LncRNA THOR acts as a retinoblastoma promoter through enhancing the combination of c-myc mRNA and IGF2BP1 protein
In conclusion, this study makes clear that lncRNA THOR is up-regulated in retinoblastoma, and its over-expression significantly enhances the malignant phenotype transformation of retinoblastoma cells through up-regulating c-myc expression via enhancing its combination with TGF2BP1 protein. Overall, our study illustrates that lncRNA THOR/c-myc molecular cascade might be another potent target for retinoblastoma treatment. (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - July 20, 2018 Category: Drugs & Pharmacology Source Type: research

LncRNA FOXD2-AS1 regulates chondrocyte proliferation in osteoarthritis by acting as a sponge of miR-206 to modulate CCND1 expression
Publication date: October 2018Source: Biomedicine & Pharmacotherapy, Volume 106Author(s): Lei Cao, Yang Wang, Qiugen Wang, Jianhua HuangAbstractRecently, accumulating evidence demonstrated that the long non-coding RNAs (lncRNAs) play important roles in osteoarthritis (OA) progression. However, the role of lncRNA FOXD2-AS1 on OA is still unclear. In the present study, qRT-PCR showed that expression of FOXD2-AS1 and Cyclin D1 (CCND1) was upregulated in OA cartilage tissues, while miR-206 expression was significantly decreased. CCK-8 and colony formation assays showed that FOXD2-AS1 could promote chondrocytes viability. F...
Source: Biomedicine and Pharmacotherapy - July 20, 2018 Category: Drugs & Pharmacology Source Type: research

Puerarin promoted proliferation and differentiation of dopamine-producing cells in Parkinson’s animal models
ConclusionThe results suggest that PR promote DA neuron survival, proliferation and differentiation.Graphical abstract (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - July 20, 2018 Category: Drugs & Pharmacology Source Type: research

Antioxidant and apoptotic effects of Callistemon lanceolatus leaves and their compounds against human cancer cells
Publication date: October 2018Source: Biomedicine & Pharmacotherapy, Volume 106Author(s): Kamal Ahmad, Zubair Bin Hafeez, Abdul Roof Bhat, Moshahid Alam Rizvi, Sonu C. Thakur, Amir Azam, Fareeda AtharAbstractCallistemon lanceolatus (Myrtaceae) has been utilized in folk medicine and its pharmacological properties are widely studied. Phytochemicals are effectively recognized as bases of pharmacologically potent drugs for the development of anticancer therapeutics. The free radical scavenging potential of numerous extracts of C. lanceolatus leaves, Hexane leaf extract (HLE), Chloroform leaf extract (CLE), Ethyl acetate le...
Source: Biomedicine and Pharmacotherapy - July 20, 2018 Category: Drugs & Pharmacology Source Type: research

Royal jelly increases peripheral circulation by inducing vasorelaxation through nitric oxide production under healthy conditions
Publication date: October 2018Source: Biomedicine & Pharmacotherapy, Volume 106Author(s): Yaoyue Liang, Satomi Kagota, Kana Maruyama, Yuri Oonishi, Shino Miyauchi-Wakuda, Yoshihiko Ito, Shizuo Yamada, Kazumasa ShinozukaAbstractAimsRoyal jelly (RJ) has a variety of reported biological activities, including vasorelaxation and blood pressure–lowering effects. Although functional foods are positively used for health, the effects of RJ on the cardiovascular system in healthy individuals have not been well studied. Therefore, we investigated the mechanisms underlying the vasorelaxation effects of RJ in healthy control ...
Source: Biomedicine and Pharmacotherapy - July 20, 2018 Category: Drugs & Pharmacology Source Type: research

Protective effect of Rotula aquatica Lour against gentamicin induced oxidative stress and nephrotoxicity in Wistar rats
Publication date: October 2018Source: Biomedicine & Pharmacotherapy, Volume 106Author(s): Vysakh A., Abhilash S., Jayesh Kuriakose, Sebastian Jose Midhun, Mathew Jyothis, M.S. LathaAbstractGentamicin is an aminoglycoside antibiotic widely used for the treatment of life-threatening infections caused by Gram-negative bacteria. The use of gentamicin was limited due to its ototoxic and nephrotoxic adverse effects. The current study was designed to evaluate the protective effect of ethyl acetate fraction from Rotula aquatica (EFRA) against gentamicin induced nephrotoxicity. The antioxidant enzymes status, lipid peroxidation...
Source: Biomedicine and Pharmacotherapy - July 19, 2018 Category: Drugs & Pharmacology Source Type: research

