High expression of HMBOX1 contributes to poor prognosis of gastric cancer by promoting cell proliferation and migration
In conclusion, HMBOX1 was upregulated in gastric cancer and correlated with gastric cancer cell proliferation and migration. Moreover, HMBOX1 combined CD133 might be useful to predict survival of patients with advanced gastric cancer. (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - April 20, 2019 Category: Drugs & Pharmacology Source Type: research

Imatinib-induced changes in the expression profile of microRNA in the plasma and heart of mice—A comparison with doxorubicin
Publication date: July 2019Source: Biomedicine & Pharmacotherapy, Volume 115Author(s): Barbora Hanousková, Mikuláš Skála, Veronika Brynychová, Tomáš Zárybnický, Veronika Skarková, Petra Kazimírová, Andrea Vernerová, Pavel Souček, Lenka Skálová, Radek Pudil, Petra MatouškováAbstractCardiotoxicity is a serious adverse reaction to cancer chemotherapy and may lead to critical heart damage. Imatinib mesylate (IMB), a selective tyrosine kinase inhibitor, is sometimes accompanied by severe cardiovascular com...
Source: Biomedicine and Pharmacotherapy - April 18, 2019 Category: Drugs & Pharmacology Source Type: research

Green propolis extract promotes in vitro proliferation, differentiation, and migration of bone marrow stromal cells
ConclusionWe have demonstrated that propolis extract was not toxic to BMMSCs (
Source: Biomedicine and Pharmacotherapy - April 18, 2019 Category: Drugs & Pharmacology Source Type: research

Toxic, cytogenetic and antitumor evaluations of [6]-gingerol in non-clinical in vitro studies
Publication date: July 2019Source: Biomedicine & Pharmacotherapy, Volume 115Author(s): Rosália Maria Tôrres de Lima, Antonielly Campinho dos Reis, José Victor de Oliveira Santos, José Roberto de Oliveira Ferreira, Antonio Lima Braga, José Williams Gomes de Oliveira Filho, Ag-Anne Pereira Melo de Menezes, Ana Maria Oliveira Ferreira da Mata, Marcus Vinícius Oliveira Barros de Alencar, Debora Caroline do Nascimento Rodrigues, Paulo Michel Pinheiro Ferreira, Teresinha de Jesus Aguiar dos Santos Andrade, Juan Carlos Ramos Gonçalves, Felipe Cavalcanti Carneiro da Silva, Jo&ati...
Source: Biomedicine and Pharmacotherapy - April 17, 2019 Category: Drugs & Pharmacology Source Type: research

Preliminary studies on the anti-osteoporosis activity of Baohuoside I
Publication date: July 2019Source: Biomedicine & Pharmacotherapy, Volume 115Author(s): Yanhai Xi, Tingwang Jiang, Jiangming Yu, Mintao Xue, Ning Xu, Jiankun Wen, Weiheng Wang, Hailong He, Xiaojian YeAbstractThe aim of the present study was to investigate the anti-osteoporotic activity of Baohuoside I, an active component of Herba Epimedii. Effects of Baohuoside I on the differentiation of BMSCs and the formation of adipocytes were evaluated using alkaline phosphatase staining and methylene blue staining method, respectively. Osteoporosis model was established in ovariectomized rats prior to the measurement of the serum...
Source: Biomedicine and Pharmacotherapy - April 17, 2019 Category: Drugs & Pharmacology Source Type: research

Hypoxia-induced microRNA-141 regulates trophoblast apoptosis, invasion, and vascularization by blocking CXCL12β/CXCR2/4 signal transduction
ConclusionInduction of miR-141 by hypoxia promotes apoptosis, and inhibits the invasion and vascularization capabilities of HTR-8/SVneo cells by suppressing the CXCL12β and CXCR2/4 signaling pathways. (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - April 17, 2019 Category: Drugs & Pharmacology Source Type: research

Corrigendum to “Herb-drug interaction: A case study of effects and involved mechanisms of cisplatin on the pharmacokinetics of ginsenoside Rb1 in tumor-bearing mice” [Biomed. Pharmacother. 110 (2019) 95–104]
Publication date: Available online 4 April 2019Source: Biomedicine & PharmacotherapyAuthor(s): Jing Zhou, Jie Wu, Cheng-Ying Wu, Fang Long, Hong Shen, Wei Zhang, Song-Lin Li (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - April 17, 2019 Category: Drugs & Pharmacology Source Type: research

