An update on Drug Repurposing: Re-written saga of the drug’s fate
Publication date: February 2019Source: Biomedicine & Pharmacotherapy, Volume 110Author(s): Hema Sree GNS, Saraswathy GR, Manikanta Murahari, Mamatha KrishnamurthyAbstractDrug repurposing is an unconventional drug discovery approach to explore new therapeutic benefits of existing, shelved and the drugs in clinical trials. This approach is currently emerging to overcome the bottleneck constraints faced during traditional drug discovery in grounds of financial support, timeline and resources. In this direction, several efforts were made for the construction of stratagems based on bioinformatics and computational tools to ...
Source: Biomedicine and Pharmacotherapy - December 13, 2018 Category: Drugs & Pharmacology Source Type: research

Fiend and friend in the renin angiotensin system: An insight on acute kidney injury
Publication date: February 2019Source: Biomedicine & Pharmacotherapy, Volume 110Author(s): Nisha Sharma, Hans-Joachim Anders, Anil Bhanudas GaikwadAbstractBesides assisting the maintenance of blood pressure and sodium homeostasis, the renin-angiotensin system (RAS) plays a pivotal role in pathogenesis of acute kidney injury (AKI). The RAS is equipped with two arms i) the pressor arm composed of Angiotensin II (Ang II)/Angiotensin converting enzyme (ACE)/Angiotensin II type 1 receptor (AT1R) also called conventional RAS, and ii) the depressor arm consisting of Angiotensin (1-7) (Ang 1-7)/Angiotensin converting enzyme 2 ...
Source: Biomedicine and Pharmacotherapy - December 13, 2018 Category: Drugs & Pharmacology Source Type: research

Salvanic acid B inhibits myocardial fibrosis through regulating TGF-β1/Smad signaling pathway
This study aimed to investigate the protective effects and the mechanisms of Sal B on myocardial fibrosis.MethodsThe mice were randomly assigned to five groups: control group, model group, positive group, low-dose group, high-dose group. Hematoxylin-Eosin (HE) staining and Masson staining were used to assess the myocardial physiological changes and measure the myocardial fibrosis area. Expression of transforming growth factor-beta (TGF-β), drosophila mothers against decapentaplegic (Smad)2, Smad3 and Smad7 were analyzed by immunohistochemistry and real-time PCR. On the other hand, mouse cardiac fibroblasts (CFs) cells...
Source: Biomedicine and Pharmacotherapy - December 13, 2018 Category: Drugs & Pharmacology Source Type: research

Glycyrrhizin alleviates Con A-induced hepatitis by differentially regulating the production of IL-17 and IL-25
Publication date: February 2019Source: Biomedicine & Pharmacotherapy, Volume 110Author(s): Yuanyue Zhang, Lingyun Li, Chang Qi, Shuyao Hua, Xiaoyuan Fei, Feili Gong, Min FangAbstractGlycyrrhizin, a triterpenoid compound, has been reported to be an anti-inflammatory agent for the treatment of a variety of inflammatory diseases including hepatitis. However, the mechanism by which glycyrrhizin inhibits inflammation is unclear. Using a Con A-induced hepatitis model in mice, we found that administration of glycyrrhizin ameliorates Con A-induced liver injury, which manifests as reduction in the production of inflammatory cyt...
Source: Biomedicine and Pharmacotherapy - December 13, 2018 Category: Drugs & Pharmacology Source Type: research

Metabotropic glutamate receptor 5 signalling induced NMDA receptor subunits alterations during the development of morphine-induced antinociceptive tolerance in mouse cortex
ConclusionsIt may be mGluR5-mediated PKC signalling that plays the most significant role in the mechanisms underlying morphine-induced antinociceptive tolerance rather than the physiological connection between mGluR5 and NMDAR.Graphical abstract (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - December 13, 2018 Category: Drugs & Pharmacology Source Type: research

Interleukin-35 expression protects against cigarette smoke-induced lung inflammation in mice
Publication date: February 2019Source: Biomedicine & Pharmacotherapy, Volume 110Author(s): Xiuhe Pan, Keye Xu, Yuan Li, Xiaoying Wang, Xiao Peng, Mingcai Li, Yan LiAbstractCigarette smoke (CS) is a very important cause of pulmonary inflammatory diseases. Interleukin (IL)-35 is a novel anti-inflammatory cytokine but its role in CS-mediated lung inflammation remains unclear. In the present study, we examined the effect of IL-35 expression on CS-induced lung inflammation in mice. A plasmid DNA expressing IL-35 was injected into mice via a hydrodynamic-based gene delivery that were subsequently exposed to CS three times a ...
Source: Biomedicine and Pharmacotherapy - December 13, 2018 Category: Drugs & Pharmacology Source Type: research

