miR ‑187‑3p inhibitor attenuates cerebral ischemia/reperfusion injury by regulating Seipin‑mediated autophagic flux.
miR‑187‑3p inhibitor attenuates cerebral ischemia/reperfusion injury by regulating Seipin‑mediated autophagic flux. Int J Mol Med. 2020 Sep;46(3):1051-1062 Authors: Ren Z, Xie P, Lv J, Hu Y, Guan Z, Chen L, Yu W Abstract MicroRNAs (miRNAs/miRs) have been reported to affect ischemia/reperfusion (I/R)‑induced cerebral damage. miRNAs cause post‑transcriptional gene silencing by binding to the protein‑coding sequence (CDS) of mRNAs. Seipin has a potential role in regulating autophagic flux. The present study investigated the involvement of miR‑187‑3p in Seipin expression, autophagic flux a...
Source: International Journal of Molecular Medicine - July 28, 2020 Category: Molecular Biology Authors: Ren Z, Xie P, Lv J, Hu Y, Guan Z, Chen L, Yu W Tags: Int J Mol Med Source Type: research

Sulforaphane suppresses the viability and metastasis, and promotes the apoptosis of bladder cancer  cells by inhibiting the expression of FAT‑1.
Sulforaphane suppresses the viability and metastasis, and promotes the apoptosis of bladder cancer cells by inhibiting the expression of FAT‑1. Int J Mol Med. 2020 Sep;46(3):1085-1095 Authors: Wang F, Liu P, An H, Zhang Y Abstract FAT atypical cadherin 1 (FAT1) regulates complex mechanisms for the promotion of oncogenesis or the suppression of malignancies. Sulforaphane (SFN) has antioxidant and anti‑tumor activities. The present study investigated the roles of SFN and FAT1 in bladder cancer (BC). The expression of FAT1 in BC cell lines and tissues was measured by western blot analysis and re...
Source: International Journal of Molecular Medicine - July 28, 2020 Category: Molecular Biology Authors: Wang F, Liu P, An H, Zhang Y Tags: Int J Mol Med Source Type: research

Neuregulin ‑1, a microvascular endothelial‑derived protein, protects against myocardial ischemia‑reperfusion injury (Review).
Neuregulin‑1, a microvascular endothelial‑derived protein, protects against myocardial ischemia‑reperfusion injury (Review). Int J Mol Med. 2020 Sep;46(3):925-935 Authors: Lin Y, Liu H, Wang X Abstract As regards acute myocardial infarction, great success has been achieved in therapies that reduce the effects of myocardial ischemic injury, while few interventions have achieved satisfactory outcomes for myocardial ischemia‑reperfusion (IR) injury. Thus, new research is urgently required to achieve breakthroughs in promising treatments. Neuregulin‑1 (NRG‑1), which is an endothelium‑derived...
Source: International Journal of Molecular Medicine - July 28, 2020 Category: Molecular Biology Authors: Lin Y, Liu H, Wang X Tags: Int J Mol Med Source Type: research

Sensitivity assessment of droplet digital PCR for SARS-CoV-2 detection.
In conclusion, ddPCR shows higher sensitivity and specificity compared to RT‑qPCR for the diagnosis of COVID‑19 infection in false‑negative samples with low viral load. Therefore, ddPCR is strongly recommended in clinical practice for the diagnosis of COVID‑19 and the follow‑up of positive patients until complete remission. PMID: 32705153 [PubMed - in process] (Source: International Journal of Molecular Medicine)
Source: International Journal of Molecular Medicine - July 28, 2020 Category: Molecular Biology Authors: Falzone L, Musso N, Gattuso G, Bongiorno D, Palermo CI, Scalia G, Libra M, Stefani S Tags: Int J Mol Med Source Type: research

[Corrigendum] Kinase inhibitors fail to induce mesenchymal ‑epithelial transition in fibroblasts from fibrotic lung tissue.
[Corrigendum] Kinase inhibitors fail to induce mesenchymal‑epithelial transition in fibroblasts from fibrotic lung tissue. Int J Mol Med. 2020 Sep;46(3):1249 Authors: Xu X, Wan X, Geng J, Li F, Wang C, Dai H Abstract Following the publication of the above article, an interested reader drew to the authors' attention that Figs. 3A and 5A contained the same image derived under a light microscope. Fig. 3A was intending to show the cell morphology of primary cultured human lung fibroblasts. In examining their source data, the authors have come to realize that, during the process of figure prepa...
Source: International Journal of Molecular Medicine - July 28, 2020 Category: Molecular Biology Authors: Xu X, Wan X, Geng J, Li F, Wang C, Dai H Tags: Int J Mol Med Source Type: research

Milk ‑derived hexapeptide PGPIPN prevents and attenuates acute alcoholic liver injury in mice by reducing endoplasmic reticulum stress.
Milk‑derived hexapeptide PGPIPN prevents and attenuates acute alcoholic liver injury in mice by reducing endoplasmic reticulum stress. Int J Mol Med. 2020 Sep;46(3):1107-1117 Authors: Xu Q, Xi H, Chen X, Xu Y, Wang P, Li J, Wei W, Gu F, Qin Y Abstract Bioactive peptides are an emerging area of biomedical research in the study of numerous human diseases, including acute alcoholic liver injury (AALI). To study the role and mechanism of the milk‑derived hexapeptide Pro‑Gly‑Pro‑Ile‑Pro‑Asn (PGPIPN) in preventing and reducing AALI, the present study established a mouse model of AALI. PGP...
Source: International Journal of Molecular Medicine - July 28, 2020 Category: Molecular Biology Authors: Xu Q, Xi H, Chen X, Xu Y, Wang P, Li J, Wei W, Gu F, Qin Y Tags: Int J Mol Med Source Type: research

miR ‑144‑3p inhibits the proliferation, migration and angiogenesis of multiple myeloma cells by targeting myocyte enhancer factor 2A.
miR‑144‑3p inhibits the proliferation, migration and angiogenesis of multiple myeloma cells by targeting myocyte enhancer factor 2A. Int J Mol Med. 2020 Sep;46(3):1155-1165 Authors: Tian F, Wang H, Ma H, Zhong Y, Liao A Abstract Multiple myelomas (MM) are the second most common haematological malignancy, for which no curative treatments have been reported to date. MicroRNAs (miRNAs or miRs) have recently been shown to be involved in the proliferation of MM cells. However, the molecular mechanisms through which miRNAs regulate migration and angiogenesis in MM are poorly understood. Accordingly...
Source: International Journal of Molecular Medicine - July 28, 2020 Category: Molecular Biology Authors: Tian F, Wang H, Ma H, Zhong Y, Liao A Tags: Int J Mol Med Source Type: research