Clerodendrum volubile inhibits key enzymes linked to type 2 diabetes but induces cytotoxicity in human embryonic kidney (HEK293) cells via exacerbated oxidative stress and proinflammation
In this study, the antidiabetic properties of the dichloromethane (DCM) fraction of C. volubile leaves were investigated in vitro. Its cytotoxic effect and mechanism of toxicity were also investigated in Human Embryonic Kidney (HEK293) cells. The fraction was subjected to in vitro antioxidant assays using the 2,2′-diphenyl-1-picrylhydrazyl (DPPH) scavenging and Ferric reducing antioxidant power (FRAP) protocols. Its enzyme-inhibitory properties were investigated on α-glucosidase and α-amylase activities. Gas Chromatography Mass Spectroscopy (GCMS) and Fourier Transform Infrared (FTIR) spectroscopic analys...
Source: Biomedicine and Pharmacotherapy - July 18, 2018 Category: Drugs & Pharmacology Source Type: research

Gypenosides reverses depressive behavior via inhibiting hippocampal neuroinflammation
In conclusion, this study demonstrates that gypenosides exhibits the antidepressant-like effects in mice, which may be mediated by the inhibition of microglia and NF-κB signaling in the hippocampus.Graphical abstract (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - July 18, 2018 Category: Drugs & Pharmacology Source Type: research

Ameliorative effects of indomethacin at different concentrations on endothelial insulin resistance through two distinct pathways
Publication date: October 2018Source: Biomedicine & Pharmacotherapy, Volume 106Author(s): Tao Xian, Yuyang Gan, Yi Lu, Mengxi Wang, Wanwan Yuan, Yumeng Zhou, Junye Chen, Kun Wang, Shaofeng Xiong, Qiren HuangAbstractIndomethacin (IDMT), a non-selective inhibitor of cycloxygenase-2 (COX-2), plays important roles in anti-inflammation and analgesia and it is commonly used to treat the patients with rheumatic and rheumatoid arthritis. Besides, various literatures reported that IDMT is a synthetic ligand of peroxisome proliferator activated receptor gamma (PPARγ). Rosiglitazone (RSG), an insulin-sensitizer, is also a s...
Source: Biomedicine and Pharmacotherapy - July 18, 2018 Category: Drugs & Pharmacology Source Type: research

Scoparone prevents IL-1β-induced inflammatory response in human osteoarthritis chondrocytes through the PI3K/Akt/NF-κB pathway
Publication date: October 2018Source: Biomedicine & Pharmacotherapy, Volume 106Author(s): Chao Lu, Yanqi Li, Shouye Hu, Yuanzhen Cai, Zhi Yang, Kan PengAbstractOsteoarthritis (OA) is a degenerative joint disease that is commonly accompanied by inflammation. Scoparone is a biologically active constituent isolated from Artemisia capillaris and possesses anti-inflammatory activity. However, the effect of scoparone on inflammatory response in OA has not been authenticated. The aim of this study was to evaluate the role of scoparone in OA in vitro. Our results showed that IL-1β treatment significantly inhibited the cel...
Source: Biomedicine and Pharmacotherapy - July 18, 2018 Category: Drugs & Pharmacology Source Type: research

Astilbin inhibits high glucose-induced autophagy and apoptosis through the PI3K/Akt pathway in human proximal tubular epithelial cells
In conclusion, astilbin attenuated HG-induced autophagy and apoptosis in HK-2 cells through the PI3K/Akt pathway. The results indicated that astilbin might be a new therapeutic agent and be useful for improving clinical management of DN. (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - July 18, 2018 Category: Drugs & Pharmacology Source Type: research

Effect of dual mTOR inhibitor on TGFβ1-induced fibrosis in primary human urethral scar fibroblasts
ConclusionOSI-027 can inhibit the pro-fibrotic effects of TGFβ1 significantly compared with rapamycin in HUSFs. These findings may provide a new therapy in the adjunctive treatment of urethral stricture disease.Graphical abstract (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - July 18, 2018 Category: Drugs & Pharmacology Source Type: research

