International Journal of Molecular Medicine This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Emerging nanomaterials targeting macrophage adapted to abnormal metabolism in cancer and atherosclerosis therapy (Review)
Int J Mol Med. 2024 Feb;53(2):13. doi: 10.3892/ijmm.2023.5337. Epub 2023 Dec 8.ABSTRACTMacrophages, as highly heterogeneous and plastic immune cells, occupy a pivotal role in both pro‑inflammatory (M1) and anti‑inflammatory (M2) responses. While M1‑type macrophages secrete pro‑inflammatory factors to initiate and sustain inflammation, M2‑type macrophages promote inflammation regression and uphold tissue homeostasis. These distinct phenotypic transitions in macrophages are closely linked to significant alterations in cellular metabolism, encompassing key response pathways such as glycolysis, pentose phosphate path...
Source: International Journal of Molecular Medicine - December 8, 2023 Category: Molecular Biology Authors: Miaomiao Xu Ying Cui Siyuan Wei Xuelong Cong Yiying Chen Shujie Tian Anqi Yao Weiwei Chen Lixing Weng Source Type: research

Role of vitamins beyond vitamin D < sub > 3 < /sub > in bone health and osteoporosis (Review)
The objective of the present review was to summarize the molecular mechanisms associated with the effects of the vitamins A, C, E and K, and group B vitamins on bone and their potential roles in the development of osteoporosis. Epidemiological findings have demonstrated an association between vitamin deficiency and a higher risk of developing osteoporosis; vitamins are positively related to bone health upon their intake at the physiological range. Excessive vitamin intake can also adversely affect bone formation, as clearly demonstrated for vitamin A. Vitamins E (tocopherols and tocotrienols), K2 (menaquinones 4 and 7) and...
Source: International Journal of Molecular Medicine - December 8, 2023 Category: Molecular Biology Authors: Anatoly V Skalny Michael Aschner Aristidis Tsatsakis Joao B T Rocha Abel Santamaria Demetrios A Spandidos Airton C Martins Rongzhu Lu Tatiana V Korobeinikova Wen Chen Jung-Su Chang Jane C J Chao Chong Li Alexey A Tinkov Source Type: research

< em > Kcnh2 < /em > deletion is associated with rat embryonic development defects via destruction of KCNH2 ‑integrin β1 complex
Int J Mol Med. 2024 Feb;53(2):14. doi: 10.3892/ijmm.2023.5338. Epub 2023 Dec 8.ABSTRACTThe Kv11.1 potassium channel encoded by the Kcnh2 gene is crucial in conducting the rapid delayed rectifier K+ current in cardiomyocytes. Homozygous mutation in Kcnh2 is embryonically lethal in humans and mice. However, the molecular signaling pathway of intrauterine fetal loss is unclear. The present study generated a Kcnh2 knockout rat based on edited rat embryonic stem cells (rESCs). Kcnh2 knockout was embryonic lethal on day 11.5 of development due to a heart configuration defect. Experiments with human embryonic heart single cells (...
Source: International Journal of Molecular Medicine - December 8, 2023 Category: Molecular Biology Authors: Sangyu Hu Zhigang Li Huan Liu Wenze Cao Yilei Meng Chang Liu Siyu He Qin Lin Mengyue Shang Fang Lin Na Yi Hanrui Wang Agapios Sachinidis Qilong Ying Li Li Luying Peng Source Type: research

[Retracted] Downregulation of ROS ‑FIG inhibits cell proliferation, colony‑formation, cell cycle progression, migration and invasion, while inducing apoptosis in intrahepatic cholangiocarcinoma cells
Int J Mol Med. 2024 Feb;53(2):11. doi: 10.3892/ijmm.2023.5335. Epub 2023 Dec 8.ABSTRACTFollowing the publication of this paper, it was drawn to the Editors' attention by a concerned reader that the western blotting data shown in Fig. 9 were strikingly similar to data appearing in different form in other articles written by different authors at different research institutes that had either already been published elsewhere prior to the submission of this paper to International Journal of Molecular Medicine, or were under consideration for publication at around the same time. In view of the fact that certain of these data had...
Source: International Journal of Molecular Medicine - December 8, 2023 Category: Molecular Biology Authors: Gang Deng Chenghuan Hu Lei Zhu Feizhou Huang Wei Huang Hongbo Xu Wanpin Nie Source Type: research

