Metformin and FTY720 Synergistically Induce Apoptosis in Multiple Myeloma Cells
Conclusions: Exposure to metformin in combination with FTY720 potently induces apoptosis in MM cells in a ROS-dependent manner, suggesting that a strategy combining these agents warrants further investigation in MM.Cell Physiol Biochem 2018;48:785 –800 (Source: Cellular Physiology and Biochemistry)
Source: Cellular Physiology and Biochemistry - July 20, 2018 Category: Cytology Source Type: research

MiR-195/-16 Family Enhances Radiotherapy via T Cell Activation in the Tumor Microenvironment by Blocking the PD-L1 Immune Checkpoint
Conclusions: Our data revealbiological and functional interactions between immunotherapy and radiotherapy through the miR-195/-16 family regulatory cascade.Cell Physiol Biochem 2018;48:801 –814 (Source: Cellular Physiology and Biochemistry)
Source: Cellular Physiology and Biochemistry - July 20, 2018 Category: Cytology Source Type: research

MicroRNA-374a Inhibits Aggressive Tumor Biological Behavior in Bladder Carcinoma by Suppressing Wnt/ β-Catenin Signaling
Conclusion: Lower expression of miR-374a is associated with poor prognosis and miR-374a improves tumor biological behavior in bladder cancer cells, suggesting that miR-374a might be a novel small-molecule therapeutic target.Cell Physiol Biochem 2018;48:815 –826 (Source: Cellular Physiology and Biochemistry)
Source: Cellular Physiology and Biochemistry - July 20, 2018 Category: Cytology Source Type: research

Non-Esterified Fatty Acids Over-Activate the TLR2/4-NF- Κb Signaling Pathway to Increase Inflammatory Cytokine Synthesis in Neutrophils from Ketotic Cows
Conclusions: High concentrations of NEFAs can over-activate the TLR2/4-mediated NF- κB signaling pathway to induce the over-production of proinflammatory cytokines, thereby increasing inflammation in cows with clinical ketosis.Cell Physiol Biochem 2018;48:827 –837 (Source: Cellular Physiology and Biochemistry)
Source: Cellular Physiology and Biochemistry - July 20, 2018 Category: Cytology Source Type: research

Human β < sub > 3 < /sub > -Adrenoreceptor is Resistant to Agonist-Induced Desensitization in Renal Epithelial Cells
Conclusions: Overall, we conclude that β3AR is less prone than AVPR2 to agonist-induced desensitization in renal collecting duct epithelial cells, showing sustained cAMP production, preserved membrane localization and delayed degradation after 12 hours agonist exposure. These results may be important for the potential use of chronic pharmacological stimulation of β3AR to promote antidiuresis overcomingin vivo renal concentrating defects caused by inactivating mutations of the AVPR2.Cell Physiol Biochem 2018;48:847 –862 (Source: Cellular Physiology and Biochemistry)
Source: Cellular Physiology and Biochemistry - July 20, 2018 Category: Cytology Source Type: research

ALKBH5 Inhibits Pancreatic Cancer Motility by Decreasing Long Non-Coding RNA KCNK15-AS1 Methylation
Conclusion: Our results have revealed a novel mechanism by which ALKBH5 inhibits pancreatic cancer motility by demethylating lncRNA KCNK15-AS1, identifying a potential therapeutic target for pancreatic cancer.Cell Physiol Biochem 2018;48:838 –846 (Source: Cellular Physiology and Biochemistry)
Source: Cellular Physiology and Biochemistry - July 20, 2018 Category: Cytology Source Type: research

Galectin-1 Restores Immune Tolerance to Liver Transplantation Through Activation of Hepatic Stellate Cells
Conclusions: The findings of the current study indicated that the overexpression of galectin-1 promoted the activation of HSCs, which reduced the inflammatory response by exerting immunosuppressive effects and accordingly contributed to immune tolerance in LT.Cell Physiol Biochem 2018;48:863 –879 (Source: Cellular Physiology and Biochemistry)
Source: Cellular Physiology and Biochemistry - July 20, 2018 Category: Cytology Source Type: research

