International Journal of Molecular Medicine This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Effects of DNA methylation and its application in inflammatory bowel disease (Review)
Int J Mol Med. 2024 Jun;53(6):55. doi: 10.3892/ijmm.2024.5379. Epub 2024 May 2.ABSTRACTInflammatory bowel disease (IBD) is marked by persistent inflammation, and its development and progression are linked to environmental, genetic, immune system and gut microbial factors. DNA methylation (DNAm), as one of the protein modifications, is a crucial epigenetic process used by cells to control gene transcription. DNAm is one of the most common areas that has drawn increasing attention recently, with studies revealing that the interleukin (IL)‑23/IL‑12, wingless‑related integration site, IL‑6‑associated signal transduce...
Source: International Journal of Molecular Medicine - May 2, 2024 Category: Molecular Biology Authors: Francis Atim Akanyibah Yi Zhu Aijun Wan Dickson Kofi Wiredu Ocansey Yuxuan Xia An-Ning Fang Fei Mao Source Type: research

Predictive DNA damage signaling for low ‑dose ionizing radiation
Int J Mol Med. 2024 Jun;53(6):56. doi: 10.3892/ijmm.2024.5380. Epub 2024 May 2.ABSTRACTNumerous studies have attempted to develop biological markers for the response to radiation for broad and straightforward application in the field of radiation. Based on a public database, the present study selected several molecules involved in the DNA damage repair response, cell cycle regulation and cytokine signaling as promising candidates for low‑dose radiation‑sensitive markers. The HuT 78 and IM‑9 cell lines were irradiated in a concentration‑dependent manner, and the expression of these molecules was analyzed using weste...
Source: International Journal of Molecular Medicine - May 2, 2024 Category: Molecular Biology Authors: Jeong-In Park Seung-Youn Jung Kyung-Hee Song Dong-Hyeon Lee Jiyeon Ahn Sang-Gu Hwang In-Su Jung Dae-Seog Lim Jie-Young Song Source Type: research

[Corrigendum] MicroRNA ‑222‑3p promotes tumor cell migration and invasion and inhibits apoptosis, and is correlated with an unfavorable prognosis of patients with renal cell carcinoma
Int J Mol Med. 2024 Jun;53(6):53. doi: 10.3892/ijmm.2024.5377. Epub 2024 Apr 26.ABSTRACTFollowing the publication of the above article, an interested reader drew to the attention of the Editorial Office that, in Fig. 3A on p. 530, two pairs of data panels were overlapping, such that certain of the panels appeared to have been derived from the same original sources where the results from differently performed experiments were intended to have been portrayed. The authors have examined their original data, and realize that errors associated with data handling/labelling during the preparation of the representative images in Fi...
Source: International Journal of Molecular Medicine - April 26, 2024 Category: Molecular Biology Authors: Liwen Zhao Jing Quan Zuwei Li Xiang Pan Jingyao Wang Jinling Xu Weijie Xu Xin Guan Hang Li Shangqi Yang Yaoting Gui Yun Chen Yongqing Lai Source Type: research

Ultrasound ‑targeted microbubble destruction technology delivering β‑klotho to the heart enhances FGF21 sensitivity and attenuates heart remodeling post‑myocardial infarction
Int J Mol Med. 2024 Jun;53(6):54. doi: 10.3892/ijmm.2024.5378. Epub 2024 Apr 26.ABSTRACTFibroblast growth factor (FGF)21 is a peptide hormone that improves mitochondrial function and energy metabolism, and the deficiency of its co‑receptor β‑klotho (KLB) causes decreased FGF21 sensitivity. The present study examined whether the cardiac delivery of plasmids containing the KLB gene via ultrasound‑targeted microbubble destruction (UTMD) enhances the efficacy of FGF21 against heart failure post‑acute myocardial infarction (AMI). For this purpose, the levels of FGF21 in patients and rats with heart dysfunction post‑i...
Source: International Journal of Molecular Medicine - April 26, 2024 Category: Molecular Biology Authors: Chaofu Yue Rong Li Chunyan Li Taoxian Yang Xian Huang Rong Lei Yongjun Yan Yuan Liu Qiaolin Li Qinyong Yan Dingrong Zuo Shisheng Liu Mei Yang Source Type: research

Cell death ‑related molecules and targets in the progression of urolithiasis (Review)
Int J Mol Med. 2024 Jun;53(6):52. doi: 10.3892/ijmm.2024.5376. Epub 2024 Apr 26.ABSTRACTUrolithiasis is a high‑incidence disease caused by calcium oxalate (mainly), uric acid, calcium phosphate, struvite, apatite, cystine and other stones. The development of kidney stones is closely related to renal tubule cell damage and crystal adhesion and aggregation. Cell death, comprising the core steps of cell damage, can be classified into various types (i.e., apoptosis, ferroptosis, necroptosis and pyroptosis). Different crystal types, concentrations, morphologies and sizes cause tubular cell damage via the regulation of differe...
Source: International Journal of Molecular Medicine - April 26, 2024 Category: Molecular Biology Authors: Liping Wu Xiaoyan Xue Chengwu He Yongchang Lai Lingfei Tong Source Type: research