Protective role of Gentianella acuta on isoprenaline induced myocardial fibrosis in rats via inhibition of NF-κB pathway
Publication date: February 2019Source: Biomedicine & Pharmacotherapy, Volume 110Author(s): Ai-Ying Li, Jing-Jing Wang, Sheng-Chang Yang, Ya-Shuo Zhao, Jie-Ru Li, Yu Liu, Jia-Huan Sun, Li-Ping An, Peng Guan, En-Sheng JiAbstractGentianella acuta (Michx.) Hulten (G. acuta) has been widely used in Mongolian medicines for the treatment of cardiovascular diseases in Ewenki and Oroqen, Inner Mongolia autonomous region, China. The aim of this study was to investigate the effects and related mechanism of G. acuta on isoproterenol (ISO)-induced oxidative stress, fibrosis, and myocardial damage in rats. Male Sprague Dawley rats w...
Source: Biomedicine and Pharmacotherapy - December 13, 2018 Category: Drugs & Pharmacology Source Type: research

Protective effects of Nigella sativa oil against carboplatin-induced liver damage in rats
ConclusionWhen used NSO before carboplatin exposure, it may protect against liver damage.Graphical abstract (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - December 13, 2018 Category: Drugs & Pharmacology Source Type: research

Manilkara zapota (L.) P. Royen leaf water extract triggered apoptosis and activated caspase-dependent pathway in HT-29 human colorectal cancer cell line
Publication date: February 2019Source: Biomedicine & Pharmacotherapy, Volume 110Author(s): Bee Ling Tan, Mohd Esa NorhaizanAbstractManilkara zapota (L.) P. Royen (Family: Sapotaceae), commonly called as sapodilla, has been applied as traditional folk medicine for diarrhea and pulmonary infections. Conventional therapy in colorectal cancer is not likely effective due to undesirable outcomes. The anti-colon cancer properties of Manilkara zapota leaf water extract have yet to be investigated thus far. Therefore, our present study aimed to evaluate the ability to induce apoptosis and the underlying mechanisms of Manilkara ...
Source: Biomedicine and Pharmacotherapy - December 13, 2018 Category: Drugs & Pharmacology Source Type: research

Inhibition of CTHRC-1 by its specific monoclonal antibody attenuates cervical cancer cell metastasis
Publication date: February 2019Source: Biomedicine & Pharmacotherapy, Volume 110Author(s): Xiao-xiao Cui, Hong-mei Ding, Fei Gu, Yuan-yuan Lv, Xin Xing, Rong ZhangAbstractAlthough combination of surgery and chemo-radiotherapy could cure 80–95% of patients with early cervical cancer, there is still no satisfactory therapeutic strategies for locally advanced and metastatic cervical cancer patients. Our previous study has already investigated that CTHRC-1 is highly expressed not only in the local tissue but also in circulating serum of patients with cervical cancer and played important function on metastasis of cerv...
Source: Biomedicine and Pharmacotherapy - December 13, 2018 Category: Drugs & Pharmacology Source Type: research

MiR-23a-3p acts as an oncogene and potential prognostic biomarker by targeting PNRC2 in RCC
ConclusionsOur results reveals that miR-23a-3p may not only serve as a new biomarker for prognosis but also serve as a new therapeutic strategy in the RCC treatment. (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - December 12, 2018 Category: Drugs & Pharmacology Source Type: research

The renoprotective effect of the dipeptidyl peptidase-4 inhibitor sitagliptin on adenine-induced kidney disease in rats
Publication date: February 2019Source: Biomedicine & Pharmacotherapy, Volume 110Author(s): Aly M. Abdelrahman, Yousuf Al Suleimani, Mohammed Al Za'abi, Mohammed Ashique, Priyadarsini Manoj, Christina Hartmann, Abderrahim Nemmar, Nicole Schupp, Badreldin H. AliAbstractWe assessed the effect of treatment with the dipeptidyl peptidase-4 inhibitor, sitagliptin, on adenine-induced chronic kidney disease (CKD). Six equal groups of rats were given either normal food or food mixed with adenine (0.25% w/w for five weeks) to induce CKD. Some of these groups were also simultaneously treated with sitagliptin (2.5 and 10 mg/...
Source: Biomedicine and Pharmacotherapy - December 12, 2018 Category: Drugs & Pharmacology Source Type: research

Therapeutic evaluation of acupoint stimulation with needle-scapelon on rat model of degenerative cervical intervertebral discs
Publication date: February 2019Source: Biomedicine & Pharmacotherapy, Volume 110Author(s): Qinran Sun, Fangming Liu, Min Gao, Wenqing Wu, Weiju Liu, Cong Yin, Zhongshu Zhu, Lijin Zhang, Xiufang Ding, Yanping Guo, Hui Gong, Xuguo Sun, Daoping ZhangAbstractCervical spondylosis (CS), which is resulted from degeneration of cervical intervertebral disc, is a common disease seriously threatening human health and quality of life. However, there is still no effective clinic strategies for the treatment of this disease. The acupoint stimulation with needle-scalpel is a widely used approach to treat orthopedic diseases. In the p...
Source: Biomedicine and Pharmacotherapy - December 12, 2018 Category: Drugs & Pharmacology Source Type: research