Propofol ‑induced HOXA11‑AS promotes proliferation, migration and invasion, but inhibits apoptosis in hepatocellular carcinoma cells by targeting miR‑4458.
Propofol‑induced HOXA11‑AS promotes proliferation, migration and invasion, but inhibits apoptosis in hepatocellular carcinoma cells by targeting miR‑4458. Int J Mol Med. 2020 Sep;46(3):1135-1145 Authors: Song F, Liu J, Feng Y, Jin Y Abstract Propofol is a commonly used drug for the induction and maintenance of anesthesia. Previous studies have reported that propofol is involved in the progression of numerous human cancer types, including hepatocellular carcinoma (HCC). However, the underlying molecular mechanisms in HCC are yet to be elucidated. The present study aimed to investigate t...
Source: International Journal of Molecular Medicine - July 28, 2020 Category: Molecular Biology Authors: Song F, Liu J, Feng Y, Jin Y Tags: Int J Mol Med Source Type: research

Knockdown of SNHG16 suppresses the proliferation and induces the apoptosis of leukemia cells via miR ‑193a‑5p/CDK8.
Knockdown of SNHG16 suppresses the proliferation and induces the apoptosis of leukemia cells via miR‑193a‑5p/CDK8. Int J Mol Med. 2020 Sep;46(3):1175-1185 Authors: Piao M, Zhang L Abstract Although small nucleolar RNA host gene 16 (SNHG16) is known to exhibit auxo‑action in certain types of tumor, its role in leukemia remains unclear. The present study analyzed the role and mechanisms of action of SNHG16 in leukemia cells in order to identify therapeutic targets for this disease. Reverse transcription‑quantitative polymerase chain reaction (RT‑qPCR) was performed to determine SNHG1...
Source: International Journal of Molecular Medicine - July 28, 2020 Category: Molecular Biology Authors: Piao M, Zhang L Tags: Int J Mol Med Source Type: research

Activation of SIRT1 promotes cartilage differentiation and reduces apoptosis of nucleus pulposus mesenchymal stem cells via the MCP1/CCR2 axis in subjects with intervertebral disc degeneration.
Abstract Intervertebral disc degeneration (IDD) is a condition involving disruption of the bone tissue distribution. Nucleus pulposus mesenchymal stem cells (NPMSCs) and Sirtuin 1 (SIRT1) play important roles in bone diseases, therefore the aim of the present study was to evaluate the roles of SIRT1 and NPMSCs in IDD. First, NPMSCs were harvested from patients with IDD. Then, the NPMSCs were treated with a SIRT activator, and monocyte chemoattractant protein 1 (MCP1) and chemokine receptor 2 (CCR2) inhibitors. Indices related to NPMSC growth, proliferation, differentiation and apoptosis were measure...
Source: International Journal of Molecular Medicine - July 28, 2020 Category: Molecular Biology Authors: Ou X, Ying J, Bai X, Wang C, Ruan D Tags: Int J Mol Med Source Type: research

Doxorubicin ‑induced oxidative and nitrosative stress: Mitochondrial connexin 43 is at the crossroads.
Doxorubicin‑induced oxidative and nitrosative stress: Mitochondrial connexin 43 is at the crossroads. Int J Mol Med. 2020 Sep;46(3):1197-1209 Authors: Pecoraro M, Pala B, Di Marcantonio MC, Muraro R, Marzocco S, Pinto A, Mincione G, Popolo A Abstract Oxidative stress is widely accepted as a key factor of doxorubicin (Doxo)‑induced cardiotoxicity. There is evidence to indicate that nitrosative stress is involved in this process, and that Doxo interacts by amplifying cell damage. Mitochondrial connexin 43 (mitoCx43) can confer cardioprotective effects through the reduction of mitochondrial reactive ...
Source: International Journal of Molecular Medicine - July 28, 2020 Category: Molecular Biology Authors: Pecoraro M, Pala B, Di Marcantonio MC, Muraro R, Marzocco S, Pinto A, Mincione G, Popolo A Tags: Int J Mol Med Source Type: research

miR ‑589‑3p sponged by the lncRNA TINCR inhibits the proliferation, migration and invasion and promotes the apoptosis of breast cancer cells by suppressing the Akt pathway via IGF1R.
miR‑589‑3p sponged by the lncRNA TINCR inhibits the proliferation, migration and invasion and promotes the apoptosis of breast cancer cells by suppressing the Akt pathway via IGF1R. Int J Mol Med. 2020 Sep;46(3):989-1002 Authors: Guo F, Zhu X, Zhao Q, Huang Q Abstract The long non‑coding (lnc)RNA named tissue differentiation inducing non‑protein coding RNA (TINCR) is a tumor marker that has not been studied in breast cancer. The present study aimed to investigate the TINCR‑targeting micro (mi)RNAs and the regulatory mechanisms of TINCR in breast cancer. Following prediction by TargetSca...
Source: International Journal of Molecular Medicine - July 28, 2020 Category: Molecular Biology Authors: Guo F, Zhu X, Zhao Q, Huang Q Tags: Int J Mol Med Source Type: research

hsa_circ_0058092 protects against hyperglycemia ‑induced endothelial progenitor cell damage via miR‑217/FOXO3.
hsa_circ_0058092 protects against hyperglycemia‑induced endothelial progenitor cell damage via miR‑217/FOXO3. Int J Mol Med. 2020 Sep;46(3):1146-1154 Authors: Cheng J, Hu W, Zheng F, Wu Y, Li M Abstract Circular RNAs (circRNAs) regulate the expression of genes that are critical for various biological and pathological processes. Previous studies have reported that the expression of hsa_circ_0058092 is decreased in patients with diabetes mellitus (DM); however, the specific role of this circRNA in DM is unknown. In the present study, endothelial progenitor cells (EPCs) were isolated and a decreased ...
Source: International Journal of Molecular Medicine - July 28, 2020 Category: Molecular Biology Authors: Cheng J, Hu W, Zheng F, Wu Y, Li M Tags: Int J Mol Med Source Type: research