Carbenoxolone ameliorates insulin sensitivity in obese mice induced by high fat diet via regulating the IκB-α/NF-κB pathway and NLRP3 inflammasome
In conclusions, we demonstrate that CBX has a significant protective effect on diet-induced obesity in mice. The potential mechanisms include inhibiting IκB-α/NF-κB pathway, restricting the production of NLRP3 inflammasome and other inflammatory factors, reducing the expression of p-IRS-1, increasing the expressions of p-PI3K and p-AKT, thus ameliorating insulin resistance in liver and skeletal muscle of high-fat diet mice. Therefore CBX is an active agent against diet-induced obesity and is given the opportunity for the treatment of obesity related diseases. (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - April 17, 2019 Category: Drugs & Pharmacology Source Type: research

Borrelia burgdorferi basic membrane protein A initiates proinflammatory chemokine storm in THP 1-derived macrophages via the receptors TLR1 and TLR2
Publication date: July 2019Source: Biomedicine & Pharmacotherapy, Volume 115Author(s): Hua Zhao, Xiting Dai, Xinlin Han, Aihua Liu, Fukai Bao, Ruolan Bai, Zhenhua Ji, Miaomiao Jian, Zhe Ding, Manzama-Esso Abi, Taigui Chen, Lisha Luo, Mingbiao Ma, Lvyan TaoAbstractLyme disease, reffered to as Lyme borreliosis, is a tick-borne zoonotic disease caused by Borrelia burgdorferi spirochetes. Lyme arthritis, the most common, serious and harmful manifestation during the late stages of Lyme disease, is closely associated with the Borrelia burgdorferi basic membrane protein A (BmpA). Chemokines are also reported to have an import...
Source: Biomedicine and Pharmacotherapy - April 17, 2019 Category: Drugs & Pharmacology Source Type: research

Current status of nanomaterial-based treatment for hepatocellular carcinoma
Publication date: August 2019Source: Biomedicine & Pharmacotherapy, Volume 116Author(s): Badriya Baig, Sulafa Abdel Halim, Aaminah Farrukh, Yaser Greish, Amr AminAbstractCancer continues to be the leading cause of death worldwide. Hepatocellular carcinoma (HCC), a prominent form of liver cancer, is the second leading cause of cancer-related deaths, thanks to the lack of efficient diagnostic tools and consequently late diagnosis and to the scarce of available suitable treatments. Thus, novel approaches to treat HCC are in demand. The fast-growing field of nanotechnology offers infinite possibilities to design materials ...
Source: Biomedicine and Pharmacotherapy - April 17, 2019 Category: Drugs & Pharmacology Source Type: research

Autophagy represses fascaplysin-induced apoptosis and angiogenesis inhibition via ROS and p8 in vascular endothelia cells
Publication date: June 2019Source: Biomedicine & Pharmacotherapy, Volume 114Author(s): Ning Meng, Xin Mu, Xin Lv, Lukui Wang, Ning Li, Yan GongAbstractFascaplysin is a natural product isolated from marine sponges that exhibits broad anticancer activity. Previous studies revealed that fascaplysin-induced apoptosis and angiogenesis inhibition in vascular endothelial cells contributed to its anticancer activity. Accumulating evidence indicates that autophagy plays a significant role in mediating the function of vascular endothelial cells (VECs) and the response to cancer therapy. However, the effect of fascaplysin on VEC ...
Source: Biomedicine and Pharmacotherapy - April 16, 2019 Category: Drugs & Pharmacology Source Type: research

MiR-219a-5p enhances cisplatin sensitivity of human non-small cell lung cancer by targeting FGF9
In conclusion, this study demonstrated miR-219a-5p plays a crucial role in the development of acquired drug resistance to DDP in NSCLC cells by targeting FGF9 and might be a therapeutic target for DDP resistance in clinical practice. (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - April 16, 2019 Category: Drugs & Pharmacology Source Type: research

Yinchenhao decoction suppresses rat liver fibrosis involved in an apoptosis regulation mechanism based on network pharmacology and transcriptomic analysis
In conclusion, 45 active components and 296 potential targets of YCHD against liver fibrosis were identified by the analysis of network pharmacology and transcriptomics combination. The mechanisms of YCHD against liver fibrosis were involved in the regulation of multiple targets, especially affecting the apoptosis-related signaling pathways.Graphical abstract (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - April 16, 2019 Category: Drugs & Pharmacology Source Type: research

