International Journal of Molecular Medicine This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Adipocyte ‑rich microenvironment promotes chemoresistance via upregulation of peroxisome proliferator‑activated receptor gamma/ABCG2 in epithelial ovarian cancer
Int J Mol Med. 2024 Apr;53(4):37. doi: 10.3892/ijmm.2024.5361. Epub 2024 Mar 1.ABSTRACTThe effects of adipocyte‑rich microenvironment (ARM) on chemoresistance have garnered increasing interest. Ovarian cancer (OVCA) is a representative adipocyte‑rich associated cancer. In the present study, epithelial OVCA (EOC) was used to investigate the influence of ARM on chemoresistance with the aim of identifying novel targets and developing novel strategies to reduce chemoresistance. Bioinformatics analysis was used to explore the effects of ARM‑associated mechanisms contributing to chemoresistance and treated EOC cells, prima...
Source: International Journal of Molecular Medicine - March 1, 2024 Category: Molecular Biology Authors: Siqi Chen Zixuan Liu Haixia Wu Bo Wang Yuqing Ouyang Junru Liu Xiaoyan Zheng Haoke Zhang Xueying Li Xiaofan Feng Yan Li Yangyang Shen Hong Zhang Bo Xiao Chunyan Yu Weimin Deng Source Type: research

Identification of novel molecules and pathways associated with fascin actin ‑bundling protein 1 in laryngeal squamous cell carcinoma through comprehensive transcriptome analysis
Int J Mol Med. 2024 Apr;53(4):39. doi: 10.3892/ijmm.2024.5363. Epub 2024 Mar 1.ABSTRACTLaryngeal squamous cell carcinoma (LSCC) is a common malignant tumor with a poor prognosis. Fascin actin‑bundling protein 1 (FSCN1) has been reported to play a crucial role in the development and progression of LSCC; however, the underlying molecular mechanisms remain unknown. Herein, a whole transcriptome microarray analysis was performed to screen for differentially expressed genes (DEGs) in cells in which FSCN1 was knocked down. A total of 462 up and 601 downregulated mRNA transcripts were identified. Functional annotation analysis ...
Source: International Journal of Molecular Medicine - March 1, 2024 Category: Molecular Biology Authors: Hongliang Liu Wenjing Hao Xinfang Wang Yuliang Zhang Long He Xuting Xue Jiao Yang Chunming Zhang Source Type: research

[Corrigendum] Bax inhibitor ‑1 suppresses early brain injury following experimental subarachnoid hemorrhage in rats
Int J Mol Med. 2024 Apr;53(4):38. doi: 10.3892/ijmm.2024.5362. Epub 2024 Mar 1.ABSTRACTFollowing the publication of the above article, an interested reader drew to the authors' attention that, in Fig. 6 on p. 2898, the 'SAH' and 'SAH+NC' data panels contained an apparently overlapping section of data, such that these data appeared to have been derived from the same original source, even though they were intended to show the results from differently performed experiments. The authors have examined their original data, and realize that the 'SAH+NC' data panel had inadvertently been selected incorrectly for this figure. In ad...
Source: International Journal of Molecular Medicine - March 1, 2024 Category: Molecular Biology Authors: Jiaxin Liu Shuai Zhou Yueting Zhang Xiuying Li Xiying Qian Weihua Tao Lide Jin Jianhua Zhao Source Type: research

Cytoplasmic localization of SETDB1 ‑induced Warburg effect via c‑MYC‑LDHA axis enhances migration and invasion in breast carcinoma
In conclusion, subcellular localization of cytoplasmic SETDB1 may be a pivotal factor in breast cancer progression. The present study offers valuable insight into the novel functions and mechanisms of cytoplasmic SETDB1.PMID:38426579 | DOI:10.3892/ijmm.2024.5364 (Source: International Journal of Molecular Medicine)
Source: International Journal of Molecular Medicine - March 1, 2024 Category: Molecular Biology Authors: Wenlin Yang Yingze Wei Ting Wang Ying Xu Xiaoxia Jin Hongyan Qian Shuyun Yang Song He Source Type: research

Elimination of intracellular Ca < sup > 2+ < /sup > overload by BAPTA ‑AM liposome nanoparticles: A promising treatment for acute pancreatitis
Int J Mol Med. 2024 Apr;53(4):34. doi: 10.3892/ijmm.2024.5358. Epub 2024 Feb 23.ABSTRACTCalcium overload, a notable instigator of acute pancreatitis (AP), induces oxidative stress and an inflammatory cascade, subsequently activating both endogenous and exogenous apoptotic pathways. However, there is currently lack of available pharmaceutical interventions to alleviate AP by addressing calcium overload. In the present study, the potential clinical application of liposome nanoparticles (LNs) loaded with 1,2‑bis(2‑aminophenoxy)ethane‑N,N,N',N'‑tetraacetic acid tetrakis (acetoxymethyl ester) (BAPTA‑AM), a cell‑perm...
Source: International Journal of Molecular Medicine - February 23, 2024 Category: Molecular Biology Authors: Zailin Fu Dingsheng Wang Caiyun Zheng Minghua Xie Yifang Chen Yi Zhou Yan Huang Ying Song Weiyong Hong Source Type: research

Lymphangiogenesis: A new strategy for heart disease treatment (Review)
Int J Mol Med. 2024 Apr;53(4):35. doi: 10.3892/ijmm.2024.5359. Epub 2024 Feb 23.ABSTRACTHeart disease remains a global health challenge, contributing notably to morbidity and mortality. The lymphatic vasculature, an integral component of the cardiovascular system, plays a crucial role in regulating essential physiological processes, including fluid balance, transportation of extravasated proteins and immune cell trafficking, all of which are important for heart function. Through thorough scientometric analysis and extensive research, the present review identified lymphangiogenesis as a hotspot in cardiovascular disease res...
Source: International Journal of Molecular Medicine - February 23, 2024 Category: Molecular Biology Authors: Liding Bai Yanyan Wang Siqi Du Yumeng Si Lu Chen Lin Li Yuhong Li Source Type: research