Jagged1 is Clinically Prognostic and Promotes Invasion of Glioma-Initiating Cells by Activating NF- κB(p65) Signaling
Conclusion: Insights gained from these findings suggest that Jagged1 plays an important oncogenic role in GICs malignancy by activation of NF- κB(p65) signaling, and Jagged1 could be employed as an effective therapeutic target for GICs.Cell Physiol Biochem 2018;51:2925 –2937 (Source: Cellular Physiology and Biochemistry)
Source: Cellular Physiology and Biochemistry - December 21, 2018 Category: Cytology Source Type: research

Characterization and Beige Adipogenic Potential of Human Embryo White Adipose Tissue-Derived Stem Cells
Conclusion: Overall, we have demonstrated the molecular characteristics and excellent beige adipogenic potential of eWAsc, providing a new reference for studying human adipocytes.Cell Physiol Biochem 2018;51:2900 –2915 (Source: Cellular Physiology and Biochemistry)
Source: Cellular Physiology and Biochemistry - December 18, 2018 Category: Cytology Source Type: research

Building a Competing Endogenous RNA Network to Find Potential Long Non-Coding RNA Biomarkers for Pheochromocytoma
Conclusion: This study improves the understanding of lncRNA-related ceRNA networks in PCC and suggests that the lncRNAs C9orf147 and BSN-AS2 could be independent prognostic biomarkers and potential therapeutic targets for PCC.Cell Physiol Biochem 2018;51:2916 –2924 (Source: Cellular Physiology and Biochemistry)
Source: Cellular Physiology and Biochemistry - December 18, 2018 Category: Cytology Source Type: research

Sinoporphyrin Sodium-Mediated Sonodynamic Therapy Inhibits RIP3 Expression and Induces Apoptosis in the H446 Small Cell Lung Cancer Cell Line
Conclusion: DVDMS-SDT induced apoptosis in H446 cells, in part by targeting mitochondria through the mitochondria-mediated apoptosis signaling pathway, and the extrinsic apoptosis pathway was also shown to be involved. Both apoptosis and changes in RIP3 expression were closely related to the generation of ROS. DVDMS-SDT will be advantageous for the management of small cell lung cancer due to its noninvasive characteristics.Cell Physiol Biochem 2018;51:2938 –2954 (Source: Cellular Physiology and Biochemistry)
Source: Cellular Physiology and Biochemistry - December 18, 2018 Category: Cytology Source Type: research

Intermittent-Hypoxia-Induced Autophagy Activation Through the ER-Stress-Related PERK/eIF2 α/ATF4 Pathway is a Protective Response to Pancreatic β-Cell Apoptosis
Conclusion: IH induces autophagy activation through the ER-stress-related PERK/eIF2 α/ATF4 signaling pathway, which is a protective response to pancreatic β-cell apoptosis caused by IH.Cell Physiol Biochem 2018;51:2955 –2971 (Source: Cellular Physiology and Biochemistry)
Source: Cellular Physiology and Biochemistry - December 18, 2018 Category: Cytology Source Type: research

ATM-Mediated Phosphorylation of Cortactin Involved in Actin Polymerization Promotes Breast Cancer Cells Migration and Invasion
Conclusion: Oxidized ATM can phosphorylate cortactin at serine 113, playing a critical role in promoting breast tumor cell mobility and invasion via actin polymerization.Cell Physiol Biochem 2018;51:2972 –2988 (Source: Cellular Physiology and Biochemistry)
Source: Cellular Physiology and Biochemistry - December 18, 2018 Category: Cytology Source Type: research

High Expressions of CUL4A and TP53 in Colorectal Cancer Predict Poor Survival
Conclusion: CUL4A expression correlated positively with the prognosis of colorectal cancer. Mechanistically, ZEB1 was confirmed to mediate the function of CUL4A in regulating the EMT. The assessment of both CUL4A and mutant TP53 expression will be helpful in predicting colon cancer prognosis.Cell Physiol Biochem 2018;51:2829 –2842 (Source: Cellular Physiology and Biochemistry)
Source: Cellular Physiology and Biochemistry - December 18, 2018 Category: Cytology Source Type: research