UCA1 promotes cell viability, proliferation and migration potential through UCA1/miR-204/CCND2 pathway in primary cystitis glandularis cells
In this study, we firstly isolated the primary cells from the tissues of CG and adjacent normal tissues, and found that UCA1 was up-regulated in the primary CG cells (pCGs). Then, we showed that knock out of UCA1 reduced the cell viability, inhibited the cell proliferation and restrained the migration potential and overexpression of UCA1 promoted that in pCGs. Furthermore, we demonstrated that UCA1 played its role via sponging of the miR-204 in pCGs. In addition, we illustrated that miR-204 exerted its function via targeting CYCLIN D2 (CCND2) 3′UTR at mRNA level in pCGs. Ultimately, we revealed the role and regulatio...
Source: Biomedicine and Pharmacotherapy - April 16, 2019 Category: Drugs & Pharmacology Source Type: research

Effects of novel antidepressant drugs on mesenchymal stem cell physiology
In conclusion, a non-toxic concentration of duloxetine and fluoxetine does not alter the stemness properties of ADSCs and does not prevent the commitment of pre-differentiated ADSCs in adipocytes or osteocyte. Probably, the weight gain and osteoporotic effects associated with the use of psychotropic drugs could be closely related to the direct action of serotonin.Graphical abstract (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - April 14, 2019 Category: Drugs & Pharmacology Source Type: research

Amplification of USP13 drives non-small cell lung cancer progression mediated by AKT/MAPK signaling
Publication date: June 2019Source: Biomedicine & Pharmacotherapy, Volume 114Author(s): Yue Wu, Yingqiu Zhang, Congcong Liu, Yang Zhang, Duchuang Wang, Shanshan Wang, Yueguang Wu, Fang Liu, Qiong Li, Xiuxiu Liu, Mohamed Y. Zaky, Dong Yan, Shuyan LiuAbstractUSP13 is emerging as a potential target in cancer therapy. However, the effect of USP13 on tumor progression is controversial. Here we focused on non-small cell lung cancer (NSCLC), a common cancer with high mortality, and studied the role of USP13 in tumor growth. By analysis of multi-level genetic database, we found USP13 is high expressed in heart among healthy pri...
Source: Biomedicine and Pharmacotherapy - April 14, 2019 Category: Drugs & Pharmacology Source Type: research

Periplaneta Americana L. as a novel therapeutics accelerates wound repair and regeneration
This study aims to investigate the influence of KFX in the various wound healing activities with cellular and animal models, including the influence of KFX in 1) proliferation and cells cycle of kerationcytes and fibroblasts; 2) migration and chemotaxis of these skin cells; 3) secretion of EGF and VEGF; 4) the healing rate; 5) synthesis and deposition of different types of collagen; 6) as well as the pro-angiogenesis effect. KFX was shown to/for 1) promote the kerationcytes proliferation and regulate the cells cycle of skin fibroblasts significantly; 2) obviously stimulate the migration of kerationcytes and chemotaxis of f...
Source: Biomedicine and Pharmacotherapy - April 14, 2019 Category: Drugs & Pharmacology Source Type: research

Molecular targets of β-elemene, a herbal extract used in traditional Chinese medicine, and its potential role in cancer therapy: A review
Publication date: June 2019Source: Biomedicine & Pharmacotherapy, Volume 114Author(s): Bingtao Zhai, Nana Zhang, Xuemeng Han, Qiujie Li, Mingming Zhang, Xiaying Chen, Guohua Li, Ruonan Zhang, Peng Chen, Wengang Wang, Chenxi Li, Yu Xiang, Shuiping Liu, Ting Duan, Jianshu Lou, Tian Xie, Xinbing SuiAbstractβ-Elemene is a sesquiterpene compound extracted from the herb Curcuma Rhizoma and is used in traditional Chinese medicine (TCM) to treat several types of cancer, with no reported severe adverse effects. Recent studies, using in vitro and in vivo studies combined with molecular methods, have shown that β-elemen...
Source: Biomedicine and Pharmacotherapy - April 12, 2019 Category: Drugs & Pharmacology Source Type: research

Midazolam: Safety of use in palliative care: A systematic critical review
ConclusionMidazolam is one of three most frequently administered drugs in palliative care. The indications for its use include anxiety, dyspnea, seizures, vomiting refractory to treatment, agitation, myoclonus, status epilepticus, restlessness, delirium, pruritus, hiccups, insomnia, analgosedation, palliative sedation and preventing or counteracting undesired effects of ketamine. (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - April 12, 2019 Category: Drugs & Pharmacology Source Type: research

