Endocrinology and Diabetes - December 15, 2022 Category: Endocrinology Authors: Garc ía, Astrid Selene Espinoza Mart ínez-Rodríguez, Tania Yadira Parra-Rojas, Isela Vald és-Miramontes, Elia H. Garc ía-Ortíz, Lidia Reyes-Castillo, Zyanya Tags: Article Source Type: research

Serum Uromodulin in Children and Adolescents with Type 1 Diabetes Mellitus and Controls: Its Potential Role in Kidney Health
Conclusions Our study shows that children/adolescents with type 1 diabetes disclose similar sUMOD concentrations as healthy controls. Serum UMOD appears to indicate higher risks for kidney tissue remodeling and possibly subsequent cardiovascular alterations. However, further studies are mandatory to settle these findings. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes)
Source: Experimental and Clinical Endocrinology and Diabetes - December 13, 2022 Category: Endocrinology Authors: Schiel, Ralf Block, Mathias Steveling, Antje Stein, G ünter L ücking, Sarah Scherberich, J ürgen Tags: Article Source Type: research

Effects of Peri-Conception and Pregnancy Glycemic Variability on Pregnancy and Perinatal Complications in Type 1 Diabetes: A Pilot Study
Conclusions Presence of a positive association between GV and pregnancy and perinatal complications depends on which pregnancy period is assessed and the GV metrics that are used. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents  |  Abstract  |  open access Full text (Source: Experimental and Clinical Endocrinology and Diabetes)
Source: Experimental and Clinical Endocrinology and Diabetes - November 21, 2022 Category: Endocrinology Authors: Hoek-Hogchem, Ri ëlle Bovenberg, Sarah A. Dekker, Pim Birnie, Erwin Veeze, Henk J. Duvekot, Hans J. Galjaard, Sander Aanstoot, Henk-Jan Tags: Article Source Type: research

Effect of Aerobic Exercise Training on Circulating Fibroblast Growth Factor-21 Response to Glucose Challenge in Overweight and Obese Men: A Pilot Study
Conclusion Lowering postprandial circulating FGF21 levels may be associated with the improved glucose tolerance induced by habitual aerobic exercise in overweight and obese men. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes)
Source: Experimental and Clinical Endocrinology and Diabetes - November 21, 2022 Category: Endocrinology Authors: Matsui, Masahiro Kosaki, Keisei Myoenzono, Kanae Yoshikawa, Toru Park, Jieyon Kuro-o, Makoto Maeda, Seiji Tags: Article Source Type: research

Effects of High-Fructose Corn Syrup Intake on Glucocorticoid Metabolism in Rats During Childhood, Adolescence and Adulthood
This study provides insight into the adverse effects of fructose on GC metabolism in children in the context of increasing rates of HFCS consumption. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes)
Source: Experimental and Clinical Endocrinology and Diabetes - November 11, 2022 Category: Endocrinology Authors: Nouchi, Yuki Munetsuna, Eiji Yamada, Hiroya Yamazaki, Mirai Ando, Yoshitaka Mizuno, Genki Fujii, Ryosuke Kageyama, Itsuki Wakasugi, Takuya Sakakibara, Tomohide Teshigawara, Atsushi Ishikawa, Hiroaki Shimono, Yohei Suzuki, Koji Hashimoto, Shuji Ohashi, Koj Tags: Article Source Type: research

Prevalence of Primary Aldosteronism in Newly Diagnosed Hypertensive Patients in Primary Care
Conclusion A 5.5% prevalence of PA was observed in our data of untreated newly diagnosed patients with hypertension. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes)
Source: Experimental and Clinical Endocrinology and Diabetes - November 8, 2022 Category: Endocrinology Authors: Asbach, Evelyn Kellnar, Antonia Bekeran, Margareta Schelling, J örg Bidlingmaier, Martin Reincke, Martin Tags: Article Source Type: research

Correlation Between Skin Advanced Glycation End Products and Cardiac Autonomic Neuropathy Among Subjects with Type 2 Diabetes Mellitus
Discussion Among T2DM subjects, skin AGEs appear to increase in the presence of CAN. This holds true both for sympathetic and parasympathetic nervous system impairment. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes)
Source: Experimental and Clinical Endocrinology and Diabetes - November 7, 2022 Category: Endocrinology Authors: Papachristou, Stella Pafili, Kalliopi Trypsianis, Grigorios Papazoglou, Dimitrios Vadikolias, Κonstantinos Papanas, Nikolaos Tags: Article Source Type: research

Cigarette Smoking Increases the Risk of Type 2 Diabetes Mellitus in Patients with Non-Alcoholic Fatty Liver Disease: A Population-Based Cohort Study
Conclusions This longitudinal study showed that current smoking may act as a “second hit” and increase the risk of type 2 diabetes in patients with non-alcoholic fatty liver disease. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes)
Source: Experimental and Clinical Endocrinology and Diabetes - November 7, 2022 Category: Endocrinology Authors: Liu, Chan Wu, Yanqin Duan, Wenjuan Xu, Wenming Tags: Article Source Type: research

Selective Inhibition of 11beta-Hydroxysteroiddehydrogenase-1 with BI 187004 in Patients with Type 2 Diabetes and Overweight or Obesity: Safety, Pharmacokinetics, and Pharmacodynamics After Multiple Dosing Over 14 Days
Conclusions BI 187004 was safe and well tolerated over 14 days and could be dosed once daily. Targeted 11beta-HSD1 enzyme inhibition of≥80% could be shown for BI 187004 doses≥40 mg. This dose should be targeted in further studies to test blood glucose lowering in patients with type 2 diabetes and overweight or obesity. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents  |  Abstract  |  open access Full text (Source: Experimental and Clinical Endocrinology and Diabetes)
Source: Experimental and Clinical Endocrinology and Diabetes - November 7, 2022 Category: Endocrinology Authors: Bianzano, Susanna Schepers, Cornelia Wolff, Michael Heise, Tim Plum-Moerschel, Leona Tags: Article Source Type: research

Advanced Glycation End Products, Bone Health, and Diabetes Mellitus
Exp Clin Endocrinol Diabetes 2022; 130: 671-677 DOI: 10.1055/a-1861-2388Advanced glycation end products (AGEs), the compounds resulting from the non-enzymatic glycosylation between reducing sugars and proteins, are derived from food or produced de novo. Over time, more and more endogenous and exogenous AGEs accumulate in various organs such as the liver, kidneys, muscle, and bone, threatening human health. Among these organs, bone is most widely reported. AGEs accumulating in bone reduce bone strength by participating in bone structure formation and breaking bone ...
Source: Experimental and Clinical Endocrinology and Diabetes - October 18, 2022 Category: Endocrinology Authors: Jiang, Jingjing Zhao, Changyu Han, Tingting Shan, Hongyan Cui, Guiyou Li, Songnan Xie, Zhongwen Wang, Jun Tags: Review Source Type: research