Erratum
Cell Physiol Biochem 2018;51:2496 –2496 (Source: Cellular Physiology and Biochemistry)
Source: Cellular Physiology and Biochemistry - December 18, 2018 Category: Cytology Source Type: research

Erratum
Cell Physiol Biochem 2018;51:2497 –2497 (Source: Cellular Physiology and Biochemistry)
Source: Cellular Physiology and Biochemistry - December 18, 2018 Category: Cytology Source Type: research

Erratum
Cell Physiol Biochem 2018;51:2498 –2498 (Source: Cellular Physiology and Biochemistry)
Source: Cellular Physiology and Biochemistry - December 18, 2018 Category: Cytology Source Type: research

Expression Profiles of microRNAs in Drug-Resistant Non-Small Cell Lung Cancer Cell Lines Using microRNA Sequencing
Conclusion: The results of this study may provide novel biomarkers for drug resistance in NSCLC and potential therapies for overcoming drug resistance, and may also reveal the potential mechanisms underlying drug resistance in this disease.Cell Physiol Biochem 2018;51:2509 –2522 (Source: Cellular Physiology and Biochemistry)
Source: Cellular Physiology and Biochemistry - December 17, 2018 Category: Cytology Source Type: research

Type I Interferons: Distinct Biological Activities and Current Applications for Viral Infection
The interferons (IFNs) are a primary defense against pathogens because of the strong antiviral activities they induce. IFNs can be classified into three groups: type I, type II and type III, according to their genetic, structural, and functional characteristics and their receptors on the cell surface. The type I IFNs are the largest group and include IFN- α, IFN-β, IFN-ε, IFN-ω, IFN-κ, IFN-δ, IFN-τ and IFN-ζ. The use of IFNs for the treatment of viral infectious diseases on their antiviral activity may become an important therapeutic option, for example, IFN-α is well kno...
Source: Cellular Physiology and Biochemistry - December 13, 2018 Category: Cytology Source Type: research

Resveratrol Ameliorates Lipid Droplet Accumulation in Liver Through a SIRT1/ ATF6-Dependent Mechanism
Conclusion: Taken together, these findings indicate that RSV supplementation improves hepatic steatosis by ameliorating the accumulation of LDs, and this might be partially mediated by a SIRT1/ATF6-dependent mechanism.Cell Physiol Biochem 2018;51:2397 –2420 (Source: Cellular Physiology and Biochemistry)
Source: Cellular Physiology and Biochemistry - December 13, 2018 Category: Cytology Source Type: research

Sodium Fluoride Arrests Renal G2/M Phase Cell-Cycle Progression by Activating ATM-Chk2-P53/Cdc25C Signaling Pathway in Mice
Conclusion: In this mouse model, NaF, at more than 12 mg/ kg, induced G2/M phase cell-cycle arrest by activating the ATM-Chk2-p53/Cdc25C signaling pathway, which inhibits the proliferation of renal cells and development of the kidney. Activation of the ATM-Chk2-p53/Cdc25C signaling pathway is the mechanism of NaF-induced renal G2/M phase cell-cycle arrest in this model.Cell Physiol Biochem 2018;51:2421 –2433 (Source: Cellular Physiology and Biochemistry)
Source: Cellular Physiology and Biochemistry - December 13, 2018 Category: Cytology Source Type: research

PGK1 is a Potential Survival Biomarker and Invasion Promoter by Regulating the HIF-1 α–Mediated Epithelial-Mesenchymal Transition Process in Breast Cancer
Conclusion: High PGK1 expression was associated with poor prognosis in breast cancer, because PGK1 and HIF-1 α formed a positive feed-forward loop and thus stimulated breast cancer progression and metastases. Based on these results, PGK1 may serve as a promising biomarker and target therapy for breast cancer.Cell Physiol Biochem 2018;51:2434 –2444 (Source: Cellular Physiology and Biochemistry)
Source: Cellular Physiology and Biochemistry - December 13, 2018 Category: Cytology Source Type: research