The effect and mechanisms of Fuzheng Huayu formula against chronic liver diseases
Publication date: June 2019Source: Biomedicine & Pharmacotherapy, Volume 114Author(s): Jiamei Chen, Yonghong Hu, Long Chen, Wei Liu, Yongping Mu, Ping LiuAbstractFuzheng Huayu formula (FZHY) is a traditional Chinese medicine formula composed of Radix Salvia Miltiorrhizae, Cordyceps, Semen Persicae, Gynostemma Pentaphyllammak, Pollen Pini, Fructus Schisandrae Chinensis that is used to treat chronic liver diseases in China. We here describe the pharmacological actions of FZHY in this review. We also describe and provide updates on recent advances in the medical applications and the basic research of mechanisms of FZHY fo...
Source: Biomedicine and Pharmacotherapy - April 12, 2019 Category: Drugs & Pharmacology Source Type: research

LncRNA SNHG16 promotes tumor growth of pancreatic cancer by targeting miR-218-5p
Publication date: June 2019Source: Biomedicine & Pharmacotherapy, Volume 114Author(s): Songyang Liu, Wei Zhang, Kai Liu, Yahui LiuAbstractSmall Nucleolar RNA Host Gene (SNHG16) is a novel cancer-related long noncoding RNA (lncRNA) and functions as an oncogene in a variety of cancers. Nonetheless, the expression patterns, biological function, and potential mechanisms in SNHG16 in pancreatic cancer (PC) remain rarely known. An increase in expression of SNHG16 in PC samples against adjacent normal tissues was shown here. Increased SNHG16 was linked intimately to the tumor-node-metastasis (TNM) stage, distant metastasis, t...
Source: Biomedicine and Pharmacotherapy - April 12, 2019 Category: Drugs & Pharmacology Source Type: research

circ-CSPP1 promotes proliferation, invasion and migration of ovarian cancer cells by acting as a miR-1236-3p sponge
Publication date: June 2019Source: Biomedicine & Pharmacotherapy, Volume 114Author(s): Qian-hui Li, Yao Liu, Shuo Chen, Zhi-hong Zong, Yu-ping Du, Xiu-jie Sheng, Yang ZhaoAbstractCircular RNAs are known to participate in tumorigenesis through a variety of pathways, and as such, have potential to serve as molecular markers in tumor diagnosis and treatment. Here, using quantitative reverse transcription (qRT)-PCR, we showed that circ-CSPP1 is highly expressed in ovarian cancer (OC) tissues. Particularly, we detected circ-CSPP1 expression in three OC cell lines; of which, OVCAR3 and A2780 demonstrated higher levels of cir...
Source: Biomedicine and Pharmacotherapy - April 12, 2019 Category: Drugs & Pharmacology Source Type: research

MicroRNA-142-3p/MALAT1 inhibits lung cancer progression through repressing β-catenin expression
The objective of this study was to explore it. The results showed that miR-142-3p expression was reduced in NSCLC tissues, while β-catenin and MALAT1 expression levels were elevated. MTT, transwell chamber, flow cytometry assays demonstrated that up-regulation of miR-142-3p with mimic transfection significantly inhibited the proliferation, migration and promoted the apoptosis of NSCLC H1299 cells, and induced a G0/G1 phase arrest and S phase reduction. Besides, miR-142-3p negatively decreased MALAT1 expression as detected by RT-PCR and luciferase reporter assays. Moreover, up-regulation of miR-142-3p decreased β-...
Source: Biomedicine and Pharmacotherapy - April 12, 2019 Category: Drugs & Pharmacology Source Type: research

Antibiotics exacerbated colitis by affecting the microbiota, Treg cells and SCFAs in IL10-deficient mice
Publication date: June 2019Source: Biomedicine & Pharmacotherapy, Volume 114Author(s): Bo Shen, Jiajia Hu, Huan Song, Zhengting Wang, Jiangao Fan, Yunwei Sun, Qijun WangAbstractMany studies have shown that antibiotic therapy can attenuate colitis in IL10-deficient (IL10−/−) mice. However, these results have indicated that antibiotics were more successful in preventing, rather than treating established colitis. Those antibiotic treatments attempted to only partially alter the intestinal microbiota and to not eliminate it completely. Therefore, we treated IL10−/− mice with the multiantibiotic regi...
Source: Biomedicine and Pharmacotherapy - April 12, 2019 Category: Drugs & Pharmacology Source Type: research