Gut microbiota metabolites as integral mediators in cardiovascular diseases (Review).
Abstract Cardiovascular diseases (CVDs), such as atherosclerosis, hypertension, myocardial infarction and diabetic heart disease, are associated with high morbidity and mortality rates worldwide, and may also induce multiple organ failure in their later stages, greatly reducing the long‑term survival of the patients. There are several causes of CVDs, but after nearly a decade of investigation, researchers have found that CVDs are usually accompanied by an imbalance of gut microbiota and a decreased abundance of flora. More importantly, the metabolites produced by intestinal flora, such as trimethylamine and trim...
Source: International Journal of Molecular Medicine - July 28, 2020 Category: Molecular Biology Authors: Zhu Y, Shui X, Liang Z, Huang Z, Qi Y, He Y, Chen C, Luo H, Lei W Tags: Int J Mol Med Source Type: research

Downregulation of LINC00707 promotes osteogenic differentiation of human bone marrow ‑derived mesenchymal stem cells by regulating DKK1 via targeting miR‑103a‑3p.
In conclusion, the present results suggested that LINC00707 regulated DKK1 expression by targeting miR‑103a‑3p to regulate osteogenic differentiation. PMID: 32705245 [PubMed - in process] (Source: International Journal of Molecular Medicine)
Source: International Journal of Molecular Medicine - July 28, 2020 Category: Molecular Biology Authors: Liu J, Wu M, Feng G, Li R, Wang Y, Jiao J Tags: Int J Mol Med Source Type: research

Ingenuity pathway analysis of differentially expressed genes involved in signaling pathways and molecular networks in RhoE gene ‑edited cardiomyocytes.
Ingenuity pathway analysis of differentially expressed genes involved in signaling pathways and molecular networks in RhoE gene‑edited cardiomyocytes. Int J Mol Med. 2020 Sep;46(3):1225-1238 Authors: Shao Z, Wang K, Zhang S, Yuan J, Liao X, Wu C, Zou Y, Ha Y, Shen Z, Guo J, Jie W Abstract RhoE/Rnd3 is an atypical member of the Rho superfamily of proteins, However, the global biological function profile of this protein remains unsolved. In the present study, a RhoE‑knockout H9C2 cardiomyocyte cell line was established using CRISPR/Cas9 technology, following which differentially expressed genes (DEG...
Source: International Journal of Molecular Medicine - July 28, 2020 Category: Molecular Biology Authors: Shao Z, Wang K, Zhang S, Yuan J, Liao X, Wu C, Zou Y, Ha Y, Shen Z, Guo J, Jie W Tags: Int J Mol Med Source Type: research

Liriopesides B induces apoptosis and cell cycle arrest in human non ‑small cell lung cancer cells.
In conclusion, the results of the present study highlight a potential novel strategy for the clinical treatment of NSCLC. PMID: 32705266 [PubMed - in process] (Source: International Journal of Molecular Medicine)
Source: International Journal of Molecular Medicine - July 28, 2020 Category: Molecular Biology Authors: Sheng H, Lv W, Zhu L, Wang L, Wang Z, Han J, Hu J Tags: Int J Mol Med Source Type: research

Platelet ‑to‑lymphocyte ratio, neutrophil‑to‑lymphocyte ratio and monocyte‑to‑HDL cholesterol ratio as markers of peripheral artery disease in elderly patients.
Platelet‑to‑lymphocyte ratio, neutrophil‑to‑lymphocyte ratio and monocyte‑to‑HDL cholesterol ratio as markers of peripheral artery disease in elderly patients. Int J Mol Med. 2020 Sep;46(3):1210-1216 Authors: Selvaggio S, Abate A, Brugaletta G, Musso C, Di Guardo M, Di Guardo C, Vicari ESD, Romano M, Luca S, Signorelli SS Abstract Solid evidence underlines the pivotal role played by inflammation regarding atherosclerosis. Peripheral artery disease (PAD) is one of atherosclerotic cardiovascular diseases (CVDs), it is highly frequently diagnosed in older individuals. In the present...
Source: International Journal of Molecular Medicine - July 28, 2020 Category: Molecular Biology Authors: Selvaggio S, Abate A, Brugaletta G, Musso C, Di Guardo M, Di Guardo C, Vicari ESD, Romano M, Luca S, Signorelli SS Tags: Int J Mol Med Source Type: research

Inhibition of miRNA ‑135a‑5p ameliorates TGF‑β1‑induced human renal fibrosis by targeting SIRT1 in diabetic nephropathy.
In conclusion, knockdown of miR‑135a‑5p inhibits TGFβ1‑induced renal fibrosis by targeting SIRT1 and inactivating Smad3 signaling, providing a novel insight into miR‑135a‑5p as a potential therapeutic approach for DN. PMID: 32705273 [PubMed - in process] (Source: International Journal of Molecular Medicine)
Source: International Journal of Molecular Medicine - July 28, 2020 Category: Molecular Biology Authors: Zhang J, Zhang L, Zha D, Wu X Tags: Int J Mol Med Source Type: research