A Novel Variant of the FZD4 Gene in a Chinese Family Causes Autosomal Dominant < b > < i > Familial Exudative Vitreoretinopathy < /i > < /b >
Conclusion: Our study is the first to identify that the novel heterozygous variant c.A749G (p.Y250C) in theFZD4 gene may be the disease-causing mutation in this FEVR family, extending its mutation spectrum. These findings further our understanding of the molecular pathogenesis of FEVR and will facilitate the development of methods for the diagnosis, prevention, and genetic counseling of this disease.Cell Physiol Biochem 2018;51:2445 –2455 (Source: Cellular Physiology and Biochemistry)
Source: Cellular Physiology and Biochemistry - December 13, 2018 Category: Cytology Source Type: research

Protective Mechanism of Adipose-Derived Stem Cells in Remodelling of the Skin Stem Cell Niche During Photoaging
Conclusion: We found that UVB irradiation results in typical photoaging signs by altering skin stem cell niches and that Bmp4 was a key factor in BMP signalling in hair follicles. ADSCs reversed these typical photoaging signs by remodelling skin stem cell niches through BMP4 pathway modulation and transdifferentiation into skin stem cells.Cell Physiol Biochem 2018;51:2456 –2471 (Source: Cellular Physiology and Biochemistry)
Source: Cellular Physiology and Biochemistry - December 13, 2018 Category: Cytology Source Type: research

Stromal Cell-Derived CCL20 Promotes Tumor Progression and Osteolysis in Giant Cell Tumor of Bone
Conclusion: Taken together, our data indicate that GCTSC secretion of CCL20 acts as a key modulator in the pathological progression of GCTB. It can promote GCTSC proliferation and migration in an autocrine manner and can recruit bone marrow monocytes to the tumor microenvironment and enhance osteoclastogenesis in a paracrine manner. These findings strongly indicate the potential prognostic and therapeutic value of CCL20 in GCTB.Cell Physiol Biochem 2018;51:2472 –2483 (Source: Cellular Physiology and Biochemistry)
Source: Cellular Physiology and Biochemistry - December 13, 2018 Category: Cytology Source Type: research

Predictive Value of Age-Bilirubin-International Normalized Ratio-Creatinine Score in Short-Term Survival of Acute-on-Chronic Hepatitis B Liver Failure
Conclusion: ABIC score is superior to MELD score in predicting short-term survival in HBV-ACLF patients. ABIC score #x3e; 9.44 predicts high short-term mortality risk in HBV-ACLF patients.Cell Physiol Biochem 2018;51:2484 –2495 (Source: Cellular Physiology and Biochemistry)
Source: Cellular Physiology and Biochemistry - December 13, 2018 Category: Cytology Source Type: research

Comparative Study of MSCA-1 and CD146 Isolated Periosteal Cell Subpopulations
Conclusion: Our results demonstrate, that MSCA-1+ cells isolated from CPCs represent a subpopulation with a higher osteogenic potential. In contrast, we found a lower osteogenic potential in CD146+ CPCs. In conclusion, only MSCA-1, but not CD146, is a suitable marker for the isolation of osteoprogenitors from CPCs.Cell Physiol Biochem 2018;51:1193 –1206 (Source: Cellular Physiology and Biochemistry)
Source: Cellular Physiology and Biochemistry - December 13, 2018 Category: Cytology Source Type: research

circZMYM2 Competed Endogenously with miR-335-5p to Regulate JMJD2C in Pancreatic Cancer
Conclusion: Our study demonstrated that circZMYM2 promoted PC progression. CircZMYM2 had a sponge effect on miR-335-5p and modulated the downstream oncogeneJMJD2C.Cell Physiol Biochem 2018;51:2224 –2236 (Source: Cellular Physiology and Biochemistry)
Source: Cellular Physiology and Biochemistry - December 7, 2018 Category: Cytology Source Type: research

Hypoxia Preconditioning of Human MSCs: a Direct Evidence of HIF-1 α and Collagen Type XV Correlation
Conclusion: These results add useful information to understand the role of a still little investigated collagen such as ColXV, and identify ColXV as a marker of successful hypoxia preconditioning. As a whole, our data give further evidence that hypoxia preconditioned hMSCs have greater osteopotency than normal hMSCs, and that the effects of hypoxic regulation of hMSCs activities should be considered before they are clinically applied.Cell Physiol Biochem 2018;51:2237 –2249 (Source: Cellular Physiology and Biochemistry)
Source: Cellular Physiology and Biochemistry - December 7, 2018 Category: Cytology Source Type: research