Cladophora glomerata methanolic extract decreases oxidative stress and improves viability and mitochondrial potential in equine adipose derived mesenchymal stem cells (ASCs)
This study aimed to evaluate the protective and antioxidant activities of methanolic extract prepared from Cladophora glomerata (C. glomerata) biomass, on equine adipose derived mesenchymal stem cells (EqASCs), under experimental oxidative stress induced by H2O2. Pre-treatment of EqASCs cells with different concentrations of C. glomerata methanolic extract (1% and 5%) provided a clear protection against cellular damage triggered by H2O2. The cell's apoptotic status was significantly regulated, with promotion of cell viability, down-regulation of pro-apoptotic (p21, p53, Bax and Casp-9) genes expression, concomitant to up-r...
Source: Biomedicine and Pharmacotherapy - December 12, 2018 Category: Drugs & Pharmacology Source Type: research

Anti-depressive effect of Shuangxinfang on rats with acute myocardial infarction: Promoting bone marrow mesenchymal stem cells mobilization and alleviating inflammatory response
In this study, we explored its psycho-cardiology effects in rats with AMI and explore its potential mechanism. Our results showed PCF inhibited inflammation caused by injured myocardium, improved heart function and depression developed from myocardial infarction, and these might partly attribute to the higher BM-MSCs mobilization efficiency promoted by PCF. (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - December 12, 2018 Category: Drugs & Pharmacology Source Type: research

Corrigendum to “Study on the efficacy and mechanism of triptolide on treating TNF transgenic mice with rheumatoid arthritis” [Biomed. Pharmacother. 106 (2018) 813–820]
Publication date: Available online 7 November 2018Source: Biomedicine & PharmacotherapyAuthor(s): Shengli Wang, Shuguang Zuo, Zhigang Liu, Xinying Ji, Zhenqiang Yao, Xinchun Wang (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - December 11, 2018 Category: Drugs & Pharmacology Source Type: research

Anti-depressive-like effect of 2-phenylethanol inhalation in mice
Publication date: Available online 8 November 2018Source: Biomedicine & PharmacotherapyAuthor(s): Hiroshi Ueno, Atsumi Shimada, Shunsuke Suemitsu, Shinji Murakami, Naoya Kitamura, Kenta Wani, Yosuke Matsumoto, Motoi Okamoto, Takeshi IshiharaAbstractRose oil has traditionally been used to treat psychiatric disorders, but the scientific basis of this treatment remains poorly understood. The main odor component of rose oil is 2-phenylethanol (2-PE), but the neuropsychological effects of 2-PE have not been investigated in detail. Thus, we aimed to investigate the effects of 2-PE on mouse behavior. We first investigated whe...
Source: Biomedicine and Pharmacotherapy - December 11, 2018 Category: Drugs & Pharmacology Source Type: research

Insight into the role of TRAIL in liver diseases
Publication date: February 2019Source: Biomedicine & Pharmacotherapy, Volume 110Author(s): Wei Jiang, Dong-Bo Wu, Si-Yu Fu, En-Qiang Chen, Hong Tang, Tao-You ZhouAbstractTNF-related apoptosis inducing ligand (TRAIL) is a potential antitumor protein known for its ability to selectively eliminate various types of tumor cells without exerting toxic effects in normal cells and tissues. TRAIL has recently been suggested as a potential therapeutic target in hepatocellular carcinoma (HCC) because it promotes apoptosis in cancer cells. Furthermore, studies on the role of TRAIL in liver injury have reported that TRAIL plays an ...
Source: Biomedicine and Pharmacotherapy - December 11, 2018 Category: Drugs & Pharmacology Source Type: research

Anticancer effects of alloxanthoxyletin and fatty acids esters – In vitro study on cancer HTB-140 and A549 cells
Publication date: February 2019Source: Biomedicine & Pharmacotherapy, Volume 110Author(s): Michał Jóźwiak, Marta Struga, Piotr Roszkowski, Agnieszka Filipek, Grażyna Nowicka, Wioletta OlejarzAbstractAlloxanthoxyletin, a natural occurring pyranocoumarin isolated from a number of plant sources, such as family of Rutaceae, and its synthetic derivatives show cytotoxic and antitumor activities. In the present study new eleven esters of alloxanthoxyletin and fatty acids were synthesized and evaluated for their anticancer toxicity. The structures of the compounds were confirmed by Proton Nuclear Magnetic Resonance (...
Source: Biomedicine and Pharmacotherapy - December 11, 2018 Category: Drugs & Pharmacology Source Type: research