Aquilariae Lignum extract attenuates glutamate-induced neuroexcitotoxicity in HT22 hippocampal cells
Publication date: October 2018Source: Biomedicine & Pharmacotherapy, Volume 106Author(s): Jin-Seok Lee, Won-Yong Kim, Yoo-Jin Jeon, Sam-Keun Lee, Chang-Gue SonAbstractAn imbalance between excitatory and inhibitory neurotransmitters is known to induce neuronal excitotoxicity which is a major cause of neurodegenerative disorders. Excessive glutamate concentration leads to the neuronal death by increasing oxidative stress and affecting the apoptotic signaling pathway. We investigated the anti-excitotoxic effects and associated working mechanisms of 30% ethanol extract of Aquilariae Lignum (ALE) against hippocampal neurona...
Source: Biomedicine and Pharmacotherapy - July 18, 2018 Category: Drugs & Pharmacology Source Type: research

MiR-32 promotes tumorigenesis of colorectal cancer by targeting BMP5
In this study, we aimed to explore the role of miR-32 in CRC using bioinformatic analysis and functional assays. We collected 28 pairs of CRC tumor tissues and adjacent normal tissues and confirmed miR-32 was significantly upregulated in CRC. Expression and clinical data from The Cancer Genome Atlas (TCGA) identified miR-32 expression is associated with CRC lymphatic invasion, metastasis, and correlates with patients’ poor survival. Functional studies demonstrated that overexpression of miR-32 in LoVo cells promoted cell proliferation and migration, whereas inhibition of miR-32 in HCT 116 cells showed the opposite re...
Source: Biomedicine and Pharmacotherapy - July 18, 2018 Category: Drugs & Pharmacology Source Type: research

Involvement of JNK1/2-NF-κBp65 in the regulation of HMGB2 in myocardial ischemia/reperfusion-induced apoptosis in human AC16 cardiomyocytes
Publication date: October 2018Source: Biomedicine & Pharmacotherapy, Volume 106Author(s): Wei Zhang, Yangyang Zhang, Keke Ding, Hengbing Zhang, Qian Zhao, Zheng Liu, Yawei XuAbstractJNK1/2 and NF-κB signal are essential signaling pathways that mediate a variety of cellular processes, including cell survival, apoptosis, inflammation and angiogenesis. JNK1/2 activation and NF-κBp65 nuclear translocation have been found in ischemia/reperfusion (I/R)-induced injury. However, the regulation of JNK1/2-NF-κBp65 signaling pathway remains unclear. To examine the function and possible mechanism of HMGB2 in I/R-...
Source: Biomedicine and Pharmacotherapy - July 18, 2018 Category: Drugs & Pharmacology Source Type: research

miR-539 enhances chemosensitivity to cisplatin in non-small cell lung cancer by targeting DCLK1
In conclusion, miR-539 increased the chemosensitivity to DDP in NSCLC cells by directly targeting DCLK1, which might provide potential biomarkers for DDP-resistant NSCLC therapy.Graphical abstract (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - July 18, 2018 Category: Drugs & Pharmacology Source Type: research

Novel steroid derivatives: synthesis, antileishmanial activity, mechanism of action, and in silico physicochemical and pharmacokinetics studies
Publication date: October 2018Source: Biomedicine & Pharmacotherapy, Volume 106Author(s): Juliana da Trindade Granato, Juliana Alves dos Santos, Stephane Lima Calixto, Natália Prado da Silva, Jefferson da Silva Martins, Adilson David da Silva, Elaine Soares CoimbraAbstractThe search for new drugs for the treatment of leishmaniasis is an important strategy for improving the current therapeutic arsenal for the disease. There are several limitations to the available drugs including high toxicity, low efficacy, prolonged parenteral administration, and high costs. Steroids are a diverse group of compounds with variou...
Source: Biomedicine and Pharmacotherapy - July 18, 2018 Category: Drugs & Pharmacology Source Type: research

Ginsenoside Re inhibits vascular neointimal hyperplasia in balloon-injured carotid arteries through activating the eNOS/NO/cGMP pathway in rats
Publication date: October 2018Source: Biomedicine & Pharmacotherapy, Volume 106Author(s): Yang Gao, Chen-Ying Gao, Ping Zhu, Shang-Fu Xu, Yun-Mei Luo, Jiang Deng, Dan-Li YangAbstractGinsenoside Re (GS-Re) is one of the main ingredients of ginseng, a widely known Chinese traditional medicine, and has a variety of beneficial effects, including vasorelaxation, antioxidative, anti-inflammatory, and anticancer properties. The aims of the present study were to observe the effect of GS-Re on balloon injury-induced neointimal hyperplasia in the arteries and to investigate the mechanisms underlying this effect. A rat vascular n...
Source: Biomedicine and Pharmacotherapy - July 18, 2018 Category: Drugs & Pharmacology Source Type: research