Nanobodies in cytokine ‑mediated immunotherapy and immunoimaging (Review)
Int J Mol Med. 2024 Feb;53(2):12. doi: 10.3892/ijmm.2023.5336. Epub 2023 Dec 8.ABSTRACTCytokines are the main regulators of innate and adaptive immunity, mediating communications between the cells of the immune system and regulating biological functions, including cell motility, differentiation, growth and apoptosis. Cytokines and cytokine receptors have been used in the treatment of tumors and autoimmune diseases, and to intervene in cytokine storms. Indeed, the use of monoclonal antibodies to block cytokine‑receptor interactions, as well as antibody‑cytokine fusion proteins has exhibited immense potential for the tre...
Source: International Journal of Molecular Medicine - December 8, 2023 Category: Molecular Biology Authors: Xiaochen Zhang Jin Wang Ying Tan Chaoting Chen Shuang Tang Shimei Zhao Qiuhong Qin Hansheng Huang Siliang Duan Source Type: research

An LGR4 agonist activates the GSK ‑3β pathway to inhibit RANK‑RANKL signaling during osteoclastogenesis in bone marrow‑derived macrophages
Int J Mol Med. 2024 Jan;53(1):10. doi: 10.3892/ijmm.2023.5334. Epub 2023 Dec 8.ABSTRACTThe binding between receptor‑activated nuclear factor‑κB (RANK) and the RANK ligand (RANKL) during osteoclast development is an important target for drugs that treat osteoporosis. The leucine‑rich repeat‑containing G‑protein‑coupled receptor 4 (LGR4) acts as a negative regulator of RANK‑RANKL that suppresses canonical RANK signaling during osteoclast differentiation. Therefore, LGR4 agonists may be useful in inhibiting osteoclastogenesis and effectively treating osteoporosis. In the present study, bone marrow‑derived mac...
Source: International Journal of Molecular Medicine - December 8, 2023 Category: Molecular Biology Authors: Yuria Jang Hyeonjoon Lee Yongjin Cho Eunseo Choi Suenghwan Jo Hong Moon Sohn Beom Chang Kim Young Jong Ko Wonbong Lim Source Type: research

Euphorbia factor L2 suppresses the generation of liver metastatic ascites in breast cancer via inhibiting NLRP3 inflammasome activation
Int J Mol Med. 2024 Jan;53(1):8. doi: 10.3892/ijmm.2023.5332. Epub 2023 Dec 8.ABSTRACTMetastasis is the leading cause of death in patients with breast cancer, in part due to the lack of effective treatments. Euphorbia factor L2 (EFL2) is a diterpenoid extracted from Euphorbia lathyris L. seeds, which has attracted increasing attention in recent years due to its anticancer effect. However, the role and molecular mechanism of EFL2 in breast cancer liver metastasis remain unclear. In the present study, a breast cancer liver metastasis model was constructed and the effect of EFL2 on ascites generation in mice was examined. H&a...
Source: International Journal of Molecular Medicine - December 8, 2023 Category: Molecular Biology Authors: Dongjing Jiang Xun Liu Rulan Tan Ye Zhu Li Zhang Source Type: research

Nrf2 protects against cartilage endplate degeneration through inhibiting NCOA4 ‑mediated ferritinophagy
Int J Mol Med. 2024 Feb;53(2):15. doi: 10.3892/ijmm.2023.5339. Epub 2023 Dec 8.ABSTRACTIron overload and ferroptosis are associated with intervertebral disc degeneration (IDD); however, the mechanism underlying the regulation of iron homeostasis remains to be elucidated. Nuclear factor erythroid 2‑related factor 2 (Nrf2) has been reported to regulate cellular iron homeostasis; however, its impact on IDD pathology and the underlying mechanism of action requires further investigation. In the present study, immunohistochemistry analysis of Nrf2 expression in the cartilage endplate (CEP) was conducted and it was demonstrated...
Source: International Journal of Molecular Medicine - December 8, 2023 Category: Molecular Biology Authors: Zhenkai Ma Hui Lu Xuemin Feng Ting Du Jianhua Li Qiang Zhang Xindong Gu Yuandong Shao Xingzhi Jing Cheng Su Source Type: research