Circular RNA circADAM9 Promotes Inflammation, Oxidative Stress, and Fibrosis of Human Mesangial Cells via the Keap1-Nrf2 Pathway in Diabetic Nephropathy
Conclusion These results indicate that the circADAM9/miR-545-3p/USP15/Keap1/Nrf2 signaling axis is critical for HG-induced cell injury in HMCs and might represent a novel therapeutic target for DN treatment. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes)
Source: Experimental and Clinical Endocrinology and Diabetes - July 18, 2023 Category: Endocrinology Authors: Zheng, Hongwei Liu, Xuezheng Song, Bing Tags: Article Source Type: research

Incidence of Stroke in People With Diabetes Compared to Those Without Diabetes: A Systematic Review
Conclusion The considerable differences between results can partly be explained by differences in study designs, statistical methods, definitions of stroke, and methods used to identify patients with diabetes. The lack of evidence arising from these differences ought to be rectified by new studies. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents  |  Abstract  |  open access Full text (Source: Experimental and Clinical Endocrinology and Diabetes)
Source: Experimental and Clinical Endocrinology and Diabetes - July 17, 2023 Category: Endocrinology Authors: Kvitkina, Tatjana Narres, Maria Claessen, Heiner Metzendorf, Maria-Inti Richter, Bernd Icks, Andrea Tags: Review Source Type: research

Adrenal Vein Sampling in the Young – Necessary or Not?
Exp Clin Endocrinol Diabetes DOI: 10.1055/a-2099-3525Current clinical guidelines from the US Endocrine Society state that adrenal venous sampling (AVS) may not be necessary in patients younger than 35 years with marked aldosteronism and a solitary adrenal adenoma on imaging. At the time when the guidelines were published, only one study supported the statement, a study that included 6 patients younger than 35 years, all of whom had unilateral adenoma on imaging and unilateral primary aldosteronism (PA), according to AVS. Since then, to our knowledge, four addition...
Source: Experimental and Clinical Endocrinology and Diabetes - July 17, 2023 Category: Endocrinology Authors: Gkaniatsa, Eleftheria Ragnarsson, Oskar Tags: Review Source Type: research

Prevalence of Thyroid Peroxidase and Thyroglobulin Autoantibodies in the Swedish Population
In conclusion, a novel RBA for the determination of TPOab was developed and validated with current methodologies. This study also reports an increasing prevalence of thyroid autoantibodies from adolescence to adulthood. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents  |  Abstract  |  open access Full text (Source: Experimental and Clinical Endocrinology and Diabetes)
Source: Experimental and Clinical Endocrinology and Diabetes - June 28, 2023 Category: Endocrinology Authors: Bergemann, Neele Jonsdottir, Berglind Nilsson, Anna-Lena Lantz, Mikael Lind, Alexander Tags: Article Source Type: research

Relapsing Syndrome of Inappropriate Antidiuretic Hormone Production Responding to Tolvaptan Treatment in a Patient With a Micronodular Formation of the Posterior Pituitary Gland
Exp Clin Endocrinol Diabetes DOI: 10.1055/a-2093-1002The syndrome of inappropriate ADH-secretion (SIADH) is a common cause of low sodium levels with diverse aetiology. Here, we report a case of a 41 years old male patient diagnosed with SIADH and a good response to Tolvaptan therapy. Of interest, as a potential unique cause, magnetic resonance imaging revealed a micronodular structure in the posterior pituitary, while no other common cause of SIADH could be identified. Hence, to the best of our knowledge, this is the first case of a Tolvaptan-responsive SIADH asso...
Source: Experimental and Clinical Endocrinology and Diabetes - June 26, 2023 Category: Endocrinology Authors: Reinke, Lennart M. Seoudy, Anna Katharina G ärtner, Friedericke Rohmann, Nathalie Schulte, Dominik M. Schreiber, Stefan Jansen, Olav Laudes, Matthias Tags: Letter to the Editor Source Type: research

Combined Training Improves Executive Functions Without Changing Brain-Derived Neurotrophic Factor Levels of Middle-Aged and Older Adults with Type 2 Diabetes
Conclusion Combined training improved executive functions independently of alterations in resting BDNF levels after 8 weeks. Furthermore, pre-training BDNF levels explained one-half of the variance in combined training-induced improvements in executive functions. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes)
Source: Experimental and Clinical Endocrinology and Diabetes - June 14, 2023 Category: Endocrinology Authors: Silveira-Rodrigues, Jo ão Gabriel Gard ênia de Holanda Marinho Nogueira, Nathálya Faria, Larissa Oliveira Pereira, Daniele Sirineu Soares, Danusa Dias Tags: Article Source Type: research

Diabetes and Migration
Exp Clin Endocrinol Diabetes 2023; 131: 319-337 DOI: 10.1055/a-1946-3878 Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes)
Source: Experimental and Clinical Endocrinology and Diabetes - June 14, 2023 Category: Endocrinology Authors: Şat, Sebahat Ayd ınkoç-Tuzcu, Kadriye Berger, Faize Barakat, Alain Danquah, Ina Schindler, Karin Fasching, Peter Tags: German Diabetes Association: Clinical Practice Guidelines Source Type: research

Insulin Secretion Capacity as a Crucial Feature to Distinguish Type 1 From Type 2 Diabetes and to Indicate the Need for Insulin Therapy – A Critical Discussion of the ADA/EASD Consensus Statement on the Management of Type 1 Diabetes in Adults
Exp Clin Endocrinol Diabetes DOI: 10.1055/a-2016-8392In the recently published consensus statement on the treatment and management of type 1 diabetes issued by experts from the American (ADA) and European (EASD) diabetes societies, measurement of endogenous insulin secretion using fasting C-peptide is recommended as a diagnostic criterion. In contrast, our group recently suggested fasting C-peptide/glucose ratio (CGR) for the determination of endogenous insulin secretion. In addition, this ratio may turn out as a potential decision aid for pathophysiologically bas...
Source: Experimental and Clinical Endocrinology and Diabetes - June 12, 2023 Category: Endocrinology Authors: Fritsche, Andreas Tags: Commentary Source Type: research

