International Journal of Molecular Medicine This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Vestibular dysfunction leads to cognitive impairments: State of knowledge in the field and clinical perspectives (Review)
Int J Mol Med. 2024 Apr;53(4):36. doi: 10.3892/ijmm.2024.5360. Epub 2024 Feb 23.ABSTRACTThe vestibular system may have a critical role in the integration of sensory information and the maintenance of cognitive function. A dysfunction in the vestibular system has a significant impact on quality of life. Recent research has provided evidence of a connection between vestibular information and cognitive functions, such as spatial memory, navigation and attention. Although the exact mechanisms linking the vestibular system to cognition remain elusive, researchers have identified various pathways. Vestibular dysfunction may lead...
Source: International Journal of Molecular Medicine - February 23, 2024 Category: Molecular Biology Authors: Jiaqi Guo Jun Wang Pei Liang E Tian Dan Liu Zhaoqi Guo Jingyu Chen Yuejin Zhang Zhanghong Zhou Weijia Kong Debbie C Crans Yisheng Lu Sulin Zhang Source Type: research

Elimination of intracellular Ca < sup > 2+ < /sup > overload by BAPTA ‑AM liposome nanoparticles: A promising treatment for acute pancreatitis
Int J Mol Med. 2024 Apr;53(4):34. doi: 10.3892/ijmm.2024.5358. Epub 2024 Feb 23.ABSTRACTCalcium overload, a notable instigator of acute pancreatitis (AP), induces oxidative stress and an inflammatory cascade, subsequently activating both endogenous and exogenous apoptotic pathways. However, there is currently lack of available pharmaceutical interventions to alleviate AP by addressing calcium overload. In the present study, the potential clinical application of liposome nanoparticles (LNs) loaded with 1,2‑bis(2‑aminophenoxy)ethane‑N,N,N',N'‑tetraacetic acid tetrakis (acetoxymethyl ester) (BAPTA‑AM), a cell‑perm...
Source: International Journal of Molecular Medicine - February 23, 2024 Category: Molecular Biology Authors: Zailin Fu Dingsheng Wang Caiyun Zheng Minghua Xie Yifang Chen Yi Zhou Yan Huang Ying Song Weiyong Hong Source Type: research

Lymphangiogenesis: A new strategy for heart disease treatment (Review)
Int J Mol Med. 2024 Apr;53(4):35. doi: 10.3892/ijmm.2024.5359. Epub 2024 Feb 23.ABSTRACTHeart disease remains a global health challenge, contributing notably to morbidity and mortality. The lymphatic vasculature, an integral component of the cardiovascular system, plays a crucial role in regulating essential physiological processes, including fluid balance, transportation of extravasated proteins and immune cell trafficking, all of which are important for heart function. Through thorough scientometric analysis and extensive research, the present review identified lymphangiogenesis as a hotspot in cardiovascular disease res...
Source: International Journal of Molecular Medicine - February 23, 2024 Category: Molecular Biology Authors: Liding Bai Yanyan Wang Siqi Du Yumeng Si Lu Chen Lin Li Yuhong Li Source Type: research

Protein aggregation and biomolecular condensation in hypoxic environments (Review)
Int J Mol Med. 2024 Apr;53(4):33. doi: 10.3892/ijmm.2024.5357. Epub 2024 Feb 16.ABSTRACTDue to molecular forces, biomacromolecules assemble into liquid condensates or solid aggregates, and their corresponding formation and dissolution processes are controlled. Protein homeostasis is disrupted by increasing age or environmental stress, leading to irreversible protein aggregation. Hypoxic pressure is an important factor in this process, and uncontrolled protein aggregation has been widely observed in hypoxia‑related conditions such as neurodegenerative disease, cardiovascular disease, hypoxic brain injury and cancer. Biomo...
Source: International Journal of Molecular Medicine - February 16, 2024 Category: Molecular Biology Authors: Chaoqun Li Bingjie Hao Haiguang Yang Kai Wang Lihong Fan Weihua Xiao Source Type: research

Research progress, challenges and perspectives of phospholipids metabolism in the LXR ‑LPCAT3 signaling pathway and its relation to NAFLD (Review)
Int J Mol Med. 2024 Apr;53(4):32. doi: 10.3892/ijmm.2024.5356. Epub 2024 Feb 16.ABSTRACTPhospholipids (PLs) are principle constituents of biofilms, with their fatty acyl chain composition significantly impacting the biophysical properties of membranes, thereby influencing biological processes. Recent studies have elucidated that fatty acyl chains, under the enzymatic action of lyso‑phosphatidyl‑choline acyltransferases (LPCATs), expedite incorporation into the sn‑2 site of phosphatidyl‑choline (PC), profoundly affecting pathophysiology. Accumulating evidence suggests that alterations in LPCAT activity are implicate...
Source: International Journal of Molecular Medicine - February 16, 2024 Category: Molecular Biology Authors: Junmin Wang Jiacheng Li Yugang Fu Yingying Zhu Liubing Lin Yong Li Source Type: research