Analyses of long non-coding RNA and mRNA profiles in right ventricle myocardium of acute right heart failure in pulmonary arterial hypertension rats
Publication date: October 2018Source: Biomedicine & Pharmacotherapy, Volume 106Author(s): Yanan Cao, Yue Yang, Lu Wang, Longyan Li, Junjie Zhang, Xiaowei Gao, Sisi Dai, Yanrong Zhang, Qulian Guo, Yong Gang Peng, E WangAbstractWe investigated the changes in expression profile and potential roles of long noncoding RNAs (lncRNAs) in right ventricle (RV) myocardium of pulmonary arterial hypertension (PAH) rats with RV failure induced by acute inflammation.Sprague-Dawley rats were given monocrotaline to establish a PAH model and acute heart failure was induced by an injection of lipopolysaccharide. The RV failure was confir...
Source: Biomedicine and Pharmacotherapy - July 18, 2018 Category: Drugs & Pharmacology Source Type: research

Boerhaavia diffusa inhibits key enzymes linked to type 2 diabetes in vitro and in silico; and modulates abdominal glucose absorption and muscle glucose uptake ex vivo
Publication date: October 2018Source: Biomedicine & Pharmacotherapy, Volume 106Author(s): Olajumoke A. Oyebode, Ochuko L. Erukainure, Chika I. Chukwuma, Collins U. Ibeji, Neil A. Koorbanally, Shahidul IslamAbstractThe present study investigated the in vitro and ex vivo antioxidant, anti-diabetic and anti-obesogenic potentials of different solvent (ethyl acetate, ethanol and water) extracts from the aerial parts of Boerhaavia diffusa. The ferric reducing antioxidant power (FRAP), DPPH scavenging activity and the ameliorative effects of the extracts on Fe2+-induced oxidative injury was investigated both in vitro and ex v...
Source: Biomedicine and Pharmacotherapy - July 18, 2018 Category: Drugs & Pharmacology Source Type: research

Hydrogen alleviates cellular senescence via regulation of ROS/p53/p21 pathway in bone marrow-derived mesenchymal stem cells in vivo
Publication date: October 2018Source: Biomedicine & Pharmacotherapy, Volume 106Author(s): Wenbo Zhang, Chao Huang, Aijun Sun, Liang Qiao, Xi Zhang, Junlong Huang, Xuejun Sun, Xiangqun Yang, Shanquan SunAbstractSenescence has become a hot point issue in recent decades and requires urgent attention. As a novel and effective antioxidant, hydrogen has been proved to alleviate cellular senescence in endothelial cells in vitro. However, the effects and mechanisms of hydrogen on senescence in vivo are still unclear. In the present study, 12-month-old Sprague Dawley (SD) rats were intraperitoneal administration of hydrogen-ric...
Source: Biomedicine and Pharmacotherapy - July 18, 2018 Category: Drugs & Pharmacology Source Type: research

Exosome-mediated miR-200b promotes colorectal cancer proliferation upon TGF-β1 exposure
Publication date: October 2018Source: Biomedicine & Pharmacotherapy, Volume 106Author(s): Zhen Zhang, Tongchao Xing, Yanhui Chen, Jiangmei XiaoAbstractExosome are emerging mediators of intercellular communication. Cancer-secreted exosome has an effect on the exosome donor cells and support cancer growth and metastasis. Here, we examine the TGF-β1, a multifunctional cytokine involved in the regulation of cellular signaling pathways in human cancers, significantly contributes to upregulate miR-200b in exosome from colorectal cancer cell lines. The miR-200b enriched in exosome can be transferred into a new target cel...
Source: Biomedicine and Pharmacotherapy - July 18, 2018 Category: Drugs & Pharmacology Source Type: research

Long noncoding RNA HOXD-AS1 aggravates osteosarcoma carcinogenesis through epigenetically inhibiting p57 via EZH2
In conclusion, our study confirmed that HOXD-AS1 could interact with EZH2, and then repress p57 expression, to aggravate osteosarcoma oncogenesis. which provide new idea for the osteosarcoma tumorigenesis.Graphical abstract (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - July 14, 2018 Category: Drugs & Pharmacology Source Type: research

Hepatoprotective effect of α-mangostin against lipopolysaccharide/d-galactosamine-induced acute liver failure in mice
In conclusion, the results indicated that α-MG could protect against LPS/D-GalN-induced liver failure by activating Nrf2 to induce antioxidant defense and inhibiting TLR4 signaling pathway to induce anti-inflammatory effect.Graphical abstract (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - July 14, 2018 Category: Drugs & Pharmacology Source Type: research

