Primary Aldosteronism Prevalence – An Unfolding Story
Exp Clin Endocrinol Diabetes DOI: 10.1055/a-2066-2696Primary aldosteronism (PA) is characterized by dysregulated, renin-independent
aldosterone excess. Long perceived as rare, PA has emerged as one of the most
common causes of secondary hypertension. Failure to recognize and treat PA
results in cardiovascular and renal complications, through processes mediated by
both direct target tissue insults and indirectly, by hypertension. PA spans a
continuum of dysregulated aldosterone secretion, which is typically recognized
in late stages after treatment-resistant hypertension and cardiovascular
and/or renal complications develop. Determining the precise disease
burden remains challenging due to heterogeneity in testing, arbitrary
thresholds, and populations studied. This review summarizes the reports on PA
prevalence among the general population and in specific high-risk subgroups,
highlighting the impact of rigid versus permissive criteria on PA prevalence
perception. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents | Abstract | Full text
Source: Experimental and Clinical Endocrinology and Diabetes - Category: Endocrinology Authors: Charoensri, Suranut Turcu, Adina F. Tags: Review Source Type: research