Adrenal Vein Sampling in the Young – Necessary or Not?
Exp Clin Endocrinol Diabetes DOI: 10.1055/a-2099-3525Current clinical guidelines from the US Endocrine Society state that adrenal
venous sampling (AVS) may not be necessary in patients younger than 35 years
with marked aldosteronism and a solitary adrenal adenoma on imaging. At the time
when the guidelines were published, only one study supported the statement, a
study that included 6 patients younger than 35 years, all of whom had unilateral
adenoma on imaging and unilateral primary aldosteronism (PA), according to AVS.
Since then, to our knowledge, four additional studies have been published that
provide data on concordance between conventional imaging and AVS among patients
younger than 35 years. In these studies, 7 of 66 patients with unilateral
disease on imaging had bilateral disease, according to AVS. We find it,
therefore, reasonable to conclude that imaging studies alone inaccurately
predict laterality in a significant number of young patients with PA and that
available data challenge the current clinical guidelines. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents | Abstract | Full text
Source: Experimental and Clinical Endocrinology and Diabetes - Category: Endocrinology Authors: Gkaniatsa, Eleftheria Ragnarsson, Oskar Tags: Review Source Type: research