Schisandrin A prevents oxidative stress-induced DNA damage and apoptosis by attenuating ROS generation in C2C12 cells
This study was conducted to evaluate the protective effect of schisandrin A on DNA damage and apoptosis induced by hydrogen peroxide (H2O2) in C2C12 cells. Results showed that schisandrin A effectively attenuated H2O2-induced cytotoxicity and DNA damage, which was related to the blockage of ROS accumulation. Schisandrin A also prevented the decrease in ATP content by H2O2 and restored the H2O2-induced activation of AMP-activated protein kinase. In addition, schisandrin A prevented the release of H2O2-induced cytochrome c into the cytoplasm presumably by inhibiting the loss of mitochondrial membrane potential and the change...
Source: Biomedicine and Pharmacotherapy - July 14, 2018 Category: Drugs & Pharmacology Source Type: research

Assessment of dose-response relationship of 5-fluorouracil to murine intestinal injury
This study aims to assess the dose-response relationship between the severity of intestinal injury and different doses of 5-FU, and to determine a proper dosing for the murine model. We found that mice in the 5-FU groups gradually lost body weight over time. Increasing doses of 5-FU resulted in more severe diarrhea, with a concomitant increase in mortality. Histopathological damage was more severe in mice that received higher doses of 5-FU. In addition, plasma diamine oxidase (DAO) activity decreased in experimental mice with intestinal injury in a dose-dependent way. TUNEL and western blot analysis showed cell apoptosis i...
Source: Biomedicine and Pharmacotherapy - July 14, 2018 Category: Drugs & Pharmacology Source Type: research

Reversible effects of anabolic steroid abuse on cyto-architectures of the heart, kidneys and testis in adult male mice
In conclusion, these results confirmed that the use of AAS is associated with a lot of deleterious effects on the cardiac, nephritic and gonadic tissues which cannot be reversible. (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - July 14, 2018 Category: Drugs & Pharmacology Source Type: research

Suppression of microRNA-495 alleviates high-glucose-induced retinal ganglion cell apoptosis by regulating Notch/PTEN/Akt signaling
In this study, we aimed to investigate whether miR-495 is involved in regulating HG-induced apoptosis of RGCs and reveal its possible relevance in diabetic retinopathy. We found that miR-495 was significantly upregulated in HG-treated RGCs. Downregulation of miR-495 protected RGCs against HG-induced apoptosis, whereas overexpression of miR-495 had the opposite effect. Notably, Notch1 was identified as a target gene of miR-495, as miR-495 negatively regulated Notch1 expression and the Notch signaling pathway. Moreover, downregulation of miR-495 inhibited PTEN expression while promoting Akt activation. However, knockdown of ...
Source: Biomedicine and Pharmacotherapy - July 14, 2018 Category: Drugs & Pharmacology Source Type: research

Time-shifted co-administration of sub-analgesic doses of ambroxol and pregabalin attenuates oxaliplatin-induced cold allodynia in mice
In this study, the ability of pregabalin and ambroxol, used as single drugs or in combinations administered in a time-shifted manner to attenuate cold allodynia was assessed in the mouse cold plate test. The hot plate test was additionally used to assess antinociceptive properties of ambroxol in the acute, thermally-induced pain model. Locomotor activity and motor coordination of mice were also evaluated. In silico studies were undertaken to predict potential binding of ambroxol to sodium channel (Nav) subtypes whose overexpression is implicated in the development of oxaliplatin-induced neuropathic pain.Key findingsA hyper...
Source: Biomedicine and Pharmacotherapy - July 14, 2018 Category: Drugs & Pharmacology Source Type: research

Betulin inhibits lipopolysaccharide/D-galactosamine-induced acute liver injury in mice through activating PPAR-γ
In conclusion, all these results revealed that betulin could possess potential therapeutic effect for LPS/D-Gal-induced acute liver injury. (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - July 14, 2018 Category: Drugs & Pharmacology Source Type: research

Cytotoxicity and apoptosis enhancement in breast and cervical cancer cells upon coadministration of mitomycin C and essential oils in nanoemulsion formulations
Publication date: October 2018Source: Biomedicine & Pharmacotherapy, Volume 106Author(s): Waad A. Al-Otaibi, Mayson H. Alkhatib, Abdulwahab Noor WaliAbstractThe present study aimed to solubilize the antineoplastic agent, mitomycin C (MMC), in two nanoemulsions (NEs) consisting of different essential oils (ginger (Gi) and frankincense (Fr)) in order to examine their anticancer activities on the HeLa cervical cancer cells and MCF-7 breast cancer cells. The two NEs-based Gi and Fr oil were produced by a high-pressure homogenization technique followed by solubilizing of the MMC in both NE formulas. The produced formulas we...
Source: Biomedicine and Pharmacotherapy - July 14, 2018 Category: Drugs & Pharmacology Source Type: research

