Insulin Secretion Capacity as a Crucial Feature to Distinguish Type 1 From Type 2 Diabetes and to Indicate the Need for Insulin Therapy – A Critical Discussion of the ADA/EASD Consensus Statement on the Management of Type 1 Diabetes in Adults
Exp Clin Endocrinol Diabetes DOI: 10.1055/a-2016-8392In the recently published consensus statement on the treatment and management of
type 1 diabetes issued by experts from the American (ADA) and European (EASD)
diabetes societies, measurement of endogenous insulin secretion using fasting
C-peptide is recommended as a diagnostic criterion. In contrast, our group
recently suggested fasting C-peptide/glucose ratio (CGR) for the
determination of endogenous insulin secretion. In addition, this ratio may turn
out as a potential decision aid for pathophysiologically based differential
therapy of diabetes. In this comment, the following points will be discussed: i)
CGR as the basis of differential diagnosis of type 1 diabetes, ii) CGR as the
basis of treatment decisions for or against insulin in diabetes, and iii) the
ease of application of CGR in clinical practice. The use of CGR may complement
the ADA/EASD recommendations and should provide a practical application
in clinical practice. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents | Abstract | open access Full text
Source: Experimental and Clinical Endocrinology and Diabetes - Category: Endocrinology Authors: Fritsche, Andreas Tags: Commentary Source Type: research