Mutant MAPK7-Induced Idiopathic Scoliosis is Linked to Impaired Osteogenesis
Conclusion: Impaired osteogenesis is linked to mutantMAPK7-induced idiopathic scoliosis , and RPS6KA3 may play an important role in this process.Cell Physiol Biochem 2018;48:880 –890 (Source: Cellular Physiology and Biochemistry)
Source: Cellular Physiology and Biochemistry - July 20, 2018 Category: Cytology Source Type: research

Long Non-Coding RNA LUCAT1 Promotes Proliferation and Invasion in Clear Cell Renal Cell Carcinoma Through AKT/GSK-3 β Signaling Pathway
Conclusions: LUCAT1 was upregulated in ccRCC tissues and renal cancer cell lines, and significantly correlated with malignant stage and poor prognosis in ccRCC. LUCAT1 promoted proliferation and invasion in ccRCC cells through the AKT/GSK-3 β signaling pathway. We also revealed that LUCAT1 overexpression was induced by chemokine CXCL2. These findings indicate that the CXCL2/LUCAT1/AKT/GSK-3β axis is a potential therapeutic target and molecular biomarker for ccRCC.Cell Physiol Biochem 2018;48:891 –904 (Source: Cellular Physiology and Biochemistry)
Source: Cellular Physiology and Biochemistry - July 20, 2018 Category: Cytology Source Type: research

MicroRNA-16 Promotes Ovarian Granulosa Cell Proliferation and Suppresses Apoptosis Through Targeting PDCD4 in Polycystic Ovarian Syndrome
Conclusions: miR-16 promoted ovarian GCs proliferation and inhibited apoptosis through directly targeting PDCD4 in PCOS, contributing to a better understanding of the molecular mechanism of GCs dysregulation and providing a promising target in PCOS.Cell Physiol Biochem 2018;48:670 –682 (Source: Cellular Physiology and Biochemistry)
Source: Cellular Physiology and Biochemistry - July 19, 2018 Category: Cytology Source Type: research

Midazolam Enhances Mutant Huntingtin Protein Accumulation via Impairment of Autophagic Degradation < b > < i > In Vitro < /i > < /b >
Conclusions: Midazolam increased mHtt levels and decreased Htt (Q74)-PC12 cell viability via impairment of autophagic degradation, which could be restored by overexpression of cathepsin D.Cell Physiol Biochem 2018;48:683 –691 (Source: Cellular Physiology and Biochemistry)
Source: Cellular Physiology and Biochemistry - July 19, 2018 Category: Cytology Source Type: research

MicroRNA-29b Regulates the Mitochondria-Dependent Apoptotic Pathway by Targeting Bax in Doxorubicin Cardiotoxicity
Conclusions: These data demonstrate that miR-29b prevents Dox-induced myocardial apoptosis through inhibition of the mitochondria-dependent pathway by directly targeting Bax, suggesting that miR-29b is a potential novel therapeutic target for the treatment of Dox cardiotoxicity.Cell Physiol Biochem 2018;48:692 –704 (Source: Cellular Physiology and Biochemistry)
Source: Cellular Physiology and Biochemistry - July 19, 2018 Category: Cytology Source Type: research

Involvement of Advanced Glycation End Products in the Pathogenesis of Diabetic Retinopathy
Diabetic retinopathy (DR) is a common and devastating microvascular complication of diabetes and a major cause of acquired blindness in young adults. Advanced glycation end products (AGEs) accumulated under hyperglycemic conditions are thought to play an important role in the pathogenesis of DR. AGEs can exert their deleterious effects by acting directly to induce aberrant crosslinking of extracellular matrix proteins, to increase vascular stiffness, altering vascular structure and function. Moreover, AGEs binding to the receptor for AGEs (RAGE) evokes intensive intracellular signaling cascades that leading to endothelial ...
Source: Cellular Physiology and Biochemistry - July 19, 2018 Category: Cytology Source Type: research

Circulating Tumor Cells Correlate with Clinicopathological Features and Outcomes in Differentiated Thyroid Cancer
Conclusion: We found CTCs ≥ 5 to be a potential predictive index for DM+ DTC; and CTCs ≥7 as a possible indicator of poor response to131I treatment and worse prognosis in DM+ DTC.Cell Physiol Biochem 2018;48:718 –730 (Source: Cellular Physiology and Biochemistry)
Source: Cellular Physiology and Biochemistry - July 19, 2018 Category: Cytology Source Type: research