MiR-299-3p functions as a tumor suppressor via targeting Sirtuin 5 in hepatocellular carcinoma
Publication date: October 2018Source: Biomedicine & Pharmacotherapy, Volume 106Author(s): Shan Dang, Jian Zhou, Zongyan Wang, Kunning Wang, Shejiao Dai, Shuixiang HeAbstractHepatocellular carcinoma(HCC) is one of the most common cancers in the world, with the characteristics of high morbidity and mortality. Though the levels of diagnosis and treatment of HCC have been largely improved recently, the prognosis of these patients remains unacceptable. Thus, it is urgent for us to discover the exact mechanisms and determine some new biomarkers for HCC. Previous studies revealed that microRNAs (miRNAs) played a critical role...
Source: Biomedicine and Pharmacotherapy - July 14, 2018 Category: Drugs & Pharmacology Source Type: research

Liquiritigenin attenuates high glucose-induced mesangial matrix accumulation, oxidative stress, and inflammation by suppression of the NF-κB and NLRP3 inflammasome pathways
In conclusion, these results demonstrated that liquiritigenin attenuated HG-induced ECM accumulation, oxidative stress, and inflammation by suppression of the NF-κB and NLRP3 inflammasome pathways, suggesting that liquiritigenin might be a promising therapeutic agent for preventing the development of DN.Graphical abstract (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - July 14, 2018 Category: Drugs & Pharmacology Source Type: research

miR-335-5p targeting ICAM-1 inhibits invasion and metastasis of thyroid cancer cells
This study will help us better understand the pathogenesis of thyroid cancer and provide new insights into the treatment of this disease. (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - July 14, 2018 Category: Drugs & Pharmacology Source Type: research

Thymoquinone: A novel strategy to combat cancer: A review
Publication date: October 2018Source: Biomedicine & Pharmacotherapy, Volume 106Author(s): Muhammad Imran, Abdur Rauf, Imtiaz Ali Khan, Muhammad Shahbaz, Tahira Batool Qaisrani, Sri Fatmawati, Tareq Abu-Izneid, Ali Imran, Khaliq Ur Rahman, Tanweer Aslam GondalAbstractThe higher consumption of fruit, herbs, spices, and vegetables is well known and practical strategy to cure human cancers owing to their presence of bioactive compounds. Among these, Nigella sativa is a promising source of bioactive compounds including thymoquinone, monoterpenes, p-cymene and α-piene etc. Thymoquinone has been found effective to inhib...
Source: Biomedicine and Pharmacotherapy - July 12, 2018 Category: Drugs & Pharmacology Source Type: research

A molecular approach in drug development for Alzheimer’s disease
Publication date: October 2018Source: Biomedicine & Pharmacotherapy, Volume 106Author(s): Snezana Agatonovic-Kustrin, Christine Kettle, David W. MortonAbstractAn increase in dementia numbers and global trends in population aging across the world prompts the need for new medications to treat the complex biological dysfunctions, such as neurodegeneration associated with dementia. Alzheimer’s disease (AD) is the most common form of dementia. Cholinergic signaling, which is important in cognition, is slowly lost in AD, so the first line therapy is to treat symptoms with acetylcholinesterase inhibitors to increase lev...
Source: Biomedicine and Pharmacotherapy - July 12, 2018 Category: Drugs & Pharmacology Source Type: research

Emerging role of lncRNAs in systemic lupus erythematosus
Publication date: October 2018Source: Biomedicine & Pharmacotherapy, Volume 106Author(s): Chan-Na Zhao, Yan-Mei Mao, Li-Na Liu, Xiao-Mei Li, De-Guang Wang, Hai-Feng PanAbstractLong non-coding RNAs (lncRNAs), defined as ≥200 base pairs in length but have little translation potential, play a key role in imprinting control, immune cell differentiation, apoptosis and immune responses. Recently, many potential lncRNAs have been revealed to contribute to a new layer of molecular regulation of systemic lupus erythematosus (SLE). Immune-related functional lncRNAs may serve as novel therapeutic targets and disease biomarkers...
Source: Biomedicine and Pharmacotherapy - July 12, 2018 Category: Drugs & Pharmacology Source Type: research