Co ‑expression of peripheral olfactory receptors with SARS‑CoV‑2 infection mediators: Potential implications beyond loss of smell as a COVID‑19 symptom.
Co‑expression of peripheral olfactory receptors with SARS‑CoV‑2 infection mediators: Potential implications beyond loss of smell as a COVID‑19 symptom. Int J Mol Med. 2020 Sep;46(3):949-956 Authors: Kerslake R, Hall M, Randeva HS, Spandidos DA, Chatha K, Kyrou I, Karteris E Abstract Severe acute respiratory syndrome (SARS) coronavirus‑2 (SARS‑CoV‑2) enters into human host cells via mechanisms facilitated mostly by angiotensin‑converting enzyme 2 (ACE2) and transmembrane protease serine 2 (TMPRSS2). New loss of smell (anosmia/hyposmia) is now recognized as a COVID‑19 related...
Source: International Journal of Molecular Medicine - July 28, 2020 Category: Molecular Biology Authors: Kerslake R, Hall M, Randeva HS, Spandidos DA, Chatha K, Kyrou I, Karteris E Tags: Int J Mol Med Source Type: research

MicroRNA ‑16 inhibits endometrial stromal cell migration and invasion through suppression of the inhibitor of nuclear factor‑κB kinase subunit β/nuclear factor‑κB pathway.
MicroRNA‑16 inhibits endometrial stromal cell migration and invasion through suppression of the inhibitor of nuclear factor‑κB kinase subunit β/nuclear factor‑κB pathway. Int J Mol Med. 2020 Aug;46(2):740-750 Authors: Wang X, Ren R, Shao M, Lan J Abstract Accumulating evidence has demonstrated that endometrial stromal cells (ESCs) are responsible for the pathogenesis of endometriosis (Ems), which is characterized by the presence of functional endometrial‑like tissues outside the uterine cavity. Abnormal expression of microRNAs (miRNAs) in ESCs may be implicated in the etiology...
Source: International Journal of Molecular Medicine - July 8, 2020 Category: Molecular Biology Authors: Wang X, Ren R, Shao M, Lan J Tags: Int J Mol Med Source Type: research

Hypercapnia exacerbates the disruption of the blood ‑brain barrier by inducing interleukin‑1β overproduction in the blood of hypoxemic adult rats.
Hypercapnia exacerbates the disruption of the blood‑brain barrier by inducing interleukin‑1β overproduction in the blood of hypoxemic adult rats. Int J Mol Med. 2020 Aug;46(2):762-772 Authors: Ding H, Liu X, Li X, Wen M, Li Y, Han Y, Huang L, Liu M, Zeng H Abstract Refractory hypoxemia is the main symptom of acute respiratory distress syndrome (ARDS). Low tidal volume ventilation is routinely applied in clinical practice to correct hypoxemia, which aims to prevent ventilator‑induced lung injury. However, this ventilation strategy inevitably leads to hypercapnia. Our previous study demonstra...
Source: International Journal of Molecular Medicine - July 8, 2020 Category: Molecular Biology Authors: Ding H, Liu X, Li X, Wen M, Li Y, Han Y, Huang L, Liu M, Zeng H Tags: Int J Mol Med Source Type: research

Circular RNA derived from TIMP2 functions as a competitive endogenous RNA and regulates intervertebral disc degeneration by targeting miR ‑185‑5p and matrix metalloproteinase 2.
In conclusion, the results of the present study revealed that circ‑TIMP2 promoted TNF‑α‑ and IL‑1β‑induced NP cell imbalance between ECM anabolism and catabolism via miR‑185‑5p‑MMP2 signaling. These findings provide a potential therapeutic option for the treatment of IDD. PMID: 32626912 [PubMed - in process] (Source: International Journal of Molecular Medicine)
Source: International Journal of Molecular Medicine - July 8, 2020 Category: Molecular Biology Authors: Guo W, Zhang B, Sun C, Duan HQ, Liu WX, Mu K, Zhao L, Li HR, Dong ZY, Cui Q Tags: Int J Mol Med Source Type: research

IL ‑27 suppresses airway inflammation, hyperresponsiveness and remodeling via the STAT1 and STAT3 pathways in mice with allergic asthma.
IL‑27 suppresses airway inflammation, hyperresponsiveness and remodeling via the STAT1 and STAT3 pathways in mice with allergic asthma. Int J Mol Med. 2020 Aug;46(2):641-652 Authors: Lu D, Lu J, Ji X, Ji Y, Zhang Z, Peng H, Sun F, Zhang C Abstract Type 2 cytokine‑associated immunity may be involved in the pathogenesis of allergic asthma. Although interleukin 27 (IL‑27) has been reported as an initiator and suppressor of T‑helper 1 (Th1) and T‑helper 2 (Th2) responses, respectively, its effects on the development of asthma remain unclear. In the present study, mice were induced and challenged...
Source: International Journal of Molecular Medicine - July 8, 2020 Category: Molecular Biology Authors: Lu D, Lu J, Ji X, Ji Y, Zhang Z, Peng H, Sun F, Zhang C Tags: Int J Mol Med Source Type: research

Inhibition of autophagy flux by sertraline attenuates TRAIL resistance in lung cancer via death receptor  5 upregulation.
Inhibition of autophagy flux by sertraline attenuates TRAIL resistance in lung cancer via death receptor 5 upregulation. Int J Mol Med. 2020 Aug;46(2):795-805 Authors: Zinnah KMA, Seol JW, Park SY Abstract Tumor necrosis factor‑related apoptosis‑inducing ligand (TRAIL) is a potential target for cancer therapy, owing to its ability to selectively kill cancer cells without causing significant toxicity to normal cells. However, due to the lack of death receptor expression, cancer cells can become highly resistant to TRAIL. Hence, it is vital to develop agents that restore TRAIL efficacy. Sertral...
Source: International Journal of Molecular Medicine - July 8, 2020 Category: Molecular Biology Authors: Zinnah KMA, Seol JW, Park SY Tags: Int J Mol Med Source Type: research

A dissection of SARS ‑CoV2 with clinical implications (Review).
A dissection of SARS‑CoV2 with clinical implications (Review). Int J Mol Med. 2020 Aug;46(2):489-508 Authors: Stancioiu F, Papadakis GZ, Kteniadakis S, Izotov BN, Coleman MD, Spandidos DA, Tsatsakis A Abstract We are being confronted with the most consequential pandemic since the Spanish flu of 1918‑1920 to the extent that never before have 4 billion people quarantined simultaneously; to address this global challenge we bring to the forefront the options for medical treatment and summarize SARS‑CoV2 structure and functions, immune responses and known treatments. Based on literature and our ...
Source: International Journal of Molecular Medicine - July 8, 2020 Category: Molecular Biology Authors: Stancioiu F, Papadakis GZ, Kteniadakis S, Izotov BN, Coleman MD, Spandidos DA, Tsatsakis A Tags: Int J Mol Med Source Type: research