Tanshinone IIA Inhibits High Glucose-Induced Collagen Synthesis via Nuclear Factor Erythroid 2-Related Factor 2 in Cardiac Fibroblasts
Conclusion: In summary, our results highlights the critical role tanshinone IIA plays as an antioxidant in attenuating high glucose-mediated collagen synthesis through inhibiting TGF- β1/Smad signaling in cardiac fibroblasts which provide a mechanistic basis for the clinical application of tanshinone IIA in the treating diabetic-related cardiac fibrosis.Cell Physiol Biochem 2018;51:2250 –2261 (Source: Cellular Physiology and Biochemistry)
Source: Cellular Physiology and Biochemistry - December 7, 2018 Category: Cytology Source Type: research

lncRNA SNHG8 Promotes the Tumorigenesis and Metastasis by Sponging miR-149-5p and Predicts Tumor Recurrence in Hepatocellular Carcinoma
Conclusion: As lncRNA SNHG8 may promote HCC tumorigenesis and metastasis by sponging miR-149, it is a potential candidate marker and therapeutic target for HCC.Cell Physiol Biochem 2018;51:2262 –2274 (Source: Cellular Physiology and Biochemistry)
Source: Cellular Physiology and Biochemistry - December 7, 2018 Category: Cytology Source Type: research

MicroRNA-128 Protects Dopamine Neurons from Apoptosis and Upregulates the Expression of Excitatory Amino Acid Transporter 4 in Parkinson ’s Disease by Binding to AXIN1
Conclusion: Evidence from experimental models revealed that miR-128 might reduce apoptosis of DA neurons while increasing the expression of EAAT4 which might be related to the downregulation of AXIN1. Thus, miR-128 may serve as a potential target for the treatment of PD.Cell Physiol Biochem 2018;51:2275 –2289 (Source: Cellular Physiology and Biochemistry)
Source: Cellular Physiology and Biochemistry - December 7, 2018 Category: Cytology Source Type: research

Dental Follicle Stem Cells Ameliorate Lipopolysaccharide-Induced Inflammation by Secreting TGF- β3 and TSP-1 to Elicit Macrophage M2 Polarization
Conclusion: These results indicated that DFSCs can reprogram macrophages into the anti-inflammatory M2 phenotype, the paracrine factors TGF- β3 and TSP-1 may be one of the underlying mechanisms. This study supports the hypothesis that DFSCs are promising for MSC-based immunotherapy.Cell Physiol Biochem 2018;51:2290 –2308 (Source: Cellular Physiology and Biochemistry)
Source: Cellular Physiology and Biochemistry - December 7, 2018 Category: Cytology Source Type: research

The Transient Receptor Potential Channel, Vanilloid 5, Induces Chondrocyte Apoptosis via Ca < sup > 2+ < /sup > CaMKII –Dependent MAPK and Akt/ mTOR Pathways in a Rat Osteoarthritis Model
Conclusion: Our results demonstrate that upregulated TRPV5 may be an important initiating factor that activates CaMKII phosphorylation via the mediation of Ca2+ influx. In turn, activated p-CaMKII plays a critical role in chondrocyte apoptosis via MAPK and Akt/mTOR pathways.Cell Physiol Biochem 2018;51:2309 –2323 (Source: Cellular Physiology and Biochemistry)
Source: Cellular Physiology and Biochemistry - December 7, 2018 Category: Cytology Source Type: research

Circular RNA circPVT1 Promotes Proliferation and Invasion Through Sponging miR-125b and Activating E2F2 Signaling in Non-Small Cell Lung Cancer
Conclusion: circPVT1 promotes NSCLC cell growth and invasion, and may serve as a promising therapeutic target for NSCLC patients. Therefore, silence of circPVT1 could be a future direction to develop a novel treatment strategy.Cell Physiol Biochem 2018;51:2324 –2340 (Source: Cellular Physiology and Biochemistry)
Source: Cellular Physiology and Biochemistry - December 7, 2018 Category: Cytology Source Type: research