MiR-92b targets p57kip2 to modulate the resistance of hepatocellular carcinoma (HCC) to ionizing radiation (IR) -based radiotherapy
Publication date: February 2019Source: Biomedicine & Pharmacotherapy, Volume 110Author(s): Jianyang Wang, Hong Zhao, Jing Yu, Xin Xu, Wenyang Liu, Hao Jing, Ning Li, Yuan Tang, Yexiong Li, Jianqiang Cai, Jing JinAbstractHepatocellular carcinoma (HCC) is one of the most common digestive system malignant tumors. Due to the resistance to radiotherapy, the prognosis in patients with HCC is poor. Based on previous studies and online tools prediction, we hypothesized that miR-92b, which was reported to promote HCC cell proliferation, might bind to p57kip2, a well-known tumor suppressor, to modulate the radioresistance of HCC...
Source: Biomedicine and Pharmacotherapy - December 11, 2018 Category: Drugs & Pharmacology Source Type: research

Recombinant human interleukin-1 receptor antagonist treatment protects rats from myocardial ischemia–reperfusion injury
Publication date: March 2019Source: Biomedicine & Pharmacotherapy, Volume 111Author(s): Jinzhou Zhu, Jiannan Huang, Daopeng Dai, Xia Wang, Jing Gao, Wei Han, Ruiyan ZhangAbstractThe interleukin-1 (IL-1) signaling pathway plays a vital role in multiple mechanisms associated with myocardial ischemia–reperfusion (I/R) injury, including inflammation and apoptosis. An IL-1 receptor antagonist (IL-1Ra) can block IL-1 by competitive binding to the IL-1 receptor type I (IL-1RI) and thus may provide a cardioprotective effect. In the present investigation, we determined whether exogenous administration of recombinant human...
Source: Biomedicine and Pharmacotherapy - December 11, 2018 Category: Drugs & Pharmacology Source Type: research

Dexamethasone induces osteoblast apoptosis through ROS-PI3K/AKT/GSK3β signaling pathway
ConclusionOur research verified that Dex induced osteoblasts apoptosis by ROS-PI3K/AKT/GSK3β signaling pathway.Graphical abstract (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - December 9, 2018 Category: Drugs & Pharmacology Source Type: research

Investigation of the diabetic effects of maternal high-glucose diet on rats
ConclusionThis study has experimentally demonstrated that high daily intake of sugar in healthy pregnancies causes adverse effects on the mother and offspring. (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - December 9, 2018 Category: Drugs & Pharmacology Source Type: research

Antidiarrheal activity of α-terpineol in mice
Publication date: February 2019Source: Biomedicine & Pharmacotherapy, Volume 110Author(s): Polyanna dos Santos Negreiros, Douglas Soares da Costa, Valdelânia Gomes da Silva, Izabela Borges de Carvalho Lima, Daniel Barbosa Nunes, Francisca Beatriz de Melo Sousa, Thiago de Souza Lopes Araújo, Jand Venes Rolim Medeiros, Rosimeire Ferreira dos Santos, Rita de Cássia Meneses OliveiraAbstractDiarrhea is one of the leading causes of infant death in the world accounting for high child mortality rate. It is also present in different pathophysiologies related to several etiological agents. The aim of this stu...
Source: Biomedicine and Pharmacotherapy - December 9, 2018 Category: Drugs & Pharmacology Source Type: research

Kojic acid applications in cosmetic and pharmaceutical preparations
Publication date: February 2019Source: Biomedicine & Pharmacotherapy, Volume 110Author(s): Majid Saeedi, Masoumeh Eslamifar, Khadijeh KhezriAbstractSkin color disorders can be caused by various factors, such as excessive exposure to sunlight, aging and hormonal imbalance during pregnancy, or taking some medications. Kojic acid (KA) is a natural metabolite produced by fungi that has the ability to inhibit tyrosinase activity in synthesis of melanin. The major applications of KA and its derivatives in medicine are based on their biocompatibility, antimicrobial and antiviral, antitumor, antidiabetic, anticancer, anti-spec...
Source: Biomedicine and Pharmacotherapy - December 8, 2018 Category: Drugs & Pharmacology Source Type: research

MiR-let-7e inhibits invasion and magration and regulates HMGB1 expression in papillary thyroid carcinoma
In this study, we showed that the overexpression of miR-let-7e or knockdown of high mobility group box 1 (HMGB1) inhibited cell migration and invasion. MiR-let-7e downregulates HMGB1 expression by directly targeting the HMGB1 3′-UTR. Furthermore, HMGB1 reintroduction reversed the anti-proliferation, anti-migration, and anti-invasion roles of miR-let-7e. miR-let-7e might function as a tumor suppressor in papillary thyroid carcinoma through HMGB1. Therefore, our study demonstrates that miR-let-7e plays an important role in papillary thyroid carcinoma progression and might represent a new potential therapeutic target fo...
Source: Biomedicine and Pharmacotherapy - December 8, 2018 Category: Drugs & Pharmacology Source Type: research