Function of SLC7A7 in T-Cell Acute Lymphoblastic Leukemia
Conclusions: SLC7A7 plays a significant role in the pathogenesis of T-cell acute lymphoblastic leukemia.Cell Physiol Biochem 2018;48:731 –740 (Source: Cellular Physiology and Biochemistry)
Source: Cellular Physiology and Biochemistry - July 19, 2018 Category: Cytology Source Type: research

Identification of the C-Reactive Protein Interaction Network Using a Bioinformatics Approach Provides Insights into the Molecular Pathogenesis of Hepatocellular Carcinoma
Conclusions: iTRAQ based proteomic profiling revealed the network of CRP interacting proteins. This network may activate the PI3K/Akt signaling pathway, thereby contributing to the pathogenesis of HCC.Cell Physiol Biochem 2018;48:741 –752 (Source: Cellular Physiology and Biochemistry)
Source: Cellular Physiology and Biochemistry - July 19, 2018 Category: Cytology Source Type: research

Activation of Cyclooxygenase-2 by ATF4 During Endoplasmic Reticulum Stress Regulates Kidney Podocyte Autophagy Induced by Lupus Nephritis
Conclusions: Our study suggests a novel molecular mechanism by which COX2 overexpression, induced by the ATF4 ER stress pathway, contributes to LN-induced kidney autophagy and injury. These data demonstrate that COX-2 may be a potential therapeutic target against LN-induced nephropathy.Cell Physiol Biochem 2018;48:753 –764 (Source: Cellular Physiology and Biochemistry)
Source: Cellular Physiology and Biochemistry - July 19, 2018 Category: Cytology Source Type: research

Rapamycin Reduces Podocyte Apoptosis and is Involved in Autophagy and mTOR/ P70S6K/4EBP1 Signaling
Conclusions: RAP can effectively inhibit the mTOR/P70S6K/4EBP1 signaling pathway, and activate podocyte autophagy, consequently reducing podocyte apoptosis. Therefore, RAP could be used for the treatment of idiopathic membranous nephropathy.Cell Physiol Biochem 2018;48:765 –772 (Source: Cellular Physiology and Biochemistry)
Source: Cellular Physiology and Biochemistry - July 19, 2018 Category: Cytology Source Type: research

Role of FGF-2 Transfected Bone Marrow Mesenchymal Stem Cells in Engineered Bone Tissue for Repair of Avascular Necrosis of Femoral Head in Rabbits
Conclusion: FGF-2 gene overexpression lentivirus transfection BMSCs combined with XACB to construct tissue engineered bone can effectively promote vascular regeneration, and improve the repair effect of avascular necrosis of the femoral head.Cell Physiol Biochem 2018;48:773 –784 (Source: Cellular Physiology and Biochemistry)
Source: Cellular Physiology and Biochemistry - July 19, 2018 Category: Cytology Source Type: research

SIRT1 Involved in the Regulation of Alternative Splicing Affects the DNA Damage Response in Neural Stem Cells
Conclusion: SIRT1 helps to regulate alternative splicing, which itself affects the DDR of NSCs. Our findings provide novel insight into the mechanisms underlying the DDR in stem cells.Cell Physiol Biochem 2018;48:657 –669 (Source: Cellular Physiology and Biochemistry)
Source: Cellular Physiology and Biochemistry - July 19, 2018 Category: Cytology Source Type: research

Beneficial Effects of Bushen Formula Combined with Enticavir on Chronic Hepatitis B Patients with Suboptimal Response to Enticavir by Regulating B-Cell Differentiation
Conclusions: The combination therapy with BSF plus ETV promotes the reduction of HBsAg level and the clearance of HBeAg in CHB patients with partial response to ETV through regulating the differentiation of B-cell subsets.Cell Physiol Biochem 2018;48:633 –643 (Source: Cellular Physiology and Biochemistry)
Source: Cellular Physiology and Biochemistry - July 19, 2018 Category: Cytology Source Type: research