Silencing of long non ‑coding antisense RNA brain‑derived neurotrophic factor attenuates hypoxia/ischemia‑induced neonatal brain injury.
Silencing of long non‑coding antisense RNA brain‑derived neurotrophic factor attenuates hypoxia/ischemia‑induced neonatal brain injury. Int J Mol Med. 2020 Aug;46(2):653-662 Authors: Qiao LX, Zhao RB, Wu MF, Zhu LH, Xia ZK Abstract Hypoxic/ischemic (HI) brain damage (HIBD) is a major cause of acute neonatal brain injury, leading to high mortality and serious neurological deficits. The antisense RNA of brain‑derived neurotrophic factor (BDNF‑AS) is transcribed from the opposite strand of the BDNF gene. The aim of the present study was to investigate the role of BDNF‑AS in HI‑induced neuro...
Source: International Journal of Molecular Medicine - July 8, 2020 Category: Molecular Biology Authors: Qiao LX, Zhao RB, Wu MF, Zhu LH, Xia ZK Tags: Int J Mol Med Source Type: research

Rotenone restrains colon cancer cell viability, motility and epithelial ‑mesenchymal transition and tumorigenesis in nude mice via the PI3K/AKT pathway.
In conclusion, the present study revealed that rotenone inhibited CC cell viability, motility, EMT and metastasis in vitro and in vivo by inhibiting the PI3K/AKT/mTOR signaling pathway. PMID: 32626924 [PubMed - in process] (Source: International Journal of Molecular Medicine)
Source: International Journal of Molecular Medicine - July 8, 2020 Category: Molecular Biology Authors: Xiao W, Liu Y, Dai M, Li Y, Peng R, Yu S, Liu H Tags: Int J Mol Med Source Type: research

miR ‑144‑3p inhibits tumor cell growth and invasion in oral squamous cell carcinoma through the downregulation of the oncogenic gene, EZH2.
miR‑144‑3p inhibits tumor cell growth and invasion in oral squamous cell carcinoma through the downregulation of the oncogenic gene, EZH2. Int J Mol Med. 2020 Aug;46(2):828-838 Authors: He L, Liao L, Du L Abstract Accumulating evidence demonstrates that microRNAs (miRNAs or miRs) play important roles in the development and progression of human malignancies, including oral squamous cell carcinoma (OSCC); however, the unique roles of miRNAs are not yet fully understood in OSCC. The present study aimed to identify novel miRNAs associated with OSCC and to elucidate their functions. Based on a mic...
Source: International Journal of Molecular Medicine - July 8, 2020 Category: Molecular Biology Authors: He L, Liao L, Du L Tags: Int J Mol Med Source Type: research

Sevoflurane preconditioning inhibits cardiomyocyte injury induced by oxygen ‑glucose deprivation by modulating TXNIP.
Sevoflurane preconditioning inhibits cardiomyocyte injury induced by oxygen‑glucose deprivation by modulating TXNIP. Int J Mol Med. 2020 Aug;46(2):889-897 Authors: Ma M, Li R, Sun W, Wang Q, Yu H, Yu H Abstract The thioredoxin interaction protein (TXNIP) has been reported to be closely related to cell oxidative stress, apoptosis and inflammation. TXNIP is involved in the regulation of oxidative stress in lung and renal injury. However, it is unclear as to whether it participates in the protective effects of sevoflurane preconditioning in cardiomyocyte injury caused by oxidative stress in ischemia. I...
Source: International Journal of Molecular Medicine - July 8, 2020 Category: Molecular Biology Authors: Ma M, Li R, Sun W, Wang Q, Yu H, Yu H Tags: Int J Mol Med Source Type: research

[Editorial] COVID ‑19: Post‑lockdown guidelines.
[Editorial] COVID‑19: Post‑lockdown guidelines. Int J Mol Med. 2020 Aug;46(2):463-466 Authors: Kostoff RN, Briggs MB, Porter AL, Aschner M, Spandidos DA, Tsatsakis A Abstract Since March, 2020, in response to the COVID‑19 pandemic, many countries have been on lockdown (at different levels of severity), restricting many activities and businesses that involve gatherings of large numbers of people in close proximity. Currently (early June, 2020), countries across the globe are in different stages of easing lockdown restrictions. Public policies for behaviors and actions during this transition perio...
Source: International Journal of Molecular Medicine - July 8, 2020 Category: Molecular Biology Authors: Kostoff RN, Briggs MB, Porter AL, Aschner M, Spandidos DA, Tsatsakis A Tags: Int J Mol Med Source Type: research

CTBP1 ‑AS2 inhibits proliferation and induces autophagy in ox‑LDL‑stimulated vascular smooth muscle cells by regulating miR‑195‑5p/ATG14.
CTBP1‑AS2 inhibits proliferation and induces autophagy in ox‑LDL‑stimulated vascular smooth muscle cells by regulating miR‑195‑5p/ATG14. Int J Mol Med. 2020 Aug;46(2):839-848 Authors: Wang Y, Zhang CX, Ge SL, Gong WH Abstract Atherosclerosis (AS) is a chronic progressive disease caused by injury and functional changes in vascular smooth muscle cells (VSMCs). Long non‑coding RNAs (lncRNAs) are pivotal regulators in AS development. The present study aimed to explore the roles and molecular mechanisms of lncRNA CTBP1‑AS2 in AS progression. A dual‑luciferase reporter assay confir...
Source: International Journal of Molecular Medicine - July 8, 2020 Category: Molecular Biology Authors: Wang Y, Zhang CX, Ge SL, Gong WH Tags: Int J Mol Med Source Type: research