High fat diet exacerbates intestinal barrier dysfunction and changes gut microbiota in intestinal-specific ACF7 knockout mice
Publication date: February 2019Source: Biomedicine & Pharmacotherapy, Volume 110Author(s): Chenzhang Shi, Hao Li, Xiao Qu, Linsheng Huang, Cheng Kong, Huanlong Qin, Zhenliang Sun, Xuebing YanAbstractMicrotubule-actin cross-linking factor-1 (ACF7, or MACF1) regulates cytoskeletal focal adhesion dynamics and migration in various tissues. High fat diet (HFD) induces gut microbiota dysbiosis and metabolic disorders, and increases intestinal permeability and inflammatory response. Here we investigated the synergistic effects of intestinal ACF7 conditional knockout (ACF7 cKO) and HFD on metabolism phenotypes, gut microbiota ...
Source: Biomedicine and Pharmacotherapy - December 8, 2018 Category: Drugs & Pharmacology Source Type: research

Salvianolic acid B attenuates experimental skin fibrosis of systemic sclerosis
Publication date: February 2019Source: Biomedicine & Pharmacotherapy, Volume 110Author(s): Qingmei Liu, Jiaying Lu, Jinran Lin, Yulong Tang, Weilin Pu, Xiangguang Shi, Shuai Jiang, Jing Liu, Yanyun Ma, Yuan Li, Jinhua Xu, Li Jin, Jiucun Wang, Wenyu WuAbstractSystemic sclerosis (SSc) is a connective tissue disease characterized mainly by fibrosis of skin and internal organs. Our previous study has shown that salvianolic acid B (SAB), a bioactive component extracted from Salvia miltiorrhiza (SM), was one of the essential ingredients in the traditional Chinese medicine Yiqihuoxue formula, which has been used to treat SSc-...
Source: Biomedicine and Pharmacotherapy - December 8, 2018 Category: Drugs & Pharmacology Source Type: research

Oxyresveratrol ameliorates ethanol-induced gastric ulcer via downregulation of IL-6, TNF-α, NF-ĸB, and COX-2 levels, and upregulation of TFF-2 levels
Publication date: February 2019Source: Biomedicine & Pharmacotherapy, Volume 110Author(s): Rao Salman Aziz, Arfah Siddiqua, Muhammad Shahzad, Arham Shabbir, Nadia NaseemAbstractOxyresveratrol, an active ingredient of Artocarpus lakoocha, is known to possess anti-inflammatory and immunomodulatory properties. Current study investigates the immunomodulatory effect of oxyresveratrol in mouse model of ethanol-induced ulcer. Anti-ulcer effect was determined using histopathological evaluation (H&E staining) and different tests like, gastric ulcer scoring, ulcer index, total acid secretion, and gastric pH. The mRNA express...
Source: Biomedicine and Pharmacotherapy - December 8, 2018 Category: Drugs & Pharmacology Source Type: research

Protective effects of Astragalin on spermatogenesis in streptozotocin-induced diabetes in male mice by improving antioxidant activity and inhibiting inflammation
In conclusion, AG is a potential beneficial agent to protect diabetic-induced spermatogenic dysfunction in male mice by increasing antioxidant enzymes activities and inhibiting inflammation.Graphical abstract (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - December 8, 2018 Category: Drugs & Pharmacology Source Type: research

Novel hepatoprotective role of Leonurine hydrochloride against experimental non-alcoholic steatohepatitis mediated via AMPK/SREBP1 signaling pathway
ConclusionsOur data reveal the promising role of Leonurine hydrochloride in the prevention and treatment of NASH, in vitro and in vivo. This effect may be partially mediated by the AMPK/SREBP1 pathway. These findings provide a novel therapeutic target for the clinical treatment of NASH. (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - December 8, 2018 Category: Drugs & Pharmacology Source Type: research

Recruitment of macrophages and bone marrow stem cells to regenerating liver promoted by sodium phthalhydrazide in mice
Publication date: February 2019Source: Biomedicine & Pharmacotherapy, Volume 110Author(s): Irina G. Danilova, Boris G. Yushkov, Irina A. Kazakova, Anna V. Belousova, Artem S. Minin, Musa T. AbidovAbstractPharmacological interventions which could be hepatoprotective, depending on bioavailability, anti-inflammatory and macrophage-targeting potential of drugs, are still at early preclinical stages. Existing evidence from many animal models of liver injury, as well as from human data, indicate that pharmacological and/or phytochemical interventions have limited impact on liver recovery. Recent studies on stem cell therapie...
Source: Biomedicine and Pharmacotherapy - December 8, 2018 Category: Drugs & Pharmacology Source Type: research