Monocrotaline Suppresses RANKL-Induced Osteoclastogenesis < b > < i > In Vitro < /i > < /b > and Prevents LPS-Induced Bone Loss < b > < i > In Vivo < /i > < /b >
Conclusion: Taken together our data demonstrate that Mon may be a potential prophylactic anti-osteoclastic agent for the treatment of osteolytic diseases caused by excessive osteoclast formation and function.Cell Physiol Biochem 2018;48:644 –656 (Source: Cellular Physiology and Biochemistry)
Source: Cellular Physiology and Biochemistry - July 19, 2018 Category: Cytology Source Type: research

Na < sup > + < /sup > -Leak Channel, Non-Selective (NALCN) Regulates Myometrial Excitability and Facilitates Successful Parturition
Conclusions: Together, our findings demonstrate that the Na+ conducting channel NALCN contributes to the myometrial action potential waveform and is important for successful labor outcomes.Cell Physiol Biochem 2018;48:503 –515 (Source: Cellular Physiology and Biochemistry)
Source: Cellular Physiology and Biochemistry - July 18, 2018 Category: Cytology Source Type: research

Association Between Hypoxia-Inducible Factor-2 α (HIF-2α) Expression and Colorectal Cancer and Its Prognostic Role: a Systematic Analysis
Conclusions: HIF-2 α expression may be associated with the carcinogenesis of CRC, which is higher in males than in females, negatively linked to tumor differentiation, and correlated with a worse DFS of CRC. Additional prospective studies are needed.Cell Physiol Biochem 2018;48:516 –527 (Source: Cellular Physiology and Biochemistry)
Source: Cellular Physiology and Biochemistry - July 18, 2018 Category: Cytology Source Type: research

MiR-298 Exacerbates Ischemia/Reperfusion Injury Following Ischemic Stroke by Targeting Act1
Conclusions: Upregulation of miR-298 following ischemic stroke promotes brain injuryin vitro and vivo by inhibiting the Act1/JNK/NF- κB signaling cascade and the downstream autophagy pathway. Therapeutic strategies that target miR-298 could be beneficial for the treatment of ischemic stroke.Cell Physiol Biochem 2018;48:528 –539 (Source: Cellular Physiology and Biochemistry)
Source: Cellular Physiology and Biochemistry - July 18, 2018 Category: Cytology Source Type: research

LncRNA NEAT1 Promotes Deterioration of Hepatocellular Carcinoma Based on < b > < i > In Vitro Experiments, Data Mining, and < /i > < /b > RT-qPCR Analysis
Conclusions:NEAT1 contributes to the deterioration of HCC and provides a potential biomarker for the diagnosis and therapy of HCC.Cell Physiol Biochem 2018;48:540 –555 (Source: Cellular Physiology and Biochemistry)
Source: Cellular Physiology and Biochemistry - July 18, 2018 Category: Cytology Source Type: research

Browning of Pig White Preadipocytes by Co-Overexpressing Pig PGC-1 α and Mice UCP1
Conclusion: Our data suggest a model in which pig PGC-1 α and mice UCP1 work collaboratively to restore uncoupling respiration in pig preadipocytes. These results have great implications for piglet survival and developing an alternative treatment for human obesity in the future.Cell Physiol Biochem 2018;48:556 –568 (Source: Cellular Physiology and Biochemistry)
Source: Cellular Physiology and Biochemistry - July 18, 2018 Category: Cytology Source Type: research

Liposomal Curcumin Targeting Endometrial Cancer Through the NF- κB Pathway
Conclusions: LC was successfully prepared and played biological roles against EC probably through negative regulation of the NF- κB pathwayin vitro andin vivo, which demonstrates its potential therapeutic effects in EC.Cell Physiol Biochem 2018;48:569 –582 (Source: Cellular Physiology and Biochemistry)
Source: Cellular Physiology and Biochemistry - July 18, 2018 Category: Cytology Source Type: research

Ergosterol Attenuates LPS-Induced Myocardial Injury by Modulating Oxidative Stress and Apoptosis in Rats
Conclusions: We demonstrated that ER has a cardioprotective effect in LPS-induced sepsis model through modulation of the antioxidant activity and anti-apoptosis effects and this process might be regulated by Nrf2 signaling.Cell Physiol Biochem 2018;48:583 –592 (Source: Cellular Physiology and Biochemistry)
Source: Cellular Physiology and Biochemistry - July 18, 2018 Category: Cytology Source Type: research