Appraisal of mechanisms of radioprotection and therapeutic approaches of radiation countermeasures
Publication date: October 2018Source: Biomedicine & Pharmacotherapy, Volume 106Author(s): Krishna N. Mishra, Belal A. Moftah, Ghazi A. AlsbeihAbstractRadiation countermeasures are radioprotective agents that reduce the harmful effects of ionizing radiation. They have wide range of applications extending from protection of normal tissues of cancer patients during radiotherapy to safeguard people aftermath of radiologic or nuclear accidents. Despite the screening of thousands of natural and synthetic compounds, only few found place in clinic with limited tolerance. Therefore, mechanistic understanding is essential in the...
Source: Biomedicine and Pharmacotherapy - July 12, 2018 Category: Drugs & Pharmacology Source Type: research

Emerging landscape in psoriasis management: From topical application to targeting biomolecules
Publication date: October 2018Source: Biomedicine & Pharmacotherapy, Volume 106Author(s): Vamshi Krishna Rapalli, Gautam Singhvi, Sunil Kumar Dubey, Gaurav Gupta, Dinesh Kumar Chellappan, Kamal DuaAbstractPsoriasis is a chronic autoimmune skin disorder affecting 2–3% of the world population. It has characteristic features such as increased keratinocyte proliferation and production of inflammatory mediators. The treatment involves various strategies including topical, systemic, phototherapy and biologics. Topical therapies are preferred for mild to moderate psoriasis conditions over the systemic therapies which ar...
Source: Biomedicine and Pharmacotherapy - July 12, 2018 Category: Drugs & Pharmacology Source Type: research

Role of oxidative stress in pathology of chronic prostatitis/chronic pelvic pain syndrome and male infertility and antioxidants function in ameliorating oxidative stress
Publication date: October 2018Source: Biomedicine & Pharmacotherapy, Volume 106Author(s): Awais Ullah Ihsan, Farhan Ullahp Khan, Puregmaa Khongorzul, Khalil Ali Ahmad, Muhammad Naveed, Sufia Yasmeen, Yanfang Cao, Abdoh Taleb, Richinandan Maiti, Fahad Akhter, Xiaoqian Liao, Xue Li, Yijie Cheng, Hidayat Ullah Khan, Khurshid Alam, Xiaohui ZhouAbstractOxidative stress (OS) is a result of the imbalance between reactive oxygen species (ROS) and antioxidants in the body that can cause tissue damage. Oxidative stress has a significant involvement in the pathogenesis of chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS)...
Source: Biomedicine and Pharmacotherapy - July 12, 2018 Category: Drugs & Pharmacology Source Type: research

HUWE1 upregulation has tumor suppressive effect in human prostate cancer cell lines through c-Myc
ConclusionHUWE1 overexpression could functionally suppress CaP development bothin vitro and in vivo, possibly by inverse regulation on c-Myc. (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - July 12, 2018 Category: Drugs & Pharmacology Source Type: research

Effects of multi and selective targeted tyrosine kinase inhibitors on function and signaling of different bladder cancer cells
ConclusionRTK and EMT related transcript analysis separate bladder cancer cells in two clusters. Functional responses towards TKI258 and BGJ398 treatment of bladder Fcancer cells were heterogeneous with deviating effects on signaling and possibly different therapeutic outcome.Graphical abstract (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - July 12, 2018 Category: Drugs & Pharmacology Source Type: research

Effect of herbal mixture composed of Alchemilla vulgaris and Mimosa on wound healing process
Publication date: October 2018Source: Biomedicine & Pharmacotherapy, Volume 106Author(s): Jawun Choi, Yang-Gyu Park, Min-Sang Yun, Jae-Won SeolAbstractAlchemilla vulgaris and Mimosa tenuiflora (Mimosa) have been used to treat cutaneous wounds as a traditional remedy due to their various biological activities. But, there are only a few studies about the effects of these herbs on wound healing. The purpose of this study is to investigate the wound healing effect of the herbal mixture, consisting of A. vulgaris and Mimosa, in mice and to determine the activity of the extract in vitro. In present study, application of an o...
Source: Biomedicine and Pharmacotherapy - July 12, 2018 Category: Drugs & Pharmacology Source Type: research

Silencing of PINK1 represses cell growth, migration and induces apoptosis of lung cancer cells
This study might lead to PINK1 kinase as a novel therapeutic target for lung cancer treatment. (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - July 12, 2018 Category: Drugs & Pharmacology Source Type: research