Inhibitory effects of total ginsenoside on bleomycin-induced pulmonary fibrosis in mice
This study determined whether TG has protective effects on pulmonary fibrosis and investigated its protective mechanisms. A pulmonary fibrosis model in BALB/c mice was established by injecting the bleomycin chemotherapeutic agent into the trachea. TG (40, 80, and 160 mg/kg/d) was given continuously for 28 days from the second day after development of the model. Pulmonary fibrosis was determined by measuring the lung coefficient, haematoxylin and eosin, and Masson’s trichrome staining of lung samples, and detection of alpha smooth muscle actin expression in lung tissues. To investigate the mechanisms of anti-pu...
Source: Biomedicine and Pharmacotherapy - April 12, 2019 Category: Drugs & Pharmacology Source Type: research

The sustained and targeted treatment of hemangiomas by propranolol-loaded CD133 aptamers conjugated liposomes-in-microspheres
Publication date: June 2019Source: Biomedicine & Pharmacotherapy, Volume 114Author(s): Xiaonan Guo, Changxian Dong, Qiuyu Liu, Xiaoshuang Zhu, Song Zuo, Hongyu ZhangAbstractWe previously developed propranolol-encapsulated liposomes-in-microspheres (PLIM) to realize the sustained propranolol release for the treatment of hemangiomas. However, the liposomes released from the microspheres still lacked specificity for CD133-positive hemangioma-derived stem cells (HemSCs) which are considered to be the seeds of hemangiomas. Therefore, we hereby encapsulated propranolol-loaded CD133 aptamers conjugated liposomes in poly(lacti...
Source: Biomedicine and Pharmacotherapy - April 12, 2019 Category: Drugs & Pharmacology Source Type: research

Docosahexaenoic acid inhibits bone remodeling and vessel formation in the osteochondral unit in a rat model
ConclusionsDHA has the ability to restrain bone remodeling and vessel formation in the osteochondral unit, which may contribute to protection of cartilage.Graphical abstract (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - April 12, 2019 Category: Drugs & Pharmacology Source Type: research

Quercetin suppresses the proliferation and metastasis of metastatic osteosarcoma cells by inhibiting parathyroid hormone receptor 1
Publication date: June 2019Source: Biomedicine & Pharmacotherapy, Volume 114Author(s): Shenglong Li, Yi Pei, Wei Wang, Fei Liu, Ke Zheng, Xiaojing ZhangAbstractOsteosarcoma is an aggressive malignant neoplasm and cancerous bone tumor. Quercetin is a well-known flavonoid abundant in vegetables, fruits, grains, leaves, and red onions. In the present study, we evaluated the effects of quercetin-induced inhibition of parathyroid hormone receptor 1 (PTHR1) on proliferation, migration, and invasion in U2OS and Saos-2 cells. Following incubation with quercetin (20, 40, 60, 80, or 100 μM) for 48 h, the cell viability...
Source: Biomedicine and Pharmacotherapy - April 12, 2019 Category: Drugs & Pharmacology Source Type: research

ACE inhibitor suppresses cardiac remodeling after myocardial infarction by regulating dendritic cells and AT2 receptor-mediated mechanism in mice
Publication date: June 2019Source: Biomedicine & Pharmacotherapy, Volume 114Author(s): Yuanji Ma, Jie Yuan, Jialu Hu, Wei Gao, Yunzeng Zou, Junbo GeAbstractDendritic cells (DCs) play a complex role in the progression of myocardial infarction (MI). The impact of angiotensin-converting enzyme (ACE) inhibitor therapy, partly via affecting DCs maturation and recruitment, was tested on a MI mouse model. Furthermore, the cardioprotective effects of ACEI were enhanced through attenuating migration of DCs from the spleen into peripheral circulation, thereby inhibiting DCs maturation and tissue inflammation. ACEI repress DCs im...
Source: Biomedicine and Pharmacotherapy - April 12, 2019 Category: Drugs & Pharmacology Source Type: research