PCAT-1: A pivotal oncogenic long non-coding RNA in human cancers
Publication date: February 2019Source: Biomedicine & Pharmacotherapy, Volume 110Author(s): Zhi Yang, Shan Zhao, Xiangyu Zhou, Haiying Zhao, Xiaofeng JiangAbstractProstate cancer-associated transcript 1 (PCAT-1) is a newly identified long non-coding RNA comprising two exons, located in the Chr8q24 gene desert approximately 725 kb upstream of the MYC oncogene. PCAT-1 is dysregulated and acts as an oncogene in different types of cancers and has been implicated in several processes correlated with carcinogenesis, such as cell proliferation, invasion, metastasis, apoptosis, cell cycle, chemoresistance, and homologous recomb...
Source: Biomedicine and Pharmacotherapy - December 7, 2018 Category: Drugs & Pharmacology Source Type: research

Phytochemicals: Current strategy to sensitize cancer cells to cisplatin
Publication date: February 2019Source: Biomedicine & Pharmacotherapy, Volume 110Author(s): Chao-Yue Sun, Qian-Yu Zhang, Guang-Juan Zheng, Bing FengAbstractCisplatin-based chemotherapeutic regimens are the most frequently used adjuvant treatments for many types of cancer. However, the development of chemoresistance to cisplatin results in treatment failure. Despite the significant developments in understanding the mechanisms of cisplatin resistance, effective strategies to enhance the chemosensitivity of cisplatin are lacking. Phytochemicals are naturally occurring plant-based compounds that can augment the anti-cancer ...
Source: Biomedicine and Pharmacotherapy - December 7, 2018 Category: Drugs & Pharmacology Source Type: research

Raspberry ketone and Garcinia Cambogia rebalanced disrupted insulin resistance and leptin signaling in rats fed high fat fructose diet
ConclusionOur study highlights the involvement ofp-IRS-1/p-Akt/GLUT-4, leptin/STAT-3 and SREBP-1c signaling trajectories in the beneficial combination of GC and RK, besides, the efficient rebalance of the redox status, insulin resistance and tissue fat deposition confirmed histopathologically.Graphical abstract (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - December 7, 2018 Category: Drugs & Pharmacology Source Type: research

Corn silk (Zea mays L.), a source of natural antioxidants with α-amylase, α-glucosidase, advanced glycation and diabetic nephropathy inhibitory activities
Publication date: February 2019Source: Biomedicine & Pharmacotherapy, Volume 110Author(s): Kai-Jin Wang, Jin-Liang ZhaoAbstractThe oxidative stress plays a critical role in the progression of diabetes mellitus (DM) and its complications. Corn silk is a traditional medicine used to treat DM. The aim of this study is to investigate the antioxidant capacity of corn silk, as well as its inhibitory potential on DM and diabetic nephropathy (DN). The ethanol extract of corn silk (CS) was liquid-liquid fractionated to get petroleum ether fraction (PCS), ethyl acetate fraction (ECS), n-butanol fraction (BCS) and water fraction ...
Source: Biomedicine and Pharmacotherapy - December 7, 2018 Category: Drugs & Pharmacology Source Type: research

Metformin increases antitumor activity of MEK inhibitor binimetinib in 2D and 3D models of human metastatic melanoma cells
Publication date: January 2019Source: Biomedicine & Pharmacotherapy, Volume 109Author(s): Oxana Ryabaya, Anastasia Prokofieva, Roman Akasov, Dmitry Khochenkov, Marina Emelyanova, Sergey Burov, Elena Markvicheva, Andrey Inshakov, Evgenia StepanovaAbstractMelanoma is one of the most aggressive and treatment-resistant tumors that responsible for majority of skin-cancer related deaths. Here we propose a combination of MEK inhibitor binimetinib with metformin as a promising therapy against human melanoma cells in vitro, including BRAF -mutated A375, Mel Z, and Mel IL cells, and NRAS-mutated Mel MTP and Mel Me cells. Additio...
Source: Biomedicine and Pharmacotherapy - December 6, 2018 Category: Drugs & Pharmacology Source Type: research

The roles of ZEB1 in tumorigenic progression and epigenetic modifications
Publication date: February 2019Source: Biomedicine & Pharmacotherapy, Volume 110Author(s): Yu Zhang, Lei Xu, Anqi Li, Xiuzhen HanAbstractHighly expressed Zinc-finger E-box binding protein 1 (ZEB1) is significantly associated with the malignancy of various cancers. Signal transduction and activation of ZEB1 play important roles in cancer transformation and epithelial-mesenchymal transition (EMT). Emerging evidence suggests that ZEB1 drives the induction of EMT with activation of stem cell traits, immune evasion and epigenetic reprogramming. As an ideal target for EMT research, ZEB1 has been extensively studied for decad...
Source: Biomedicine and Pharmacotherapy - December 6, 2018 Category: Drugs & Pharmacology Source Type: research