MiR-4319 Suppress the Malignancy of Triple-Negative Breast Cancer by Regulating Self-Renewal and Tumorigenesis of Stem Cells
Conclusions: MiR-4319 suppresses the malignancy of TNBC by regulating self-renewal and tumorigenesis of stem cells and might be a remarkable prognostic factor or therapeutic target for patients with TNBC.Cell Physiol Biochem 2018;48:593 –604 (Source: Cellular Physiology and Biochemistry)
Source: Cellular Physiology and Biochemistry - July 18, 2018 Category: Cytology Source Type: research

Fibroblast Growth Factor 9 Suppresses Striatal Cell Death Dominantly Through ERK Signaling in Huntington ’s Disease
Conclusions: These results not only show the neuroprotective effects of FGF9, but also clarify the critical mechanisms in HD cells, further providing an insight for the therapeutic potential of FGF9 in HD.Cell Physiol Biochem 2018;48:605 –617 (Source: Cellular Physiology and Biochemistry)
Source: Cellular Physiology and Biochemistry - July 18, 2018 Category: Cytology Source Type: research

Abnormal Expression of Long Noncoding RNAs in Primary Immune Thrombocytopenia: A Microarray Related Study
Conclusions: These results suggest that lncRNAs act through targeted genes to mediate their functions and to mediate their functions and affect the pathogenesis of ITP.Cell Physiol Biochem 2018;48:618 –632 (Source: Cellular Physiology and Biochemistry)
Source: Cellular Physiology and Biochemistry - July 18, 2018 Category: Cytology Source Type: research

MicroRNA-141 Inhibits the Proliferation of Penile Cavernous Smooth Muscle Cells Associated with Down-Regulation of the Rhoa/Rho Kinase Signaling Pathway
Conclusion: Decreased expression of miR-141 is associated with up-regulation of RhoA and ROCK2 in the RhoA/ROCK signaling pathway in rats with diabetic erectile dysfunction. miR-141 inhibits the growth of penile cavernous smooth muscle cells associated with down-regulation of the RhoA/ROCK signaling pathwayin vitro.Cell Physiol Biochem 2018;48:348 –360 (Source: Cellular Physiology and Biochemistry)
Source: Cellular Physiology and Biochemistry - July 17, 2018 Category: Cytology Source Type: research

IL-8 Enhances Therapeutic Effects of BMSCs on Bone Regeneration via CXCR2-Mediated PI3k/Akt Signaling Pathway
Conclusions: IL-8 enhances therapeutic effects of MSCs on bone regeneration via CXCR2-mediated PI3k/Akt signaling pathway.Cell Physiol Biochem 2018;48:361 –370 (Source: Cellular Physiology and Biochemistry)
Source: Cellular Physiology and Biochemistry - July 17, 2018 Category: Cytology Source Type: research

LncRNA TP73-AS1 Promotes Cell Proliferation and Inhibits Cell Apoptosis in Clear Cell Renal Cell Carcinoma Through Repressing KISS1 Expression and Inactivation of PI3K/Akt/mTOR Signaling Pathway
Conclusion: In conclusion, we identified that TP73-AS1 as an oncogenic lncRNA in the development of ccRCC and a potential target for human renal carcinoma treatment.Cell Physiol Biochem 2018;48:371 –384 (Source: Cellular Physiology and Biochemistry)
Source: Cellular Physiology and Biochemistry - July 17, 2018 Category: Cytology Source Type: research

Comparison of the Effects of Ticagrelor and Clopidogrel on Inflammatory Factors, Vascular Endothelium Functions and Short-Term Prognosis in Patients with Acute ST-Segment Elevation Myocardial Infarction Undergoing Emergency Percutaneous Coronary Intervention: a Pilot Study
Conclusions: Compared with clopidogrel, ticagrelor appears to rapidly reduce the prevalence of inflammatory reactions and stabilize the functions of vascular endothelium to improve the stability of atherosclerotic plaque and decrease the occurrence rate of thrombosis as well as ischemic outcome events without any obvious increase in the risk of bleeding in patients with acute STEMI receiving urgent PCI. This renders it a potential drug for clinical practice. At the same time, measurement of ESM-1, a new biological marker for vascular endothelial function disorder, could possibly become a simple, effective, and practical ne...
Source: Cellular Physiology and Biochemistry - July 17, 2018 Category: Cytology Source Type: research