Dexmedetomidine preconditioning attenuates ischemia/reperfusion injury in isolated rat hearts with endothelial dysfunction
Publication date: June 2019Source: Biomedicine & Pharmacotherapy, Volume 114Author(s): Liang He, Shuqing Hao, Yanqiong Wang, Wei Yang, Lan Liu, Hongmei Chen, Jinqiao QianAbstractBackground and purposesDexmedetomidine preconditioning (DP) can mimic pharmacological preconditioning and induce cardiac protection. There are controversies on the roles of coronary endothelia in cardioprotection of dexmedetomidine. Herein, we tested the hypothesis that protection of dexmedetomidine is not endothelial dependent in heart against myocardial ischemia/reperfusion (I/R) injury.MethodsLangendorff-perfused rat hearts were pretreated b...
Source: Biomedicine and Pharmacotherapy - April 12, 2019 Category: Drugs & Pharmacology Source Type: research

Identification of survival-related predictors in hepatocellular carcinoma through integrated genomic, transcriptomic, and proteomic analyses
In this study, we aimed to comprehensively characterize the prognosis-associated molecular alterations in hepatocellular carcinoma (HCC). In this study, copy-number changes, gene mutations, mRNA expression, and reverse phase protein arrays data in HCC samples profiled by The Cancer Genome Atlas (TCGA) were obtained. Tumors were then stratified into two groups based on the clinical outcome and identified genomic, transcriptomic, and proteomic traits associated to HCC prognosis. We found that several copy number amplifications and deletions can discriminate HCC patients with poor prognosis from those with better prognosis. M...
Source: Biomedicine and Pharmacotherapy - April 12, 2019 Category: Drugs & Pharmacology Source Type: research

Increased expression of SLC46A3 to oppose the progression of hepatocellular carcinoma and its effect on sorafenib therapy
In conclusion, increased expression of SLC46A3 could favor a better clinical prognosis for patients with HCC, ameliorate sorafenib resistance, and improve drug response. SLC46A3 might serve as a potential prognostic biomarker and therapeutic target in HCC.Graphical abstract (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - April 12, 2019 Category: Drugs & Pharmacology Source Type: research

Huangqi Fuzheng decoction exerts antitumor activity by inhibiting cell growth and inducing cell death in osteosarcoma
Publication date: June 2019Source: Biomedicine & Pharmacotherapy, Volume 114Author(s): Jinghao Qin, Wei Wang, Luolin Sha, Ling GeAbstractHuangqi Fuzheng decoction (HFD) is a traditional Chinese medicine and has been used as adjuvant clinical therapy for breast, ovarian and thyroid cancer. However, the potential roles and molecular mechanisms of HFD in osteosarcoma remain unclear. Here, we investigated the antitumor activity of HFD in osteosarcoma and analyzed its active compounds and therapeutic targets using an integrated systems pharmacology approach. We found that HFD treatment obviously suppressed cell proliferatio...
Source: Biomedicine and Pharmacotherapy - April 12, 2019 Category: Drugs & Pharmacology Source Type: research

Overexpression of macrophage stimulating 1 enhances the anti-tumor effects of IL-24 in esophageal cancer via inhibiting ERK-Mfn2 signaling-dependent mitophagy
Publication date: June 2019Source: Biomedicine & Pharmacotherapy, Volume 114Author(s): Jianpeng Zhang, Lin Sun, Weiqiang Li, Yanyu Wang, Xinzhen Li, Yang LiuAbstractAlthough cytokine-based therapy is a promising tool to control the progression of esophageal cancer, low therapeutic responses largely compromise treatment efficacy through unidentified mechanisms. The goal of our study was to explore the roles of macrophage stimulating 1 (Mst1) and mitophagy in enhancing IL-24-based cytokine therapy in esophageal cancer. Our data demonstrated that IL-24 application promoted cancer death by inducing mitochondrial stress, as...
Source: Biomedicine and Pharmacotherapy - April 12, 2019 Category: Drugs & Pharmacology Source Type: research

Modulation of YrdC promotes hepatocellular carcinoma progression via MEK/ERK signaling pathway
Publication date: June 2019Source: Biomedicine & Pharmacotherapy, Volume 114Author(s): Shiqiong Huang, Peng Zhu, Bao Sun, Jun Guo, Honghao Zhou, Yan Shu, Qing LiAbstractAccumulating evidence suggested that YrdC involved in growth, telomere homeostasis, translation and the N6-threonylcarbamoylation (t6A) of tRNA was abnormally expressed in the progression of tumor. However, the role of YrdC in hepatocellular carcinoma remained elusive. Our study aimed to investigate the clinical significance and oncogenic phenotypes of YrdC in hepatocellular carcinoma, and to determine its related mechanism of this disease. With the usa...
Source: Biomedicine and Pharmacotherapy - April 12, 2019 Category: Drugs & Pharmacology Source Type: research