Establishment of a Mouse Model of Premature Ovarian Failure Using Consecutive Superovulation
Conclusion: Consecutive superovulation significantly decreased ovarian function and oocyte quality and increased oxidative stress and apoptosis in the ovary via a mechanism involving the p16 and SIRT1/FOXO1 signaling pathways. These findings suggest that consecutive superovulation may be used to establish a mouse model of ovarian aging.Cell Physiol Biochem 2018;51:2341 –2358 (Source: Cellular Physiology and Biochemistry)
Source: Cellular Physiology and Biochemistry - December 7, 2018 Category: Cytology Source Type: research

Mammalian STE20-Like Kinase 1 Deletion Alleviates Renal Ischaemia-Reperfusion Injury via Modulating Mitophagy and the AMPK-YAP Signalling Pathway
Conclusion: Overall, our results demonstrate that the pathogenesis of renal I/R injury is closely associated with an increase in Mst1 expression and the inactive AMPK-YAP-OPA1 signalling pathway. Based on this, strategies to repress Mst1 expression and activate mitophagy could serve as therapeutic targets to treat kidney ischaemia-reperfusion injury.Cell Physiol Biochem 2018;51:2359 –2376 (Source: Cellular Physiology and Biochemistry)
Source: Cellular Physiology and Biochemistry - December 7, 2018 Category: Cytology Source Type: research

Clinicopathologic Features and Prognostic Factors in Alpha-Fetoprotein-Producing Colorectal Cancer: Analysis of 78 Cases
Conclusion: AFP-positivity is a significant negative predictor of overall survival in patients with colorectal cancer, which may be mediated by HGF/c-Met signaling pathway.Cell Physiol Biochem 2018;51:2052 –2064 (Source: Cellular Physiology and Biochemistry)
Source: Cellular Physiology and Biochemistry - December 6, 2018 Category: Cytology Source Type: research

Potential Role of microRNA-183 as a Tumor Suppressor in Hepatocellular Carcinoma
Conclusion: Our results reveal a novel post-transcriptional regulatory mechanism forMTA1 expression via miR-183, which is suppressed during HCC pathogenesis.Cell Physiol Biochem 2018;51:2065 –2072 (Source: Cellular Physiology and Biochemistry)
Source: Cellular Physiology and Biochemistry - December 6, 2018 Category: Cytology Source Type: research

Clinical Drug Response Prediction by Using a Lq Penalized Network-Constrained Logistic Regression Method
Conclusion: The proposed method is much better than the existing approach and can capture a more accurate reflection of the relationship between genotypes and phenotypes.Cell Physiol Biochem 2018;51:2073 –2084 (Source: Cellular Physiology and Biochemistry)
Source: Cellular Physiology and Biochemistry - December 6, 2018 Category: Cytology Source Type: research

Gliquidone Alleviates Diabetic Nephropathy by Inhibiting Notch/Snail Signaling Pathway
Conclusion: Taken together, our results suggested that gliquidone can ameliorate the diabetic symptoms of diabetic nephropathy through inhibiting Notch / Snail1 signaling pathway, improving anti -oxidative response and delaying renal interstitial fibrosis. The efficacy of gliquidone is dose-dependent.Cell Physiol Biochem 2018;51:2085 –2097 (Source: Cellular Physiology and Biochemistry)
Source: Cellular Physiology and Biochemistry - December 6, 2018 Category: Cytology Source Type: research

Blocking TRPA1 and TNF- α Signal Improves Bortezomib-Induced Neuropathic Pain
Conclusion: We revealed specific signaling pathways leading to neuropathic pain induced by chemotherapeutic BTZ. The data also suggest that blocking TRPA1 and tumor necrosis factor alpha is beneficial to alleviate neuropathic pain during BTZ intervention.Cell Physiol Biochem 2018;51:2098 –2110 (Source: Cellular Physiology and Biochemistry)
Source: Cellular Physiology and Biochemistry - December 6, 2018 Category: Cytology Source Type: research