Role of 1 α,25-Dihydroxyvitamin D < sub > 3 < /sub > in Adipogenesis of SGBS Cells: New Insights into Human Preadipocyte Proliferation
Conclusions: We demonstrated for the first time that 1,25(OH)2D3 induces changes in preadipocytes, includingVDR expression and growth arrest, and increases the lipid content in adipocytes treated for 16 days. Preadipocytes are important cells in adipose tissue homeostasis, and understanding the role of 1,25(OH)2D3 in adipogenesis is a crucial step in ensuring adequate vitamin D supplementation, especially for obese individuals.Cell Physiol Biochem 2018;48:407 –418 (Source: Cellular Physiology and Biochemistry)
Source: Cellular Physiology and Biochemistry - July 17, 2018 Category: Cytology Source Type: research

VEGF-A and VEGF-B Coordinate the Arteriogenesis to Repair the Infarcted Heart with Vagus Nerve Stimulation
Conclusion: VNS promoted angiogenesis/arteriogenesis to repair the infracted heart through the synergistic effects of VEGF-A and VEGF-B.Cell Physiol Biochem 2018;48:433 –449 (Source: Cellular Physiology and Biochemistry)
Source: Cellular Physiology and Biochemistry - July 17, 2018 Category: Cytology Source Type: research

MicroRNA-29a-3p Downregulation Causes Gab1 Upregulation to Promote Glioma Cell Proliferation
Conclusions: miR-29a-3p downregulation leads to Gab1 upregulation to promote glioma cell proliferation.Cell Physiol Biochem 2018;48:450 –460 (Source: Cellular Physiology and Biochemistry)
Source: Cellular Physiology and Biochemistry - July 17, 2018 Category: Cytology Source Type: research

MiR-410 Acts as a Tumor Suppressor in Estrogen Receptor-Positive Breast Cancer Cells by Directly Targeting ERLIN2 via the ERS Pathway
Conclusions: Our study indicates that miR-410 suppresses cell growth, migration and invasion by directly downregulating ERLIN2 in ER positive breast cancer, acting as a tumor suppressor. Our study also suggests that miR-410 may serve as a potential therapeutic target for patients with ER positive breast cancer.Cell Physiol Biochem 2018;48:461 –474 (Source: Cellular Physiology and Biochemistry)
Source: Cellular Physiology and Biochemistry - July 17, 2018 Category: Cytology Source Type: research

Distinguishable Prognostic Signatures of Left- and Right-Sided Colon Cancer: a Study Based on Sequencing Data
Conclusions: This study constructs a panel of potential prognostic model of left- and right-sided colon cancers, respectively. We also provide molecular biological alterations between left- and right-sided colon cancers.Cell Physiol Biochem 2018;48:475 –490 (Source: Cellular Physiology and Biochemistry)
Source: Cellular Physiology and Biochemistry - July 17, 2018 Category: Cytology Source Type: research

Development of a Genetic and Clinical Data-Based (GC) Risk Score for Predicting Survival of Hepatocellular Carcinoma Patients After Tumor Resection
Conclusions: The genetic and clinical data-based risk scoring model can be a promising predictive tool for liver cancer patients ’ prognosis after operation.Cell Physiol Biochem 2018;48:491 –502 (Source: Cellular Physiology and Biochemistry)
Source: Cellular Physiology and Biochemistry - July 17, 2018 Category: Cytology Source Type: research

Regulation of Apoptosis and Radiation Sensitization in Lung Cancer Cells via the Sirt1/NF- κB/Smac Pathway
Conclusion: Our results indicate that SirT1 regulates apoptosis and radiation sensitization in lung cancer cell lines A549 and H460 via the SirT1/NF- κB/Smac pathway.Cell Physiol Biochem 2018;48:304 –316 (Source: Cellular Physiology and Biochemistry)
Source: Cellular Physiology and Biochemistry - July 17, 2018 Category: Cytology Source Type: research