Therapeutic potential of targeting the Wnt/β-catenin signaling pathway in colorectal cancer
Publication date: February 2019Source: Biomedicine & Pharmacotherapy, Volume 110Author(s): Xiaofei Cheng, Xiangming Xu, Dong Chen, Feng Zhao, Weilin WangAbstractAberrant Wnt/β-catenin signaling has often been reported in different cancers, particularly colorectal cancer (CRC), and this signaling cascade is central to carcinogenesis. Approximately 80% of CRC cases harbor mutations in the adenomatous polyposis coli gene, and half of the remaining cases feature mutations in the β-catenin gene that affect the Wnt/β-catenin signaling pathway. Unsurprisingly, the Wnt/β-catenin signaling pathway has potent...
Source: Biomedicine and Pharmacotherapy - December 6, 2018 Category: Drugs & Pharmacology Source Type: research

Neuroprotection and improvement of the histopathological and behavioral impairments in a murine Alzheimer’s model treated with Zephyranthes carinata alkaloids
Publication date: February 2019Source: Biomedicine & Pharmacotherapy, Volume 110Author(s): Natalie Cortes, Angelica Maria Sabogal-Guaqueta, Gloria Patricia Cardona-Gomez, Edison OsorioAbstractIn Alzheimer’s disease (AD), amyloid beta (Aβ) plaques initiates a cascade of pathological events where the overactivation of N-methyl-d-aspartate receptors (NMDA) by excess glutamate (Glu) triggers oxidative processes that lead to the activation of microglial cells, inflammation, and finally neuronal death. Amaryllidaceae alkaloids exert neuroprotective activities against different neurotoxin-induced injuries in vitro,...
Source: Biomedicine and Pharmacotherapy - December 6, 2018 Category: Drugs & Pharmacology Source Type: research

Effect of antiepileptic drug (Topiramate) and cold pressed ginger oil on testicular genes expression, sexual hormones and histopathological alterations in mice
Publication date: February 2019Source: Biomedicine & Pharmacotherapy, Volume 110Author(s): Aida I. El Makawy, Faten M. Ibrahim, Dalia M. Mabrouk, Kawkab A. Ahmed, Mohamed Fawzy RamadanAbstractSexual dysfunction in the epileptic patient is difficult to confirm whether it is ailment or therapy related. Antiepileptic drugs often use in reproductive age, through reproductive progress and maturation. On the other side, cold-pressed oils are rich in bioactive phytochemicals with health-promoting traits. The target of this work was to appraise the sexual dysfunction of antiepileptic Topiramate (TPM) and cold pressed ginger oi...
Source: Biomedicine and Pharmacotherapy - December 6, 2018 Category: Drugs & Pharmacology Source Type: research

Wnt/β-catenin signaling pathway contributes to isoflurane postconditioning against cerebral ischemia-reperfusion injury and is possibly related to the transforming growth factorβ1/Smad3 signaling pathway
ConclusionISO postconditioning can reduce cerebral I/R injury by activating the Wnt/β-catenin signaling pathway and may be related to the TGF-β/Smad3 signaling pathway. (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - December 6, 2018 Category: Drugs & Pharmacology Source Type: research

SUR2B/Kir6.1 channel openers correct endothelial dysfunction in chronic heart failure via the miR-1-3p/ET-1 pathway
In this study, we investigated the microRNAs (miRs) involved in the molecular mechanisms of SUR2B/Kir6.1 channel opening in chronic heart failure. Both iptakalim and natakalim significantly upregulated the expression of miR-1-3p, suggesting that this miR is closely associated with the therapeutic effects against chronic heart failure. Bioinformatic analysis showed that many of the 183 target genes of miR-1-3p are involved in cardiovascular diseases, suggesting that miR-1-3p plays a vital role in such diseases and vascular remodeling. Target gene prediction showed that miR-1-3p combines with the 3′ untranslated region...
Source: Biomedicine and Pharmacotherapy - December 6, 2018 Category: Drugs & Pharmacology Source Type: research