Preliminary research on the effects and mechanisms of umbilical cord ‑derived mesenchymal stem cells in streptozotocin‑induced diabetic retinopathy.
Preliminary research on the effects and mechanisms of umbilical cord‑derived mesenchymal stem cells in streptozotocin‑induced diabetic retinopathy. Int J Mol Med. 2020 Aug;46(2):849-858 Authors: Zhao K, Liu J, Dong G, Xia H, Wang P, Xiao X, Chen Z Abstract Diabetic retinopathy (DR) is one of the most prevalent microvascular complications of diabetes, and a common cause of blindness in working‑age individuals. Mesenchymal stem cell (MSC) transplantation has been considered a promising intervention therapy for DR, wherein the differentiation of MSCs into nerve cells plays an essential role. Howeve...
Source: International Journal of Molecular Medicine - July 8, 2020 Category: Molecular Biology Authors: Zhao K, Liu J, Dong G, Xia H, Wang P, Xiao X, Chen Z Tags: Int J Mol Med Source Type: research

Long non ‑coding RNAs are novel players in oral inflammatory disorders, potentially premalignant oral epithelial lesions and oral squamous cell carcinoma (Review).
Long non‑coding RNAs are novel players in oral inflammatory disorders, potentially premalignant oral epithelial lesions and oral squamous cell carcinoma (Review). Int J Mol Med. 2020 Aug;46(2):535-545 Authors: Zhang K, Qiu W, Wu B, Fang F Abstract In recent years, a large number of studies have shown that the abnormal expression of long non‑coding (lnc)RNAs can lead to a variety of different diseases, including inflammatory disorders, cardiovascular disease, nervous system diseases, and cancers. Recent research has demonstrated the biological characteristics of lncRNAs and the important funct...
Source: International Journal of Molecular Medicine - July 8, 2020 Category: Molecular Biology Authors: Zhang K, Qiu W, Wu B, Fang F Tags: Int J Mol Med Source Type: research

Inhibitory effects of brusatol delivered using glycosaminoglycan ‑placental chondroitin sulfate A‑modified nanoparticles on the proliferation, migration and invasion of cancer cells.
Inhibitory effects of brusatol delivered using glycosaminoglycan‑placental chondroitin sulfate A‑modified nanoparticles on the proliferation, migration and invasion of cancer cells. Int J Mol Med. 2020 Aug;46(2):817-827 Authors: Chen X, Yin T, Zhang B, Sun B, Chen J, Xiao T, Wang B, Li M, Yang J, Fan X Abstract Breakthroughs in cancer management result from the development of drugs that can be used for early diagnosis and effective treatment. Surgery, chemotherapy, radiotherapy and hormone therapy are the main anticancer therapies. However, traditional cancer chemotherapy is associated w...
Source: International Journal of Molecular Medicine - July 8, 2020 Category: Molecular Biology Authors: Chen X, Yin T, Zhang B, Sun B, Chen J, Xiao T, Wang B, Li M, Yang J, Fan X Tags: Int J Mol Med Source Type: research

IL ‑18 knockout alleviates atopic dermatitis‑like skin lesions induced by MC903 in a mouse model.
IL‑18 knockout alleviates atopic dermatitis‑like skin lesions induced by MC903 in a mouse model. Int J Mol Med. 2020 Aug;46(2):880-888 Authors: Chen JL, Niu XL, Gao YL, Ma L, Gao XH, Chen HD, Qi RQ Abstract Interleukin (IL)‑18, a pro‑inflammatory cytokine, plays an important role in a number of skin diseases. The aim of the present study was to investigate the role of IL‑18 in the development of atopic dermatitis (AD). For this purpose, mice were divided into 4 groups (n=5/group) as follows: i) The wild‑type (WT) controls; ii) IL18 knockout (KO) controls; iii) MC90...
Source: International Journal of Molecular Medicine - July 8, 2020 Category: Molecular Biology Authors: Chen JL, Niu XL, Gao YL, Ma L, Gao XH, Chen HD, Qi RQ Tags: Int J Mol Med Source Type: research

lncRNA DGCR 5/miR ‑27a‑3p/BNIP3 promotes cell apoptosis in pancreatic cancer by regulating the p38 MAPK pathway.
lncRNA DGCR 5/miR‑27a‑3p/BNIP3 promotes cell apoptosis in pancreatic cancer by regulating the p38 MAPK pathway. Int J Mol Med. 2020 Aug;46(2):729-739 Authors: Li X, Zhou S, Fan T, Feng X Abstract Long non‑coding RNA (lncRNA) DGCR5 has been identified as a tumor suppressor in several types of cancer. However, its biological functions in pancreatic cancer (PaCa) have not yet been fully elucidated. The present study was designed to investigate the role of lncRNA DGCR5 in the regulation of PaCa cell apoptosis. For this purpose, lncRNA DGCR5, miR‑27a‑3p and Bcl‑2/adenovirus E1B‑19kDa‑intera...
Source: International Journal of Molecular Medicine - July 8, 2020 Category: Molecular Biology Authors: Li X, Zhou S, Fan T, Feng X Tags: Int J Mol Med Source Type: research

Exosomal microRNA ‑146a derived from mesenchymal stem cells increases the sensitivity of ovarian cancer cells to docetaxel and taxane via a LAMC2‑mediated PI3K/Akt axis.
Exosomal microRNA‑146a derived from mesenchymal stem cells increases the sensitivity of ovarian cancer cells to docetaxel and taxane via a LAMC2‑mediated PI3K/Akt axis. Int J Mol Med. 2020 Aug;46(2):609-620 Authors: Qiu L, Wang J, Chen M, Chen F, Tu W Abstract The carrier role of exosomes from human umbilical cord mesenchymal stem cells (hUCMSCs) containing microRNAs (miRNAs) has been implicated in gene and drug therapy. The aim of the present study was to investigate the role of exosomal microRNA‑146a (miR‑146a) from hUCMSCs in ovarian cancer (OC). Following the generation of docetaxel (DTX)...
Source: International Journal of Molecular Medicine - July 8, 2020 Category: Molecular Biology Authors: Qiu L, Wang J, Chen M, Chen F, Tu W Tags: Int J Mol Med Source Type: research