Locally Produced IGF-1 Promotes Hypertrophy of the Ligamentum Flavum via the mTORC1 Signaling Pathway
Conclusions: Enhanced IGF-1 promotes the synthesis of collagen I and collagen III via the mTORC1 signaling pathway, which eventually contributes to hypertrophy of the ligamentum flavum.Cell Physiol Biochem 2018;48:293 –303 (Source: Cellular Physiology and Biochemistry)
Source: Cellular Physiology and Biochemistry - July 17, 2018 Category: Cytology Source Type: research

Prognostic Value of Circulating Lipoprotein in Patients with Locoregionally Advanced Nasopharyngeal Carcinoma
Conclusions: Circulating HDL is significantly associated with treatment outcomes in patients with locoregionally advanced NPC. We suggest that HDL measurements will be of great clinical significance in the management of NPC.Cell Physiol Biochem 2018;48:285 –292 (Source: Cellular Physiology and Biochemistry)
Source: Cellular Physiology and Biochemistry - July 16, 2018 Category: Cytology Source Type: research

Regulation of Memory CD8 < sup > + < /sup > T Cell Differentiation by MicroRNAs
MicroRNAs (miRNAs) have emerged as crucial regulators of T lymphocyte survival, differentiation and function, all of which are key factors impacting the outcome of adoptive T cell-based immunotherapy. It has become increasingly clear that the adoptive transfer of memory CD8+ T cell subsets is highly correlated with objective clinical responses for patients with advanced cancer. However, it is unclear how to improve the long-term persistence of transferred CD8+ T cells using miRNAs. Here, we highlight the current advances in our understanding of the role of miRNAs in regulating the differentiation of memory CD8+ T cells. We...
Source: Cellular Physiology and Biochemistry - July 16, 2018 Category: Cytology Source Type: research

CircRNA8924 Promotes Cervical Cancer Cell Proliferation, Migration and Invasion by Competitively Binding to MiR-518d-5p /519-5p Family and Modulating the Expression of CBX8
Conclusions: CircRNA8924 is highly expressed in CC tissue and can be considered a competitive endogenous RNA of the miR-518d-5p/519-5p family to promote the malignant biological behavior of CC cells. It is suggested that it may serve as a new biomarker for CC diagnosis and disease progression and provide potential targets for targeted therapy.Cell Physiol Biochem 2018;48:173 –184 (Source: Cellular Physiology and Biochemistry)
Source: Cellular Physiology and Biochemistry - July 13, 2018 Category: Cytology Source Type: research

Identification of a Panel of MiRNAs as Positive Regulators of Insulin Release in Pancreatic Β-Cells
Conclusions: Thus, our results shed further light on the regulatory network in β-cells consisting of miRNAs, UCP2, and insulin and provide novel therapeutic targets for diabetes.Cell Physiol Biochem 2018;48:185 –193 (Source: Cellular Physiology and Biochemistry)
Source: Cellular Physiology and Biochemistry - July 13, 2018 Category: Cytology Source Type: research

Effect of the LncRNA GAS5-MiR-23a-ATG3 Axis in Regulating Autophagy in Patients with Breast Cancer
Conclusions: In summary, we report that the GAS5-miR-23a-ATG3 axis can be regarded as a key regulator of autophagy pathways in breast cancer; it may constitute a promising biomarker and therapeutic target in the future.Cell Physiol Biochem 2018;48:194 –207 (Source: Cellular Physiology and Biochemistry)
Source: Cellular Physiology and Biochemistry - July 13, 2018 Category: Cytology Source Type: research

Apocynin Attenuates Cobalt Chloride-Induced Pheochromocytoma Cell Apoptosis by Inhibiting P38-MAPK/Caspase-3 Pathway
Conclusions: Our findings show that apocynin attenuated CoCl2-induced apoptosis by potently restraining p38-MAPK-caspase-3 signaling pathway in PC12 cells, suggesting that apocynin may be a potent prophylactic reagent against CoCl2-mediated PC12 cell apoptosis.Cell Physiol Biochem 2018;48:208 –214 (Source: Cellular Physiology and Biochemistry)
Source: Cellular Physiology and Biochemistry - July 13, 2018 Category: Cytology Source Type: research