Sestrin 2 Attenuates Rat Hepatic Stellate Cell (HSC) Activation and Liver Fibrosis via an mTOR/AMPK-Dependent Mechanism
Conclusion: Our findings indicate that Sestrin 2 may attenuate the activation of HSCs and ameliorate liver fibrosis, most likely via upregulation of AMPK phosphorylation and suppression of the mTOR signaling pathway.Cell Physiol Biochem 2018;51:2111 –2122 (Source: Cellular Physiology and Biochemistry)
Source: Cellular Physiology and Biochemistry - December 6, 2018 Category: Cytology Source Type: research

Microbial Intervention as a Novel Target in Treatment of Non-Alcoholic Fatty Liver Disease Progression
Conclusion: Our results suggested that both gut microbiota alteration and adiponectin variability may be drivers of NAFLD progression and that targeting the gut microbiota, such as via administration of a probiotic, may delay NAFLD progression via adiponectin.Cell Physiol Biochem 2018;51:2123 –2135 (Source: Cellular Physiology and Biochemistry)
Source: Cellular Physiology and Biochemistry - December 6, 2018 Category: Cytology Source Type: research

Gastric Adenocarcinoma Predictive Long Intergenic Non-Coding RNA Promotes Tumor Occurrence and Progression in Non-Small Cell Lung Cancer via Regulation of the miR-661/eEF2K Signaling Pathway
Conclusion: Our findings indicate that GAPLINC promotes NSCLC tumorigenesis by regulating miR-661/eEF2K cascade and provide new insights for the pathogenesis underlying NSCLC and potential targets for therapeutic strategy.Cell Physiol Biochem 2018;51:2136 –2147 (Source: Cellular Physiology and Biochemistry)
Source: Cellular Physiology and Biochemistry - December 6, 2018 Category: Cytology Source Type: research

miR-122 Targets X-Linked Inhibitor of Apoptosis Protein to Sensitize Oxaliplatin-Resistant Colorectal Cancer Cells to Oxaliplatin-Mediated Cytotoxicity
Conclusion: Upregulation of XIAP in CRC cells is responsible for the acquired resistance to oxaliplatin. Furthermore, miR-122 reversed oxaliplatin resistance in CRC by targeting XIAP.Cell Physiol Biochem 2018;51:2148 –2159 (Source: Cellular Physiology and Biochemistry)
Source: Cellular Physiology and Biochemistry - December 6, 2018 Category: Cytology Source Type: research

miR-202 Enhances the Anti-Tumor Effect of Cisplatin on Non-Small Cell Lung Cancer by Targeting the Ras/MAPK Pathway
Conclusion: The miR-202/KRas axis controlled the chemosensitivity of NSCLC by mediating the Ras/MAPK pathway. Thus, the combination of platinum-based drugs with miR-202 may represent a novel strategy to enhance the anti-tumor effect against NSCLC.Cell Physiol Biochem 2018;51:2160 –2171 (Source: Cellular Physiology and Biochemistry)
Source: Cellular Physiology and Biochemistry - December 6, 2018 Category: Cytology Source Type: research

miRNA-544a Regulates the Inflammation of Spinal Cord Injury by Inhibiting the Expression of NEUROD4
Conclusion: The expression of miR-544a was significantly decreased after spinal cord injury. High expression of miR-544a could alleviate the inflammation caused by spinal cord injury and promote the recovery of spinal cord via the inhibition of NEUROD4.Cell Physiol Biochem 2018;51:1921 –1931 (Source: Cellular Physiology and Biochemistry)
Source: Cellular Physiology and Biochemistry - December 4, 2018 Category: Cytology Source Type: research

microRNA-15 Activates NF- κB Pathway via Down Regulating Expression of Adenosine A2 Receptor in Ulcerative Colitis
Conclusion: Our data suggest that miR-15 modulates inflammatory and immune responses by suppressing the expression of A2aAR and regulating the NF- κB cascade.Cell Physiol Biochem 2018;51:1932 –1944 (Source: Cellular Physiology and Biochemistry)
Source: Cellular Physiology and Biochemistry - December 4, 2018 Category: Cytology Source Type: research

IGF2BP2 Overexpression Indicates Poor Survival in Patients with Acute Myelocytic Leukemia
Conclusion: Thus, IGF2BP2 may serve as a biomarker to predict the prognosis of AML and as a potential target in AML.Cell Physiol Biochem 2018;51:1945 –1956 (Source: Cellular Physiology and Biochemistry)
Source: Cellular Physiology and Biochemistry - December 4, 2018 Category: Cytology Source Type: research