Paeonol exerts anti ‑tumor activity against colorectal cancer cells by inducing G0/G1 phase arrest and cell apoptosis via inhibiting the Wnt/β‑catenin signaling pathway.
Paeonol exerts anti‑tumor activity against colorectal cancer cells by inducing G0/G1 phase arrest and cell apoptosis via inhibiting the Wnt/β‑catenin signaling pathway. Int J Mol Med. 2020 Aug;46(2):675-684 Authors: Liu LH, Shi RJ, Chen ZC Abstract Paeonol is a simple phenolic compound isolated from herbal root bark, which has been reported to possess numerous biological and pharmacological characteristics, including a desirable anti‑tumor effect. To date, the effect of paeonol against colorectal cancer (CRC) cells is yet to be fully elucidated. Therefore, the present study aimed to identif...
Source: International Journal of Molecular Medicine - July 8, 2020 Category: Molecular Biology Authors: Liu LH, Shi RJ, Chen ZC Tags: Int J Mol Med Source Type: research

Ursolic acid protects against cisplatin ‑induced ototoxicity by inhibiting oxidative stress and TRPV1‑mediated Ca2+‑signaling.
Ursolic acid protects against cisplatin‑induced ototoxicity by inhibiting oxidative stress and TRPV1‑mediated Ca2+‑signaling. Int J Mol Med. 2020 Aug;46(2):806-816 Authors: Di Y, Xu T, Tian Y, Ma T, Qu D, Wang Y, Lin Y, Bao D, Yu L, Liu S, Wang A Abstract Cisplatin (CDDP) is widely used in clinical settings for the treatment of various cancers. However, ototoxicity is a major side effect of CDDP, and there is an associated risk of irreversible hearing loss. We previously demonstrated that CDDP could induce ototoxicity via activation of the transient receptor potential vanilloid receptor 1 (TRPV1...
Source: International Journal of Molecular Medicine - July 8, 2020 Category: Molecular Biology Authors: Di Y, Xu T, Tian Y, Ma T, Qu D, Wang Y, Lin Y, Bao D, Yu L, Liu S, Wang A Tags: Int J Mol Med Source Type: research

TRAP1 attenuates H9C2 myocardial cell injury induced by  extracellular acidification via the inhibition of MPTP opening.
TRAP1 attenuates H9C2 myocardial cell injury induced by extracellular acidification via the inhibition of MPTP opening. Int J Mol Med. 2020 Aug;46(2):663-674 Authors: Zhang L, Liu L, Li X, Zhang X, Zhao J, Luo Y, Guo X, Zhao T Abstract Extracellular acidification leads to cardiac dysfunction in numerous diseases. Mitochondrial dysfunction plays an important role in this process. However, the mechanisms through which extracellular acidification induces mitochondrial dysfunction remain unclear. Tumor necrosis factor receptor‑associated protein 1 (TRAP1) maintains mitochondrial function and cell v...
Source: International Journal of Molecular Medicine - July 8, 2020 Category: Molecular Biology Authors: Zhang L, Liu L, Li X, Zhang X, Zhao J, Luo Y, Guo X, Zhao T Tags: Int J Mol Med Source Type: research

Placental exosomes isolated from urine of patients with gestational diabetes exhibit a differential profile expression of microRNAs across gestation.
z DP, Salgado-Bustamante M, López-Hernández Y Abstract Placenta‑derived exosomes play an important role in cellular communication both in the mother and the fetus. Their concentration and composition are altered in several pregnancy disorders, such as gestational diabetes mellitus (GDM). The isolation and characterization of placental exosomes from serum, plasma and tissues from patients with GDM have been previously described; however, to the best of our knowledge, to date, there is no study available on placental exosomes isolated from urine of patients with GDM. In the present study, placen...
Source: International Journal of Molecular Medicine - July 8, 2020 Category: Molecular Biology Authors: Herrera-Van Oostdam AS, Toro-Ortíz JC, López JA, Noyola DE, García-López DA, Durán-Figueroa NV, Martínez-Martínez E, Portales-Pérez DP, Salgado-Bustamante M, López-Hernández Y Tags: Int J Mol Med Source Type: research

Update on current views and advances on RSV infection (Review).
Abstract Respiratory syncytial virus (RSV) infection represents an excellent paradigm of precision medicine in modern paediatrics and several clinical trials are currently performed in the prevention and management of RSV infection. A new taxonomic terminology for RSV was recently adopted, while the diagnostic and omics techniques have revealed new modalities in the early identification of RSV infections and for better understanding of the disease pathogenesis. Coordinated clinical and research efforts constitute an important step in limiting RSV global predominance, improving epidemiological surveillance, and adv...
Source: International Journal of Molecular Medicine - July 8, 2020 Category: Molecular Biology Authors: Mammas IN, Drysdale SB, Rath B, Theodoridou M, Papaioannou G, Papatheodoropoulou A, Koutsounaki E, Koutsaftiki C, Kozanidou E, Achtsidis V, Korovessi P, Chrousos GP, Spandidos DA Tags: Int J Mol Med Source Type: research

Phorbol myristate acetate induces cellular senescence in rat microglia in  vitro.
Phorbol myristate acetate induces cellular senescence in rat microglia in vitro. Int J Mol Med. 2020 Jul;46(1):415-426 Authors: Cao D, Li XH, Luo XG, Yu HM, Wan LS, Wei L, Ren Y Abstract The present study aimed to establish a cellular model to test the hypothesis that oncogene-induced senescence (OIS) is triggered by aging-related activation of microglia. Primary microglia were incubated with phorbol 12-myristate 13-acetate (PMA), and β-galactosidase (β-Gal) staining was applied to subsequent assessment of cellular senescence. Moreover, flow cytometry was employed for examinations of ce...
Source: International Journal of Molecular Medicine - July 1, 2020 Category: Molecular Biology Authors: Cao D, Li XH, Luo XG, Yu HM, Wan LS, Wei L, Ren Y Tags: Int J Mol Med Source Type: research

