International Journal of Molecular Medicine This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Circular RNAs and the regulation of gene expression in diabetic nephropathy (Review)
Int J Mol Med. 2024 May;53(5):44. doi: 10.3892/ijmm.2024.5368. Epub 2024 Mar 22.ABSTRACTCircular RNAs (circRNAs) are non‑coding single‑stranded covalently closed RNA molecules that are considered important as regulators of gene expression at the transcriptional and post‑transcriptional levels. These molecules have been implicated in the initiation and progression of multiple human diseases, ranging from cancer to inflammatory and metabolic diseases, including diabetes mellitus and its vascular complications. The present article aimed to review the current knowledge on the biogenesis and functions of circRNAs, as well...
Source: International Journal of Molecular Medicine - March 22, 2024 Category: Molecular Biology Authors: Maximo Berto Martinez Benitez Yussel P érez Navarro Elisa Azuara-Liceaga Angeles Tecalco Cruz Jes ús Valdés Flores Lilia Lopez-Canovas Source Type: research

[Retracted] Sulforaphane regulates apoptosis ‑ and proliferation‑related signaling pathways and synergizes with cisplatin to suppress human ovarian cancer
Int J Mol Med. 2024 May;53(5):43. doi: 10.3892/ijmm.2024.5367. Epub 2024 Mar 22.ABSTRACTFollowing the publication of this paper, the authors realized that they had made an error in assembling the data shown in Fig. 6B on p. 2455, and requested the publication of a corrigendum to rectify this error. However, following an independent investigation of the data published in this paper made by the Editorial Office, it was noted that one set of the immunofluorescence assay images shown in Fig. 4A appeared to be strikingly similar to data appearing in different form in a paper published previously in the journal BMC Medicine by d...
Source: International Journal of Molecular Medicine - March 22, 2024 Category: Molecular Biology Authors: Shi-Feng Kan Jian Wang Guan-Xing Sun Source Type: research

Methylation ‑sensitive restriction enzyme‑droplet digital PCR assay for the one‑step highly sensitive analysis of DNA methylation hotspots
Int J Mol Med. 2024 May;53(5):42. doi: 10.3892/ijmm.2024.5366. Epub 2024 Mar 15.ABSTRACTDNA methylation is an epigenetic modification that plays a key role in several cellular processes mediating the fine regulation of gene expression. Aberrant DNA methylation is observed in a wide range of pathologies, including cancer. Since these DNA modifications are transferred to the cell progenies and are stable over the time, the analysis of DNA methylation status has been proposed for diagnostic and prognostic purposes in cancer. Currently, DNA bisulfite conversion is the gold standard method for the high‑throughput analysis of ...
Source: International Journal of Molecular Medicine - March 15, 2024 Category: Molecular Biology Authors: Giuseppe Gattuso Alessandro Lavoro Rosario Caltabiano Gabriele Madonna Mariaelena Capone Paolo Antonio Ascierto Luca Falzone Massimo Libra Saverio Candido Source Type: research

Role of circular RNA as competing endogenous RNA in ovarian cancer (Review)
Int J Mol Med. 2024 May;53(5):41. doi: 10.3892/ijmm.2024.5365. Epub 2024 Mar 8.ABSTRACTCircular RNA (circRNA), a type of non‑coding RNA, plays a regulatory role in biological processes. The special loop structure of circRNA makes it highly stable and specific in diseased tissues and cells, especially in tumors. Competing endogenous RNAs (ceRNAs) compete for the binding of microRNA (miRNA) at specific binding sites and thus regulate gene expression. ceRNAs play an important role in various diseases and are currently recognized as the most prominent mechanism of action of circRNAs. circRNAs can modulate the proliferation, ...
Source: International Journal of Molecular Medicine - March 8, 2024 Category: Molecular Biology Authors: Wanlu Ye Nan Xiang Qing Wang Yanming Lu Source Type: research