Anti-tumor effect of LATS2 on liver cancer death: Role of DRP1-mediated mitochondrial division and the Wnt/β-catenin pathway
Publication date: June 2019Source: Biomedicine & Pharmacotherapy, Volume 114Author(s): Lijuan Zhang, Shuping Li, Rong Wang, Changyuan Chen, Wen Ma, Hongyi CaiAbstractLarge tumor suppressor 2 (LATS2), an important mediator of the cell apoptotic response pathway, has been linked to the progression of several cancers. Here, we described the molecular feature of LATS2 as a novel antitumor factor in liver cancer cells in vitro. Western blotting was used to detect the expression of LATS2 and its downstream factors. ELISA, immunofluorescence, and flow cytometry were used to evaluate the alterations of mitochondrial function i...
Source: Biomedicine and Pharmacotherapy - April 12, 2019 Category: Drugs & Pharmacology Source Type: research

POLD1 deficiency is involved in cognitive function impairment in AD patients and SAMP8 mice
In conclusion, this is the first study suggesting that the deficiency of POLD1 may aggravate AD progression, and POLD1 is a potential diagnostic marker and therapeutic target for AD. (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - April 12, 2019 Category: Drugs & Pharmacology Source Type: research

Anticancer activity of grassy Hystrix brachyura bezoar and its mechanisms of action: An in vitro and in vivo based study
This study provides scientific evidence that the porcupine bezoar do possess anti-cancer efficacy and further justifies its traditional utility. However, more experiments with higher vertebrae models are still warranted to validate its traditional claims as an anticancer agent. (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - April 12, 2019 Category: Drugs & Pharmacology Source Type: research

IL-11 activated by lnc-ATB promotes cell proliferation and invasion in esophageal squamous cell cancer
Publication date: June 2019Source: Biomedicine & Pharmacotherapy, Volume 114Author(s): Shou-mei Yang, Su-yi Li, Yu Hao-bin, Xu Lin-yan, Xiang ShengAbstractIL-11 exerts important functions involved in tumorigenesis and cancer progression. However, the underlying functional role of IL-11 in esophageal squamous cell cancer (ESCC) is not well known. In this paper, we demonstrated that IL-11 expression was increased in esophageal cancer compared with normal tissues, whereas knockdown of IL-11 could inhibit the proliferation and invasion of Eca109 and KYSE410 ESCC cells. Besides, we found that the stability and expression of...
Source: Biomedicine and Pharmacotherapy - April 6, 2019 Category: Drugs & Pharmacology Source Type: research

Hydroxysafflor yellow A (HSYA) alleviates apoptosis and autophagy of neural stem cells induced by heat stress via p38 MAPK/MK2/Hsp27-78 signaling pathway
In conclusion, HSYA significantly reversed the apoptosis and autophagy of NSCs induced by heat stress (P 
Source: Biomedicine and Pharmacotherapy - April 6, 2019 Category: Drugs & Pharmacology Source Type: research

Regulating role of ethyl acetate fraction of Tephrosia tinctoria pers. in carbohydrate metabolism and oxidative stress in diabetic rats
Publication date: June 2019Source: Biomedicine & Pharmacotherapy, Volume 114Author(s): Rajaram Krishnasamy, Sureshkumar PeriyasamyAbstractTraditionally, Tephrosia tinctoria (TT) is used as antimicrobial, larvicidal, antidiabetic and antioxidant agents. In the present study, the diabetes was induced in male albino - rats using alloxan (140 mg/kg b.w.) and treated with ethyl acetate extract (100 and 200 mg/kg b.w.) of T. tinctoria (TTEA) orally for 28 days. The effects of TTEA on biochemical paramets were studied. The results of this comprehensive study revealed that the TTEA significantly restored the alte...
Source: Biomedicine and Pharmacotherapy - April 6, 2019 Category: Drugs & Pharmacology Source Type: research

lncRNA PEG10 promotes cell survival, invasion and migration by sponging miR-134 in human bladder cancer
ConclusionlncRNA PEG10 functioned as an oncogene in bladder cancer by sponging miR-134 and thus preventing LRP6 from degradation by miR-134. LRP6 promoted bladder cancer progression probably through activating Wnt/β-catenin and JAK/STAT signal pathways. (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - April 4, 2019 Category: Drugs & Pharmacology Source Type: research