Effects of applying amoxicillin in juvenile mice on enamel mineralization and the expression of  kallikrein‑related peptidase 4 and tight junction proteins in ameloblasts.
Effects of applying amoxicillin in juvenile mice on enamel mineralization and the expression of kallikrein‑related peptidase 4 and tight junction proteins in ameloblasts. Int J Mol Med. 2020 Jul;46(1):179-190 Authors: Gao J, Li X, Gao L, Chen H, Baras BH, Liu X, Liu H, Rana A, Gao M, Ruan J Abstract Amoxicillin is a common pediatric drug. However, to the best of our knowledge, the role of amoxicillin in enamel hypomineralization has not yet been fully elucidated. The aim of the present study was to assess the effects of amoxicillin on enamel mineralization, the morphology of ameloblasts, a...
Source: International Journal of Molecular Medicine - July 1, 2020 Category: Molecular Biology Authors: Gao J, Li X, Gao L, Chen H, Baras BH, Liu X, Liu H, Rana A, Gao M, Ruan J Tags: Int J Mol Med Source Type: research

Astragaloside IV protects retinal pigment epithelial cells from apoptosis by upregulating miR ‑128 expression in diabetic rats.
Astragaloside IV protects retinal pigment epithelial cells from apoptosis by upregulating miR‑128 expression in diabetic rats. Int J Mol Med. 2020 Jul;46(1):340-350 Authors: Wang T, Zhang Z, Song C, Sun L, Sui X, Qu Q, Liu J Abstract The present study aimed to investigate the protective effects exerted by astragaloside‑IV (AIV) on retinal pigment epithelial (RPE) cells of rats with diabetes mellitus (DM), and to explore the underlying molecular mechanisms. For this purpose, a rat model of DM was established by injecting rats with an intraperitoneal injection of streptozotocin. AIV was then intraga...
Source: International Journal of Molecular Medicine - July 1, 2020 Category: Molecular Biology Authors: Wang T, Zhang Z, Song C, Sun L, Sui X, Qu Q, Liu J Tags: Int J Mol Med Source Type: research

MicroRNA ‑17 contributes to the suppression of the inflammatory response in lipopolysaccharide‑induced acute lung injury in mice via targeting the toll‑like receptor 4/nuclear factor‑κB pathway.
MicroRNA‑17 contributes to the suppression of the inflammatory response in lipopolysaccharide‑induced acute lung injury in mice via targeting the toll‑like receptor 4/nuclear factor‑κB pathway. Int J Mol Med. 2020 Jul;46(1):131-140 Authors: Fu S Abstract Acute lung injury (ALI) is a common lung disease with a high mortality rate, which is characterized by an excessive uncontrolled inflammatory response. MicroRNA (miR)‑17 has previously emerged as a novel regulatory molecule of inflammatory response in various complex diseases; however, the anti‑inflammatory action and associated mole...
Source: International Journal of Molecular Medicine - July 1, 2020 Category: Molecular Biology Authors: Fu S Tags: Int J Mol Med Source Type: research

MicroRNA ‑383‑5p inhibits the proliferation and promotes the apoptosis of gastric cancer cells by targeting cancerous inhibitor of PP2A.
MicroRNA‑383‑5p inhibits the proliferation and promotes the apoptosis of gastric cancer cells by targeting cancerous inhibitor of PP2A. Int J Mol Med. 2020 Jul;46(1):397-405 Authors: Li X, Yuan J, Cao Q, Xie A, Chen J Abstract The aberrant expression of microRNA (miRNAor miR)‑383‑5p has been found in numerous types of cancer. However, the function of miR‑383‑5p in gastric cancer (GC) remains elusive and requires further investigation. In the present study, the level of miR‑383‑5p and cancerous inhibitor of PP2A (CIP2A) in GC cell lines was determined by reverse transcription...
Source: International Journal of Molecular Medicine - July 1, 2020 Category: Molecular Biology Authors: Li X, Yuan J, Cao Q, Xie A, Chen J Tags: Int J Mol Med Source Type: research

miR ‑199a decreases Neuritin expression involved in the development of Alzheimer's disease in APP/PS1 mice.
miR‑199a decreases Neuritin expression involved in the development of Alzheimer's disease in APP/PS1 mice. Int J Mol Med. 2020 Jul;46(1):384-396 Authors: Song D, Li G, Hong Y, Zhang P, Zhu J, Yang L, Huang J Abstract Neuritin plays an important role in neural development and plasticity. A recent study demonstrated that increasing Neuritin levels attenuated synaptic damage in mice with Alzheimer's disease (AD), which exhibit a decreased Neuritin expression. However, it remains unclear as to whether Neuritin expression is regulated by microRNAs (miRNAs or miRs) in AD. In the present study, i...
Source: International Journal of Molecular Medicine - July 1, 2020 Category: Molecular Biology Authors: Song D, Li G, Hong Y, Zhang P, Zhu J, Yang L, Huang J Tags: Int J Mol Med Source Type: research

MicroRNA ‑1 regulates the development of osteoarthritis in a Col2a1‑Cre‑ERT2/GFPfl/fl‑RFP‑miR‑1 mouse model of osteoarthritis through the downregulation of Indian hedgehog expression.
MicroRNA‑1 regulates the development of osteoarthritis in a Col2a1‑Cre‑ERT2/GFPfl/fl‑RFP‑miR‑1 mouse model of osteoarthritis through the downregulation of Indian hedgehog expression. Int J Mol Med. 2020 Jul;46(1):360-370 Authors: Che X, Chen T, Wei L, Gu X, Gao Y, Liang S, Li P, Shi D, Liang B, Wang C, Li P Abstract The present study assessed the effects of microRNA‑1 (miR‑1) on the development of osteoarthritis using human tissues and a Col2a1‑Cre‑ERT2/GFPfl/fl‑RFP‑miR‑1 mouse model of osteoarthritis. Human cartilage tissues (n=20) were collected for reverse transcripti...
Source: International Journal of Molecular Medicine - July 1, 2020 Category: Molecular Biology Authors: Che X, Chen T, Wei L, Gu X, Gao Y, Liang S, Li P, Shi D, Liang B, Wang C, Li P Tags: Int J Mol Med Source Type: research