Azithromycin treats diffuse panbronchiolitis by targeting T cells via inhibition of mTOR pathway
Publication date: February 2019Source: Biomedicine & Pharmacotherapy, Volume 110Author(s): Dong Weng, Qin Wu, Xian-Qiu Chen, Yu-Kui Du, Tao Chen, Hong Li, Dan-Li Tang, Qiu-Hong Li, Yuan Zhang, Li-Qin Lu, Nian-Yu Zhou, Jia-Cui Song, Chen Wang, Hui-Ping LiAbstractAzithromycin (AZM), that is a macrolide antibiotic, has been found to treat diffuse panbronchiolitis (DPB) effectively. However, the mechanism of action underlying the therapeutic effects remains unclear. We selected 64 patients with DPB from 305 patients who were diagnosed with DPB at the outpatient clinic in Shanghai Pulmonary Hospital from Jan 2010 to Oct 201...
Source: Biomedicine and Pharmacotherapy - December 6, 2018 Category: Drugs & Pharmacology Source Type: research

Hypoglycemic activity of the extracts of Belamcanda chinensis leaves (BCLE) on KK-Ay mice
In this study, the effects of BCLE on obese diabetes were investigated using the KK-Ay mice. The component F2 of BCLE alleviate hyperglycemia and insulin resistance, as indicated by decreased levels of FBG, AUC, GSP, LDH and insulin. High levels of hepatic G6Pase and PEPCK in KK-Ay mice were markedly attenuated by F2. The inhibitory effect of F2 on GSK-3β and the enhancement effect on liver glycogen demonstrated that F2 could significantly inhibit hepatic gluconeogenesis and glycogen accumulation. The higher PPAR γ showed F2 may prevent insulin resistance by PI3K signal transduction pathway. In addition, the com...
Source: Biomedicine and Pharmacotherapy - December 6, 2018 Category: Drugs & Pharmacology Source Type: research

Dyslipidemia induced inflammatory status, platelet activation and endothelial dysfunction in rabbits: Protective role of 10-Dehydrogingerdione
Publication date: February 2019Source: Biomedicine & Pharmacotherapy, Volume 110Author(s): Mohamed Mahmoud El-Seweidy, Rawia sarhan Amin, Hebatallah Husseini Atteia, Reham Raafat El-Zeiky, Naif A. Al-gabriAbstract10-Dehydrogingerdione is a novel cholesteryl ester transfer protein (CETP) inhibitor of natural origin. Some synthetic CETP inhibitors have recently been reported to suppress proprotein convertase subtilisin/kexin type 9 (PCSK9). Therefore, the present study aimed mainly to clarify the effect of 10-Dehydrogingerdione on cellular adhesion inflammatory molecules, platelet activation and endothelial dysfunction m...
Source: Biomedicine and Pharmacotherapy - December 6, 2018 Category: Drugs & Pharmacology Source Type: research

Expression of Mac-2 binding protein in human carotid atheroma is associated with plaque instability and clinical manifestations
ConclusionsM2BP is highly expressed in advanced plaques and vulnerable regions and significantly correlated with clinical ischemic manifestations. Therefore, M2BP may serve as an important biomarker of plaque destabilization.Graphical abstract (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - December 6, 2018 Category: Drugs & Pharmacology Source Type: research

Targeting Nrf2/HO-1 signaling by crocin: Role in attenuation of AA-induced ulcerative colitis in rats
In conclusion; crocin demonstrated anti-ulcerogenic and coloprotective effect mediated primarily by its antioxidant, anti-inflammatory and anti-apoptotic properties. The therapeutic impact is mediated primarily via enhancement of colon Nrf2 content by 211% in protective protocol and by 350% in curative and HO-1 signaling by 49% in protective protocol and, 288% in the curative protocol. Enhancement of Nrf2 and HO-1 signaling and down-regulation of caspase-3 activity are believed to underly the observed therapeutic effect.Graphical abstract (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - December 5, 2018 Category: Drugs & Pharmacology Source Type: research

Antiproliferative and antiangiogenic effect of Amblyomma sculptum (Acari: Ixodidae) crude saliva in endothelial cells in vitro
Publication date: February 2019Source: Biomedicine & Pharmacotherapy, Volume 110Author(s): Paulo Luiz de Sá Junior, Diana Aparecida Dias Câmara, Juliana Mozer Sciani, Allan Saj Porcacchia, Pâmela Maria Moreira Fonseca, Ronaldo Zucatelli Mendonça, Selene Elifio-Esposito, Simone Michaela SimonsAbstractNeovascularization, a process that includes vasculogenesis and angiogenesis, may be a physiological or pathologic event, but in any cases the phenomenon is related to the formation of vascular net and sprouting of endothelial cells from preexisting blood vessel. The tumor environment, which counts ...
Source: Biomedicine and Pharmacotherapy - December 5, 2018 Category: Drugs & Pharmacology Source Type: research

The effect of divalent metal cations on the αv integrin binding site is ligand and integrin specific
In conclusion, this study demonstrates the need to determine the individual relationship between RGD ligands and the integrins they may engage in vivo, especially when determining selectivity profiles for potential RGD-mimetic small molecule therapeutics, with organ and disease state also considered. (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - December 5, 2018 Category: Drugs & Pharmacology Source Type: research