Xuezhikang improves the outcomes of cardiopulmonary resuscitation in rats by suppressing the inflammation response through TLR4/NF-κB pathway
ConclusionThese results indicated that XZK had a protective effect against brain injury post-CA/CPR. The mechanisms underlying the protective effects of XZK may be related to the suppressing of CA/CPR-induced inflammatory response through the inhibiting TLR4/NF-κB signaling pathway. (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - April 4, 2019 Category: Drugs & Pharmacology Source Type: research

Effect of tumor necrosis factor α on ability of SHED to promote osteoclastogenesis during physiological root resorption
In conclusion, inflammatory cytokine TNF-α appeared to activate NF-κB pathway to up-regulate expression of NF-κB, enhancing ability of SHED in promoting osteoclastogenesis via regulating RANKL/OPG expression. (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - April 3, 2019 Category: Drugs & Pharmacology Source Type: research

S-amlodipine improves endothelial dysfunction via the RANK/RANKL/OPG system by regulating microRNA-155 in hypertension
Publication date: June 2019Source: Biomedicine & Pharmacotherapy, Volume 114Author(s): Jining Yang, Daoyuan Si, Yanan Zhao, Chengyan He, Ping YangAbstractS-amlodipine has been broadly used to treat hypertension, but its protective effects and underlying mechanism remain controversial. The purpose of our study was to investigate the mechanism by which S-amlodipine improves endothelial dysfunction. Specifically, we investigated if S-amlodipine regulates RANK/RANKL/OPG and micro-RNA 155 (miR-155) levels. Spontaneous hypertensive rats (SHR) were randomly divided into two groups: SHR (n = 12) and S-amlodipine (n = 1...
Source: Biomedicine and Pharmacotherapy - April 3, 2019 Category: Drugs & Pharmacology Source Type: research

Nasopharyngeal cancer combination chemoradiation therapy based on folic acid modified, gefitinib and yttrium 90 co-loaded, core-shell structured lipid-polymer hybrid nanoparticles
Publication date: June 2019Source: Biomedicine & Pharmacotherapy, Volume 114Author(s): Fu Yugui, Hailan Wang, Dezhong Sun, Xiaoyan ZhangAbstractCurrent treatment of advanced-stage nasopharyngeal carcinoma (NPC) is not satisfactory. Here, we developed a folic acid (FA) modified, gefitinib (GEF) and yttrium 90 (Y90) co-loaded, core-shell structured lipid-polymer hybrid nanoparticles (FA-GEF-Y90-LPNP). The size and zeta potential, drug release behavior, and uptake by tumor cells were investigated. The antitumor efficiency and toxicity of LPNP were evaluated in cancer cells and in tumor bearing mice. FA-GEF-Y90-LPNP with a...
Source: Biomedicine and Pharmacotherapy - April 3, 2019 Category: Drugs & Pharmacology Source Type: research

MicroRNA-384 is lowly expressed in human prostate cancer cells and has anti-tumor functions by acting on HOXB7
ConclusionMiR-384 was downregulated in CAP cells. MiR-384 overexpression suppressed CAP in vitro and in vivo development, possibly via acting through its downstream target gene of HOXB7. (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - April 3, 2019 Category: Drugs & Pharmacology Source Type: research

Hsa-miR-889-3p promotes the proliferation of osteosarcoma through inhibiting myeloid cell nuclear differentiation antigen expression
In conclusion, hsa-miR-889-3p could promote the proliferation of osteosarcoma through inhibiting MNDA expression, which provides a potential therapeutic strategy in treatment for osteosarcoma. (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - April 3, 2019 Category: Drugs & Pharmacology Source Type: research

Prebiotic oligosaccharides from dragon fruits alter gut motility in mice
In conclusion, DFO increased colonic SM contractions without morphological change and acted as a bulk-forming and stimulant laxative to increase fecal output and intestinal motility. Thus, DFO as a dietary supplement may promote gut health and correct gastrointestinal motility disorders.Graphical abstract (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - April 3, 2019 Category: Drugs & Pharmacology Source Type: research

Small RNA-sequencing identified the potential roles of neuron differentiation and MAPK signaling pathway in dilated cardiomyopathy
In conclusion, forty-eight dysregulated miRNAs were identified by small RNA-sequencing. Bioinformatics analysis suggested these miRNAs might be involved in the pathogenesis of dilated cardiomyopathy via regulating neuron differentiation process and MAPK signaling pathway. (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - April 3, 2019 Category: Drugs & Pharmacology Source Type: research