Simvastatin Protects Dopaminergic Neurons Against MPP < sup > + < /sup > -Induced Oxidative Stress and Regulates the Endogenous Anti-Oxidant System Through ERK
Conclusion: Our results provide strong evidence that ERK1/2-mediated modulation of the anti-oxidant system after simvastatin treatment may partially explain the anti-oxidant activity in experimental parkinsonian models. These findings contribute to a better understanding of the critical roles of simvastatin via the ERK1/2-mediated modulation of the anti-oxidant system, which may be relevant for treating PD.Cell Physiol Biochem 2018;51:1957 –1968 (Source: Cellular Physiology and Biochemistry)
Source: Cellular Physiology and Biochemistry - December 4, 2018 Category: Cytology Source Type: research

miR-142-3p Suppresses Cell Growth by Targeting CDK4 in Colorectal Cancer
Conclusion: From our results we conclude that miR-142-3p may act as a tumor suppressor in CRC and may serve as a tool for miRNA-based CRC therapy.Cell Physiol Biochem 2018;51:1969 –1981 (Source: Cellular Physiology and Biochemistry)
Source: Cellular Physiology and Biochemistry - December 4, 2018 Category: Cytology Source Type: research

Pituitary Adenylate Cyclase Activating Polypeptide Elicits Neuroprotection Against Acute Ischemic Neuronal Cell Death Associated with NMDA Receptors
Conclusion: This study provides evidence that PACAP regulated NMDAR subunits, affording neuroprotection after OGD/R injury.Cell Physiol Biochem 2018;51:1982 –1995 (Source: Cellular Physiology and Biochemistry)
Source: Cellular Physiology and Biochemistry - December 4, 2018 Category: Cytology Source Type: research

Hyperglycaemia Stress-Induced Renal Injury is Caused by Extensive Mitochondrial Fragmentation, Attenuated MKP1 Signalling, and Activated JNK-CaMKII-Fis1 Biological Axis
Conclusion: Taken together, our data identified the protective role played by MKP1 in regulating diabetic renal injury via repressing mitochondrial fragmentation and inactivating the JNK-CaMKII-Fis1 pathway, which may pave the road to new therapeutic modalities for the treatment of diabetic nephropathy.Cell Physiol Biochem 2018;51:1778 –1798 (Source: Cellular Physiology and Biochemistry)
Source: Cellular Physiology and Biochemistry - November 30, 2018 Category: Cytology Source Type: research

B-Cell Receptor-Associated Protein 31 Regulates the Expression of Valosin-Containing Protein Through Elf2
Conclusion: These results indicate that Bap31 regulates the expression of VCP possibly via Elf2 and support the potential molecular function of Bap31 in CNS diseases.Cell Physiol Biochem 2018;51:1799 –1814 (Source: Cellular Physiology and Biochemistry)
Source: Cellular Physiology and Biochemistry - November 30, 2018 Category: Cytology Source Type: research

Mycobacterial Infection is Promoted by Neutral Sphingomyelinase 2 Regulating a Signaling Cascade Leading to Activation of β1-Integrin
Conclusion: The findings indicate that the Nsm2/ ceramide system plays an important role in systemic infection of mice with mycobacteria by regulating a signaling cascade via p38K, JNK, b1-integrin and Rac1.Cell Physiol Biochem 2018;51:1815 –1829 (Source: Cellular Physiology and Biochemistry)
Source: Cellular Physiology and Biochemistry - November 30, 2018 Category: Cytology Source Type: research

Morin Exhibits Anti-Inflammatory Effects on IL-1 β-Stimulated Human Osteoarthritis Chondrocytes by Activating the Nrf2 Signaling Pathway
Conclusion: In conclusion, this study suggested that morin attenuated IL-1 β-induced inflammation by activating the Nrf2 signaling pathway.Cell Physiol Biochem 2018;51:1830 –1838 (Source: Cellular Physiology and Biochemistry)
Source: Cellular Physiology and Biochemistry - November 30, 2018 Category: Cytology Source Type: research