Serum Periostin Levels are Significantly Higher in Patients with Primary Hyperparathyroidism and Closely Related to Osteoporosis
Conclusion This is the first study to determine that serum periostin levels are higher in PHPT patients than those without PHPT and to demonstrate a significant association between serum periostin levels and T scores on DEXA in patients with PHPT. These findings will aid in detecting osteoporosis in patients with PHPT and making the decision for surgery in PHPT patients with no need for DEXA imaging that involves radiation. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full te...
Source: Experimental and Clinical Endocrinology and Diabetes - June 5, 2023 Category: Endocrinology Authors: Yigitdol, Ismail Gulumsek, Erdinc Ozturk, Huseyin Ali Arici, Fatih Necip Akbal, Kubilay Pirinci, Okan Karacay, Mert Cihan, Tutku Naz Totik, Zeynep Gizem Akyildiz, Mustafa Aykut Avci, Begum Seyda Avci, Akkan Sumbul, Hilmi Erdem Tags: Article Source Type: research

Primary Aldosteronism and Drug Resistant Hypertension: A “Chicken-Egg” Story
Exp Clin Endocrinol Diabetes DOI: 10.1055/a-2073-3202Drug-resistant arterial hypertension (RH) is a major risk factor for cardiovascular disease, often due to overlooked underlying causes. Identification of such causes poses significant clinical challenges. In this setting, primary aldosteronism (PA) is a frequent cause of RH and its prevalence in RH patients is likely higher than 20%.The pathophysiological link between PA and the development and maintenance of RH involves target organ damage and the cellular and extracellular effects of aldosterone excess that pr...
Source: Experimental and Clinical Endocrinology and Diabetes - May 31, 2023 Category: Endocrinology Authors: Lenzini, L Pintus, G Rossitto, G Seccia, T M Rossi, G P Tags: Review Source Type: research

Primary Aldosteronism Prevalence – An Unfolding Story
Exp Clin Endocrinol Diabetes DOI: 10.1055/a-2066-2696Primary aldosteronism (PA) is characterized by dysregulated, renin-independent aldosterone excess. Long perceived as rare, PA has emerged as one of the most common causes of secondary hypertension. Failure to recognize and treat PA results in cardiovascular and renal complications, through processes mediated by both direct target tissue insults and indirectly, by hypertension. PA spans a continuum of dysregulated aldosterone secretion, which is typically recognized in late stages after treatment-resistant hypert...
Source: Experimental and Clinical Endocrinology and Diabetes - May 31, 2023 Category: Endocrinology Authors: Charoensri, Suranut Turcu, Adina F. Tags: Review Source Type: research

Association of Dietary Niacin Intake with Diabetes in Adults in the United States
Conclusions Our results suggest that the consumption of adequate amounts of niacin can reduce the risk of diabetes. Furthermore, this protective effect disappeared when the niacin intake was insufficient (less than 15.01 mg/d). [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes)
Source: Experimental and Clinical Endocrinology and Diabetes - May 22, 2023 Category: Endocrinology Authors: Liu, Chan Duan, Wenjuan Xu, Wenming Tags: Article Source Type: research

Association Between Prehospital Blood Glucose Levels and Outcomes in Patients With COVID-19 Infection: A Retrospective Cohort Study
Conclusions In patients with acute COVID-19 infection, prehospital blood glucose levels do not seem to be associated with acute medical unit admission. However, there was an increased risk of 30-day mortality in COVID-19 patients who presented high prehospital blood glucose levels. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents  |  Abstract  |  open access Full text (Source: Experimental and Clinical Endocrinology and Diabetes)
Source: Experimental and Clinical Endocrinology and Diabetes - May 22, 2023 Category: Endocrinology Authors: Fehlmann, Christophe A. Suppan, Laurent Gaudet-Blavignac, Christophe Elia, Nadia Gariani, Karim Tags: Article Source Type: research

Metabolic and Endocrine Complications of Long-COVID-19: A Review
Exp Clin Endocrinol Diabetes DOI: 10.1055/a-2063-8697Over the past two years, the outbreak of coronavirus disease of 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has centralized the interest of the health care systems and the scientific world. The majority of COVID-19-infected individuals recover fully. However, about 12–50% of patients experience various mid- and long-term effects after recovering from the initial illness. These mid- and long-term effects are collectively known as post-COVID-19 condition or 'long-COVID'...
Source: Experimental and Clinical Endocrinology and Diabetes - May 17, 2023 Category: Endocrinology Authors: Bandara, Thushari Deshmukh, Harshal A Abdalla, Mohammed Sathyapalan, Thozhukat Tags: Review Source Type: research

Digestive, Anorectal, and Urogenital Functions in Patients with Type 2 Diabetes Mellitus, Impaired Glucose Tolerance and Normal Glucose Tolerance: Association with Autonomic Neuropathy
Conclusions Long-standing T2DM increases anorectal sphincter activity, and constipation symptoms are associated with higher HbA1c levels. The lack of an association of symptoms with autonomic neuropathy suggests glucotoxicity as the primary mechanism. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes)
Source: Experimental and Clinical Endocrinology and Diabetes - May 17, 2023 Category: Endocrinology Authors: Quast, Daniel R Boronikolos, Georgios C Menge, Bjoern A Breuer, Thomas GK Schenker, Nina Meier, Juris J Tags: Article Source Type: research