Calycosin inhibits nasopharyngeal carcinoma cells by influencing EWSAT1 expression to regulate the TRAF6-related pathways
Publication date: October 2018Source: Biomedicine & Pharmacotherapy, Volume 106Author(s): Lingping Kong, Xin Li, Hong Wang, Guangyao He, Anzhou TangAbstractThe incidence of nasopharyngeal carcinoma (NPC) in China is relatively higher than that throughout the rest of the world, and NPC is geographically distributed. Long non-coding RNA (lncRNA) plays a key role in the development of tumors. Recent studies have found that the lncRNA Ewing sarcoma-associated transcript 1 (EWSAT1) is highly expressed in various tumors and also in NPCs. The isoflavone calycosin, which is a typical Chinese herbal medicine, can inhibit the gr...
Source: Biomedicine and Pharmacotherapy - July 12, 2018 Category: Drugs & Pharmacology Source Type: research

Neuroprotective effect of formononetin against TBI in rats via suppressing inflammatory reaction in cortical neurons
Publication date: October 2018Source: Biomedicine & Pharmacotherapy, Volume 106Author(s): Zhengzhao Li, Guang Zeng, Xiaowen Zheng, Wenbo Wang, Yun Ling, Huamin Tang, Jianfeng ZhangAbstractTraumatic brain injury (TBI) refers to external force-induced brain damage, characterized with necrosis and cell loss in cerebral cortex. Interestingly, a plant-extract named formononetin (FN) is found to possess promising pharmacological activities, including cellular neuroprotection. Thus, we propose that FN may exert biological protection against TBI and discuss the underlying mechanism. In the current study, a rat TBI model was es...
Source: Biomedicine and Pharmacotherapy - July 12, 2018 Category: Drugs & Pharmacology Source Type: research

Heshouwu (Polygonum multiflorum Thunb.) ethanol extract suppresses pre-adipocytes differentiation in 3T3-L1 cells and adiposity in obese mice
This study investigated whether Heshouwu (Polygonum multiflorum Thunb.) root ethanol extract (PME) has anti-obesity activity using 3T3-L1 cells and high-fat diet (HFD)-induced obese mice. Treatment with PME (5 and 10 μg/mL) dose-dependently suppressed 3T3-L1 pre-adipocyte differentiation to adipocytes and cellular triglyceride contents. In addition, PME inhibited mRNA and protein expression of adipogenic transcription factors such as CCAAT/enhancer-binding protein α (C/EBPα) and peroxisome proliferator-activated receptor γ (PPARγ), which led to down-regulation of fatty acid synthase gene expres...
Source: Biomedicine and Pharmacotherapy - July 12, 2018 Category: Drugs & Pharmacology Source Type: research

Evidence of hypoglycemic, lipid-lowering and hepatoprotective effects of the Bixin and Bixin: β-CD inclusion compound in high-fat-fed obese mice
In conclusion, our study suggested that the oral administration of the Bixin and Bix: β-CD inclusion compound improved the metabolic parameters evaluate in obese mice, being more palatable and hepatoprotective.Graphical abstract (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - July 12, 2018 Category: Drugs & Pharmacology Source Type: research

Apigenin suppresses mouse peritoneal fibrosis by down-regulating miR34a expression
Publication date: October 2018Source: Biomedicine & Pharmacotherapy, Volume 106Author(s): Yiming Zhang, Qiaoling Sun, Xiang Li, Xiaofen Ma, Yang Li, Zhanfeng Jiao, Xiang-Dong YangAbstractPeritoneal fibrosis is a severe side-effect of chronic peritoneal dialysis in patients with end-stage renal disease, but not enough effective therapeutic drugs are currently available in clinics. The aim of this study was to evaluate the effects of apigenin and miRNA on the progression of peritoneal fibrosis. We treated isolated mouse mesothelial peritoneal cells (MMCs) with high glucose (HG), to induce fibrosis. We used qRT-PCR and We...
Source: Biomedicine and Pharmacotherapy - July 12, 2018 Category: Drugs & Pharmacology Source Type: research

Ginger alleviates hyperglycemia-induced oxidative stress, inflammation and apoptosis and protects rats against diabetic nephropathy
In conclusion, this study strongly suggests that Z. officinale rhizome extract exerts a protective role against diabetes-induced renal injury by ameliorating oxidative stress, inflammation and apoptosis.Graphical abstract (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - July 12, 2018 Category: Drugs & Pharmacology Source Type: research